LOCUS       NM_006509               2258 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens RELB proto-oncogene, NF-kB subunit (RELB), transcript
            variant 1, mRNA.
ACCESSION   NM_006509
VERSION     NM_006509.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2258)
  AUTHORS   Le Voyer,T., Maglorius Renkilaraj,M.R.L., Moriya,K., Perez
            Lorenzo,M., Nguyen,T., Gao,L., Rubin,T., Cederholm,A., Ogishi,M.,
            Arango-Franco,C.A., Beziat,V., Levy,R., Migaud,M., Rapaport,F.,
            Itan,Y., Deenick,E.K., Cortese,I., Lisco,A., Boztug,K., Abel,L.,
            Boisson-Dupuis,S., Boisson,B., Frosk,P., Ma,C.S., Landegren,N.,
            Celmeli,F., Casanova,J.L., Tangye,S.G. and Puel,A.
  TITLE     Inherited human RelB deficiency impairs innate and adaptive
            immunity to infection
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2321794121 (2024)
   PUBMED   39231201
  REMARK    GeneRIF: Inherited human RelB deficiency impairs innate and
            adaptive immunity to infection.
REFERENCE   2  (bases 1 to 2258)
  AUTHORS   Ulrich,C., Canim,Z., Herberger,E., Girndt,M. and Fiedler,R.
  TITLE     Inflammation in Hypervolemic Hemodialysis Patients: The Roles of
            RelB and Caspase-4
  JOURNAL   Int J Mol Sci 24 (24), 17550 (2023)
   PUBMED   38139378
  REMARK    GeneRIF: Inflammation in Hypervolemic Hemodialysis Patients: The
            Roles of RelB and Caspase-4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2258)
  AUTHORS   Liu,Y., Tian,X., Liu,D., Zhang,X., Yan,C. and Han,Y.
  TITLE     RelB represses miR-193a-5p expression to promote the phenotypic
            transformation of vascular smooth muscle cells in aortic aneurysm
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1866 (2), 194926 (2023)
   PUBMED   36863451
  REMARK    GeneRIF: RelB represses miR-193a-5p expression to promote the
            phenotypic transformation of vascular smooth muscle cells in aortic
            aneurysm.
REFERENCE   4  (bases 1 to 2258)
  AUTHORS   Sharfe,N., Dalal,I., Naghdi,Z., Lefaudeux,D., Vong,L., Dadi,H.,
            Navarro,H., Tasher,D., Ovadia,A., Zangen,T., Ater,D., Ngan,B.,
            Hoffmann,A. and Roifman,C.M.
  TITLE     NFkappaB pathway dysregulation due to reduced RelB expression leads
            to severe autoimmune disorders and declining immunity
  JOURNAL   J Autoimmun 137, 102946 (2023)
   PUBMED   36402602
  REMARK    GeneRIF: NFkappaB pathway dysregulation due to reduced RelB
            expression leads to severe autoimmune disorders and declining
            immunity.
REFERENCE   5  (bases 1 to 2258)
  AUTHORS   Kamdar,R.D., Harrington,B.S., Attar,E., Korrapati,S., Shetty,J.,
            Zhao,Y., Tran,B., Wong,N., House,C.D. and Annunziata,C.M.
  TITLE     NF-kappaB Signaling Modulates miR-452-5p and miR-335-5p Expression
            to Functionally Decrease Epithelial Ovarian Cancer Progression in
            Tumor-Initiating Cells
  JOURNAL   Int J Mol Sci 24 (9), 7826 (2023)
   PUBMED   37175530
  REMARK    GeneRIF: NF-kappaB Signaling Modulates miR-452-5p and miR-335-5p
            Expression to Functionally Decrease Epithelial Ovarian Cancer
            Progression in Tumor-Initiating Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2258)
  AUTHORS   Biswas,D.K., Salas,T.R., Wang,F., Ahlers,C.M., Dezube,B.J. and
            Pardee,A.B.
  TITLE     A Tat-induced auto-up-regulatory loop for superactivation of the
            human immunodeficiency virus type 1 promoter
  JOURNAL   J Virol 69 (12), 7437-7444 (1995)
   PUBMED   7494249
REFERENCE   7  (bases 1 to 2258)
  AUTHORS   Taylor,J.P., Pomerantz,R., Bagasra,O., Chowdhury,M., Rappaport,J.,
            Khalili,K. and Amini,S.
