LOCUS       NM_001346231            8617 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RAB11 binding and LisH domain, coiled-coil and HEAT
            repeat containing (RELCH), transcript variant 4, mRNA.
ACCESSION   NM_001346231 NM_001346232
VERSION     NM_001346231.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8617)
  AUTHORS   Sobajima,T., Yoshimura,S.I., Maeda,T., Miyata,H., Miyoshi,E. and
            Harada,A.
  TITLE     The Rab11-binding protein RELCH/KIAA1468 controls intracellular
            cholesterol distribution
  JOURNAL   J Cell Biol 217 (5), 1777-1796 (2018)
   PUBMED   29514919
  REMARK    GeneRIF: These data suggest that RELCH promotes nonvesicular
            cholesterol transport from recycling endosomes to the trans-Golgi
            network through membrane tethering.
REFERENCE   2  (bases 1 to 8617)
  AUTHORS   Golla,A., Jansson,A., Ramser,J., Hellebrand,H., Zahn,R.,
            Meitinger,T., Belohradsky,B.H. and Meindl,A.
  TITLE     Chronic recurrent multifocal osteomyelitis (CRMO): evidence for a
            susceptibility gene located on chromosome 18q21.3-18q22
  JOURNAL   Eur J Hum Genet 10 (3), 217-221 (2002)
   PUBMED   11973628
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090396.9 and AC027514.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001346231.1.
            
            Transcript Variant: This variant (4), as well as variant 3, encodes
            isoform c.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.260022.1,
                                           SRR1660807.67652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000644646.2/ ENSP00000494314.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-777               AC090396.9         20944-21720         c
            778-867             AC027514.6         106775-106864       c
            868-939             AC027514.6         96909-96980         c
            940-995             AC027514.6         96743-96798         c
            996-1109            AC027514.6         96520-96633         c
            1110-1313           AC027514.6         90525-90728         c
            1314-1405           AC027514.6         90328-90419         c
            1406-1699           AC027514.6         89419-89712         c
            1700-1775           AC027514.6         86748-86823         c
            1776-1871           AC027514.6         85590-85685         c
            1872-1984           AC027514.6         73141-73253         c
            1985-2075           AC027514.6         65263-65353         c
            2076-2147           AC027514.6         62539-62610         c
            2148-2288           AC027514.6         59929-60069         c
            2289-2453           AC027514.6         59341-59505         c
            2454-2601           AC027514.6         56359-56506         c
            2602-2758           AC027514.6         53872-54028         c
            2759-2882           AC027514.6         53165-53288         c
            2883-2931           AC027514.6         51268-51316         c
            2932-3011           AC027514.6         49069-49148         c
            3012-3118           AC027514.6         43931-44037         c
            3119-3218           AC027514.6         42544-42643         c
            3219-3301           AC027514.6         38161-38243         c
