LOCUS       NM_001085400            3617 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RELT like 1 (RELL1), transcript variant 1, mRNA.
ACCESSION   NM_001085400
VERSION     NM_001085400.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3617)
  AUTHORS   Jin,X., Xie,H., Liu,X., Shen,Q., Wang,Z., Hao,H. and Gu,Y.
  TITLE     RELL1, a novel oncogene, accelerates tumor progression and
            regulates immune infiltrates in glioma
  JOURNAL   Int Immunopharmacol 87, 106707 (2020)
   PUBMED   32683297
  REMARK    GeneRIF: RELL1, a novel oncogene, accelerates tumor progression and
            regulates immune infiltrates in glioma.
REFERENCE   2  (bases 1 to 3617)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3617)
  AUTHORS   Moua,P., Checketts,M., Xu,L.G., Shu,H.B., Reyland,M.E. and
            Cusick,J.K.
  TITLE     RELT family members activate p38 and induce apoptosis by a
            mechanism distinct from TNFR1
  JOURNAL   Biochem Biophys Res Commun 491 (1), 25-32 (2017)
   PUBMED   28688764
REFERENCE   4  (bases 1 to 3617)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   5  (bases 1 to 3617)
  AUTHORS   Cusick,J.K., Mustian,A., Jacobs,A.T. and Reyland,M.E.
  TITLE     Identification of PLSCR1 as a protein that interacts with RELT
            family members
  JOURNAL   Mol Cell Biochem 362 (1-2), 55-63 (2012)
   PUBMED   22052202
REFERENCE   6  (bases 1 to 3617)
  AUTHORS   Cusick,J.K., Mustian,A., Goldberg,K. and Reyland,M.E.
  TITLE     RELT induces cellular death in HEK 293 epithelial cells
  JOURNAL   Cell Immunol 261 (1), 1-8 (2010)
   PUBMED   19969290
  REMARK    GeneRIF: report that overexpression of RELT or its homologues RELL1
            and RELL2 in HEK 293 epithelial cells results in cell death with
            morphological characteristics consistent with the activation of an
            apoptotic pathway.
REFERENCE   7  (bases 1 to 3617)
  AUTHORS   Cusick,J.K., Xu,L.G., Bin,L.H., Han,K.J. and Shu,H.B.
  TITLE     Identification of RELT homologues that associate with RELT and are
            phosphorylated by OSR1
  JOURNAL   Biochem Biophys Res Commun 340 (2), 535-543 (2006)
   PUBMED   16389068
  REMARK    GeneRIF: Binds to the TNF receptor family member RELT; homologue of
            RELT.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108022.3 and AC027607.7.
            
            On Nov 22, 2018 this sequence version replaced NM_001085400.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.219262.1,
                                           SRR1803614.77317.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454158.7/ ENSP00000398778.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC108022.3         13062-13238         c
            178-402             AC027607.7         135208-135432       c
            403-474             AC027607.7         133300-133371       c
            475-532             AC027607.7         124379-124436       c
            533-769             AC027607.7         120819-121055       c
            770-908             AC027607.7         117317-117455       c
            909-3617            AC027607.7         96566-99274         c
FEATURES             Location/Qualifiers
     source          1..3617
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..3617
