LOCUS       NM_006507                775 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regenerating family member 1 beta (REG1B), mRNA.
ACCESSION   NM_006507
VERSION     NM_006507.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 775)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 775)
  AUTHORS   Liu,Z., Fan,Y.M., Ashorn,P., Cheung,Y.B., Hallamaa,L., Hyoty,H.,
            Maleta,K., Lehto,K.M., Oikarinen,S., Parkkila,S. and Ashorn,U.
  TITLE     Faecal regenerating 1B protein concentration is not associated with
            child growth in rural Malawi
  JOURNAL   J Paediatr Child Health 57 (3), 388-394 (2021)
   PUBMED   33112481
  REMARK    GeneRIF: Faecal regenerating 1B protein concentration is not
            associated with child growth in rural Malawi.
REFERENCE   3  (bases 1 to 775)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 775)
  AUTHORS   Aboshanif,M., Kawasaki,Y., Omori,Y., Suzuki,S., Honda,K.,
            Motoyama,S. and Ishikawa,K.
  TITLE     Prognostic role of regenerating gene-I in patients with stage-IV
            head and neck squamous cell carcinoma
  JOURNAL   Diagn Pathol 11 (1), 79 (2016)
   PUBMED   27539087
  REMARK    GeneRIF: REG-I is expressed in head and neck squamous cell
            carcinoma and is associated with a longer survival status.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 775)
  AUTHORS   Yamauchi,A., Itaya-Hironaka,A., Sakuramoto-Tsuchida,S., Takeda,M.,
            Yoshimoto,K., Miyaoka,T., Fujimura,T., Tsujinaka,H., Tsuchida,C.,
            Ota,H. and Takasawa,S.
  TITLE     Synergistic activations of REG I alpha and REG I beta promoters by
            IL-6 and Glucocorticoids through JAK/STAT pathway in human
            pancreatic beta cells
  JOURNAL   J Diabetes Res 2015, 173058 (2015)
   PUBMED   25767811
  REMARK    GeneRIF: the expression of REG Ialpha and REG Ibeta may be
            upregulated in human beta cells under inflammatory conditions
            through the JAK/STAT pathway
REFERENCE   6  (bases 1 to 775)
  AUTHORS   Itoh,T., Tsuzuki,H., Katoh,T., Teraoka,H., Matsumoto,K.,
            Yoshida,N., Terazono,K., Watanabe,T., Yonekura,H., Yamamoto,H. et
            al.
  TITLE     Isolation and characterization of human reg protein produced in
            Saccharomyces cerevisiae
  JOURNAL   FEBS Lett 272 (1-2), 85-88 (1990)
   PUBMED   2226837
REFERENCE   7  (bases 1 to 775)
  AUTHORS   de la Monte,S.M., Ozturk,M. and Wands,J.R.
  TITLE     Enhanced expression of an exocrine pancreatic protein in
            Alzheimer's disease and the developing human brain
  JOURNAL   J Clin Invest 86 (3), 1004-1013 (1990)
   PUBMED   2394826
REFERENCE   8  (bases 1 to 775)
  AUTHORS   Watanabe,T., Yonekura,H., Terazono,K., Yamamoto,H. and Okamoto,H.
  TITLE     Complete nucleotide sequence of human reg gene and its expression
            in normal and tumoral tissues. The reg protein, pancreatic stone
            protein, and pancreatic thread protein are one and the same product
            of the gene
  JOURNAL   J Biol Chem 265 (13), 7432-7439 (1990)
   PUBMED   2332435
REFERENCE   9  (bases 1 to 775)
  AUTHORS   Giorgi,D., Bernard,J.P., Rouquier,S., Iovanna,J., Sarles,H. and
            Dagorn,J.C.
  TITLE     Secretory pancreatic stone protein messenger RNA. Nucleotide
            sequence and expression in chronic calcifying pancreatitis
  JOURNAL   J Clin Invest 84 (1), 100-106 (1989)
   PUBMED   2525567
REFERENCE   10 (bases 1 to 775)
  AUTHORS   De Caro,A.M., Adrich,Z., Fournet,B., Capon,C., Bonicel,J.J., De
            Caro,J.D. and Rovery,M.
  TITLE     N-terminal sequence extension in the glycosylated forms of human
            pancreatic stone protein. The 5-oxoproline N-terminal chain is
            O-glycosylated on the 5th amino acid residue
  JOURNAL   Biochim Biophys Acta 994 (3), 281-284 (1989)
   PUBMED   2493268
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D16816.1 and CA867116.1.
            
            On May 17, 2019 this sequence version replaced NM_006507.3.
