LOCUS       NM_173828               2536 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RELT like 2 (RELL2), transcript variant 1, mRNA.
ACCESSION   NM_173828
VERSION     NM_173828.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2536)
  AUTHORS   Musha,K., Ge,X., Ablikim,N., Lu,B., Chen,C. and Huang,J.
  TITLE     Comprehensive Analysis of RELL2 as a Potential Biomarker Associated
            with Tumor Immune Infiltrating Cells in a Pan-Cancer Analysis
  JOURNAL   Dis Markers 2022, 5009512 (2022)
   PUBMED   35634441
  REMARK    GeneRIF: Comprehensive Analysis of RELL2 as a Potential Biomarker
            Associated with Tumor Immune Infiltrating Cells in a Pan-Cancer
            Analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2536)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2536)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2536)
  AUTHORS   Moua,P., Checketts,M., Xu,L.G., Shu,H.B., Reyland,M.E. and
            Cusick,J.K.
  TITLE     RELT family members activate p38 and induce apoptosis by a
            mechanism distinct from TNFR1
  JOURNAL   Biochem Biophys Res Commun 491 (1), 25-32 (2017)
   PUBMED   28688764
REFERENCE   5  (bases 1 to 2536)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2536)
  AUTHORS   Cusick,J.K., Mustian,A., Jacobs,A.T. and Reyland,M.E.
  TITLE     Identification of PLSCR1 as a protein that interacts with RELT
            family members
  JOURNAL   Mol Cell Biochem 362 (1-2), 55-63 (2012)
   PUBMED   22052202
REFERENCE   7  (bases 1 to 2536)
  AUTHORS   Cusick,J.K., Mustian,A., Goldberg,K. and Reyland,M.E.
  TITLE     RELT induces cellular death in HEK 293 epithelial cells
  JOURNAL   Cell Immunol 261 (1), 1-8 (2010)
   PUBMED   19969290
  REMARK    GeneRIF: report that overexpression of RELT or its homologues RELL1
            and RELL2 in HEK 293 epithelial cells results in cell death with
            morphological characteristics consistent with the activation of an
            apoptotic pathway.
REFERENCE   8  (bases 1 to 2536)
  AUTHORS   Cusick,J.K., Xu,L.G., Bin,L.H., Han,K.J. and Shu,H.B.
  TITLE     Identification of RELT homologues that associate with RELT and are
            phosphorylated by OSR1
  JOURNAL   Biochem Biophys Res Commun 340 (2), 535-543 (2006)
   PUBMED   16389068
  REMARK    GeneRIF: Binds to the TNF receptor family member RELT; homologue of
            RELT.
REFERENCE   9  (bases 1 to 2536)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054889.1, AY358163.1 and AK075064.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173828.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1150035.1, AK075064.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297164.8/ ENSP00000297164.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AK054889.1         48-78
            32-1625             AY358163.1         15-1608
            1626-2201           AK075064.1         500-1075
            2202-2536           AY358163.1         2185-2519
FEATURES             Location/Qualifiers
     source          1..2536
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..2536
                     /gene="RELL2"
                     /gene_synonym="C5orf16"
                     /note="RELT like 2"
                     /db_xref="GeneID:285613"
                     /db_xref="HGNC:HGNC:26902"
                     /db_xref="MIM:611213"
     exon            1..1413
                     /gene="RELL2"
                     /gene_synonym="C5orf16"
                     /inference="alignment:Splign:2.1.0"
     CDS             1230..2141
                     /gene="RELL2"
                     /gene_synonym="C5orf16"
                     /note="receptor expressed in lymphoid tissues like 2"
                     /codon_start=1
                     /product="RELT-like protein 2"
                     /protein_id="NP_776189.3"
                     /db_xref="CCDS:CCDS4265.1"
                     /db_xref="GeneID:285613"
                     /db_xref="HGNC:HGNC:26902"
                     /db_xref="MIM:611213"
                     /translation="MSEPQPDLEPPQHGLYMLFLLVLVFFLMGLVGFMICHVLKKKGY
                     RCRTSRGSEPDDAQLQPPEDDDMNEDTVERIVRCIIQNEANAEALKEMLGDSEGEGTV
                     QLSSVDATSSLQDGAPSHHHTVHLGSAAPCLHCSRSKRPPLVRQGRSKEGKSRPRTGE
                     TTVFSVGRFRVTHIEKRYGLHEHRDGSPTDRSWGSGGGQDPGGGQGSGGGQPKAGMPA
                     MERLPPERPQPQVLASPPVQNGGLRDSSLTPRALEGNPRASAEPTLRAGGRGPSPGLP