            3302-3365           AC027514.6         37308-37371         c
            3366-3504           AC027514.6         35573-35711         c
            3505-3621           AC027514.6         30550-30666         c
            3622-3710           AC027514.6         26386-26474         c
            3711-3781           AC027514.6         19157-19227         c
            3782-8617           AC027514.6         7768-12603          c
FEATURES             Location/Qualifiers
     source          1..8617
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33"
     gene            1..8617
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="RAB11 binding and LisH domain, coiled-coil and HEAT
                     repeat containing"
                     /db_xref="GeneID:57614"
                     /db_xref="HGNC:HGNC:29289"
                     /db_xref="MIM:618001"
     exon            1..777
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..3902
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="isoform g is encoded by transcript variant 4;
                     RAB11-binding protein containing LisH, coiled-coil, and
                     HEAT repeats; RAB11-binding protein RELCH"
                     /codon_start=1
                     /product="RAB11-binding protein RELCH isoform g"
                     /protein_id="NP_001333160.1"
                     /db_xref="CCDS:CCDS86676.1"
                     /db_xref="GeneID:57614"
                     /db_xref="HGNC:HGNC:29289"
                     /db_xref="MIM:618001"
                     /translation="MAAMAPGGSGSGGGVNPFLSDSDEDDDEVAATEERRAVLRLGAG
                     SGLDPGSAGSLSPQDPVALGSSARPGLPGEASAAAVALGGTGETPARLSIDAIAAQLL
                     RDQYLLTALELHTELLESGRELPRLRDYFSNPGNFERQSGTPPGMGAPGVPGAAGVGG
                     AGGREPSTASGGGQLNRAGSISTLDSLDFARYSDDGNRETDEKVAVLEFELRKAKETI
                     QALRANLTKAAEHEVPLQERKNYKSSPEIQEPIKPLEKRALNFLVNEFLLKNNYKLTS
                     ITFSDENDDQDFELWDDVGLNIPKPPDLLQLYRDFGNHQVTGKDLVDVASGVEEDELE
                     ALTPIISNLPPTLETPQPAENSMLVQKLEDKISLLNSEKWSLMEQIRRLKSEMDFLKN
                     EHFAIPAVCDSVQPPLDQLPHKDSEDSGQHPDVNSSDKGKNTDIHLSISDEADSTIPK
                     ENSPNSFPRREREGMPPSSLSSKKTVHFDKPNRKLSPAFHQALLSFCRMSADSRLGYE
                     VSRIADSEKSVMLMLGRCLPHIVPNVLLAKREELIPLILCTACLHPEPKERDQLLHIL
                     FNLIKRPDDEQRQMILTGCVAFARHVGPTRVEAELLPQCWEQINHKYPERRLLVAESC
                     GALAPYLPKEIRSSLVLSMLQQMLMEDKADLVREAVIKSLGIIMGYIDDPDKYHQGFE
                     LLLSALGDPSERVVSATHQVFLPAYAAWTTELGNLQSHLILTLLNKIEKLLREGEHGL
                     DEHKLHMYLSALQSLIPSLFALVLQNAPFSSKAKLHGEVPQIEVTRFPRPMSPLQDVS
                     TIIGSREQLAVLLQLYDYQLEQEGTTGWESLLWVVNQLLPQLIEIVGKINVTSTACVH
                     EFSRFFWRLCRTFGKIFTNTKVKPQFQEILRLSEENIDSSAGNGVLTKATVPIYATGV
                     LTCYIQEEDRKLLVGFLEDVMTLLSLSHAPLDSLKASFVELGANPAYHELLLTVLWYG
                     VVHTSALVRCTAARMFELLVKGVNETLVAQRVVPALITLSSDPEISVRIATIPAFGTI
                     METVIQRELLERVKMQLASFLEDPQYQDQHSLHTEIIKTFGRVGPNAEPRFRDEFVIP
                     HLHKLALVNNLQIVDSKRLDIATHLFEAYSALSCCFISEDLMVNHFLPGLRCLRTDME
                     HLSPEHEVILSSMIKECEQKVENKTVQEPQGSMSIAASLVSEDTKTKFLNKMGQLTTS
                     GAMLANVFQRKK"
     exon            778..867
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            868..939
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            940..995
