LOCUS       NM_021975               2517 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens RELA proto-oncogene, NF-kB subunit (RELA), transcript
            variant 1, mRNA.
ACCESSION   NM_021975
VERSION     NM_021975.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2517)
  AUTHORS   De Paolis,V., Troisi,V., Bordin,A., Pagano,F., Caputo,V. and
            Parisi,C.
  TITLE     Unconventional p65/p52 NF-kappaB module regulates key tumor
            microenvironment-related genes in breast tumor-associated
            macrophages (TAMs)
  JOURNAL   Life Sci 357, 123059 (2024)
   PUBMED   39278618
  REMARK    GeneRIF: Unconventional p65/p52 NF-kappaB module regulates key
            tumor microenvironment-related genes in breast tumor-associated
            macrophages (TAMs).
REFERENCE   2  (bases 1 to 2517)
  AUTHORS   Lu,J., Zhang,J., Jiang,H., Hu,Z., Zhang,Y., He,L., Yang,J., Xie,Y.,
            Wu,D., Li,H., Zeng,K., Tan,P., Xiao,Q., Song,Z., Pan,C., Bai,X. and
            Yu,X.
  TITLE     Vangl2 suppresses NF-kappaB signaling and ameliorates sepsis by
            targeting p65 for NDP52-mediated autophagic degradation
  JOURNAL   Elife 12, 87935 (2024)
   PUBMED   39269442
  REMARK    GeneRIF: Vangl2 suppresses NF-kappaB signaling and ameliorates
            sepsis by targeting p65 for NDP52-mediated autophagic degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2517)
  AUTHORS   Campbell,C.A., Calderon,R., Pavani,G., Cheng,X., Barakat,R.,
            Snella,E., Liu,F., Peng,X., Essner,J.J., Dorman,K.S., McGrail,M.,
            Gadue,P., French,D.L. and Espin-Palazon,R.
  TITLE     p65 signaling dynamics drive the developmental progression of
            hematopoietic stem and progenitor cells through cell cycle
            regulation
  JOURNAL   Nat Commun 15 (1), 7787 (2024)
   PUBMED   39242546
  REMARK    GeneRIF: p65 signaling dynamics drive the developmental progression
            of hematopoietic stem and progenitor cells through cell cycle
            regulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2517)
  AUTHORS   Elkrewi,E.Z., Al Abdulqader,A.A., Khasanov,R., Maas-Omlor,S.,
            Boettcher,M., Wessel,L.M., Schafer,K.H. and Tapia-Laliena,M.A.
  TITLE     Role of Inflammation and the NF-kappaB Signaling Pathway in
            Hirschsprung's Disease
  JOURNAL   Biomolecules 14 (8), 992 (2024)
   PUBMED   39199380
  REMARK    GeneRIF: Role of Inflammation and the NF-kappaB Signaling Pathway
            in Hirschsprung's Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2517)
  AUTHORS   Feng,W., Niu,N., Lu,P., Chen,Z., Rao,H., Zhang,W., Ma,C., Liu,C.,
            Xu,Y., Gao,W.Q., Xue,J. and Li,L.
  TITLE     Multilevel Regulation of NF-kappaB Signaling by NSD2 Suppresses
            Kras-Driven Pancreatic Tumorigenesis
  JOURNAL   Adv Sci (Weinh) 11 (30), e2309387 (2024)
   PUBMED   38889281
  REMARK    GeneRIF: Multilevel Regulation of NF-kappaB Signaling by NSD2
            Suppresses Kras-Driven Pancreatic Tumorigenesis.
REFERENCE   6  (bases 1 to 2517)
  AUTHORS   Ganchi,P.A., Sun,S.C., Greene,W.C. and Ballard,D.W.
  TITLE     I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B
            p65 and requires the transactivation domain to inhibit NF-kappa B
            p65 DNA binding
  JOURNAL   Mol Biol Cell 3 (12), 1339-1352 (1992)
   PUBMED   1493333
REFERENCE   7  (bases 1 to 2517)
  AUTHORS   Kunsch,C., Ruben,S.M. and Rosen,C.A.
  TITLE     Selection of optimal kappa B/Rel DNA-binding motifs: interaction of
            both subunits of NF-kappa B with DNA is required for
            transcriptional activation
  JOURNAL   Mol Cell Biol 12 (10), 4412-4421 (1992)
   PUBMED   1406630
REFERENCE   8  (bases 1 to 2517)
  AUTHORS   Taylor,J.P., Pomerantz,R., Bagasra,O., Chowdhury,M., Rappaport,J.,
            Khalili,K. and Amini,S.