                     TQEANGQPSKPDTSDHQVSLPQGAGSM"
     exon            1414..1479
                     /gene="RELL2"
                     /gene_synonym="C5orf16"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1546
                     /gene="RELL2"
                     /gene_synonym="C5orf16"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1732
                     /gene="RELL2"
                     /gene_synonym="C5orf16"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..2108
                     /gene="RELL2"
                     /gene_synonym="C5orf16"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2142
                     /gene="RELL2"
                     /gene_synonym="C5orf16"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2536
                     /gene="RELL2"
                     /gene_synonym="C5orf16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2515..2520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELL2"
                     /gene_synonym="C5orf16"
                     /note="hexamer: AATAAA"
     polyA_site      2536
                     /gene="RELL2"
                     /gene_synonym="C5orf16"
                     /note="major polyA site"
ORIGIN      
        1 gagcgtcccg ggttgggcag ggaactggca gcatagctcc taggatgcga gggccatttg
       61 tctccggccg ggggtcagat cctcgggaag ccgagccatc ccatccagcc gcttgcccca
      121 aaccgggcgc aggccgtggt cacttctcta ggaagctccg aagatcccgc cactccgtcc
      181 ctcaaaggtg cggaaagccg gcttccccca gccctcggag aagattcctg actctccgct
      241 cggtcggggc atctgagggc aggagctgcg ccaggcgtac cggatagacc agtggacaac
      301 acccacgccg gaccgcctgt cccctacccg gacccagact cggcgccgca cattgccccg
      361 ggggggcccg gcgcagtcac gcgcgcgcag agctcacgct ctccgccccg cacacctgcg
      421 ctccgccccc tggtcctggg cccgcgacgg gtgaaggcat ttgggaagcc agggcggctg
      481 cggaggcgat ctccctgacc cagggccgga gttgcccgga gcctgccacc gctctcagcc
      541 agcccgcatc cttctctgtt cttccctccc cccgcctgcc acggcgcggg tatccgcagc
      601 cacagcccgg ggccggtgag gcggcgaagg gggaggggag gaatcaaggg atgagcgccg
      661 gaagggcgtc gggggccctg agccgcacta ggacgcccct ggagccggaa ccccagcaga
      721 agccggaacc agaaccaaat caccggtacc gggtcggcca ggtggtcagg gtgggagaaa
      781 ccaaaaaggg agaggggtgc gggagtactg agaggaaggg gctgcagagg cctggctcag
      841 gccggcgtgg aggaggtgcg ggcgctgact caggcaggat ttctgctccc gccgcctaag
      901 aatgccgtcc catctcgtgc tgcagtgtcc ttgggaggga cagaagcgcg aacaagctgg
      961 aaaggggaac gctcggggcg tcggggaagc gggaccaggg tcgtggtaga gagcttgcgt
     1021 tgccgctgac ctcttgccga aaggcgaaac agcactcctg gcccggacag ctccctggtt
     1081 gggtaggggg tggggccgga cctcagccgg acgtcttaga cgtgcttgtt tcagatcctg
     1141 aggacggcat tcctacccct cccccattcc cagctgcagc cccctaaacc caggaggcgc
     1201 cctggcccgc gctcgccccc cagggcctca tgtcggaacc acagcctgac ctggaaccgc
     1261 cccaacatgg gctatatatg ctcttcctgc ttgtgctggt cttcttcctc atgggcctgg
     1321 taggcttcat gatctgccac gtgctcaaga agaagggcta ccgctgccgc acgtcgaggg
     1381 gctctgagcc tgacgatgcc cagcttcagc cccctgagga cgatgacatg aatgaggaca
     1441 cagtagagag gattgttcgc tgcatcatcc agaatgaagc caatgctgag gccttgaagg
     1501 agatgctggg ggacagtgaa ggagaaggga cagtgcagct gtccagtgtg gatgccacct
     1561 ccagcctgca ggacggagcc ccctcccatc atcacacagt gcacctgggc tctgcagccc
     1621 cttgcctcca ttgcagccgc agcaagaggc ctccacttgt ccgtcaggga cgctccaagg
     1681 aaggaaaaag ccgcccccgg acaggggaga ccactgtgtt ctctgtgggc aggttccggg
     1741 tgacacacat tgagaagcgc tatggactgc acgaacaccg tgatggctcc cccacagaca
     1801 ggagctgggg ctctggtggg ggacaggacc cagggggtgg tcaggggtct gggggagggc
     1861 agcccaaggc agggatgcct gccatggaga ggctgccccc tgagaggcca cagccccagg
     1921 tcctagccag ccccccagta cagaatggag gactcaggga cagcagccta acccctcgtg
     1981 cacttgaagg gaaccccaga gcttctgcag agccaacact gagggccgga gggaggggcc
     2041 caagcccagg gctgcccact caagaggcaa atgggcagcc aagcaaacca gacacttctg
     2101 atcaccaggt gtctctacca cagggagcag ggagtatgtg agtctccttc attgtgctga
     2161 tggactacca gctggcaggg ccagggggtg ggtgggcgtg aaagccctcc cctccactgg
     2221 acagcactgc cccccagctg agggaccagc tctacttcca cctggagttg cacagtctca
     2281 ggctgggggc ctcaggagag gtcacagccc ctcagtctct tctccttccc ctgcctgcaa
     2341 caggctgcct gccccgcctt ccccaacacc tcgctccata tgatagagcg tggcagctgg
     2401 gagcaggccc ctgcccgtgg tgggccccta aagcaatagc accgtaggcc ccctgccctc
     2461 ttagcacaag aggcccaggc cctggcctgg ccttcgtgcc ctttattcat tgtcaataaa
     2521 tccgctcaga ccatta
//
