LOCUS       NM_002580                808 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens regenerating family member 3 alpha (REG3A), transcript
            variant 1, mRNA.
ACCESSION   NM_002580
VERSION     NM_002580.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 808)
  AUTHORS   Jin,X., Yang,S., Lu,X., Chen,X. and Dai,W.
  TITLE     Increased expression of REG3A promotes tumorigenic behavior in
            triple negative breast cancer cells
  JOURNAL   Breast Cancer Res 26 (1), 92 (2024)
   PUBMED   38840145
  REMARK    GeneRIF: Increased expression of REG3A promotes tumorigenic
            behavior in triple negative breast cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 808)
  AUTHORS   Yu,L., Zhou,Y., Sun,S., Wang,R., Yu,W., Xiao,H., Yu,Z. and Luo,C.
  TITLE     Tumor-suppressive effect of Reg3A in COAD is mediated by T cell
            activation in nude mice
  JOURNAL   Biomed Pharmacother 169, 115922 (2023)
   PUBMED   38011786
  REMARK    GeneRIF: Tumor-suppressive effect of Reg3A in COAD is mediated by T
            cell activation in nude mice.
REFERENCE   3  (bases 1 to 808)
  AUTHORS   He,X. and Zhou,H.
  TITLE     Decoding the IBD paradox: A triadic interplay between REG3,
            enterococci, and NOD2
  JOURNAL   Cell Host Microbe 31 (9), 1425-1427 (2023)
   PUBMED   37708849
  REMARK    GeneRIF: Decoding the IBD paradox: A triadic interplay between
            REG3, enterococci, and NOD2.
REFERENCE   4  (bases 1 to 808)
  AUTHORS   Cash,H.L., Whitham,C.V., Behrendt,C.L. and Hooper,L.V.
  TITLE     Symbiotic bacteria direct expression of an intestinal bactericidal
            lectin
  JOURNAL   Science 313 (5790), 1126-1130 (2006)
   PUBMED   16931762
  REMARK    GeneRIF: findings show that RegIIIgamma and its human counterpart,
            HIP/PAP, are directly antimicrobial proteins that bind their
            bacterial targets via interactions with peptidoglycan carbohydrate
REFERENCE   5  (bases 1 to 808)
  AUTHORS   Itoh,T., Sawabu,N., Motoo,Y., Funakoshi,A. and Teraoka,H.
  TITLE     The human pancreatitis-associated protein (PAP)-encoding gene
            generates multiple transcripts through alternative use of 5' exons
  JOURNAL   Gene 155 (2), 283-287 (1995)
   PUBMED   7721106
REFERENCE   6  (bases 1 to 808)
  AUTHORS   Lasserre,C., Simon,M.T., Ishikawa,H., Diriong,S., Nguyen,V.C.,
            Christa,L., Vernier,P. and Brechot,C.
  TITLE     Structural organization and chromosomal localization of a human
            gene (HIP/PAP) encoding a C-type lectin overexpressed in primary
            liver cancer
  JOURNAL   Eur J Biochem 224 (1), 29-38 (1994)
   PUBMED   8076648
REFERENCE   7  (bases 1 to 808)
  AUTHORS   Dusetti,N.J., Frigerio,J.M., Fox,M.F., Swallow,D.M., Dagorn,J.C.
            and Iovanna,J.L.
  TITLE     Molecular cloning, genomic organization, and chromosomal
            localization of the human pancreatitis-associated protein (PAP)
            gene
  JOURNAL   Genomics 19 (1), 108-114 (1994)
   PUBMED   8188210
REFERENCE   8  (bases 1 to 808)
  AUTHORS   Itoh,T. and Teraoka,H.
  TITLE     Cloning and tissue-specific expression of cDNAs for the human and
            mouse homologues of rat pancreatitis-associated protein (PAP)
  JOURNAL   Biochim Biophys Acta 1172 (1-2), 184-186 (1993)
   PUBMED   7679928
REFERENCE   9  (bases 1 to 808)
  AUTHORS   Orelle,B., Keim,V., Masciotra,L., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Human pancreatitis-associated protein. Messenger RNA cloning and
            expression in pancreatic diseases
  JOURNAL   J Clin Invest 90 (6), 2284-2291 (1992)
   PUBMED   1469087
REFERENCE   10 (bases 1 to 808)
  AUTHORS   Lasserre,C., Christa,L., Simon,M.T., Vernier,P. and Brechot,C.
  TITLE     A novel gene (HIP) activated in human primary liver cancer
  JOURNAL   Cancer Res 52 (18), 5089-5095 (1992)
   PUBMED   1325291
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ777112.1 and BC036776.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002580.2.
            
            Summary: This gene encodes a pancreatic secretory protein that may
            be involved in cell proliferation or differentiation. It has
            similarity to the C-type lectin superfamily. The enhanced
            expression of this gene is observed during pancreatic inflammation
            and liver carcinogenesis. The mature protein also functions as an
            antimicrobial protein with antibacterial activity. Alternate
            splicing results in multiple transcript variants that encode the
            same protein.[provided by RefSeq, Nov 2014].