  TITLE     TAR-independent transactivation by Tat in cells derived from the
            CNS: a novel mechanism of HIV-1 gene regulation
  JOURNAL   EMBO J 11 (9), 3395-3403 (1992)
   PUBMED   1505523
REFERENCE   8  (bases 1 to 2258)
  AUTHORS   Liu,J., Perkins,N.D., Schmid,R.M. and Nabel,G.J.
  TITLE     Specific NF-kappa B subunits act in concert with Tat to stimulate
            human immunodeficiency virus type 1 transcription
  JOURNAL   J Virol 66 (6), 3883-3887 (1992)
   PUBMED   1583734
REFERENCE   9  (bases 1 to 2258)
  AUTHORS   Ruben,S.M., Klement,J.F., Coleman,T.A., Maher,M., Chen,C.H. and
            Rosen,C.A.
  TITLE     I-Rel: a novel rel-related protein that inhibits NF-kappa B
            transcriptional activity
  JOURNAL   Genes Dev 6 (5), 745-760 (1992)
   PUBMED   1577270
REFERENCE   10 (bases 1 to 2258)
  AUTHORS   Bours,V., Burd,P.R., Brown,K., Villalobos,J., Park,S., Ryseck,R.P.,
            Bravo,R., Kelly,K. and Siebenlist,U.
  TITLE     A novel mitogen-inducible gene product related to p50/p105-NF-kappa
            B participates in transactivation through a kappa B site
  JOURNAL   Mol Cell Biol 12 (2), 685-695 (1992)
   PUBMED   1531086
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA940587.1, BC028013.1 and BM684710.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006509.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M83221.1, SRR1163657.379298.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221452.13/ ENSP00000221452.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DA940587.1         16-48
            34-2255             BC028013.1         1-2222
            2256-2258           BM684710.1         25-27               c
FEATURES             Location/Qualifiers
     source          1..2258
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2258
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /note="RELB proto-oncogene, NF-kB subunit"
                     /db_xref="GeneID:5971"
                     /db_xref="HGNC:HGNC:9956"
                     /db_xref="MIM:604758"
     exon            1..222
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1856
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /note="isoform 1 is encoded by transcript variant 1; v-rel
                     avian reticuloendotheliosis viral oncogene homolog B
                     (nuclear factor of kappa light polypeptide gene enhancer
                     in B-cells 3); transcription factor RelB; v-rel
                     reticuloendotheliosis viral oncogene homolog B, nuclear
                     factor of kappa light polypeptide gene enhancer in B-cells
                     3"
                     /codon_start=1
                     /product="transcription factor RelB isoform 1"
                     /protein_id="NP_006500.2"
                     /db_xref="CCDS:CCDS46110.1"
                     /db_xref="GeneID:5971"
                     /db_xref="HGNC:HGNC:9956"
                     /db_xref="MIM:604758"
                     /translation="MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLS
                     LAVSRSTDELEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASLSTVTLGPVAPPA
                     TPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEA
                     SKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSP
                     RHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRD
                     QQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKEDIS
                     VVFSRASWEGRADFSQADVHRQIAIVFKTPPYEDLEIVEPVTVNVFLQRLTDGVCSEP
                     LPFTYLPRDHDSYGVDKKRKRGMPDVLGELNSSDPHGIESKRRKKKPAILDHFLPNHG
                     SGPFLPPSALLPDPDFFSGTVSLPGLEPPGGPDLLDDGFAYDPTAPTLFTMLDLLPPA
                     PPHASAVVCSGGAGAVVGETPGPEPLTLDSYQAPGPGDGGTASLVGSNMFPNHYREAA
                     FGGGLLSPGPEAT"
     exon            223..270
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /inference="alignment:Splign:2.1.0"
