LOCUS       NM_152222               3402 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens RELT TNF receptor (RELT), transcript variant 2, mRNA.
ACCESSION   NM_152222
VERSION     NM_152222.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3402)
  AUTHORS   Yao,W., Chen,Q., Li,S., Jia,X., Xu,L. and Wei,L.
  TITLE     RELT promotes the growth of esophageal squamous cell carcinoma by
            activating the NF-kappaB pathway
  JOURNAL   Cell Cycle 20 (13), 1231-1241 (2021)
   PUBMED   34121605
  REMARK    GeneRIF: RELT promotes the growth of esophageal squamous cell
            carcinoma by activating the NF-kappaB pathway.
REFERENCE   2  (bases 1 to 3402)
  AUTHORS   Nikolopoulos,G., Smith,C.E.L., Brookes,S.J., El-Asrag,M.E.,
            Brown,C.J., Patel,A., Murillo,G., O'Connell,M.J., Inglehearn,C.F.
            and Mighell,A.J.
  TITLE     New missense variants in RELT causing hypomineralised amelogenesis
            imperfecta
  JOURNAL   Clin Genet 97 (5), 688-695 (2020)
   PUBMED   32052416
  REMARK    GeneRIF: New missense variants in RELT causing hypomineralised
            amelogenesis imperfecta.
REFERENCE   3  (bases 1 to 3402)
  AUTHORS   Kim,J.W., Zhang,H., Seymen,F., Koruyucu,M., Hu,Y., Kang,J.,
            Kim,Y.J., Ikeda,A., Kasimoglu,Y., Bayram,M., Zhang,C., Kawasaki,K.,
            Bartlett,J.D., Saunders,T.L., Simmer,J.P. and Hu,J.C.
  TITLE     Mutations in RELT cause autosomal recessive amelogenesis imperfecta
  JOURNAL   Clin Genet 95 (3), 375-383 (2019)
   PUBMED   30506946
REFERENCE   4  (bases 1 to 3402)
  AUTHORS   Moua,P., Checketts,M., Xu,L.G., Shu,H.B., Reyland,M.E. and
            Cusick,J.K.
  TITLE     RELT family members activate p38 and induce apoptosis by a
            mechanism distinct from TNFR1
  JOURNAL   Biochem Biophys Res Commun 491 (1), 25-32 (2017)
   PUBMED   28688764
  REMARK    GeneRIF: Collectively, this study provides more insights into RELT
            expression, RELT family member function, and the mechanism of
            RELT-induced death.
REFERENCE   5  (bases 1 to 3402)
  AUTHORS   Cusick,J.K., Mustian,A., Jacobs,A.T. and Reyland,M.E.
  TITLE     Identification of PLSCR1 as a protein that interacts with RELT
            family members
  JOURNAL   Mol Cell Biochem 362 (1-2), 55-63 (2012)
   PUBMED   22052202
REFERENCE   6  (bases 1 to 3402)
  AUTHORS   Bossen,C., Ingold,K., Tardivel,A., Bodmer,J.L., Gaide,O.,
            Hertig,S., Ambrose,C., Tschopp,J. and Schneider,P.
  TITLE     Interactions of tumor necrosis factor (TNF) and TNF receptor family
            members in the mouse and human
  JOURNAL   J Biol Chem 281 (20), 13964-13971 (2006)
   PUBMED   16547002
REFERENCE   7  (bases 1 to 3402)
  AUTHORS   Polek,T.C., Talpaz,M. and Spivak-Kroizman,T.
  TITLE     The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and
            JNK activation
  JOURNAL   Biochem Biophys Res Commun 343 (1), 125-134 (2006)
   PUBMED   16530727
REFERENCE   8  (bases 1 to 3402)
  AUTHORS   Cusick,J.K., Xu,L.G., Bin,L.H., Han,K.J. and Shu,H.B.
  TITLE     Identification of RELT homologues that associate with RELT and are
            phosphorylated by OSR1
  JOURNAL   Biochem Biophys Res Commun 340 (2), 535-543 (2006)
   PUBMED   16389068
  REMARK    GeneRIF: Receptor expressed in lymphoid tissue (RELT) and its novel
            homologues RELL1 and RELL2 co-localize with one another at the
            plasma membrane.
REFERENCE   9  (bases 1 to 3402)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   10 (bases 1 to 3402)
  AUTHORS   Sica,G.L., Zhu,G., Tamada,K., Liu,D., Ni,J. and Chen,L.
  TITLE     RELT, a new member of the tumor necrosis factor receptor
            superfamily, is selectively expressed in hematopoietic tissues and
            activates transcription factor NF-kappaB
  JOURNAL   Blood 97 (9), 2702-2707 (2001)
   PUBMED   11313261
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000562.5 and AP000763.5.
            
            On Nov 26, 2018 this sequence version replaced NM_152222.1.
