LOCUS       NM_001291746           11108 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens REL proto-oncogene, NF-kB subunit (REL), transcript
            variant 2, mRNA.
ACCESSION   NM_001291746 XM_005264470
VERSION     NM_001291746.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11108)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 11108)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 11108)
  AUTHORS   Shah,J.A., Warr,A.J., Graustein,A.D., Saha,A., Dunstan,S.J.,
            Thuong,N.T.T., Thwaites,G.E., Caws,M., Thai,P.V.K., Bang,N.D.,
            Chau,T.T.H., Khor,C.C., Li,Z., Hibberd,M., Chang,X., Nguyen,F.K.,
            Hernandez,C.A., Jones,M.A., Sassetti,C.M., Fitzgerald,K.A.,
            Musvosvi,M., Gela,A., Hanekom,W.A., Hatherill,M., Scriba,T.J. and
            Hawn,T.R.
  TITLE     REL and BHLHE40 Variants Are Associated with IL-12 and IL-10
            Responses and Tuberculosis Risk
  JOURNAL   J Immunol 208 (6), 1352-1361 (2022)
   PUBMED   35217585
  REMARK    GeneRIF: REL and BHLHE40 Variants Are Associated with IL-12 and
            IL-10 Responses and Tuberculosis Risk.
REFERENCE   4  (bases 1 to 11108)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 11108)
  AUTHORS   Neumann,M., Tsapos,K., Scheppler,J.A., Ross,J. and Franza,B.R. Jr.
  TITLE     Identification of complex formation between two intracellular
            tyrosine kinase substrates: human c-Rel and the p105 precursor of
            p50 NF-kappa B
  JOURNAL   Oncogene 7 (11), 2095-2104 (1992)
   PUBMED   1437141
REFERENCE   6  (bases 1 to 11108)
  AUTHORS   Kunsch,C., Ruben,S.M. and Rosen,C.A.
  TITLE     Selection of optimal kappa B/Rel DNA-binding motifs: interaction of
            both subunits of NF-kappa B with DNA is required for
            transcriptional activation
  JOURNAL   Mol Cell Biol 12 (10), 4412-4421 (1992)
   PUBMED   1406630
REFERENCE   7  (bases 1 to 11108)
  AUTHORS   Ruben,S.M., Klement,J.F., Coleman,T.A., Maher,M., Chen,C.H. and
            Rosen,C.A.
  TITLE     I-Rel: a novel rel-related protein that inhibits NF-kappa B
            transcriptional activity
  JOURNAL   Genes Dev 6 (5), 745-760 (1992)
   PUBMED   1577270
REFERENCE   8  (bases 1 to 11108)
  AUTHORS   Kochel,T. and Rice,N.R.
  TITLE     v-rel- and c-rel-protein complexes bind to the NF-kappa B site in
            vitro
  JOURNAL   Oncogene 7 (3), 567-572 (1992)
   PUBMED   1549370
REFERENCE   9  (bases 1 to 11108)
  AUTHORS   Brownell,E., Mittereder,N. and Rice,N.R.
  TITLE     A human rel proto-oncogene cDNA containing an Alu fragment as a
            potential coding exon
  JOURNAL   Oncogene 4 (7), 935-942 (1989)
   PUBMED   2666912
REFERENCE   10 (bases 1 to 11108)
  AUTHORS   Brownell,E., Kozak,C.A., Fowle,J.R. 3rd, Modi,W.S., Rice,N.R. and
            O'Brien,S.J.
  TITLE     Comparative genetic mapping of cellular rel sequences in man,
            mouse, and the domestic cat
  JOURNAL   Am J Hum Genet 39 (2), 194-202 (1986)
   PUBMED   3529946
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY123671.1, BC143885.1,
            AC010733.8 and BG036646.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001291746.1.
