LOCUS       NM_001346230            8641 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RAB11 binding and LisH domain, coiled-coil and HEAT
            repeat containing (RELCH), transcript variant 2, mRNA.
ACCESSION   NM_001346230 XM_011526110
VERSION     NM_001346230.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8641)
  AUTHORS   Sobajima,T., Yoshimura,S.I., Maeda,T., Miyata,H., Miyoshi,E. and
            Harada,A.
  TITLE     The Rab11-binding protein RELCH/KIAA1468 controls intracellular
            cholesterol distribution
  JOURNAL   J Cell Biol 217 (5), 1777-1796 (2018)
   PUBMED   29514919
  REMARK    GeneRIF: These data suggest that RELCH promotes nonvesicular
            cholesterol transport from recycling endosomes to the trans-Golgi
            network through membrane tethering.
REFERENCE   2  (bases 1 to 8641)
  AUTHORS   Golla,A., Jansson,A., Ramser,J., Hellebrand,H., Zahn,R.,
            Meitinger,T., Belohradsky,B.H. and Meindl,A.
  TITLE     Chronic recurrent multifocal osteomyelitis (CRMO): evidence for a
            susceptibility gene located on chromosome 18q21.3-18q22
  JOURNAL   Eur J Hum Genet 10 (3), 217-221 (2002)
   PUBMED   11973628
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090396.9 and AC027514.6.
            
            On Jun 3, 2019 this sequence version replaced NM_001346230.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.187357.1,
                                           SRR1660807.32218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-777               AC090396.9         20944-21720         c
            778-867             AC027514.6         106775-106864       c
            868-939             AC027514.6         96909-96980         c
            940-995             AC027514.6         96743-96798         c
            996-1109            AC027514.6         96520-96633         c
            1110-1313           AC027514.6         90525-90728         c
            1314-1405           AC027514.6         90328-90419         c
            1406-1699           AC027514.6         89419-89712         c
            1700-1775           AC027514.6         86748-86823         c
            1776-1871           AC027514.6         85590-85685         c
            1872-1895           AC027514.6         85417-85440         c
            1896-2008           AC027514.6         73141-73253         c
            2009-2099           AC027514.6         65263-65353         c
            2100-2171           AC027514.6         62539-62610         c
            2172-2312           AC027514.6         59929-60069         c
            2313-2477           AC027514.6         59341-59505         c
            2478-2625           AC027514.6         56359-56506         c
            2626-2782           AC027514.6         53872-54028         c
            2783-2906           AC027514.6         53165-53288         c
            2907-2955           AC027514.6         51268-51316         c
            2956-3035           AC027514.6         49069-49148         c
            3036-3142           AC027514.6         43931-44037         c
            3143-3242           AC027514.6         42544-42643         c
            3243-3325           AC027514.6         38161-38243         c
            3326-3389           AC027514.6         37308-37371         c
            3390-3528           AC027514.6         35573-35711         c
