LOCUS       NM_001008387             936 bp    mRNA    linear   PRI 12-SEP-2021
DEFINITION  Homo sapiens regenerating family member 3 gamma (REG3G), transcript
            variant 1, mRNA.
ACCESSION   NM_001008387
VERSION     NM_001008387.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 936)
  AUTHORS   Gajawada P, Cetinkaya A, von Gerlach S, Kubin N, Burger H, Nabauer
            M, Grinninger C, Rolf A, Schonburg M, Choi YH, Kubin T and Richter
            M.
  TITLE     Myocardial Accumulations of Reg3A, Reg3gamma and Oncostatin M Are
            Associated with the Formation of Granulomata in Patients with
            Cardiac Sarcoidosis
  JOURNAL   Int J Mol Sci 22 (8), 4148 (2021)
   PUBMED   33923774
  REMARK    GeneRIF: Myocardial Accumulations of Reg3A, Reg3gamma and
            Oncostatin M Are Associated with the Formation of Granulomata in
            Patients with Cardiac Sarcoidosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 936)
  AUTHORS   Shen M, Wang Q, Xu S, Chen G, Xu H, Li X and Zhao S.
  TITLE     Role of oncogenic REGgamma in cancer
  JOURNAL   Biomed Pharmacother 130, 110614 (2020)
   PUBMED   32935661
  REMARK    GeneRIF: Role of oncogenic REGgamma in cancer.
            Review article
REFERENCE   3  (bases 1 to 936)
  AUTHORS   Tong L, Shen S, Huang Q, Fu J, Wang T, Pan L, Zhang P, Chen G,
            Huang T, Li K, Liu Q, Xie S, Yang X, Moses RE, Li X and Li L.
  TITLE     Proteasome-dependent degradation of Smad7 is critical for lung
            cancer metastasis
  JOURNAL   Cell Death Differ 27 (6), 1795-1806 (2020)
   PUBMED   31767934
  REMARK    GeneRIF: Proteasome-dependent degradation of Smad7 is critical for
            lung cancer metastasis.
REFERENCE   4  (bases 1 to 936)
  AUTHORS   Goodbourn PT, Bosten JM, Bargary G, Hogg RE, Lawrance-Owen AJ and
            Mollon JD.
  TITLE     Variants in the 1q21 risk region are associated with a visual
            endophenotype of autism and schizophrenia
  JOURNAL   Genes Brain Behav 13 (2), 144-151 (2014)
   PUBMED   24152035
REFERENCE   5  (bases 1 to 936)
  AUTHORS   Lee KS, Kalantzis A, Jackson CB, O'Connor L, Murata-Kamiya N,
            Hatakeyama M, Judd LM, Giraud AS and Menheniott TR.
  TITLE     Helicobacter pylori CagA triggers expression of the bactericidal
            lectin REG3gamma via gastric STAT3 activation
  JOURNAL   PLoS One 7 (2), e30786 (2012)
   PUBMED   22312430
  REMARK    GeneRIF: a model of CagA-directed REG3gamma expression in gastric
            epithelial cells via activation of the IL-11/gp130/STAT3 pathway
REFERENCE   6  (bases 1 to 936)
  AUTHORS   Cash HL, Whitham CV, Behrendt CL and Hooper LV.
  TITLE     Symbiotic bacteria direct expression of an intestinal bactericidal
            lectin
  JOURNAL   Science 313 (5790), 1126-1130 (2006)
   PUBMED   16931762
  REMARK    GeneRIF: This gene encodes a secreted peptide that displays
            antimicrobial activity against Gram-positive bacteria.
REFERENCE   7  (bases 1 to 936)
  AUTHORS   Laurine E, Manival X, Montgelard C, Bideau C, Berge-Lefranc JL,
            Erard M and Verdier JM.
  TITLE     PAP IB, a new member of the Reg gene family: cloning, expression,
            structural properties, and evolution by gene duplication
  JOURNAL   Biochim Biophys Acta 1727 (3), 177-187 (2005)
   PUBMED   15777617
  REMARK    GeneRIF: PAP IB represents a good example of duplication and
            divergence, probably with the acquisition of new functions, thus
            participating in the evolution of the protein repertoire.
REFERENCE   8  (bases 1 to 936)
  AUTHORS   Zhang Z and Henzel WJ.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   9  (bases 1 to 936)
  AUTHORS   Nata K, Liu Y, Xu L, Ikeda T, Akiyama T, Noguchi N, Kawaguchi S,
            Yamauchi A, Takahashi I, Shervani NJ, Onogawa T, Takasawa S and
            Okamoto H.
  TITLE     Molecular cloning, expression and chromosomal localization of a
            novel human REG family gene, REG III
  JOURNAL   Gene 340 (1), 161-170 (2004)
   PUBMED   15556304
  REMARK    GeneRIF: REG III was identified and expressed predominantly in
            pancreas and testis, but not in small intestine
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB161038.1 and AK292595.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001008387.2.
            
            Summary: This gene encodes a member of the regenerating
            islet-derived genes (REG)3 protein family. These proteins are
            secreted, C-type lectins with a carbohydrate recognition domain and
            N-terminal signal peptide. The protein encoded by this gene is an
            antimicrobial lectin with activity against Gram-positive bacteria.
