LOCUS       NM_002909                768 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens regenerating family member 1 alpha (REG1A), mRNA.
ACCESSION   NM_002909
VERSION     NM_002909.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 768)
  AUTHORS   Xu,Z.H., Zhang,H., Zhang,C.J., Yu,S.J., Yuan,J., Jin,K. and
            Jin,Z.B.
  TITLE     REG1A protects retinal photoreceptors from blue light damage
  JOURNAL   Ann N Y Acad Sci 1527 (1), 60-74 (2023)
   PUBMED   37531162
  REMARK    GeneRIF: REG1A protects retinal photoreceptors from blue light
            damage.
REFERENCE   2  (bases 1 to 768)
  AUTHORS   Lagadinou,M., Paraskevas,T., Velissaris,D., Michailides,C.,
            Eleftherakis,G., Sampsonas,F., Siakallis,G., Assimakopoulos,S.F.
            and Marangos,M.
  TITLE     The role of pancreatic stone protein as a prognostic factor for
            COVID-19 patients
  JOURNAL   Eur Rev Med Pharmacol Sci 26 (17), 6391-6395 (2022)
   PUBMED   36111942
  REMARK    GeneRIF: The role of pancreatic stone protein as a prognostic
            factor for COVID-19 patients.
REFERENCE   3  (bases 1 to 768)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 768)
  AUTHORS   Mao,H., Jia,J., Sheng,J., Zhang,S., Huang,K., Li,H. and He,F.
  TITLE     Protective and anti-inflammatory role of REG1A in inflammatory
            bowel disease induced by JAK/STAT3 signaling axis
  JOURNAL   Int Immunopharmacol 92, 107304 (2021)
   PUBMED   33513463
  REMARK    GeneRIF: Protective and anti-inflammatory role of REG1A in
            inflammatory bowel disease induced by JAK/STAT3 signaling axis.
REFERENCE   5  (bases 1 to 768)
  AUTHORS   Said,S., Kurtin,P.J., Nasr,S.H., Graham,R.P., Dasari,S.,
            Vrana,J.A., Yasir,S., Torbenson,M.S., Zhang,L., Mounajjed,T., Eric
            Chen,Z.M., Lee,H.E. and Wu,T.T.
  TITLE     Carboxypeptidase A1 and regenerating islet-derived 1alpha as new
            markers for pancreatic acinar cell carcinoma
  JOURNAL   Hum Pathol 103, 120-126 (2020)
   PUBMED   32702400
  REMARK    GeneRIF: Carboxypeptidase A1 and regenerating islet-derived 1alpha
            as new markers for pancreatic acinar cell carcinoma.
REFERENCE   6  (bases 1 to 768)
  AUTHORS   Bernard,J.P., Adrich,Z., Montalto,G., De Caro,A., De Reggi,M.,
            Sarles,H. and Dagorn,J.C.
  TITLE     Inhibition of nucleation and crystal growth of calcium carbonate by
            human lithostathine
  JOURNAL   Gastroenterology 103 (4), 1277-1284 (1992)
   PUBMED   1397886
REFERENCE   7  (bases 1 to 768)
  AUTHORS   Itoh,T., Tsuzuki,H., Katoh,T., Teraoka,H., Matsumoto,K.,
            Yoshida,N., Terazono,K., Watanabe,T., Yonekura,H., Yamamoto,H. et
            al.
  TITLE     Isolation and characterization of human reg protein produced in
            Saccharomyces cerevisiae
  JOURNAL   FEBS Lett 272 (1-2), 85-88 (1990)
   PUBMED   2226837
REFERENCE   8  (bases 1 to 768)
  AUTHORS   de la Monte,S.M., Ozturk,M. and Wands,J.R.
  TITLE     Enhanced expression of an exocrine pancreatic protein in
            Alzheimer's disease and the developing human brain
  JOURNAL   J Clin Invest 86 (3), 1004-1013 (1990)
   PUBMED   2394826
REFERENCE   9  (bases 1 to 768)
  AUTHORS   Watanabe,T., Yonekura,H., Terazono,K., Yamamoto,H. and Okamoto,H.
  TITLE     Complete nucleotide sequence of human reg gene and its expression
            in normal and tumoral tissues. The reg protein, pancreatic stone
            protein, and pancreatic thread protein are one and the same product
            of the gene
  JOURNAL   J Biol Chem 265 (13), 7432-7439 (1990)
   PUBMED   2332435
REFERENCE   10 (bases 1 to 768)
  AUTHORS   De Caro,A.M., Adrich,Z., Fournet,B., Capon,C., Bonicel,J.J., De
            Caro,J.D. and Rovery,M.
  TITLE     N-terminal sequence extension in the glycosylated forms of human
            pancreatic stone protein. The 5-oxoproline N-terminal chain is
            O-glycosylated on the 5th amino acid residue
  JOURNAL   Biochim Biophys Acta 994 (3), 281-284 (1989)
   PUBMED   2493268
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM769434.1, AK291981.1,
            W38384.1 and AW873911.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002909.4.