                     /gene="RELL1"
                     /note="RELT like 1"
                     /db_xref="GeneID:768211"
                     /db_xref="HGNC:HGNC:27379"
                     /db_xref="MIM:611212"
     exon            1..177
                     /gene="RELL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..905
                     /gene="RELL1"
                     /note="receptor expressed in lymphoid tissues like 1;
                     RELT-like protein 1; tmp_locus_29"
                     /codon_start=1
                     /product="RELT-like protein 1 precursor"
                     /protein_id="NP_001078869.1"
                     /db_xref="CCDS:CCDS43221.1"
                     /db_xref="GeneID:768211"
                     /db_xref="HGNC:HGNC:27379"
                     /db_xref="MIM:611212"
                     /translation="MAPRALPGSAVLAAAVFVGGAVSSPLVAPDNGSSRTLHSRTETT
                     PSPSNDTGNGHPEYIAYALVPVFFIMGLFGVLICHLLKKKGYRCTTEAEQDIEEEKVE
                     KIELNDSVNENSDTVGQIVHYIMKNEANADVLKAMVADNSLYDPESPVTPSTPGSPPV
                     SPGPLSPGGTPGKHVCGHHLHTVGGVVERDVCHRCRHKRWHFIKPTNKSRESRPRRQG
                     EVTVLSVGRFRVTKVEHKSNQKERRSLMSVSGAETVNGEVPATPVKRERSGTE"
     exon            178..402
                     /gene="RELL1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..474
                     /gene="RELL1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..532
                     /gene="RELL1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..769
                     /gene="RELL1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..908
                     /gene="RELL1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..3617
                     /gene="RELL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3599..3604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELL1"
                     /note="hexamer: AATAAA"
     polyA_site      3617
                     /gene="RELL1"
                     /note="major polyA site"
ORIGIN      
        1 actcgatcag cccgccggct ccggagcggc tctgccttcc cgagcgcggg acgcggcgcc
       61 ctgggggagg agggcgaagc gacgcggcga tggctccgcg ggcactcccg gggtccgccg
      121 tcctagccgc tgctgtcttc gtgggaggcg ccgtgagttc gccgctggtg gctccggaca
      181 atgggagcag ccgcacattg cactccagaa cagagacgac cccgtcgccc agcaacgata
      241 ctgggaatgg acacccagaa tatattgcat acgcgcttgt ccctgtgttc tttatcatgg
      301 gtctctttgg cgtcctcatt tgccacctgc ttaagaagaa aggctatcgt tgtacaacag
      361 aagcagagca agatatcgaa gaggaaaagg ttgaaaagat agaattgaat gacagtgtga
      421 atgaaaacag tgacactgtt gggcaaatcg tccactacat catgaaaaat gaagcgaatg
      481 ctgatgtctt aaaggcgatg gtagcagata acagcctgta tgatcctgaa agccccgtga
      541 cccccagcac accagggagc ccgccagtga gtcctgggcc tttgtcacca ggggggacgc
      601 cagggaagca cgtctgtggc catcatctgc atacggtggg cggtgttgtc gagagggatg
      661 tgtgtcatcg gtgtaggcac aagcggtggc actttataaa gcccactaac aagtccagag
      721 agagcagacc acggcgccaa ggcgaggtca cggtcctttc tgttggcaga tttagagtta
      781 caaaagtgga gcacaagtca aaccagaagg aacggagaag cctgatgtct gttagtgggg
      841 ctgaaaccgt caatggggag gtgccggcaa cacctgtgaa gagagaacgc agtggcacag
      901 agtagcagca atgacttgac ttgaagagct ctaagagact gaaaacttat atgaagttgc
      961 cttgggaata tttttatata ttttatacag tttctatcat ggagtcagca ggcacgtgga