            3529-3645           AC027514.6         30550-30666         c
            3646-3734           AC027514.6         26386-26474         c
            3735-3805           AC027514.6         19157-19227         c
            3806-8641           AC027514.6         7768-12603          c
FEATURES             Location/Qualifiers
     source          1..8641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33"
     gene            1..8641
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="RAB11 binding and LisH domain, coiled-coil and HEAT
                     repeat containing"
                     /db_xref="GeneID:57614"
                     /db_xref="HGNC:HGNC:29289"
                     /db_xref="MIM:618001"
     exon            1..777
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..3926
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="isoform b is encoded by transcript variant 2;
                     RAB11-binding protein containing LisH, coiled-coil, and
                     HEAT repeats; RAB11-binding protein RELCH"
                     /codon_start=1
                     /product="RAB11-binding protein RELCH isoform b"
                     /protein_id="NP_001333159.1"
                     /db_xref="GeneID:57614"
                     /db_xref="HGNC:HGNC:29289"
                     /db_xref="MIM:618001"
                     /translation="MAAMAPGGSGSGGGVNPFLSDSDEDDDEVAATEERRAVLRLGAG
                     SGLDPGSAGSLSPQDPVALGSSARPGLPGEASAAAVALGGTGETPARLSIDAIAAQLL
                     RDQYLLTALELHTELLESGRELPRLRDYFSNPGNFERQSGTPPGMGAPGVPGAAGVGG
                     AGGREPSTASGGGQLNRAGSISTLDSLDFARYSDDGNRETDEKVAVLEFELRKAKETI
                     QALRANLTKAAEHEVPLQERKNYKSSPEIQEPIKPLEKRALNFLVNEFLLKNNYKLTS
                     ITFSDENDDQDFELWDDVGLNIPKPPDLLQLYRDFGNHQVTGKDLVDVASGVEEDELE
                     ALTPIISNLPPTLETPQPAENSMLVQKLEDKISLLNSEKWSLMEQIRRLKSEMDFLKN
                     EHFAIPAVCDSVQPPLDQLPHKDSEDSGQHPDVNSSDKGKNTDIHLSISDEADSTIPK
                     ENSPNSFPRREREGMPPSSLSSKKTVHFDKPNRKLSPAFHQALLSFCRMSADSRLGYE
                     VSRIADSEKSVMLMLGRCLPHIVPNVLLAKRERMVLHLCQELIPLILCTACLHPEPKE
                     RDQLLHILFNLIKRPDDEQRQMILTGCVAFARHVGPTRVEAELLPQCWEQINHKYPER
                     RLLVAESCGALAPYLPKEIRSSLVLSMLQQMLMEDKADLVREAVIKSLGIIMGYIDDP
                     DKYHQGFELLLSALGDPSERVVSATHQVFLPAYAAWTTELGNLQSHLILTLLNKIEKL
                     LREGEHGLDEHKLHMYLSALQSLIPSLFALVLQNAPFSSKAKLHGEVPQIEVTRFPRP
                     MSPLQDVSTIIGSREQLAVLLQLYDYQLEQEGTTGWESLLWVVNQLLPQLIEIVGKIN
                     VTSTACVHEFSRFFWRLCRTFGKIFTNTKVKPQFQEILRLSEENIDSSAGNGVLTKAT
                     VPIYATGVLTCYIQEEDRKLLVGFLEDVMTLLSLSHAPLDSLKASFVELGANPAYHEL
                     LLTVLWYGVVHTSALVRCTAARMFELLVKGVNETLVAQRVVPALITLSSDPEISVRIA
                     TIPAFGTIMETVIQRELLERVKMQLASFLEDPQYQDQHSLHTEIIKTFGRVGPNAEPR
                     FRDEFVIPHLHKLALVNNLQIVDSKRLDIATHLFEAYSALSCCFISEDLMVNHFLPGL
                     RCLRTDMEHLSPEHEVILSSMIKECEQKVENKTVQEPQGSMSIAASLVSEDTKTKFLN
                     KMGQLTTSGAMLANVFQRKK"
     exon            778..867
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            868..939
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            940..995
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1109
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1313