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1109
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1313
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1405
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1699
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1775
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1871
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1984
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2075
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2147
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2288
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2453
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2601
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2758
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2882
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2931
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3011
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3118
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3218
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3301
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3365
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3366..3504
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3621
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..3710
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..3781
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..8617
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4297..4302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="hexamer: AATAAA"
     polyA_site      4329
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="major polyA site"
     regulatory      5463..5468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="hexamer: AATAAA"
     polyA_site      5490
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="major polyA site"
     regulatory      8243..8248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="hexamer: ATTAAA"
     polyA_site      8262
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
     regulatory      8456..8461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="hexamer: AATATA"
     polyA_site      8476
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
     regulatory      8575..8580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="hexamer: ATTAAA"
     regulatory      8582..8587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="hexamer: AATGAA"
     polyA_site      8594
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
     polyA_site      8617
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
ORIGIN      
        1 agttctcgcg agactggaga ccaggaagac gcctgcagag ccgggctgct ggtgcagcag
       61 aggctgaggc atcaggtgca gctgcatccg gatctcctgc cttggagcgt actccttgtc
      121 tctaagtcgg gaggcaggac gtggtcaggc cggggctgtg gaggtgcgct gtgtcccctg
      181 aggcctagag gattcgggct gcggcccgtc ggaaccagtc agggaggcgc ccacactcct
      241 gacaggataa gatggcggcg atggcgcctg gaggtagtgg cagtggtggc ggcgtgaatc
      301 catttctcag tgattcggat gaggacgatg acgaggtagc tgcaacagag gaacggcggg
      361 cagtacttcg gctgggcgcc ggaagtggcc tagatcctgg ctctgcgggc tcgctgtcgc
      421 cacaggatcc cgtggcctta ggaagcagtg cgcggccagg gctccctggg gaggcgtcgg
      481 cggctgcagt ggccctgggg ggcaccgggg agaccccggc ccgattatca attgatgcga
      541 tcgctgctca gctgttgcgc gatcaatact tgctgaccgc cctggagctg cataccgagc