     1021 taaaacctaa aagggaatat tattgctgtg ccatatacag aattcagttt gctttgaaac
     1081 aagttttggt tgaaagagtc tgttgaaaat tttattatac ttccagggaa ggaaagagct
     1141 gtttttatct tcttaaccac tcccagcctc tactcttccc agcccctaat cccaggcctt
     1201 ggtgtacaca ctgtagtttt tccattatga tgagtatgtg cagtgatact attcatgtac
     1261 agtctgagct tatgctcagg ggtgtgtgtg tatatgtgta tgcatgtgtg cacgtgagtg
     1321 tgtgtttctt tttccagttc ctgcatccta ttttgacact ggttgtaaga agatcttgat
     1381 acatacaggt tagctgttac aaaagataaa agatgaatct tcagtggtaa aagctcagtg
     1441 gaaataatct agttagccct gaggagttga ttccccaagg gaccatggag tcagatggga
     1501 ccagatgcta gactttggat tccttgacca caaattcagc attaactcct gccaccacca
     1561 tgtcactcct acagcactta cacattttga gaaggttttt tttttttttt ttttgaggca
     1621 gagtctcgct gtgtccccta ggctggagtg cagtggcaca atctccactc acctcaatct
     1681 ccacctcccc aggttcaagc gattctcctg cctcagcctc ccaagtagct gggattacag
     1741 gcatgcacca ccacgctcga ctaatttttg tatttttagt agagacgggg tatcactata
     1801 ttggtcaggc tggtcttgaa ctcctgacct caggcgatct acccgcctcg gcctcccaaa
     1861 gtgctgggaa tataggcgtg ggccactgca cccggttttt tgtttttttt tgtttttttt
     1921 ttttttttaa cctttagctg agcgattctt ggttaatcca ttgaataaag gagaaaatgg
     1981 ttgaaagtca cacacacaca aatttgtttg gacaacccaa ggccaaaaca aaagaaccct
     2041 gcttctctct tttttttttt tttttttttt ttttgaggcg gagtctcgct ctgtcgccca
     2101 ggctggagtg cagtggcacg atctcagctc actgcaagct ccaccttctg agttcacgcc
     2161 attctcctgc ctcagcctcc tgagtagctg ggactacagg tgcccaccac cacgcttggc
     2221 ttattttttt tgtattttta ggagagacgg ggtttcaccg cattagcgaa gatggtctcg
     2281 atctcctgac ctcgtgatcc acccgcctcg gcctcccaaa gttctgggat tacaggcttg
     2341 agccactgcg cccggcctag aaccctgctt ctcatataag atgggcctgc acctacctct
     2401 ggcatgtttt tctttgtgta tttcctgttt ttcatcctgt aactaatgct cattatttaa
     2461 aacactccag ttacttttcc ctttaggcct ggcaaacttt tctttttctt tttttttttt
     2521 ataactgtac attttacaaa acacctgaaa ggacccagag gcataaatag tattacatga
     2581 tttatggtag ctctggggtg agctgtgggg gaggccagtt acaaggtctc caagacccgc
     2641 ctccatgtca gtgttggggg gtgccttgag cacttctttt atttcatata ggaaaatgca
     2701 catctttcat ttgtctccca aaagatgatt tccataaaaa tatacttcaa agtatttact
     2761 gtacatagac ttcaatgatt ttatttccag catcaaacta aacatttcta accttttaaa
     2821 taaatgggga atttagtttc atgagaattt ttactgacaa ctaataaaca ctgtatgtgt
     2881 acatattcat atacactgtg gactggagaa agtcagtatg gaaataaatt tcactgagat
     2941 ccagaaagta gcaatatagg acttttaggg gtatgtatta gtgtaaataa tatatgtgca
     3001 gtctaggcta atcattttaa ttaaaaacaa ataagcatac ttttttgctt taaaaatatg
     3061 ccctcaaaat ggtgggggat aaaatgtaag atattcttta gctttaatta tttttccatc
     3121 ttattcaagt cagagcactt ttttttaaat agcaatacaa caggcaagag aatactcaaa
     3181 aatatttaaa actgtattga taccaagagt atgttttaaa tattttctaa taaatacttg
     3241 agcggttttt gtctggcagg cttccaaatt tgccaaaatt aagcgttcag tattttcaac
     3301 acatacgctt tttactggtt tatactgaac tatctgatga gaattcctgt gttcccaaag
     3361 caactgatgt ttacaggtct tgtgttactc ctcctccttt ctaaggatga gggaatccac
     3421 aacagacttt ctctagaaaa cactaatgat ggacaacttt ttggtgtcat caatgagttg
     3481 gctactacct tgatgtaaaa atttgtaagg aaaattttca ccatttcgag tgtcaagtgt
     3541 atttttaact gtctggtttg tacttttatg acttttgtac taccaaagcg gagttaaaaa
     3601 taaaaatgtt aaacgca
//