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1405
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1699
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1775
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1871
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1895
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2008
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2099
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2171
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2312
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2477
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2625
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2782
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2906
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..2955
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3035
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3142
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3242
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3325
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3389
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3528
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3645
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..3734
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..3805
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     exon            3806..8641
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4321..4326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="hexamer: AATAAA"
     polyA_site      4353
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="major polyA site"
     regulatory      5487..5492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="hexamer: AATAAA"
     polyA_site      5514
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="major polyA site"
     regulatory      8267..8272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="hexamer: ATTAAA"
     polyA_site      8286
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
     regulatory      8480..8485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="hexamer: AATATA"
     polyA_site      8500
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
     regulatory      8599..8604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="hexamer: ATTAAA"
     regulatory      8606..8611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
                     /note="hexamer: AATGAA"
     polyA_site      8618
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
     polyA_site      8641
                     /gene="RELCH"
                     /gene_synonym="HsT3308; HsT885; KIAA1468"
ORIGIN      
        1 agttctcgcg agactggaga ccaggaagac gcctgcagag ccgggctgct ggtgcagcag
       61 aggctgaggc atcaggtgca gctgcatccg gatctcctgc cttggagcgt actccttgtc
      121 tctaagtcgg gaggcaggac gtggtcaggc cggggctgtg gaggtgcgct gtgtcccctg
      181 aggcctagag gattcgggct gcggcccgtc ggaaccagtc agggaggcgc ccacactcct
      241 gacaggataa gatggcggcg atggcgcctg gaggtagtgg cagtggtggc ggcgtgaatc
      301 catttctcag tgattcggat gaggacgatg acgaggtagc tgcaacagag gaacggcggg
      361 cagtacttcg gctgggcgcc ggaagtggcc tagatcctgg ctctgcgggc tcgctgtcgc
      421 cacaggatcc cgtggcctta ggaagcagtg cgcggccagg gctccctggg gaggcgtcgg
      481 cggctgcagt ggccctgggg ggcaccgggg agaccccggc ccgattatca attgatgcga
      541 tcgctgctca gctgttgcgc gatcaatact tgctgaccgc cctggagctg cataccgagc