            
            Summary: This gene is a type I subclass member of the Reg gene
            family. The Reg gene family is a multigene family grouped into four
            subclasses, types I, II, III and IV, based on the primary
            structures of the encoded proteins. This gene encodes a protein
            that is secreted by the exocrine pancreas. It is associated with
            islet cell regeneration and diabetogenesis and may be involved in
            pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and
            this gene are tandemly clustered on chromosome 2p12 and may have
            arisen from the same ancestral gene by gene duplication. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279838.5622.1, AK291981.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233735.2/ ENSP00000233735.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BM769434.1         43-44
            3-568               AK291981.1         1-566
            569-764             W38384.1           7-202               c
            765-768             AW873911.1         24-27               c
FEATURES             Location/Qualifiers
     source          1..768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p12"
     gene            1..768
                     /gene="REG1A"
                     /gene_synonym="ICRF; P19; PSP; PSPS; PSPS1; PTP; REG"
                     /note="regenerating family member 1 alpha"
                     /db_xref="GeneID:5967"
                     /db_xref="HGNC:HGNC:9951"
                     /db_xref="MIM:167770"
     exon            1..27
                     /gene="REG1A"
                     /gene_synonym="ICRF; P19; PSP; PSPS; PSPS1; PTP; REG"
                     /inference="alignment:Splign:2.1.0"
     exon            28..137
                     /gene="REG1A"
                     /gene_synonym="ICRF; P19; PSP; PSPS; PSPS1; PTP; REG"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..574
                     /gene="REG1A"
                     /gene_synonym="ICRF; P19; PSP; PSPS; PSPS1; PTP; REG"
                     /note="pancreatic thread protein; islet cells regeneration
                     factor; pancreatic stone protein, secretory; protein-X;
                     regenerating protein I alpha; islet of langerhans
                     regenerating protein; lithostathine-1-alpha; REG-1-alpha;
                     regenerating islet-derived protein 1-alpha"
                     /codon_start=1
                     /product="lithostathine-1-alpha precursor"
                     /protein_id="NP_002900.2"
                     /db_xref="CCDS:CCDS1964.1"
                     /db_xref="GeneID:5967"
                     /db_xref="HGNC:HGNC:9951"
                     /db_xref="MIM:167770"
                     /translation="MAQTSSYFMLISCLMFLSQSQGQEAQTELPQARISCPEGTNAYR
                     SYCYYFNEDRETWVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESGTDDFNVWIGL
                     HDPKKNRRWHWSSGSLVSYKSWGIGAPSSVNPGYCVSLTSSTGFQKWKDVPCEDKFSF
                     VCKFKN"
     exon            138..256
                     /gene="REG1A"
                     /gene_synonym="ICRF; P19; PSP; PSPS; PSPS1; PTP; REG"
                     /inference="alignment:Splign:2.1.0"
     exon            257..394
                     /gene="REG1A"
                     /gene_synonym="ICRF; P19; PSP; PSPS; PSPS1; PTP; REG"
                     /inference="alignment:Splign:2.1.0"
     exon            395..506
                     /gene="REG1A"
                     /gene_synonym="ICRF; P19; PSP; PSPS; PSPS1; PTP; REG"
                     /inference="alignment:Splign:2.1.0"
     exon            507..768
                     /gene="REG1A"
                     /gene_synonym="ICRF; P19; PSP; PSPS; PSPS1; PTP; REG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      744..749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REG1A"
                     /gene_synonym="ICRF; P19; PSP; PSPS; PSPS1; PTP; REG"
                     /note="hexamer: AATAAA"
     polyA_site      768
                     /gene="REG1A"
                     /gene_synonym="ICRF; P19; PSP; PSPS; PSPS1; PTP; REG"
                     /note="major polyA site"
ORIGIN      
        1 agaagccaac tcagactcag ccaacagaga ttgttgattt gcctcttaag caagagattc
       61 attgcagctc agcatggctc agaccagctc atacttcatg ctgatctcct gcctgatgtt
      121 tctgtctcag agccaaggcc aagaggccca gacagagttg ccccaggccc ggatcagctg
      181 cccagaaggc accaatgcct atcgctccta ctgctactac tttaatgaag accgtgagac
      241 ctgggttgat gcagatctct attgccagaa catgaattcg ggcaacctgg tgtctgtgct
      301 cacccaggcc gagggtgcct ttgtggcctc actgattaag gagagtggca ctgatgactt
      361 caatgtctgg attggcctcc atgaccccaa aaagaaccgc cgctggcact ggagcagtgg
      421 gtccctggtc tcctacaagt cctggggcat tggagcccca agcagtgtta atcctggcta
      481 ctgtgtgagc ctgacctcaa gcacaggatt ccagaaatgg aaggatgtgc cttgtgaaga
      541 caagttctcc tttgtctgca agttcaaaaa ctagaggcaa ctggaaaata catgtctaga
      601 actgatccag caattacaac ggagtcaaaa attaaaccgg accatctctc caactcaact
      661 caacctggac actctcttct ctgctgagtt tgccttgtta atcttcaata gttttaccta
      721 ccccagtctt tggaacccta aataataaaa ataaacatgt ttccacta
//