            
            Transcript Variant: This variant (1) represents the functional
            protein. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138519.380797.1,
                                           DRR138519.38737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153733 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000305165.3/
                                                  ENSP00000304311.2
            Protein has antimicrobial activity :: PMID: 16931762
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BQ777112.1         2-19
            19-808              BC036776.1         1-790
FEATURES             Location/Qualifiers
     source          1..808
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p12"
     gene            1..808
                     /gene="REG3A"
                     /gene_synonym="HIP; HIP/PAP; INGAP; PAP; PAP-H; PAP1;
                     PBCGF; REG-III; REG3"
                     /note="regenerating family member 3 alpha"
                     /db_xref="GeneID:5068"
                     /db_xref="HGNC:HGNC:8601"
                     /db_xref="MIM:167805"
     exon            1..26
                     /gene="REG3A"
                     /gene_synonym="HIP; HIP/PAP; INGAP; PAP; PAP-H; PAP1;
                     PBCGF; REG-III; REG3"
                     /inference="alignment:Splign:2.1.0"
     exon            27..136
                     /gene="REG3A"
                     /gene_synonym="HIP; HIP/PAP; INGAP; PAP; PAP-H; PAP1;
                     PBCGF; REG-III; REG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..588
                     /gene="REG3A"
                     /gene_synonym="HIP; HIP/PAP; INGAP; PAP; PAP-H; PAP1;
                     PBCGF; REG-III; REG3"
                     /note="pancreatic beta cell growth factor;
                     hepatointestinal pancreatic protein;
                     hepatocarcinoma-intestine-pancreas; PAP homologous
                     protein; regenerating islet-derived protein 3-alpha;
                     proliferation-inducing protein 34; proliferation-inducing
                     protein 42; REG-3-alpha; reg III-alpha;
                     pancreatitis-associated protein 1; regenerating
                     islet-derived protein III-alpha; human proislet peptide;
                     regenerating islet-derived 3 alpha"
                     /codon_start=1
                     /product="regenerating islet-derived protein 3-alpha
                     precursor"
                     /protein_id="NP_002571.1"
                     /db_xref="CCDS:CCDS1965.1"
                     /db_xref="GeneID:5068"
                     /db_xref="HGNC:HGNC:8601"
                     /db_xref="MIM:167805"
                     /translation="MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGS
                     KAYGSHCYALFLSPKSWTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYV
                     WIGLHDPTQGTEPNGEGWEWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKD
                     YNCNVRLPYVCKFTD"
     exon            137..255
                     /gene="REG3A"
                     /gene_synonym="HIP; HIP/PAP; INGAP; PAP; PAP-H; PAP1;
                     PBCGF; REG-III; REG3"
                     /inference="alignment:Splign:2.1.0"
     exon            256..393
                     /gene="REG3A"
                     /gene_synonym="HIP; HIP/PAP; INGAP; PAP; PAP-H; PAP1;
                     PBCGF; REG-III; REG3"
                     /inference="alignment:Splign:2.1.0"
     exon            394..520
                     /gene="REG3A"
                     /gene_synonym="HIP; HIP/PAP; INGAP; PAP; PAP-H; PAP1;
                     PBCGF; REG-III; REG3"
                     /inference="alignment:Splign:2.1.0"
     exon            521..808
                     /gene="REG3A"
                     /gene_synonym="HIP; HIP/PAP; INGAP; PAP; PAP-H; PAP1;
                     PBCGF; REG-III; REG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      789..794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REG3A"
                     /gene_synonym="HIP; HIP/PAP; INGAP; PAP; PAP-H; PAP1;
                     PBCGF; REG-III; REG3"
                     /note="hexamer: AATAAA"
     polyA_site      808
                     /gene="REG3A"
                     /gene_synonym="HIP; HIP/PAP; INGAP; PAP; PAP-H; PAP1;
                     PBCGF; REG-III; REG3"
                     /note="major polyA site"
ORIGIN      
        1 aaaccatacc atatcccacc agagagtgac tcctgattgc ctcctcaagt cgcagacact
       61 atgctgcctc ccatggccct gcccagtgta tcttggatgc tgctttcctg cctcatgctg
      121 ctgtctcagg ttcaaggtga agaaccccag agggaactgc cctctgcacg gatccgctgt
      181 cccaaaggct ccaaggccta tggctcccac tgctatgcct tgtttttgtc accaaaatcc
      241 tggacagatg cagatctggc ctgccagaag cggccctctg gaaacctggt gtctgtgctc
      301 agtggggctg agggatcctt cgtgtcctcc ctggtgaaga gcattggtaa cagctactca
      361 tacgtctgga ttgggctcca tgaccccaca cagggcaccg agcccaatgg agaaggttgg
      421 gagtggagta gcagtgatgt gatgaattac tttgcatggg agagaaatcc ctccaccatc
      481 tcaagccccg gccactgtgc gagcctgtcg agaagcacag catttctgag gtggaaagat
      541 tataactgta atgtgaggtt accctatgtc tgcaagttca ctgactagtg caggagggaa
      601 gtcagcagcc tgtgtttggt gtgcaactca tcatgggcat gagaccagtg tgaggactca
      661 ccctggaaga gaatattcgc ttaattcccc caacctgacc acctcattct tatctttctt
      721 ctgtttcttc ctccccgctg tcatttcagt ctcttcattt tgtcatacgg cctaaggctt
      781 taaagagcaa taaaattttt agtctgca
//