  TITLE     TAR-independent transactivation by Tat in cells derived from the
            CNS: a novel mechanism of HIV-1 gene regulation
  JOURNAL   EMBO J 11 (9), 3395-3403 (1992)
   PUBMED   1505523
REFERENCE   9  (bases 1 to 2517)
  AUTHORS   Liu,J., Perkins,N.D., Schmid,R.M. and Nabel,G.J.
  TITLE     Specific NF-kappa B subunits act in concert with Tat to stimulate
            human immunodeficiency virus type 1 transcription
  JOURNAL   J Virol 66 (6), 3883-3887 (1992)
   PUBMED   1583734
REFERENCE   10 (bases 1 to 2517)
  AUTHORS   Ruben,S.M., Narayanan,R., Klement,J.F., Chen,C.H. and Rosen,C.A.
  TITLE     Functional characterization of the NF-kappa B p65 transcriptional
            activator and an alternatively spliced derivative
  JOURNAL   Mol Cell Biol 12 (2), 444-454 (1992)
   PUBMED   1732726
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA020095.1, M62399.1,
            BC033522.1 and BU633061.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_021975.3.
            
            Summary: NF-kappa-B is a ubiquitous transcription factor involved
            in several biological processes. It is held in the cytoplasm in an
            inactive state by specific inhibitors. Upon degradation of the
            inhibitor, NF-kappa-B moves to the nucleus and activates
            transcription of specific genes. NF-kappa-B is composed of NFKB1 or
            NFKB2 bound to either REL, RELA, or RELB. The most abundant form of
            NF-kappa-B is NFKB1 complexed with the product of this gene, RELA.
            Four transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.5253.1,
                                           SRR11853559.6240.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406246.8/ ENSP00000384273.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               DA020095.1         179-524
            347-621             M62399.1           342-616
            622-2516            BC033522.1         535-2429
            2517-2517           BU633061.1         23-23               c
FEATURES             Location/Qualifiers
     source          1..2517
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2517
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /note="RELA proto-oncogene, NF-kB subunit"
                     /db_xref="GeneID:5970"
                     /db_xref="HGNC:HGNC:9955"
                     /db_xref="MIM:164014"
     exon            1..91
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1740
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor of kappa light polypeptide gene enhancer in
                     B-cells 3; transcription factor p65; nuclear factor
                     NF-kappa-B p65 subunit; NF-kappa-B transcription factor
                     p65; NF-kappa-B p65delta3; v-rel avian
                     reticuloendotheliosis viral oncogene homolog A"
                     /codon_start=1
                     /product="transcription factor p65 isoform 1"
                     /protein_id="NP_068810.3"
                     /db_xref="CCDS:CCDS31609.1"
                     /db_xref="GeneID:5970"
                     /db_xref="HGNC:HGNC:9955"
                     /db_xref="MIM:164014"
                     /translation="MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAG
                     SIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEA
                     ELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLC
                     FQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDK
                     VQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPS
                     DRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVP
                     SRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPA
                     PAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDL
                     GALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQ
                     RPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS"
     exon            92..118
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /inference="alignment:Splign:2.1.0"
     exon            119..270