      601 tgttagagag tggccgggag ctgcctcggc tgcgcgacta cttctccaat ccaggcaact
      661 tcgagaggca aagtggaacc ccgccgggga tgggggcgcc aggggtccct ggagcagccg
      721 gcgttggggg cgctggaggt cgggaaccga gtacagcgtc gggcggggga cagctcaatc
      781 gagctgggag cattagtacc cttgattctt tagactttgc aagatattca gatgatggta
      841 acagggaaac agatgaaaaa gtggcagtcc tggagtttga actacggaaa gccaaggaga
      901 ccattcaggc cctccgagcc aacctgacaa aggccgcaga acatgaagtt cctttacagg
      961 aacgaaaaaa ttacaaatca agtcctgaaa ttcaggagcc aatcaaacct cttgaaaaga
     1021 gagctctaaa cttcttagtc aatgaatttt tattgaagaa taactataag cttacatcaa
     1081 taaccttttc agatgaaaac gatgatcagg attttgaatt atgggatgat gtaggattaa
     1141 acattccaaa acctccagac ttattgcaac tctaccggga ttttggaaat catcaagtaa
     1201 ctggaaaaga tcttgtagat gtggccagtg gagtagaaga agatgaatta gaggccctta
     1261 caccaattat aagcaacctt cctccaactc ttgaaactcc ccagcctgca gagaactcca
     1321 tgttagtaca gaaattagaa gataaaatta gtttgttaaa tagtgagaaa tggtcattga
     1381 tggagcaaat cagaagactt aaaagtgaaa tggacttcct caaaaatgaa cactttgcca
     1441 tcccagcagt ttgtgactct gttcagcctc ctttggatca gttgccccac aaagactctg
     1501 aggacagtgg acagcatcca gatgtaaata gttcagacaa gggaaaaaac acagacatcc
     1561 atctttcaat atcagatgaa gctgattcca ctattcctaa agagaattcc ccaaattcat
     1621 tccccaggag agaaagagaa ggaatgccac cttcttctct atcaagtaaa aagacagttc
     1681 attttgataa acctaatagg aaattgtctc ctgcattcca tcaagcacta ctctcttttt
     1741 gtcgaatgtc agcagatagt cgtttaggat acgaggtgtc tcgtattgca gacagtgaaa
     1801 aaagcgttat gttaatgctg ggacgctgcc tgccacacat tgttcccaat gtgctattgg
     1861 caaagagaga gagaatggtt ttacacctct gtcaggagtt gatccccctc atattgtgta
     1921 cagcatgtct acatcctgag cctaaagagc gagatcagct tctccacata cttttcaatt
     1981 tgatcaagag gccagatgat gagcaaaggc aaatgatact gacaggttgt gtggcatttg
     2041 cgcgtcatgt tggaccaaca cgtgtagaag ctgaactttt accacagtgt tgggaacaga
     2101 ttaatcacaa atacccagaa agacgactgc ttgtggcaga atcctgtgga gcactggcac
     2161 cttaccttcc taaagaaatc cgtagctcct tggttctttc aatgttgcaa caaatgttaa
     2221 tggaagataa ggcagatttg gtaagagaag ctgttatcaa aagccttggt atcattatgg
     2281 gatacattga tgatccagac aaatatcatc agggttttga attgttgctg tcagccttgg
     2341 gtgatccctc agaaagagta gttagtgcta cacatcaagt atttttacca gcttacgctg
     2401 cgtggactac agaacttgga aatttacagt ctcatcttat acttacacta ctgaacaaga
     2461 ttgaaaaact tctcagggaa ggagaacatg gactggatga acacaaactc cacatgtatc
     2521 tttctgcctt gcagtccttg atcccatctc tctttgcatt agtgctacag aatgcacctt
     2581 tctccagcaa agccaagctt catggtgaag tgccacagat agaagtgact aggtttcctc
     2641 ggcctatgtc gcctcttcaa gatgtgtcca ctattatcgg aagtcgtgag caattggcag
     2701 tgctgctgca actttatgac taccagctag aacaagaggg tacaacaggc tgggagagtt
     2761 tactgtgggt tgtcaatcaa ttgttgccac aacttataga aatagttggc aaaattaatg
     2821 ttacttcaac tgcctgtgtc catgaattct ccagattttt ctggcgcctt tgccggacat
     2881 ttggcaaaat ttttacaaac actaaggtaa aacctcagtt ccaggagatt ttaagactat
     2941 ctgaagaaaa cattgattcc tcagcaggaa atggggtcct cactaaagct acagtcccca
     3001 tttatgcaac aggagtcctt acgtgttata ttcaggaaga agaccgaaaa ctgttagttg
     3061 gattcttaga agatgtaatg acgctgcttt cattatctca tgctcctctt gatagcctga
     3121 aggcttcttt tgtggaattg ggtgcaaacc cagcctacca tgagttacta ttaactgttt
     3181 tgtggtatgg tgttgtccat acttcagcac tcgtgaggtg tactgctgct agaatgtttg
     3241 agctgttggt gaagggggtg aatgaaactc tggtagctca gagggttgtt cctgctctca