            
            Summary: This gene encodes a protein that belongs to the Rel
            homology domain/immunoglobulin-like fold, plexin, transcription
            factor (RHD/IPT) family. Members of this family regulate genes
            involved in apoptosis, inflammation, the immune response, and
            oncogenic processes. This proto-oncogene plays a role in the
            survival and proliferation of B lymphocytes. Mutation or
            amplification of this gene is associated with B-cell lymphomas,
            including Hodgkin's lymphoma. Single nucleotide polymorphisms in
            this gene are associated with susceptibility to ulcerative colitis
            and rheumatoid arthritis. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Apr 2014].
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            central coding region compared to variant 1. The encoded isoform
            (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK303926.1, SRR1803616.262836.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394479.4/ ENSP00000377989.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                HY123671.1         81-160
            81-120              BC143885.1         1-40
            121-121             AC010733.8         35149-35149
            122-2480            BC143885.1         42-2400
            2481-7100           AC010733.8         76440-81059
            7101-7667           BG036646.1         1-567
            7668-11108          AC010733.8         81627-85067
FEATURES             Location/Qualifiers
     source          1..11108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.1"
     gene            1..11108
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /note="REL proto-oncogene, NF-kB subunit"
                     /db_xref="GeneID:5966"
                     /db_xref="HGNC:HGNC:9954"
                     /db_xref="MIM:164910"
     exon            1..277
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..2031
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /note="isoform 2 is encoded by transcript variant 2;
                     proto-oncogene c-Rel; oncogene REL, avian
                     reticuloendotheliosis; v-rel avian reticuloendotheliosis
                     viral oncogene homolog"
                     /codon_start=1
                     /product="proto-oncogene c-Rel isoform 2"
                     /protein_id="NP_001278675.1"
                     /db_xref="CCDS:CCDS74515.1"
                     /db_xref="GeneID:5966"
                     /db_xref="HGNC:HGNC:9954"
                     /db_xref="MIM:164910"
                     /translation="MASGAYNPYIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNN
                     RTYPSIQIMNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGQERRPLFF
                     QNLGIRCVKKKEVKEAIITRIKAGINPFNVPEKQLNDIEDCDLNVVRLCFQVFLPDEH
                     GNLTTALPPVVSNPIYDNRAPNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEV
                     RFVLNDWEAKGIFSQADVHRQVAIVFKTPPYCKAITEPVTVKMQLRRPSDQEVSESMD