     exon            271..279
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /inference="alignment:Splign:2.1.0"
     exon            280..620
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /inference="alignment:Splign:2.1.0"
     exon            621..778
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /inference="alignment:Splign:2.1.0"
     exon            779..870
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1002
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1107
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1323
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1392
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1470
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..2258
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2237..2242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /note="hexamer: AATAAA"
     polyA_site      2258
                     /gene="RELB"
                     /gene_synonym="I-REL; IMD53; IREL; REL-B"
                     /note="major polyA site"
ORIGIN      
        1 gcagccccgg gcgccgcgcg tcctgcccgg cctgcggccc cagcccttgc gccgctcgtc
       61 cgacccgcga tcgtccacca gaccgtgcct cccggccgcc cggccggccc gcgtgcatgc
      121 ttcggtctgg gccagcctct gggccgtccg tccccactgg ccgggccatg ccgagtcgcc
      181 gcgtcgccag accgccggct gcgccggagc tgggggcctt agggtccccc gacctctcct
      241 cactctcgct cgccgtttcc aggagcacag atgaattgga gatcatcgac gagtacatca
      301 aggagaacgg cttcggcctg gacgggggac agccgggccc gggcgagggg ctgccacgcc
      361 tggtgtctcg cggggctgcg tccctgagca cggtcaccct gggccctgtg gcgcccccag
      421 ccacgccgcc gccttggggc tgccccctgg gccgactagt gtccccagcg ccgggcccgg
      481 gcccgcagcc gcacctggtc atcacggagc agcccaagca gcgcggcatg cgcttccgct
      541 acgagtgcga gggccgctcg gccggcagca tccttgggga gagcagcacc gaggccagca
      601 agacgctgcc cgccatcgag ctccgggatt gtggagggct gcgggaggtg gaggtgactg
      661 cctgcctggt gtggaaggac tggcctcacc gagtccaccc ccacagcctc gtggggaaag
      721 actgcaccga cggcatctgc agggtgcggc tccggcctca cgtcagcccc cggcacagtt
      781 ttaacaacct gggcatccag tgtgtgagga agaaggagat tgaggctgcc attgagcgga
      841 agattcaact gggcattgac ccctacaacg ctgggtccct gaagaaccat caggaagtag
      901 acatgaatgt ggtgaggatc tgcttccagg cctcatatcg ggaccagcag ggacagatgc
      961 gccggatgga tcctgtgctt tccgagcccg tctatgacaa gaaatccaca aacacatcag
     1021 agctgcggat ttgccgaatt aacaaggaaa gcgggccgtg caccggtggc gaggagctct
     1081 acttgctctg cgacaaggtg cagaaagagg acatatcagt ggtgttcagc agggcctcct
     1141 gggaaggtcg ggctgacttc tcccaggccg acgtgcaccg ccagattgcc attgtgttca
     1201 agacgccgcc ctacgaggac ctggagattg tcgagcccgt gacagtcaac gtcttcctgc
     1261 agcggctcac cgatggggtc tgcagcgagc cattgccttt cacgtacctg cctcgcgacc
     1321 atgacagcta cggcgtggac aagaagcgga aacgggggat gcccgacgtc cttggggagc
     1381 tgaacagctc tgacccccat ggcatcgaga gcaaacggcg gaagaaaaag ccggccatcc
     1441 tggaccactt cctgcccaac cacggctcag gcccgttcct cccgccgtca gccctgctgc
     1501 cagaccctga cttcttctct ggcaccgtgt ccctgcccgg cctggagccc cctggcgggc
     1561 ctgacctcct ggacgatggc tttgcctacg accctacggc ccccacactc ttcaccatgc
     1621 tggacctgct gcccccggca ccgccacacg ctagcgctgt tgtgtgcagc ggaggtgccg
     1681 gggccgtggt tggggagacc cccggccctg aaccactgac actggactcg taccaggccc
     1741 cgggccccgg ggatggaggc accgccagcc ttgtgggcag caacatgttc cccaatcatt
     1801 accgcgaggc ggcctttggg ggcggcctcc tatccccggg gcctgaagcc acgtagcccc
     1861 gcgatgccag aggaggggca ctgggtgggg agggaggtgg aggagccgtg caatcccaac
     1921 caggatgtct agcaccccca tccccttggc ccttcctcat gcttctgaag tggacatatt
     1981 cagccttggc gagaagctcc gttgcacggg tttccccttg agcccatttt acagatgagg
     2041 aaactgagtc cggagaggaa aagggacatg gctcccgtgc actagcttgt tacagctgcc
     2101 tctgtcccca catgtggggg caccttctcc agtaggattc ggaaaagatt gtacatatgg
     2161 gaggaggggg cagattcctg gccctccctc cccagacttg aaggtggggg gtaggttggt
     2221 tgttcagagt cttcccaata aagatgagtt tttgagcc
//