     3301 ttactctctc cagtgaccct gaaatctctg tcaggattgc cacaattcca gcctttggca
     3361 ctattatgga aacagtaatt caaagagagt tgctggaaag agtgaaaatg cagttggctt
     3421 ctttcctgga agatcctcag tatcaagacc aacattcttt gcatacagag atcataaaaa
     3481 catttggtag agttggccct aacgcagaac ccaggttccg agatgagttt gttataccac
     3541 atttgcataa gttagccttg gtgaacaact tacagattgt ggattctaaa agactggaca
     3601 ttgctacgca tctttttgaa gcctacagtg cactttcctg ttgtttcatt tcagaggatt
     3661 taatggttaa tcacttttta cctggtctca gatgtttacg gactgacatg gaacatctct
     3721 ctccagagca tgaggttatt ttaagttcca tgataaaaga atgtgaacaa aaagttgaaa
     3781 acaagaccgt ccaagagcct caaggctcaa tgtcaattgc tgcaagctta gtgagtgaag
     3841 atacaaagac caagtttttg aacaaaatgg gccagttgac aacatcaggt gccatgttgg
     3901 ccaatgtatt tcagagaaag aagtagaagc aggaaagaag cccccagtaa acactaagat
     3961 ggacctcaag ccgactggtt ccttgtactt gaagtacttg ccttttttgt ttcctcagtt
     4021 ttatgttctt gcattataat tttatcctaa cctccaaaga tatttgcact gcttttaatt
     4081 actgctgtat atttgttgat tttggagtta caactgtggt gatagaaaat tgagttgatg
     4141 gtctgtacca agtcccttgt ctatgttctt gtctttcaga ataattttta tataaatata
     4201 tatatagtga agaagttttt tttaattttt ggatgggata ttcgcaaata tctgtattat
     4261 acactaagct attacaatgg tacttaaaat aatgtaaatt tgaagtcatt gttataaaat
     4321 aataaagtgg agattactta agtatttaaa ttatgaaaga ataatgcaga ctttttattg
     4381 tttcttaact gactagaaag agccaccagc attactctgt gccttttgga catcagtttg
     4441 tgtgttctgt aggaattgtg tgcattccat tcacacagta tttctttagg atgctgtgat
     4501 gatttgaatt acaaatccta cagtcaatag ctaaagacga aaccttcatt tcagaactct
     4561 catgaatatt ctttaagtgc tatttaaacc tccccagcac ttagatgcat ataatggact
     4621 tacctgagga aagacagcac ataggcatgg ggagaggtaa ccaaggtgaa ttttacaaac
     4681 tggtgtatag tagatttaaa tgctcaaaaa taaatgtaac tgagaagagt taataattgt
     4741 gagatttttc ccaaattgag atacagaaga aaatatagtt tgaatctgaa atttaacact
     4801 tatttatgta aaacacttta tttaagatat tttctaatga ttttaatttt agagagtacc
     4861 ttttcattct gtgtgttaca gagaagtact gaaaagttaa ggacacttgg gggctacttt
     4921 tttccctcta aactaaaaaa gacattggct gaattataac tagttagtta tcacctcgtc
     4981 ccttaaagtc agtgacctcc tgtgtttgat gtatattaca tagagtctta agtcagtgta
     5041 cagttccact ggaatttgac agttgtctct acagtcatgc aactcgaagt agaaaagagt
     5101 gctggacata ggaagggggt gcttggtttg aggggttaat gtgaggcctt tttgaaaaat
     5161 gaatattttg ataaaaagaa ttcttgtttt agcacagttg atgcacataa gtgattctca
     5221 tatttgttgt ataaactggt ttaatacatt tggaacatag ttggattaca ttcatttcct
     5281 gggaaagcta gcttaccata cattcaagtt tataaaacaa tttgccatag gcaaagccat
     5341 ttaaaaagtt cattctgaaa ttatttcatt tacctacagt gaaataattg tgaactaagt
     5401 agtctttctg aaaactgttg ggttctaggc attcctgaga aattgaaagt ggctaccttt
     5461 catgtcaaaa atgttgatct attataaata aaatgttttt gcatatgttt ttgatttggt
     5521 ttgggctatg cattttactt tcgttttgaa acactatact ttctattaag caaaaaaatg
     5581 agaaaagcct atattcatga gaatatacta atattttgta aatataattt atataaattt
     5641 acctattttg gtttattttt actaaaaggg gaccatgttg ctataaaact aatacatttc
     5701 agaggtacct ggaagaaaaa tgtttaaact ctgatttgct tcaaactata gtagaatatg
     5761 tgtatgtttg ttatcaggtg aatgggtaga atgtattttt attgtgaaca tttttcttaa
     5821 ttaatgaata tatttattta agtgctaatg tttttttaaa ggcaatagta ggcaagattc
     5881 acagtgtatt tcaagtgaga gtctcttttc ttaaatattt taatatcatt aagatttcac