                     FRYLPDEKDTYGNKAKKQKTTLLFQKLCQDHVNFPERPRPGLLGSIGEGRYFKKEPNL
                     FSHDAVVREMPTGVSSQAESYYPSPGPISSGLSHHASMAPLPSSSWSSVAHPTPRSGN
                     TNPLSSFSTRTLPSNSQGIPPFLRIPVGNDLNASNACIYNNADDIVGMEASSMPSADL
                     YGISDPNMLSNCSVNMMTTSSDSMGETDNPRLLSMNLENPSCNSVLDPRDLRQLHQMS
                     SSSMSAGANSNTTVFVSQSDAFEGSDFSCADNSMINESGPSNSTNPNSHGFVQDSQYS
                     GIGSMQNEQLSDSFPYEFFQV"
     exon            278..420
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /inference="alignment:Splign:2.1.0"
     exon            421..569
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /inference="alignment:Splign:2.1.0"
     exon            570..661
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /inference="alignment:Splign:2.1.0"
     exon            662..802
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /inference="alignment:Splign:2.1.0"
     exon            803..907
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1120
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1189
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1258
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..11108
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11085..11090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /note="hexamer: AATAAA"
     polyA_site      11108
                     /gene="REL"
                     /gene_synonym="C-Rel; HIVEN86A; IMD92"
                     /note="major polyA site"
ORIGIN      
        1 actcggctct ccccgctccg ccccctgccc ctggctcccg tacggtggac ggcgacgctg
       61 ggtgacccgg ggtgcaagaa ttcaggggtt gggaaggtgt gagccgcaaa cccagcggag
      121 ggcgggaaga aggaggaggc ctctagggtg gtcgggggac tgggggcccc gccggcagag
      181 gtccctcggc ctcctgactg actgactgcg gccgcctccg gccaggacgc tgggagctgc
      241 ctgcgggaag gtgcggggag cggagccatg gcctccggtg cgtataaccc gtatatagag
      301 ataattgaac aacccaggca gaggggaatg cgttttagat acaaatgtga agggcgatca
      361 gcaggcagca ttccagggga gcacagcaca gacaacaacc gaacataccc ttctatccag
      421 attatgaact attatggaaa aggaaaagtg agaattacat tagtaacaaa gaatgaccca
      481 tataaacctc atcctcatga tttagttgga aaagactgca gagacggcta ctatgaagca
      541 gaatttggac aagaacgcag acctttgttt ttccaaaatt tgggtattcg atgtgtgaag
      601 aaaaaagaag taaaagaagc tattattaca agaataaagg caggaatcaa tccattcaat
      661 gtccctgaaa aacagctgaa tgatattgaa gattgtgacc tcaatgtggt gagactgtgt
      721 tttcaagttt ttctccctga tgaacatggt aatttgacga ctgctcttcc tcctgttgtc
      781 tcgaacccaa tttatgacaa ccgtgctcca aatactgcag aattaaggat ttgtcgtgta
      841 aacaagaatt gtggaagtgt cagaggagga gatgaaatat ttctactttg tgacaaagtt
      901 cagaaagatg acatagaagt tcgttttgtg ttgaacgatt gggaagcaaa aggcatcttt
      961 tcacaagctg atgtacaccg tcaagtagcc attgttttca aaactccacc atattgcaaa
     1021 gctatcacag aacccgtaac agtaaaaatg cagttgcgga gaccttctga ccaggaagtt
     1081 agtgaatcta tggattttag atatctgcca gatgaaaaag atacttacgg caataaagca
     1141 aagaaacaaa agacaactct gcttttccag aaactgtgcc aggatcacgt taattttcct
     1201 gagagaccaa gacctggtct cctcggttca attggagaag gaagatactt caaaaaagaa