            Alternative splicing results in multiple transcript variants
            encoding multiple isoforms. [provided by RefSeq, Nov 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 2
            encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.97751.1, AB161038.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000272324.10/
                                                  ENSP00000272324.5
            Protein has antimicrobial activity :: PMID: 16931762
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-479               AB161038.1         2-480
            480-936             AK292595.1         380-836
FEATURES             Location/Qualifiers
     source          1..936
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p12"
     gene            1..936
                     /gene="REG3G"
                     /gene_synonym="LPPM429; PAP IB; PAP-1B; PAP1B; PAPIB; REG
                     III; REG-III; UNQ429"
                     /note="regenerating family member 3 gamma"
                     /db_xref="GeneID:130120"
                     /db_xref="HGNC:HGNC:29595"
                     /db_xref="MIM:609933"
     exon            1..72
                     /gene="REG3G"
                     /gene_synonym="LPPM429; PAP IB; PAP-1B; PAP1B; PAPIB; REG
                     III; REG-III; UNQ429"
                     /inference="alignment:Splign:2.1.0"
     exon            73..259
                     /gene="REG3G"
                     /gene_synonym="LPPM429; PAP IB; PAP-1B; PAP1B; PAPIB; REG
                     III; REG-III; UNQ429"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..711
                     /gene="REG3G"
                     /gene_synonym="LPPM429; PAP IB; PAP-1B; PAP1B; PAPIB; REG
                     III; REG-III; UNQ429"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; regenerating gene III; regenerating
                     islet-derived protein 3-gamma; reg III-gamma;
                     pancreatitis-associated protein 1B;
                     pancreatitis-associated protein IB; regenerating
                     islet-derived protein III-gamma; REG-3-gamma; regenerating
                     islet-derived 3 gamma"
                     /codon_start=1
                     /product="regenerating islet-derived protein 3-gamma
                     isoform 1 preproprotein"
                     /protein_id="NP_001008388.1"
                     /db_xref="CCDS:CCDS1962.1"
                     /db_xref="GeneID:130120"
                     /db_xref="HGNC:HGNC:29595"
                     /db_xref="MIM:609933"
                     /translation="MLPPMALPSVSWMLLSCLILLCQVQGEETQKELPSPRISCPKGS
                     KAYGSPCYALFLSPKSWMDADLACQKRPSGKLVSVLSGAEGSFVSSLVRSISNSYSYI
                     WIGLHDPTQGSEPDGDGWEWSSTDVMNYFAWEKNPSTILNPGHCGSLSRSTGFLKWKD
                     YNCDAKLPYVCKFKD"
     exon            260..378
                     /gene="REG3G"
                     /gene_synonym="LPPM429; PAP IB; PAP-1B; PAP1B; PAPIB; REG
                     III; REG-III; UNQ429"
                     /inference="alignment:Splign:2.1.0"
     exon            379..516
                     /gene="REG3G"
                     /gene_synonym="LPPM429; PAP IB; PAP-1B; PAP1B; PAPIB; REG
                     III; REG-III; UNQ429"
                     /inference="alignment:Splign:2.1.0"
     exon            517..643
                     /gene="REG3G"
                     /gene_synonym="LPPM429; PAP IB; PAP-1B; PAP1B; PAPIB; REG
                     III; REG-III; UNQ429"
                     /inference="alignment:Splign:2.1.0"
     exon            644..936
                     /gene="REG3G"
                     /gene_synonym="LPPM429; PAP IB; PAP-1B; PAP1B; PAPIB; REG
                     III; REG-III; UNQ429"
                     /inference="alignment:Splign:2.1.0"
     regulatory      917..922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REG3G"
                     /gene_synonym="LPPM429; PAP IB; PAP-1B; PAP1B; PAPIB; REG
                     III; REG-III; UNQ429"
                     /note="hexamer: AATAAA"
     polyA_site      936
                     /gene="REG3G"
                     /gene_synonym="LPPM429; PAP IB; PAP-1B; PAP1B; PAPIB; REG
                     III; REG-III; UNQ429"
                     /note="major polyA site"
ORIGIN      
        1 atccctgaga tctttttata aaaaacccag tctttgctga ccagacaaag cataccagat
       61 ctcaccagag agtcctaggg gactacagaa ggaaaaagac aagaggcagt aggatatctg
      121 tgtgtcctcc cgctgaccac acttccttta gtgacccgat tgcctcctca agtcgcagac
      181 actatgctgc ctcccatggc cctgcccagt gtgtcctgga tgctgctttc ctgcctcatt
      241 ctcctgtgtc aggttcaagg tgaagaaacc cagaaggaac tgccctctcc acggatcagc
      301 tgtcccaaag gctccaaggc ctatggctcc ccctgctatg ccttgttttt gtcaccaaaa
      361 tcctggatgg atgcagatct ggcttgccag aagcggccct ctggaaaact ggtgtctgtg
      421 ctcagtgggg ctgagggatc cttcgtgtcc tccctggtga ggagcattag taacagctat
      481 tcatacatct ggattgggct ccatgacccc acacagggct ctgagcctga tggagatgga
      541 tgggagtgga gtagcactga tgtgatgaat tactttgcat gggagaaaaa tccctccacc
      601 atcttaaacc ctggccactg tgggagcctg tcaagaagca caggatttct gaagtggaaa
      661 gattataact gtgatgcaaa gttaccctat gtctgcaagt tcaaggacta gggcaggtgg
      721 gaagtcagca gcctgagctt ggcgtgcagc tcatcatgga catgagacca gtgtgaagac
      781 tcaccctgga agagaatatt ctccccaaac tgccctacct gactaccttg tcatgatcct
      841 ccttcttttt cctttttctt caccttcatt tcaggctttt ctctgtcttc catgtcttga
      901 gatctcagag aataataata aaaatgttac tttata
//
