LOCUS       NM_014012               1660 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RRAD and GEM like GTPase 1 (REM1), mRNA.
ACCESSION   NM_014012
VERSION     NM_014012.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1660)
  AUTHORS   Jhun,B.S., O-Uchi,J., Wang,W., Ha,C.H., Zhao,J., Kim,J.Y., Wong,C.,
            Dirksen,R.T., Lopes,C.M.B. and Jin,Z.G.
  TITLE     Adrenergic signaling controls RGK-dependent trafficking of cardiac
            voltage-gated L-type Ca2+ channels through PKD1
  JOURNAL   Circ Res 110 (1), 59-70 (2012)
   PUBMED   22076634
REFERENCE   2  (bases 1 to 1660)
  AUTHORS   Correll,R.N., Pang,C., Finlin,B.S., Dailey,A.M., Satin,J. and
            Andres,D.A.
  TITLE     Plasma membrane targeting is essential for Rem-mediated Ca2+
            channel inhibition
  JOURNAL   J Biol Chem 282 (39), 28431-28440 (2007)
   PUBMED   17686775
  REMARK    GeneRIF: a role for the Rem C terminus in plasma membrane
            localization through association with phosphatidylinositol lipids.
REFERENCE   3  (bases 1 to 1660)
  AUTHORS   Crump,S.M., Correll,R.N., Schroder,E.A., Lester,W.C., Finlin,B.S.,
            Andres,D.A. and Satin,J.
  TITLE     L-type calcium channel alpha-subunit and protein kinase inhibitors
            modulate Rem-mediated regulation of current
  JOURNAL   Am J Physiol Heart Circ Physiol 291 (4), H1959-H1971 (2006)
   PUBMED   16648185
  REMARK    GeneRIF: We conclude that Rem is capable of regulating L-type
            current, that release of Rem block is modulated by cellular kinase
            pathways, and that the Ca(V)1.2 COOH terminus contributes to
            Rem-dependent channel inhibition.
REFERENCE   4  (bases 1 to 1660)
  AUTHORS   Finlin,B.S., Crump,S.M., Satin,J. and Andres,D.A.
  TITLE     Regulation of voltage-gated calcium channel activity by the Rem and
            Rad GTPases
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 14469-14474 (2003)
   PUBMED   14623965
REFERENCE   5  (bases 1 to 1660)
  AUTHORS   Pan,J.Y., Fieles,W.E., White,A.M., Egerton,M.M. and
            Silberstein,D.S.
  TITLE     Ges, A human GTPase of the Rad/Gem/Kir family, promotes endothelial
            cell sprouting and cytoskeleton reorganization
  JOURNAL   J Cell Biol 149 (5), 1107-1116 (2000)
   PUBMED   10831614
  REMARK    Erratum:[J Cell Biol 2000 Jul 24;150(2):following 401]
REFERENCE   6  (bases 1 to 1660)
  AUTHORS   Finlin,B.S. and Andres,D.A.
  TITLE     Phosphorylation-dependent association of the Ras-related
            GTP-binding protein Rem with 14-3-3 proteins
  JOURNAL   Arch Biochem Biophys 368 (2), 401-412 (1999)
   PUBMED   10441394
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313060.1 and AF152863.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014012.5.
            
            Summary: The protein encoded by this gene is a GTPase and member of
            the RAS-like GTP-binding protein family. The encoded protein is
            expressed in endothelial cells, where it promotes reorganization of
            the actin cytoskeleton and morphological changes in the cells.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.462911.1, AF152863.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000201979.3/ ENSP00000201979.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AK313060.1         1-20
            21-1660             AF152863.1         3-1642
FEATURES             Location/Qualifiers
     source          1..1660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..1660
                     /gene="REM1"
                     /gene_synonym="GD:REM; GES"
                     /note="RRAD and GEM like GTPase 1"
                     /db_xref="GeneID:28954"
                     /db_xref="HGNC:HGNC:15922"
                     /db_xref="MIM:610388"
     exon            1..79
                     /gene="REM1"
                     /gene_synonym="GD:REM; GES"
                     /inference="alignment:Splign:2.1.0"
     exon            80..638
                     /gene="REM1"
                     /gene_synonym="GD:REM; GES"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1195
                     /gene="REM1"
