LOCUS       NM_005669               3008 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens receptor accessory protein 5 (REEP5), mRNA.
ACCESSION   NM_005669
VERSION     NM_005669.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3008)
  AUTHORS   Li,J., Gui,Q., Liang,F.-X., Sall,J., Zhang,Q., Duan,Y.,
            Dhabaria,A., Askenazi,M., Ueberheide,B., Stapleford,K.A. and
            Pagano,M.
  TITLE     The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus
            replication
  JOURNAL   J Virol 97 (10), e0050723 (2023)
   PUBMED   37768083
  REMARK    GeneRIF: The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes
            virus replication.
REFERENCE   2  (bases 1 to 3008)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3008)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3008)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3008)
  AUTHORS   Lee,S.H., Hadipour-Lakmehsari,S., Murthy,H.R., Gibb,N., Miyake,T.,
            Teng,A.C.T., Cosme,J., Yu,J.C., Moon,M., Lim,S., Wong,V., Liu,P.,
            Billia,F., Fernandez-Gonzalez,R., Stagljar,I., Sharma,P.,
            Kislinger,T., Scott,I.C. and Gramolini,A.O.
  TITLE     REEP5 depletion causes sarco-endoplasmic reticulum vacuolization
            and cardiac functional defects
  JOURNAL   Nat Commun 11 (1), 965 (2020)
   PUBMED   32075961
  REMARK    GeneRIF: The sarco-endoplasmic reticulum (SR/ER) plays an important
            role in the development and progression of many heart diseases.
            Receptor accessory protein 5 (REEP5), a cardiac enriched,
            sarco-endoplasmic reticulum (SR/ER) membrane protein,is centrally
            involved in regulating SR/ER organization and cellular stress
            responses in cardiac myocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3008)
  AUTHORS   Prieschl,E.E., Pendl,G.G., Harrer,N.E. and Baumruker,T.
  TITLE     The murine homolog of TB2/DP1, a gene of the familial adenomatous
            polyposis (FAP) locus
  JOURNAL   Gene 169 (2), 215-218 (1996)
   PUBMED   8647449
REFERENCE   7  (bases 1 to 3008)
  AUTHORS   Spirio,L., Joslyn,G., Nelson,L., Leppert,M. and White,R.
  TITLE     A CA repeat 30-70 KB downstream from the adenomatous polyposis coli
            (APC) gene
  JOURNAL   Nucleic Acids Res 19 (22), 6348 (1991)
   PUBMED   1659692
  REMARK    Erratum:[Nucleic Acids Res. 1992 Feb 11;20(3):642. doi:
            10.1093/nar/20.3.642-a.. PMID: 1312235]
REFERENCE   8  (bases 1 to 3008)
  AUTHORS   Joslyn,G., Carlson,M., Thliveris,A., Albertsen,H., Gelbert,L.,
            Samowitz,W., Groden,J., Stevens,J., Spirio,L., Robertson,M. et al.
  TITLE     Identification of deletion mutations and three new genes at the
            familial polyposis locus
  JOURNAL   Cell 66 (3), 601-613 (1991)
   PUBMED   1678319
REFERENCE   9  (bases 1 to 3008)
  AUTHORS   Nishisho,I., Nakamura,Y., Miyoshi,Y., Miki,Y., Ando,H., Horii,A.,
            Koyama,K., Utsunomiya,J., Baba,S. and Hedge,P.
  TITLE     Mutations of chromosome 5q21 genes in FAP and colorectal cancer
            patients
  JOURNAL   Science 253 (5020), 665-669 (1991)
   PUBMED   1651563
REFERENCE   10 (bases 1 to 3008)
  AUTHORS   Kinzler,K.W., Nilbert,M.C., Su,L.K., Vogelstein,B., Bryan,T.M.,
            Levy,D.B., Smith,K.J., Preisinger,A.C., Hedge,P., McKechnie,D. et
            al.
  TITLE     Identification of FAP locus genes from chromosome 5q21
  JOURNAL   Science 253 (5020), 661-665 (1991)
   PUBMED   1651562
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA807043.1, BC000232.1 and AC008575.7.