     1261 ccaaacttgt tttctcatga tgcagttgtg agagaaatgc ctacaggggt ttcaagtcaa
     1321 gcagaatcct actatccctc acctgggccc atctcaagtg gattgtcaca tcatgcctca
     1381 atggcacctc tgccttcttc aagctggtca tcagtggccc accccacccc acgctcaggc
     1441 aatacaaacc cactgagtag tttttcaaca aggacacttc cttctaattc gcaaggtatc
     1501 ccaccattcc tgagaatacc tgttgggaat gatttaaatg cttctaatgc ttgcatttac
     1561 aacaatgccg atgacatagt cggaatggaa gcgtcatcca tgccatcagc agatttatat
     1621 ggtatttctg atcccaacat gctgtctaat tgttctgtga atatgatgac aaccagcagt
     1681 gacagcatgg gagagactga taatccaaga cttctgagca tgaatcttga aaacccctca
     1741 tgtaattcag tgttagaccc aagagacttg agacagctcc atcagatgtc ctcttccagt
     1801 atgtcagcag gcgccaattc caatactact gtttttgttt cacaatcaga tgcatttgag
     1861 ggatctgact tcagttgtgc agataacagc atgataaatg agtcgggacc atcaaacagt
     1921 actaatccaa acagtcatgg ttttgttcaa gatagtcagt attcaggtat tggcagtatg
     1981 caaaatgagc aattgagtga ctcctttcca tatgaatttt ttcaagtata acttgcaaga
     2041 tttaaatcct tttaaatctt gataccacct atatagatgc agcattttgt atttgtctaa
     2101 ctggggatat aatactatat ttatactgta tatataatac tgactgagaa tataatactg
     2161 tatttgagaa tataaaaaac ttttttcagg gaagaagcat acaactttgg acatagcgaa
     2221 tacaaaattg gaagctgtca taaaaagaca actcagaggc caggcgcagg ggctcacacc
     2281 tgtaatccta gcactttggg aggccaaggc gggtggatca cttgagacca ggaattcgag
     2341 accagcctgg ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa ttagctgagc
     2401 atggtggtac gtgcctgtac tgtcagctac ttgggaggct gaggcacaat aattgtttga
     2461 acccaggaag cagaggttgc agtgagctga gatcacacca ccgcactcca gcctgggtga
     2521 cagagtgaga ctctgtctca aaaaaaaaaa aacaaaaaaa acacactttt ttatatttct
     2581 ttttataatg ttttaatgta ttcttaaatt tcaagcaaat ttaagataaa acttgtaatg
     2641 gctatgccat tgaaaaactt aattttttat ttttgaggcc catgggccaa ggtaacccct
     2701 aaggggtttt cttaggcttc ttggagctta gatttgtatg tatatcaaaa tgtctttaaa
     2761 atgttaagtt gggcagaagg cagttgaagt gagctttcaa ggtatgggag gttttctaca
     2821 ttttatacta tttcaatcta tgcctttaaa gttgcttatg attttagctg tacactcatt
     2881 ttttaagggg aagaagtttc cttggaccat tcgcctttct tagatgtcct cactccctgt
     2941 gatctcataa aactgcctat ttgacatctc tatctagaaa tctaattaaa gctcacactc
     3001 agcatatcca aaactgaatt cttggtcttc cctcccaaac ttgcttctcc ttcagtcttc
     3061 tccaactcag taaatggcaa tgccatactt ctggttgctc aggccaaaaa ccctgaagtc
     3121 atccttgatt cttcttttag cacccatatc caatccatta gcaaatctgg tagaccctac
     3181 cttcacaata tatctaaagc tgaccacctc ttttgacctc tactattaac gccctattcc
     3241 aagccaccat catctcttcc ctggattgaa gctgtcatct acaaaaattc ttcttatatc
     3301 cttgcattcc tacagtctgt tccccataaa gtagccagaa tgattatttt taaaacaagt
     3361 caactcatac cattcatctg ctcaaaacca ttcattggct tctcatctca ctcagagcag
     3421 tcaaagtcct taaaagttgc aggcctagac tccctgtcct acctcaggta ccaccatatc
     3481 ccacctcctc atgcagctcc aggcaccttg gcctcagtgc tcctcaaagc atcaagtatg
     3541 cacttgcctt ggacagtctg tacttggtat tccctctgcc ttgaatgttg ttctcccaga
     3601 aaaatgcata gttcactctt acatccttca ggtgtcactc cactgttacc tgagcaggtc
     3661 gtccttgaat atatacatca gcattccctt tcccccctgc tttatgtatg tccatagcac