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /inference="alignment:Splign:2.1.0"
     exon            271..419
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /inference="alignment:Splign:2.1.0"
     exon            420..511
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /inference="alignment:Splign:2.1.0"
     exon            512..643
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /inference="alignment:Splign:2.1.0"
     exon            644..748
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /inference="alignment:Splign:2.1.0"
     exon            749..961
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1042
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1117
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..2517
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2496..2501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /note="hexamer: AATAAA"
     polyA_site      2517
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /note="major polyA site"
ORIGIN      
        1 atttccgcct ctggcgaatg gctcgtctgt agtgcacgcc gcgggcccag ctgcgacccc
       61 ggccccgccc ccgggacccc ggccatggac gaactgttcc ccctcatctt cccggcagag
      121 ccagcccagg cctctggccc ctatgtggag atcattgagc agcccaagca gcggggcatg
      181 cgcttccgct acaagtgcga ggggcgctcc gcgggcagca tcccaggcga gaggagcaca
      241 gataccacca agacccaccc caccatcaag atcaatggct acacaggacc agggacagtg
      301 cgcatctccc tggtcaccaa ggaccctcct caccggcctc acccccacga gcttgtagga
      361 aaggactgcc gggatggctt ctatgaggct gagctctgcc cggaccgctg catccacagt
      421 ttccagaacc tgggaatcca gtgtgtgaag aagcgggacc tggagcaggc tatcagtcag
      481 cgcatccaga ccaacaacaa ccccttccaa gttcctatag aagagcagcg tggggactac
      541 gacctgaatg ctgtgcggct ctgcttccag gtgacagtgc gggacccatc aggcaggccc
      601 ctccgcctgc cgcctgtcct ttctcatccc atctttgaca atcgtgcccc caacactgcc
      661 gagctcaaga tctgccgagt gaaccgaaac tctggcagct gcctcggtgg ggatgagatc
      721 ttcctactgt gtgacaaggt gcagaaagag gacattgagg tgtatttcac gggaccaggc
      781 tgggaggccc gaggctcctt ttcgcaagct gatgtgcacc gacaagtggc cattgtgttc
      841 cggacccctc cctacgcaga ccccagcctg caggctcctg tgcgtgtctc catgcagctg
      901 cggcggcctt ccgaccggga gctcagtgag cccatggaat tccagtacct gccagataca
      961 gacgatcgtc accggattga ggagaaacgt aaaaggacat atgagacctt caagagcatc
     1021 atgaagaaga gtcctttcag cggacccacc gacccccggc ctccacctcg acgcattgct
     1081 gtgccttccc gcagctcagc ttctgtcccc aagccagcac cccagcccta tccctttacg
     1141 tcatccctga gcaccatcaa ctatgatgag tttcccacca tggtgtttcc ttctgggcag
     1201 atcagccagg cctcggcctt ggccccggcc cctccccaag tcctgcccca ggctccagcc
     1261 cctgcccctg ctccagccat ggtatcagct ctggcccagg ccccagcccc tgtcccagtc
     1321 ctagccccag gccctcctca ggctgtggcc ccacctgccc ccaagcccac ccaggctggg
     1381 gaaggaacgc tgtcagaggc cctgctgcag ctgcagtttg atgatgaaga cctgggggcc
     1441 ttgcttggca acagcacaga cccagctgtg ttcacagacc tggcatccgt cgacaactcc
     1501 gagtttcagc agctgctgaa ccagggcata cctgtggccc cccacacaac tgagcccatg
     1561 ctgatggagt accctgaggc tataactcgc ctagtgacag gggcccagag gccccccgac
     1621 ccagctcctg ctccactggg ggccccgggg ctccccaatg gcctcctttc aggagatgaa
     1681 gacttctcct ccattgcgga catggacttc tcagccctgc tgagtcagat cagctcctaa
     1741 gggggtgacg cctgccctcc ccagagcact gggttgcagg ggattgaagc cctccaaaag
     1801 cacttacgga ttctggtggg gtgtgttcca actgccccca actttgtgga tgtcttcctt
     1861 ggagggggga gccatatttt attcttttat tgtcagtatc tgtatctctc tctctttttg
     1921 gaggtgctta agcagaagca ttaacttctc tggaaagggg ggagctgggg aaactcaaac
     1981 ttttcccctg tcctgatggt cagctccctt ctctgtaggg aactctgggg tcccccatcc
     2041 ccatcctcca gcttctggta ctctcctaga gacagaagca ggctggaggt aaggcctttg
     2101 agcccacaaa gccttatcaa gtgtcttcca tcatggattc attacagctt aatcaaaata
     2161 acgccccaga taccagcccc tgtatggcac tggcattgtc cctgtgccta acaccagcgt
     2221 ttgaggggct ggccttcctg ccctacagag gtctctgccg gctctttcct tgctcaacca
     2281 tggctgaagg aaaccagtgc aacagcactg gctctctcca ggatccagaa ggggtttggt
     2341 ctgggacttc cttgctctcc ctcttctcaa gtgccttaat agtagggtaa gttgttaaga
     2401 gtgggggaga gcaggctggc agctctccag tcaggaggca tagtttttac tgaacaatca
     2461 aagcacttgg actcttgctc tttctactct gaactaataa atctgttgcc aagctgg
//