                     /gene_synonym="GD:REM; GES"
                     /EC_number="3.6.5.2"
                     /note="RAS (RAD and GEM)-like GTP-binding 1;
                     GTPase-regulating endothelial cell sprouting"
                     /codon_start=1
                     /product="GTP-binding protein REM 1"
                     /protein_id="NP_054731.2"
                     /db_xref="CCDS:CCDS13181.1"
                     /db_xref="GeneID:28954"
                     /db_xref="HGNC:HGNC:15922"
                     /db_xref="MIM:610388"
                     /translation="MTLNTEQEAKTPLHRRASTPLPLSPRGHQPGRLSTVPSTQSQHP
                     RLGQSASLNPPTQKPSPAPDDWSSESSDSEGSWEALYRVVLLGDPGVGKTSLASLFAG
                     KQERDLHEQLGEDVYERTLTVDGEDTTLVVVDTWEAEKLDKSWSQESCLQGGSAYVIV
                     YSIADRGSFESASELRIQLRRTHQADHVPIILVGNKADLARCREVSVEEGRACAVVFD
                     CKFIETSATLQHNVAELFEGVVRQLRLRRRDSAAKEPPAPRRPASLAQRARRFLARLT
                     ARSARRRALKARSKSCHNLAVL"
     exon            639..721
                     /gene="REM1"
                     /gene_synonym="GD:REM; GES"
                     /inference="alignment:Splign:2.1.0"
     exon            722..923
                     /gene="REM1"
                     /gene_synonym="GD:REM; GES"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1660
                     /gene="REM1"
                     /gene_synonym="GD:REM; GES"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1498..1503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REM1"
                     /gene_synonym="GD:REM; GES"
                     /note="hexamer: AATAAA"
     polyA_site      1530
                     /gene="REM1"
                     /gene_synonym="GD:REM; GES"
     regulatory      1641..1646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REM1"
                     /gene_synonym="GD:REM; GES"
                     /note="hexamer: AATAAA"
     polyA_site      1660
                     /gene="REM1"
                     /gene_synonym="GD:REM; GES"
                     /note="major polyA site"
ORIGIN      
        1 gctcactgag gcgggtggta cagcctggag catccagccg ctggagctgc gagggaccct
       61 ggacccctcc cacgccgagg tttatgcaga gcctgaggcc agaaaaccta gggactttct
      121 gccccaagaa gctgaggcac ctcctactcc catctgaaca agagggggat ctggaagaag
      181 ccatacagca gctcatcagg acactataga aagaagcagc tcaaagcaat tggctgacag
      241 ccaattcccc cttctttcag aaggaaagaa ggaagaagca aacccccccc taccaaagat
      301 gacactcaac accgagcagg aagcaaagac ccctctgcac cggcgagcca gcaccccact
      361 gcccctgtcc ccacggggcc accagcctgg ccgcctgagc acagtgcctt ccactcaatc
      421 ccagcatccc cggctgggcc aatcagcctc cctcaaccct cccacccaga aaccttcacc
      481 tgccccagat gattggtctt ctgaatccag cgactctgaa ggctcctggg aggctctcta
      541 ccgtgtggtg ctacttggag atcctggagt ggggaagacc agcttggcca gcctctttgc
      601 agggaagcaa gagagggacc tccatgaaca gctgggagaa gatgtatatg agaggaccct
      661 cacggtggat ggagaagaca ccacactggt ggtcgtggac acctgggagg ccgagaaact
      721 ggataaaagc tggagccagg agtcatgcct gcaggggggc agtgcctatg tcatcgtata
      781 ctccatcgca gaccgaggca gctttgagag tgcctctgag ctccgcatcc agctgcggcg
      841 cacacatcag gcagaccatg tgcccatcat cctcgtgggc aacaaggcag acttggcccg
      901 ctgccgagaa gtctctgtgg aagagggccg cgcctgcgct gtggtgttcg actgtaaatt
      961 catcgagaca tccgccacgc tgcagcacaa tgtggccgag ctcttcgagg gcgtggtgcg
     1021 ccaactgcgc ttgcgccgcc gggacagtgc ggccaaggaa cccccagcac cccgacggcc
     1081 ggccagccta gcccagcgcg ctcgtcgctt cctggcacgc ctgacagccc gcagcgcacg
     1141 ccgccgggca ctcaaggccc gctccaagtc ctgccacaat ctggccgtgc tctgaagccc
     1201 cccgcccttc tgagagttgg cgggtcactg aggtgcattc tgggctccag ggacgccact
     1261 gcggggcaaa ggcgccgtta cctggagtct gcatcatggg tcttgcttgc ctgctgccct
     1321 gatggcctga gcatccccca gatccaagcc tgggggatcc cgggaaagcg atggacagac
     1381 agacgatggg gccgaagccc caagctgggc acaaagtagt tttttacgtg gtgggtgtct
     1441 ttttgtaaaa aaatcttcct tgtccctggg ctctggccaa ccctcagaaa ccctcacaat
     1501 aaaccagacc agaaggatgt cccatctgaa tgcccagacc tctccatctc ggctcttcca
     1561 ggcgtctcca cctactgccc tcccatctac acttgactgt agactggtct ggcctgctgg
     1621 cctgggcgtc agggcgcatc aataaagtac ttggaccagt
//