            
            Summary: This gene is a type I subclass member of the Reg gene
            family. The Reg gene family is a multigene family grouped into four
            subclasses, types I, II, III and IV based on the primary structures
            of the encoded proteins. This gene encodes a protein secreted by
            the exocrine pancreas that is highly similar to the REG1A protein.
            The related REG1A protein is associated with islet cell
            regeneration and diabetogenesis, and may be involved in pancreatic
            lithogenesis. Reg family members REG1A, REGL, PAP and this gene are
            tandemly clustered on chromosome 2p12 and may have arisen from the
            same ancestral gene by gene duplication. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D16816.1, BM769964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153733, SAMEA2153932
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305089.8/ ENSP00000303206.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-723               D16816.1           1-723
            724-775             CA867116.1         7-58                c
FEATURES             Location/Qualifiers
     source          1..775
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p12"
     gene            1..775
                     /gene="REG1B"
                     /gene_synonym="PSPS2; REGH; REGI-BETA; REGL"
                     /note="regenerating family member 1 beta"
                     /db_xref="GeneID:5968"
                     /db_xref="HGNC:HGNC:9952"
                     /db_xref="MIM:167771"
     exon            1..35
                     /gene="REG1B"
                     /gene_synonym="PSPS2; REGH; REGI-BETA; REGL"
                     /inference="alignment:Splign:2.1.0"
     exon            36..145
                     /gene="REG1B"
                     /gene_synonym="PSPS2; REGH; REGI-BETA; REGL"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..582
                     /gene="REG1B"
                     /gene_synonym="PSPS2; REGH; REGI-BETA; REGL"
                     /note="regenerating islet-derived 1 beta (pancreatic stone
                     protein, pancreatic thread protein); regenerating protein
                     I beta; secretory pancreatic stone protein 2;
                     lithostathine-1-beta; PSP-2; REG-1-beta; regenerating
                     islet-derived protein 1-beta"
                     /codon_start=1
                     /product="lithostathine-1-beta precursor"
                     /protein_id="NP_006498.1"
                     /db_xref="CCDS:CCDS1963.1"
                     /db_xref="GeneID:5968"
                     /db_xref="HGNC:HGNC:9952"
                     /db_xref="MIM:167771"
                     /translation="MAQTNSFFMLISSLMFLSLSQGQESQTELPNPRISCPEGTNAYR
                     SYCYYFNEDPETWVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESSTDDSNVWIGL
                     HDPKKNRRWHWSSGSLVSYKSWDTGSPSSANAGYCASLTSCSGFKKWKDESCEKKFSF
                     VCKFKN"
     exon            146..264
                     /gene="REG1B"
                     /gene_synonym="PSPS2; REGH; REGI-BETA; REGL"
                     /inference="alignment:Splign:2.1.0"
     exon            265..402
                     /gene="REG1B"
                     /gene_synonym="PSPS2; REGH; REGI-BETA; REGL"
                     /inference="alignment:Splign:2.1.0"
     exon            403..514
                     /gene="REG1B"
                     /gene_synonym="PSPS2; REGH; REGI-BETA; REGL"
                     /inference="alignment:Splign:2.1.0"
     exon            515..775
                     /gene="REG1B"
                     /gene_synonym="PSPS2; REGH; REGI-BETA; REGL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccacctc aagtggacaa ggcacttacc aacagagatt gctgatttgc tccttaagca
       61 agagattcac tgccgctaag catggctcag accaactcgt tcttcatgct gatctcctcc
      121 ctgatgttcc tgtctctgag ccaaggccag gagtcccaga cagagctgcc taatccccga
      181 atcagctgcc cagaaggcac caatgcctat cgctcctact gctactactt taatgaagac
      241 cctgagacct gggttgatgc agatctctat tgccagaaca tgaattcagg caacctggtg
      301 tctgtgctca cccaggcgga gggtgccttc gtggcctcac tgattaagga gagtagcact
      361 gatgacagca atgtctggat tggcctccat gacccaaaaa agaaccgccg ctggcactgg
      421 agtagtgggt ccctggtctc ctacaagtcc tgggacactg gatccccgag cagtgctaat
      481 gctggctact gtgcaagcct gacttcatgc tcaggattca agaaatggaa ggatgaatct
      541 tgtgagaaga agttctcctt tgtttgcaag ttcaaaaact agaggaagct gaaaaatgga
      601 tgtctagaac tggtcctgca attactatga agtcaaaaat taaactagac tatgtctcca
      661 actcagttca gaccatctcc tccctaatga gtttgcatcg ctgatcttca gtaccttcac
      721 ctgtctcagt ctctagagcc ctgaaaaata aaaacaaact tatttttatc cagtg
//