     5941 attgtggttt tgttttttgt ttgtttgttt gtttttagta aaatatgtct tgtctttaca
     6001 gacaagacag acactaatca ttgagactga gatttggact gagtccaaaa tagggcataa
     6061 aactcccata ctcattcctt ttaaacagaa gtaaacttac ggtacaagtt tttaagtgtt
     6121 caacttaatg aaaaactaag tttgcaaagt aatgaaaagc taatttgaaa ttatacctgt
     6181 gtttccagag taatccagag attaaatttt ttcagaaatc cagaagtgcc ataattacta
     6241 atttagctga attcttccaa gaacagtgct tgaatgatgg cagtatctat ctctatacat
     6301 aggtgtctat gaccttcatt ggtttgcatt attcacccct ttagagagat tattttgcta
     6361 aacatcaaat tgattttcaa cctgaacgaa attgtgagta atttaagtca tgccatcctc
     6421 attatccata gcttttagga tatgtcacta ctataggata tgtcactact atacactata
     6481 attctaatgg gggtctcaag tcaaggtgct atcacattct tgtttttaaa aagttggctc
     6541 aaatagtctc tcttaaaatt tagagaggtg agatcaggat gtattgaatt gtcttttcat
     6601 catcccattt ttcaagacaa cctattttgg accattattt gaactccaag gatgtaactt
     6661 tctgtagtta ctaccctgct gatctttgaa ctgcagtagc taactacagc taacattctg
     6721 tgctggttat attttcttaa ctattctttg tgtaaagatt gtactaattt tttcagttca
     6781 ttaaagaaag ttacacttta gctcttcaat gttacactta aagagctttg gactgtgcgc
     6841 tgtggctcac gcctgtaatc tcagcacttt gggaggccaa ggtgacgaat cacttgaggt
     6901 cagtagttca agaccagcct ggccaacgtg gtgaaacccc gcctctaaaa atacaaaaat
     6961 tagccaggcg tggtgacgtg ggcctgtaat ccctgctact cgggaggctg agacaggaga
     7021 atcgtttgaa cctgggaagc ggagattgca gtgggccgct attgcaccac tgcactccag
     7081 cctggtccac agagcaagac tccatctcaa aaacaaaaaa aaaagctttg taagtagcaa
     7141 ttctaattca taattcatga aatactccag attagccagg taacaaaatt caaccttcaa
     7201 ggttggatgt taattctctt acaagaaaac tacaaaataa atttagcctt ttgtatgagt
     7261 agacatctat ttcaaagttc tactgtaact ttacagtgtg cttagttttg atactatttt
     7321 tttcagtaca ttaaaaagaa atagagactg gccgggcacg gtggctcatg cctgtaatac
     7381 cagcactttg ggaggctgag gcgggaagat cacttgaggc cgggagttca agactagcct
     7441 gaccaacatg gtgaaaccgt ctctactaaa aatacaaaat tagccgggta tggtggcgca
     7501 cacctgtaat cccagctact ctggagtctg aggcaggaga atcacttgaa cccagggagt
     7561 ggaggttgca gtgagccaag atcgtgccac tgcactctag cctgggcgag agtgagacta
     7621 catctcaaaa aaaaaaaata ataatagaga caaactacta atcaaaaata atgtatcagg
     7681 taagtttctg catattggta aaaaaattga attttagaca attttcatac tgcgtaagaa
     7741 tgtgttctgt atgcattttg tgtgtgagcc tacactgtga tcacagtctc caagtggcac
     7801 atctcatcat tcatattttc tcttcagaac caagtacagg aaactgtttt gattgtcttt
     7861 tttgtggttt actttgcatg tttaagaaaa atcttaaaac atcctattct ctgttaagac
     7921 cacaccaatc ataaagtaca taacagttaa tataaactta atattgcatc aaaaacaaat
     7981 atattttatt ttgatagtat ataaataata tcttcagttc agtgttatga ggaatgtaaa
     8041 ctgtttgctt ttctccagag aggcgtcaat aaatctggga aattctgtcc cccgcatatc
     8101 tacatggaga actatattac tattttaatt ccttttattc cattacagac taatccacca
     8161 tatttatttc agttagatca ttgcatgaat agatttctgg agggacttta atgtagtaaa
     8221 atatatgtag tttataaact ggtattttgt gttgtgtgtt atgtatatta aattcttggt
     8281 cagtgatctt tttagggtgt catttgttga tagtaatctg ctttttataa ttttaacaaa
     8341 ctgcttccct cctggaaaag taaccctttc ttaattgttg gcattttaaa ccttagatat
     8401 tttcaggaca tgcatcttca atgaagctgg aaatgttaca gataatctct ctataaaatg
     8461 tacattgctg agtaatataa atataataat ttctcattga ctttatgatt tcatagatgc
     8521 tttatcttca tttctgatca ttacttgaca gttctttaaa ttcttagctt tctctgttca
     8581 taagccttcc catcatgtat taaataatga aacttaaagg tgaatacttt cataatgtaa
     8641 a
//