      601 tgttagagag tggccgggag ctgcctcggc tgcgcgacta cttctccaat ccaggcaact
      661 tcgagaggca aagtggaacc ccgccgggga tgggggcgcc aggggtccct ggagcagccg
      721 gcgttggggg cgctggaggt cgggaaccga gtacagcgtc gggcggggga cagctcaatc
      781 gagctgggag cattagtacc cttgattctt tagactttgc aagatattca gatgatggta
      841 acagggaaac agatgaaaaa gtggcagtcc tggagtttga actacggaaa gccaaggaga
      901 ccattcaggc cctccgagcc aacctgacaa aggccgcaga acatgaagtt cctttacagg
      961 aacgaaaaaa ttacaaatca agtcctgaaa ttcaggagcc aatcaaacct cttgaaaaga
     1021 gagctctaaa cttcttagtc aatgaatttt tattgaagaa taactataag cttacatcaa
     1081 taaccttttc agatgaaaac gatgatcagg attttgaatt atgggatgat gtaggattaa
     1141 acattccaaa acctccagac ttattgcaac tctaccggga ttttggaaat catcaagtaa
     1201 ctggaaaaga tcttgtagat gtggccagtg gagtagaaga agatgaatta gaggccctta
     1261 caccaattat aagcaacctt cctccaactc ttgaaactcc ccagcctgca gagaactcca
     1321 tgttagtaca gaaattagaa gataaaatta gtttgttaaa tagtgagaaa tggtcattga
     1381 tggagcaaat cagaagactt aaaagtgaaa tggacttcct caaaaatgaa cactttgcca
     1441 tcccagcagt ttgtgactct gttcagcctc ctttggatca gttgccccac aaagactctg
     1501 aggacagtgg acagcatcca gatgtaaata gttcagacaa gggaaaaaac acagacatcc
     1561 atctttcaat atcagatgaa gctgattcca ctattcctaa agagaattcc ccaaattcat
     1621 tccccaggag agaaagagaa ggaatgccac cttcttctct atcaagtaaa aagacagttc
     1681 attttgataa acctaatagg aaattgtctc ctgcattcca tcaagcacta ctctcttttt
     1741 gtcgaatgtc agcagatagt cgtttaggat acgaggtgtc tcgtattgca gacagtgaaa
     1801 aaagcgttat gttaatgctg ggacgctgcc tgccacacat tgttcccaat gtgctattgg
     1861 caaagagaga ggagttgatc cccctcatat tgtgtacagc atgtctacat cctgagccta
     1921 aagagcgaga tcagcttctc cacatacttt tcaatttgat caagaggcca gatgatgagc
     1981 aaaggcaaat gatactgaca ggttgtgtgg catttgcgcg tcatgttgga ccaacacgtg
     2041 tagaagctga acttttacca cagtgttggg aacagattaa tcacaaatac ccagaaagac
     2101 gactgcttgt ggcagaatcc tgtggagcac tggcacctta ccttcctaaa gaaatccgta
     2161 gctccttggt tctttcaatg ttgcaacaaa tgttaatgga agataaggca gatttggtaa
     2221 gagaagctgt tatcaaaagc cttggtatca ttatgggata cattgatgat ccagacaaat
     2281 atcatcaggg ttttgaattg ttgctgtcag ccttgggtga tccctcagaa agagtagtta
     2341 gtgctacaca tcaagtattt ttaccagctt acgctgcgtg gactacagaa cttggaaatt
     2401 tacagtctca tcttatactt acactactga acaagattga aaaacttctc agggaaggag
     2461 aacatggact ggatgaacac aaactccaca tgtatctttc tgccttgcag tccttgatcc
     2521 catctctctt tgcattagtg ctacagaatg cacctttctc cagcaaagcc aagcttcatg
     2581 gtgaagtgcc acagatagaa gtgactaggt ttcctcggcc tatgtcgcct cttcaagatg
     2641 tgtccactat tatcggaagt cgtgagcaat tggcagtgct gctgcaactt tatgactacc
     2701 agctagaaca agagggtaca acaggctggg agagtttact gtgggttgtc aatcaattgt
     2761 tgccacaact tatagaaata gttggcaaaa ttaatgttac ttcaactgcc tgtgtccatg
     2821 aattctccag atttttctgg cgcctttgcc ggacatttgg caaaattttt acaaacacta
     2881 aggtaaaacc tcagttccag gagattttaa gactatctga agaaaacatt gattcctcag
     2941 caggaaatgg ggtcctcact aaagctacag tccccattta tgcaacagga gtccttacgt
     3001 gttatattca ggaagaagac cgaaaactgt tagttggatt cttagaagat gtaatgacgc
     3061 tgctttcatt atctcatgct cctcttgata gcctgaaggc ttcttttgtg gaattgggtg
     3121 caaacccagc ctaccatgag ttactattaa ctgttttgtg gtatggtgtt gtccatactt
     3181 cagcactcgt gaggtgtact gctgctagaa tgtttgagct gttggtgaag ggggtgaatg