     3721 tcaccacgat ctgactttac taagtattta ttcatttact gtttgttttc ccataccgaa
     3781 atataaactt tctaaggaca gaaatttttg tgctttattg ttgaatctcc aatttgtaga
     3841 aaaatgccta ccttatatta aacactcagt aaatgtttat tgaacattaa aagtattact
     3901 aatagaactt tggtttttga aagaaataat aactttaatt ataagacgta tatgattttt
     3961 gcagttttac ttagtgtgac attgggttta tgagaatcgt gtacattcaa gtccaggaat
     4021 aataatggtc atccaaattg tttgaaagga aaataatccc agtggcaaaa tgatggtaga
     4081 atttgggtaa tctttttttt ccttttatga aaagagattt tattgaaggt aaaacattag
     4141 aggttcattg agaatctcta aatccatgtt ttgacattgt caagctcatt gcaacttcca
     4201 gattgagtaa cacttataac acatttcctt ttcaaagtgc aagattttta aaagagactt
     4261 gtcacatatt catttggctg gtttcaaatg gtgagctgaa tgctgggtaa tctctactag
     4321 ctccttaatc agatttaaaa ttctcagtgt ttcctagttg tttctgcata ctttatgtga
     4381 gttgttatag ctgtaacatt acactttatt tgctgtttgt gtttcgtgac ttttggtaat
     4441 tctggcattt agaaaccttt cactttgctt caaaacgtag ttatattttg gagttttcat
     4501 ttgatatata attatttatt ttgccctttt atttcccaaa gacattgtaa gggttaatta
     4561 gatcattata ttttattatt acagattaaa gttgggcagt aatcttaatt atgatggaat
     4621 tatcattatg ctaagtaatt aactttacct agtttgtttt acaactagaa cctgccctaa
     4681 atgttgaata tcttcctagc aagaaacagt ctgtcatttt acttacacga tgtctaacca
     4741 aaccataact ttacataaac tagtcgtttc ggtcaaatag aaaaatgtgt gaatgccata
     4801 aaaacaaaaa ttctcagtta aatgatactg ggaaataggg aagacagcaa agtgagactt
     4861 gggctcagga tggttcagga agaaaaaaaa agaaagaccc ctgagtacca ttaatattcc
     4921 tcagaaatta ttatttcaaa aggaaatatt tctgtattat aaatttttca tgagcagcca
     4981 ttatgaaatc tcacaagaat catagaattc aataaaaaag gtagaaagta atttttttac
     5041 ttaaaaatat aaattaaaat aaatttttaa aatcataagc acataaatag aacttaccag
     5101 ggagaaagaa aaacctgaag gcacaatttc ttttctgttc aaaatgtgaa cccaggatgt
     5161 ctctagatga tgatggatga taggtgggga gatttttttt ttttttaata cagaatctca
     5221 tagttttgga ttaattagca ccaatcagtt taaacactga ctgttagaat agctgcatgg
     5281 gtttttttct ttaaactaat taagcgttgg ctacttagta taagtaagta taagccgaat
     5341 taaggttctg ctacatctgt gtttagaata tttttttaaa actaaataag tgttggctag
     5401 ttttgcggtg taagcagaat taaggttctg ctacctctgt gtgtagaata ttcccaatgg
     5461 atttttcatt tttcaggtgc tattttttga ccctgtatag actttaattt aaaatgaatt
     5521 tggtaacgtt tctcctctgt ctctacatat attcatgctt tcacctgctc ttttaacacc
     5581 tgcttttagt atctgaggca ctttttctga actctacttg tgcactggat ccctcctcct
     5641 ttctctgcca ggctgtgttt actttatcct tacatcacca cttagtgatt cctttctttg
     5701 tataaacatg gtaaatgtct tcattagcct aaaaggaaag accaaataaa acctttccta
     5761 ccacttggat gcatttgcat cctgacttct gaaatgcctc cagcctccat tttctccctt
     5821 cccagttatt ccttagccca gccatctctg tctttagctc ctacaatttt cttaggatat
     5881 tctgggaaag atgagcggag actgcccgcc ttgtcaaatc tagtgtcttt ttttcagtcc
     5941 tcacactgct tgacctatgt ataacctcct atacttccct ctttgcatac tcctctgggt
     6001 tttctgtggt agtcaagatt cctccctgag atttatttcc catgagtctt gacccctccc
     6061 ctcagttggt gctatttccc cctacccgcc ctccgatgat cttatcagag cccacaggtt
     6121 cagttttctt tcatgctacc tgaatgtcct gataaactgg ctcgctctct tctttacctt