            
            Summary: The protein encoded by this gene is a member of the
            TNF-receptor superfamily. This receptor is especially abundant in
            hematologic tissues. It has been shown to activate the NF-kappaB
            pathway and selectively bind TNF receptor-associated factor 1
            (TRAF1). This receptor is capable of stimulating T-cell
            proliferation in the presence of CD3 signaling, which suggests its
            regulatory role in immune response. Two alternatively spliced
            transcript variants of this gene encoding the same protein have
            been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.628144.1, BC051810.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000064780.7/ ENSP00000064780.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AP000562.5         83892-83992
            102-171             AP000763.5         10594-10663
            172-246             AP000763.5         12033-12107
            247-413             AP000763.5         12237-12403
            414-493             AP000763.5         12626-12705
            494-751             AP000763.5         13693-13950
            752-832             AP000763.5         15319-15399
            833-914             AP000763.5         15718-15799
            915-1172            AP000763.5         15959-16216
            1173-1371           AP000763.5         16569-16767
            1372-3402           AP000763.5         16926-18956
FEATURES             Location/Qualifiers
     source          1..3402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..3402
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /note="RELT TNF receptor"
                     /db_xref="GeneID:84957"
                     /db_xref="HGNC:HGNC:13764"
                     /db_xref="MIM:611211"
     exon            1..101
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /inference="alignment:Splign:2.1.0"
     exon            102..171
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1419
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; receptor expressed in lymphoid tissues; RELT
                     tumor necrosis factor receptor"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 19L isoform 1 precursor"
                     /protein_id="NP_689408.1"
                     /db_xref="CCDS:CCDS8222.1"
                     /db_xref="GeneID:84957"
                     /db_xref="HGNC:HGNC:13764"
                     /db_xref="MIM:611211"
                     /translation="MKPSLLCRPLSCFLMLLPWPLATLTSTTLWQCPPGEEPDLDPGQ
                     GTLCRPCPPGTFSAAWGSSPCQPHARCSLWRRLEAQVGMATRDTLCGDCWPGWFGPWG
                     VPRVPCQPCSWAPLGTHGCDEWGRRARRGVEVAAGASSGGETRQPGNGTRAGGPEETA
                     AQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAHKEVGPGPGGGGSGINPAYRTED
                     ANEDTIGVLVRLITEKKENAAALEELLKEYHSKQLVQTSHRPVSKLPPAPPNVPHICP
                     HRHHLHTVQGLASLSGPCCSRCSQKKWPEVLLSPEAVAATTPVPSLLPNPTRVPKAGA
                     KAGRQGEITILSVGRFRVARIPEQRTSSMVSEVKTITEAGPSWGDLPDSPQPGLPPEQ
                     QALLGSGGSRTKWLKPPAENKAEENRYVVRLSESNLVI"
     exon            172..246
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /inference="alignment:Splign:2.1.0"
     exon            247..413
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /inference="alignment:Splign:2.1.0"
     exon            414..493
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /inference="alignment:Splign:2.1.0"
     exon            494..751
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /inference="alignment:Splign:2.1.0"
     exon            752..832
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /inference="alignment:Splign:2.1.0"
     exon            833..914
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1172
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1371
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..3402
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2549..2554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /note="hexamer: AATAAA"
     polyA_site      2573
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /note="major polyA site"
     regulatory      2906..2911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /note="hexamer: TATAAA"
     polyA_site      2931
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
     regulatory      3380..3385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /note="hexamer: CATAAA"