     3241 aaactctggt agctcagagg gttgttcctg ctctcattac tctctccagt gaccctgaaa
     3301 tctctgtcag gattgccaca attccagcct ttggcactat tatggaaaca gtaattcaaa
     3361 gagagttgct ggaaagagtg aaaatgcagt tggcttcttt cctggaagat cctcagtatc
     3421 aagaccaaca ttctttgcat acagagatca taaaaacatt tggtagagtt ggccctaacg
     3481 cagaacccag gttccgagat gagtttgtta taccacattt gcataagtta gccttggtga
     3541 acaacttaca gattgtggat tctaaaagac tggacattgc tacgcatctt tttgaagcct
     3601 acagtgcact ttcctgttgt ttcatttcag aggatttaat ggttaatcac tttttacctg
     3661 gtctcagatg tttacggact gacatggaac atctctctcc agagcatgag gttattttaa
     3721 gttccatgat aaaagaatgt gaacaaaaag ttgaaaacaa gaccgtccaa gagcctcaag
     3781 gctcaatgtc aattgctgca agcttagtga gtgaagatac aaagaccaag tttttgaaca
     3841 aaatgggcca gttgacaaca tcaggtgcca tgttggccaa tgtatttcag agaaagaagt
     3901 agaagcagga aagaagcccc cagtaaacac taagatggac ctcaagccga ctggttcctt
     3961 gtacttgaag tacttgcctt ttttgtttcc tcagttttat gttcttgcat tataatttta
     4021 tcctaacctc caaagatatt tgcactgctt ttaattactg ctgtatattt gttgattttg
     4081 gagttacaac tgtggtgata gaaaattgag ttgatggtct gtaccaagtc ccttgtctat
     4141 gttcttgtct ttcagaataa tttttatata aatatatata tagtgaagaa gtttttttta
     4201 atttttggat gggatattcg caaatatctg tattatacac taagctatta caatggtact
     4261 taaaataatg taaatttgaa gtcattgtta taaaataata aagtggagat tacttaagta
     4321 tttaaattat gaaagaataa tgcagacttt ttattgtttc ttaactgact agaaagagcc
     4381 accagcatta ctctgtgcct tttggacatc agtttgtgtg ttctgtagga attgtgtgca
     4441 ttccattcac acagtatttc tttaggatgc tgtgatgatt tgaattacaa atcctacagt
     4501 caatagctaa agacgaaacc ttcatttcag aactctcatg aatattcttt aagtgctatt
     4561 taaacctccc cagcacttag atgcatataa tggacttacc tgaggaaaga cagcacatag
     4621 gcatggggag aggtaaccaa ggtgaatttt acaaactggt gtatagtaga tttaaatgct
     4681 caaaaataaa tgtaactgag aagagttaat aattgtgaga tttttcccaa attgagatac
     4741 agaagaaaat atagtttgaa tctgaaattt aacacttatt tatgtaaaac actttattta
     4801 agatattttc taatgatttt aattttagag agtacctttt cattctgtgt gttacagaga
     4861 agtactgaaa agttaaggac acttgggggc tacttttttc cctctaaact aaaaaagaca
     4921 ttggctgaat tataactagt tagttatcac ctcgtccctt aaagtcagtg acctcctgtg
     4981 tttgatgtat attacataga gtcttaagtc agtgtacagt tccactggaa tttgacagtt
     5041 gtctctacag tcatgcaact cgaagtagaa aagagtgctg gacataggaa gggggtgctt
     5101 ggtttgaggg gttaatgtga ggcctttttg aaaaatgaat attttgataa aaagaattct
     5161 tgttttagca cagttgatgc acataagtga ttctcatatt tgttgtataa actggtttaa
     5221 tacatttgga acatagttgg attacattca tttcctggga aagctagctt accatacatt
     5281 caagtttata aaacaatttg ccataggcaa agccatttaa aaagttcatt ctgaaattat
     5341 ttcatttacc tacagtgaaa taattgtgaa ctaagtagtc tttctgaaaa ctgttgggtt
     5401 ctaggcattc ctgagaaatt gaaagtggct acctttcatg tcaaaaatgt tgatctatta
     5461 taaataaaat gtttttgcat atgtttttga tttggtttgg gctatgcatt ttactttcgt
     5521 tttgaaacac tatactttct attaagcaaa aaaatgagaa aagcctatat tcatgagaat
     5581 atactaatat tttgtaaata taatttatat aaatttacct attttggttt atttttacta
     5641 aaaggggacc atgttgctat aaaactaata catttcagag gtacctggaa gaaaaatgtt
     5701 taaactctga tttgcttcaa actatagtag aatatgtgta tgtttgttat caggtgaatg
     5761 ggtagaatgt atttttattg tgaacatttt tcttaattaa tgaatatatt tatttaagtg
     5821 ctaatgtttt tttaaaggca atagtaggca agattcacag tgtatttcaa gtgagagtct
     5881 cttttcttaa atattttaat atcattaaga tttcacattg tggttttgtt ttttgtttgt