            
            On Nov 22, 2018 this sequence version replaced NM_005669.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.41716.1,
                                           SRR1803612.60533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379638.9/ ENSP00000368959.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA807043.1         108-119
            13-996              BC000232.1         1-984
            997-3008            AC008575.7         165765-167776       c
FEATURES             Location/Qualifiers
     source          1..3008
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.2"
     gene            1..3008
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /note="receptor accessory protein 5"
                     /db_xref="GeneID:7905"
                     /db_xref="HGNC:HGNC:30077"
                     /db_xref="MIM:125265"
     exon            1..155
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..607
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /note="polyposis locus protein 1; deleted in polyposis 1;
                     polyposis coli region hypothetical protein DP1"
                     /codon_start=1
                     /product="receptor expression-enhancing protein 5"
                     /protein_id="NP_005660.4"
                     /db_xref="CCDS:CCDS4109.2"
                     /db_xref="GeneID:7905"
                     /db_xref="HGNC:HGNC:30077"
                     /db_xref="MIM:125265"
                     /translation="MSAAMRERFDRFLHEKNCMTDLLAKLEAKTGVNRSFIALGVIGL
                     VALYLVFGYGASLLCNLIGFGYPAYISIKAIESPNKEDDTQWLTYWVVYGVFSIAEFF
                     SDIFLSWFPFYYMLKCGFLLWCMAPSPSNGAELLYKRIIRPFFLKHESQMDSVVKDLK
                     DKAKETADAITKEAKKATVNLLGEEKKST"
     exon            156..249
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..388
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..557
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..3008
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      725..730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /note="hexamer: ATTAAA"
     polyA_site      748
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
     regulatory      895..900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /note="hexamer: AATAAA"
     polyA_site      913
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /note="major polyA site"
     regulatory      2986..2991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /note="hexamer: AATAAA"
     polyA_site      3008
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /note="major polyA site"
ORIGIN      
        1 actaggaaca gccccgagcg gcgagacggt ccccgccatg tctgcggcca tgagggagag
       61 gttcgaccgg ttcctgcacg agaagaactg catgactgac cttctggcca agctcgaggc
      121 caaaaccggc gtgaacagga gcttcatcgc tcttggtgtc atcggactgg tggccttgta
      181 cctggtgttc ggttatggag cctctctcct ctgcaacctg ataggatttg gctacccagc
      241 ctacatctca attaaagcta tagagagtcc caacaaagaa gatgataccc agtggctgac
      301 ctactgggta gtgtatggtg tgttcagcat tgctgaattc ttctctgata tcttcctgtc
      361 atggttcccc ttctactaca tgctgaagtg tggcttcctg ttgtggtgca tggccccgag
      421 cccttctaat ggggctgaac tgctctacaa gcgcatcatc cgtcctttct tcctgaagca
      481 cgagtcccag atggacagtg tggtcaagga ccttaaagac aaggccaaag agactgcaga
      541 tgccatcact aaagaagcga agaaagctac cgtgaattta ctgggtgaag aaaagaagag
      601 cacctaaacc agactggatg gaaacttcct gccctctctg taccttccta ctggagcttg
      661 atgttatatt agggactgtg gtataattat tttaataatg ttgccttgga aacatttttg
      721 agatattaaa gattggaatg tgttgtaagt ttctttgctt acttttactg tctatatata
      781 tagggagcac tttaaactta atgcagtggg cagtgtccac gtttttggaa aatgtatttt
      841 gcctctgggt aggaaaagat gtatgttgct atcctgcagg aaatataaac ttaaaataaa
      901 attatatacc ccacaggctg tgtactttac tgggctctcc ctgcacgcat tttctctgta
      961 gttacattta ggataatctt tatggttcta cttcctgtaa tgtacaattt tatataattc
     1021 tgaaatgttt ttaatgtatt tgtgcacatg tacatatgga aatgttactg tctgactaca
     1081 acatgcatca tgctcatggg gagggagcag gggaaggttg tatgtgtcat ttataacttc
     1141 tgtacagtaa gaccacctgc caaaagctgg aggaaccatt gtgctggtgt ggtctactaa
     1201 ataatacttt aggaaatacg tgattaatat gcaagtgaac aaagtgagaa atgaaatcga
     1261 atggagattg gcctggttgt ttccgtagta tatggcatat gaataccagg atagctttat
     1321 aaagcagtta gttagttagt tactcactct agtgataaat cgggaaattt acacacacac
     1381 acacacacac acacacacac acacacacac agagtaacct gtaactctca attccctgaa
     1441 aaactagtaa tactgtctta tctgctataa actttacata tttgtctatt gtcaagatgc
     1501 tacaatggaa accatttctg gttttatctt caaagcggag aaacatgttg atttagtctt
     1561 ctttcccaat cttctttttt aaaccagttt aaggaacttc tgaagatttg tccacctctg
     1621 attacatgta tgttcttgtt tgtatcatta gcaacaacat gctaatgacg acacctagct
     1681 ctaagagcaa ttctgggaga atgaaaggaa gtataaagta acccataatc tgcttggcaa
     1741 tagttaagtc aatctatctt cagtttttct ctggccttta aggtcaaaca caagaggctt
     1801 ccctagttta caagtcagag tcacttgtag tccatttaaa tgccctcatc cgtattcttt
     1861 gtgttgataa gctgcacatg actacatagt aagtacagaa cagtaaagtt aaaacggatg
     1921 tctccattga tctgccaaat cgttatagag agcaatttgt ctggactaga aaatctgagt
     1981 tttacaccat actgttaaga gtccttttga attaaactcg actaaaacaa gtgtataact
     2041 aaactaacaa gattaaatat ccagccagta cagtattttt taaggcaaat aaagatgatt
     2101 agctcacctt gagataacaa tcaggtaaga tcataacaat gtctcatgat gtaaaaaata
     2161 ttaaagatat caatactaag tgacagtatc actctaatat aatatggatc agagcattta
     2221 ttttggggag gaaaacagtg gtgattaccg gcattttatt aaacttaaaa ctttgtagaa
     2281 agcaaacaaa attgttcttg ggagaaaatc aacttttaga ttaaaaaaat tttaagtatc
     2341 taggagtatt taaatccttt tcccataaat aaaagtacag ttttcttggt ggcagaatga
     2401 aaatcagcaa cttctagcat atagactata taatcagatt gacagcatat agaatatatt
     2461 atcagacaag atgaggaggt acaaaagtta ctattgctca taatgactta caggctaaaa
     2521 ttagttttaa aatactatat taaattctga atgcaatttt tttttgttcc cttgagacca
     2581 aaatttaagt taactgttgc tggcagtcta agtgtaaatg ttaacagcag gagaagttaa
     2641 gaattgagca gttctgttgc atgatttccc aaatgaaata ctgccttggc tagagtttga
     2701 aaaactaatt gagcctgtgc ctggctagaa aacaagcgtt tatttgaatg tgaatagtgt
     2761 ttcaaaggta tgtagttaca gaattcctac caaacagctt aaattcttca agaaagaatt
     2821 cctgcagcag ttattccctt acctgaaggc ttcaatcatt tggatcaaca actgctactc
     2881 tcgggaagac tcctctactc acagctgaag aaaatgagca cacccttcac actgttatca
     2941 cctatcctga agatgtgata cactgaatgg aaataaatag atgtaaataa aattgagttc
     3001 tcatttaa
//