     polyA_site      3402
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
ORIGIN      
        1 aaaaggcgcg caggctgcgc ggctgtccgg gcgctcgccg agccgggccg cggcgccgag
       61 tcgaacgggg agccgagctg gagctgccgc ggcgcagcca ggccggcgac caccaggggc
      121 ctgaggatga agccaagtct gctgtgccgg cccctgtcct gcttccttat gctgctgccc
      181 tggcctctcg ccaccctgac atcaacaacc ctttggcagt gcccacctgg ggaggagccc
      241 gacctggacc cagggcaggg cacattatgc aggccctgcc ccccaggcac cttctcagct
      301 gcatggggct ccagcccatg ccagccccat gcccgttgca gcctttggag gaggctggag
      361 gcccaggtgg gcatggcaac tcgagataca ctctgtggag actgctggcc tgggtggttt
      421 gggccttggg gggttccccg cgttccatgt caaccatgtt cctgggcacc tctgggtact
      481 catggctgtg atgagtgggg gcggcgggcc cgacgtggcg tggaggtggc agcaggggcc
      541 agcagcggtg gtgagacacg gcagcctggg aacggcaccc gggcaggtgg cccagaggag
      601 acagccgccc agtacgcggt catcgccatc gtccctgtct tctgcctcat ggggctgttg
      661 ggcatcctgg tgtgcaacct cctcaagcgg aagggctacc actgcacggc gcacaaggag
      721 gtcgggcccg gccctggagg tggaggcagt ggaatcaacc ctgcctaccg gactgaggat
      781 gccaatgagg acaccattgg ggtcctggtg cgcttgatca cagagaagaa agagaatgct
      841 gcggccctgg aggagctgct gaaagagtac cacagcaaac agctggtgca gacgagccac
      901 aggcctgtgt ccaagctgcc gccagcgccc ccgaacgtgc cacacatctg cccgcaccgc
      961 caccatctcc acaccgtgca gggcctggcc tcgctctctg gcccctgctg ctcccgctgt
     1021 agccagaaga agtggcccga ggtgctgctg tcccctgagg ctgtagccgc cactactcct
     1081 gttcccagcc ttctgcctaa cccgaccagg gttcccaagg ccggggccaa ggcagggcgt
     1141 cagggcgaga tcaccatctt gtctgtgggc aggttccgcg tggctcgaat tcctgagcag
     1201 cggacaagtt caatggtgtc tgaggtgaag accatcacgg aggctgggcc ctcgtggggt
     1261 gatctccctg actccccaca gcctggcctc ccccctgagc agcaggccct gctaggaagt
     1321 ggcggaagcc gtacaaagtg gctgaagccc ccagcagaga acaaggccga ggagaaccgc
     1381 tatgtggtcc ggctaagtga gagcaacctg gtcatctgag gggcggtcta gtctaaggac
     1441 actgcggccc tgccctggga ggttccgaag gcttcctgga ggaggtggag ctgcagctgg
     1501 gactgtgagg accgagaagc aatggcccag cagacgagac agcaaagacc aaggcctgga
     1561 ggtgggagcg tctgccccag tgaggaggca ggtggccggc gggcactgtg tacaggagca
     1621 ggctgagccc cgcccctggc cctgctgcca tgttgctccc ctgaaggatg ccccgacccc
     1681 cgtgcctgcc ctggctggat cctaggagcc cacgggattc tctgtatcat cagaggctgg
     1741 gcttggcaga ggggaggggc ctgtgcccgt cacccctggc cccattcctt ggtaattagc
     1801 cacacccttg cctctgtaca gggccctaga gcagatgtgc gtccccctcc tcttccagca
     1861 ggtctataaa gggaaggggt agcagaaagt cctgggctag gagagtgagt ccctgggttc
     1921 taatcttggg cacatctgtg gccatcgctg ggtccatttt tctgactgtg aagtaaggag
     1981 agacgtctca gtacccaggg cctcttcagc tctttgtagg ttctgggctg ggttgtgggg
     2041 gactggggag ctgggctcta ccatccctcc cattagtagc tttatccagc cccgtttttg
     2101 ctgcttccag ggcctctgcc ttcaaggccc ccatggggct gtccatccat ggctctgcct
     2161 acggaagggg cttaatgcat gtgcctgccc ctcccccagc tgtttttaat gaaactgaaa
     2221 aaatagactt gatcccggca ggactgtgat acagagccct agcctgccca gccagcccca
     2281 agatctcagg agctttaggg agaagacttg gtggggctgg agcacacctt gggcctcagt
     2341 ggtttctgtg tccctgtggt gccagtgctt ctgggcagtg caggcggctg ccaggcccag
     2401 ccctgacttc cactctggct cagcaacctg gttatttatg tggggccgtg caggcatggg
     2461 cccactgcct gtccatcctg tttctcttat ttattgaaac tcaccattgc cctatccttg
     2521 tgtctccacc cccttccatg tgttgaataa taaaaggtgg gaaagtgctg tcacgaggag
     2581 ctccttttct ctgtgccctt cccagcttat ccgcctgttc cacttgtacc tgtccagccc
     2641 tgccctgtgt tgggcaccgt gacaggctgc cctcccctca cagttcctgc acctcagcag
     2701 ccagggaagc agggcccaga ggagacccat caactcatct ggttctcacc aaagccccta
     2761 gctagaggca gggctgtccc acagaaatag tgtgagccac atatgtgact ttaaattttc
     2821 tgacagtcac atttcaaaaa gtaaaaagaa gcaggtgaac ttaatttttt tttaacccag
     2881 tctatccaaa atattttcat ttcaatataa aatcagtata aaaagtgtga atgagctgtt
     2941 tttgcttttg ctttgaaatc tggagtgtat cttacacatc ttgattggaa ctcaaatatt
     3001 tcaagggctc catagccacg tggccagcag ctaccacact ggtcagcgca gcacctgagg
     3061 aaatgcactg tgtggagccc gggaggtaat tgggggtgag gaagatgtgc gggccaggga
     3121 atgtgttcca cagagaggga cagcatgtgc aaaggctgag caccaacaca tagtggtcac
     3181 ctgggcctta tgcccaggga gcctccaaag cattcagctc ctgcttggcc agtgtggaga
     3241 ggaaaggagc cacaggagcg ggtgctacac ccggcaagac agagcgtctc catctaaaat
     3301 tcctagggca agcttccaac ccggcccaag ggccgcatgt ggcccaggat atggctttga
     3361 atggggccta acacaaattc ataaactttc ttaaaacatt ga
//