     6181 ccataatggc attaccattt accacgccac ccaagatact tactaggaac ctcaaagtat
     6241 tgtattcttt ttctccatca cactcatact taatcatcaa gtccttttga gcttgtctcc
     6301 tcttgaatat gtcccttctt aattcctgct gccttcttag taaaggcctt cattcttttt
     6361 tccctagtaa taatcttttc catatgttcc agttaaaata ccatgttctc cctattcctt
     6421 attacatagc tagcattcct tgaaaaaaaa caattctctc aggcctccat acctttagca
     6481 tgttacccac tctgcctctg ctcttctgga actagaacac tcatccttga aggctgggct
     6541 tctgtatgaa ggttggtcct gcctccttac ttgaggtgaa gctttgtaca tgcctgtatt
     6601 acggacatcc tcttatttaa gtgtttgtct ctttcgtcat tgggactcca gcacccagca
     6661 tagtccctag tatactagtt ggtgctgaat aaatagtagc tattattaga aaaggaaggg
     6721 tgaaattgac atgggagtta gtaaaatgta tatggaaatg atttttaaag ggaaaggtaa
     6781 tgattttctg gcaggaaaag cagcaatgac aagattactt aagtcttgtg aaataacact
     6841 tctcttcctt gacctgctgc ttcccttttt taccacacac acacgcacac ataccacagc
     6901 cctttgagac tgaaagcagc tctattgaga atagtagtgt caactgtatt atgtagaaat
     6961 tctaaagttt ttgggattat ttcatagccc tgaccttgct acttctctcc actttatgtg
     7021 gcaggtttaa tctcaggtct ccctcataca cttctcagcc tcagcaccta accctcacac
     7081 aacactccag tattgatgca gtcaatcttg tataacattt tttgaatgtc caatgtgcaa
     7141 agcacgatgt tggaaattat acagaggtga ataagacaaa aactcttgct ctcaaagatg
     7201 tcagtctttt tctttgcaag gataacacat gtagagtaaa atgcataaag gggactaatt
     7261 ttaaatgtac agcttaatta atttttatgt atgttaacac ccatgtcacc accatgttta
     7321 ggacatttcc agcacccctg aaatttcctt catgcccctt cccagtctgt acctacacct
     7381 ctaaatctat tttcaatctt aatggccttt taaataactg ggcttctcac aaccatagtg
     7441 aacagaaaca gctgggttgt caacgtctaa cctaatactt caggaaaact catgatggtt
     7501 tccatgttaa gagagacatg gagcagggca ctggcatggt ggatggatca cgcctgtaat
     7561 cccagcactt tgggaggccg aggtaggggg attgcttgag cccaggagtt caagactagc
     7621 ctgggtaata taaggaaaac ctgtctctgc aaaaaaaaaa aaaaaaagag gatacaacca
     7681 aatggaagaa cattccatgc tcatgggtag gaagaatcaa tatcgtgaaa atggccatac
     7741 tgcccaaggt aatttacaga ttcagtgcca tccccatcaa gctaccaatg cctttcttca
     7801 cagaattgga aaaaactact ttaaagttca tatggaacca aaaaagagcc catatcgcca
     7861 agtcaatcct aagccaaaag aacaaagctg gaggcatcac actacctgac ttcaaactat
     7921 actacaaggc tacagtaacc aaaacagcat ggtactggta ccaaaacaga gatatagatc
     7981 actggaacag aacagagccc tcagaaataa cgccgcatat ctacaactat ctgatctttg
     8041 acaaacctga gaaaaacaag caatggggaa aggattccct atttaataaa tggtgctggg
     8101 aaaactggct agccatatgt agaaagctga aactggatcc cttccttaca ccttatacaa
     8161 aaatcaattc aagatggatt aaagacttaa acgttagacc taaaaccata aaaaccctag
     8221 aagaaaacct aggcattacc attcaggaca taggcatggg caaggacttc atgtctaaaa
     8281 caccaaaagc aatggcaaca aaagccaaaa ttgacaaatg ggatctaatt aaactaaaga
     8341 gctgctgcac agcaaaagaa actaccatca gagtgaacag gcaacctaca aaatgggaga
     8401 aaattttcgc aacctactta tctgacaaag ggctaatatc cagaatctac aatgaactca
     8461 aacaaattta caagaaaaaa acaaccccat caaaaagtgg gcgaaggaca tgaacagaca
     8521 cttctcaaaa gaagacattt atgcagccaa aaaacacatg aaaaaatgct catcatgact
     8581 ggccatcaga gaaatgcaaa tcaaaaccac aatgagatac catctcacac cagttagaat