     5941 ttgtttgttt ttagtaaaat atgtcttgtc tttacagaca agacagacac taatcattga
     6001 gactgagatt tggactgagt ccaaaatagg gcataaaact cccatactca ttccttttaa
     6061 acagaagtaa acttacggta caagttttta agtgttcaac ttaatgaaaa actaagtttg
     6121 caaagtaatg aaaagctaat ttgaaattat acctgtgttt ccagagtaat ccagagatta
     6181 aattttttca gaaatccaga agtgccataa ttactaattt agctgaattc ttccaagaac
     6241 agtgcttgaa tgatggcagt atctatctct atacataggt gtctatgacc ttcattggtt
     6301 tgcattattc acccctttag agagattatt ttgctaaaca tcaaattgat tttcaacctg
     6361 aacgaaattg tgagtaattt aagtcatgcc atcctcatta tccatagctt ttaggatatg
     6421 tcactactat aggatatgtc actactatac actataattc taatgggggt ctcaagtcaa
     6481 ggtgctatca cattcttgtt tttaaaaagt tggctcaaat agtctctctt aaaatttaga
     6541 gaggtgagat caggatgtat tgaattgtct tttcatcatc ccatttttca agacaaccta
     6601 ttttggacca ttatttgaac tccaaggatg taactttctg tagttactac cctgctgatc
     6661 tttgaactgc agtagctaac tacagctaac attctgtgct ggttatattt tcttaactat
     6721 tctttgtgta aagattgtac taattttttc agttcattaa agaaagttac actttagctc
     6781 ttcaatgtta cacttaaaga gctttggact gtgcgctgtg gctcacgcct gtaatctcag
     6841 cactttggga ggccaaggtg acgaatcact tgaggtcagt agttcaagac cagcctggcc
     6901 aacgtggtga aaccccgcct ctaaaaatac aaaaattagc caggcgtggt gacgtgggcc
     6961 tgtaatccct gctactcggg aggctgagac aggagaatcg tttgaacctg ggaagcggag
     7021 attgcagtgg gccgctattg caccactgca ctccagcctg gtccacagag caagactcca
     7081 tctcaaaaac aaaaaaaaaa gctttgtaag tagcaattct aattcataat tcatgaaata
     7141 ctccagatta gccaggtaac aaaattcaac cttcaaggtt ggatgttaat tctcttacaa
     7201 gaaaactaca aaataaattt agccttttgt atgagtagac atctatttca aagttctact
     7261 gtaactttac agtgtgctta gttttgatac tatttttttc agtacattaa aaagaaatag
     7321 agactggccg ggcacggtgg ctcatgcctg taataccagc actttgggag gctgaggcgg
     7381 gaagatcact tgaggccggg agttcaagac tagcctgacc aacatggtga aaccgtctct
     7441 actaaaaata caaaattagc cgggtatggt ggcgcacacc tgtaatccca gctactctgg
     7501 agtctgaggc aggagaatca cttgaaccca gggagtggag gttgcagtga gccaagatcg
     7561 tgccactgca ctctagcctg ggcgagagtg agactacatc tcaaaaaaaa aaaataataa
     7621 tagagacaaa ctactaatca aaaataatgt atcaggtaag tttctgcata ttggtaaaaa
     7681 aattgaattt tagacaattt tcatactgcg taagaatgtg ttctgtatgc attttgtgtg
     7741 tgagcctaca ctgtgatcac agtctccaag tggcacatct catcattcat attttctctt
     7801 cagaaccaag tacaggaaac tgttttgatt gtcttttttg tggtttactt tgcatgttta
     7861 agaaaaatct taaaacatcc tattctctgt taagaccaca ccaatcataa agtacataac
     7921 agttaatata aacttaatat tgcatcaaaa acaaatatat tttattttga tagtatataa
     7981 ataatatctt cagttcagtg ttatgaggaa tgtaaactgt ttgcttttct ccagagaggc
     8041 gtcaataaat ctgggaaatt ctgtcccccg catatctaca tggagaacta tattactatt
     8101 ttaattcctt ttattccatt acagactaat ccaccatatt tatttcagtt agatcattgc
     8161 atgaatagat ttctggaggg actttaatgt agtaaaatat atgtagttta taaactggta
     8221 ttttgtgttg tgtgttatgt atattaaatt cttggtcagt gatcttttta gggtgtcatt
     8281 tgttgatagt aatctgcttt ttataatttt aacaaactgc ttccctcctg gaaaagtaac
     8341 cctttcttaa ttgttggcat tttaaacctt agatattttc aggacatgca tcttcaatga
     8401 agctggaaat gttacagata atctctctat aaaatgtaca ttgctgagta atataaatat
     8461 aataatttct cattgacttt atgatttcat agatgcttta tcttcatttc tgatcattac
     8521 ttgacagttc tttaaattct tagctttctc tgttcataag ccttcccatc atgtattaaa
     8581 taatgaaact taaaggtgaa tactttcata atgtaaa
//