     8641 ggcaatcatt aaaaagtcag gagacaacag gtgctggaga ggatgtggag aaataggaac
     8701 acttttacac tgttggtggg actgtaaact agttcaacca ttgtggaagt cagtgtggcg
     8761 attcctcagg gatgtagaac tggaaatacc gtttgaccca gccatcccat tactgggtat
     8821 atacccaaag gactataaat catgctgcta taaagacaca tgcacacgta tgtttattgc
     8881 ggcattattc acaatagcaa agacttggaa ccaacccaaa tgtccaacaa tgatagactg
     8941 gattaagaaa atgtggcaca tatacaccat ggaatactat gcagccataa aaaatgatga
     9001 attcatgtcc tttgtaggga catggatgaa attggaaaac atcattctca gtaaactatc
     9061 gcaagaacaa gaaaccaaac accacatatt ctcactcata ggtgggaatt gaacaatgag
     9121 aacacatgga cacaggaagg ggaatatcac actggggact gttgtggggt ggggggaggg
     9181 gggagggata gcattgggag atatacctaa tgctagatga cgagttagtg ggtgcagtgc
     9241 accagcatgg cacatgtata catatgtaag taacctgcac aatgtgcaca tgtaccctaa
     9301 agcttaaagt ataataaaaa ataaataaat aaataaataa gaaaaagaaa gccaggcatg
     9361 gtgacatgtg cctgtggtcc cagctattag ggaggctgag gtgggaggat cccttgaacc
     9421 caggaggttg agtctgtagt gagcagtgat tacgccactg cactccagcc tgggcaagac
     9481 cctgtctcaa aaaaaaaaaa gacttagaat tggtgatcca ggccgcctaa tggcatcaaa
     9541 taatttgtta tatctttaat ttattgaagg atcaccacat gcttttaaat agcatggaga
     9601 aatggaaaga atagggactt tttactcagg taatacccag cctgctacct aacaggttgt
     9661 gttgtactaa ataaaatggt acataagaag aaacactgta aattatatag tgcgaatcaa
     9721 atattgttaa taaaccaata tctgtatatc ctatgtcccg gattaatctt taatttagat
     9781 actccttcta gttatctaat acacagcaga gtgagaaaaa tcattatgga ttaggttctt
     9841 tagtaagaaa cctgagatgg acttctcatt agcattaact agttattgcc cagctttgga
     9901 gagccttctt ttggcttatc atttattata agcccagaaa taggtgacta atcagagata
     9961 aatgtatggg ttgtctgtat ctagttttat gccttttttt tgcctaagac gtagtcaaat
    10021 taatatttta actaatacat cttagcagag tttagttaag cacaaagtta acagtgggta
    10081 ggattgaatc ttgaaagtaa tcatgtctgt aatgtttttc atgcatgcaa aaagcacaga
    10141 caaaaccact catgccctat taataaacaa aatacagatc aaagttttca aaagtaatca
    10201 ctctatttat tctaaatgtc tgtggcttta ggaaaatacc accagctagt acttacctat
    10261 ttaaagatgt agaatttatt atcctctaat attcttatca gttgtttcca caactttagt
    10321 ttactattgg actttcaaaa atttaaagaa ttacaagtaa aattcattaa acacttgtgt
    10381 gtgaatagta atacacagta attagtacag catgttgctt cttcaacaaa ttgagttttc
    10441 agggaaatca gcaagtaaat gaaatataaa tttttggtaa aagtatcaaa cattcatctt
    10501 gcccattttt cctcttaaac tttattatct aatcaaacat agttttccat aagatgtaat
    10561 aaaatataga taaggttgga atatttgagg atccatttgt ggaactgaat ttaatgagac
    10621 ttcattggtg atacactcaa tttttactgg gtaattagct aataatgttg gtcactgtct
    10681 cacagttcaa gtagctttaa gatgatgtgg caaggaaaac acaaagcttt tgggtaacca
    10741 gcgttcttaa atgtatggtt tttgaccagg tgaacccttt agaagtgatt tctgttttaa
    10801 aagtatgtac ttaaaatacc tttggctgtg atgaatgtag atcccagcag aataccaaaa
    10861 tcctattttt tttgactgag tatttgtaga tgcttaatga ctgaaatgaa tttggaggca
    10921 ctgatgaaag tgattttttt aaagttctca ggtactgttc aattatttaa tgttaagttt
    10981 agtatcaaga tacagttgtt tttaaaatgc caaaatgctg tttattatac agaatatttt
    11041 attacatttg caatatcttt gtatatagtg atttttttct tgataataaa tggaaaaatt
    11101 ctaaaaca
//
