LOCUS       NP_005660                189 aa            linear   PRI 11-FEB-2025
DEFINITION  receptor expression-enhancing protein 5 [Homo sapiens].
ACCESSION   NP_005660
VERSION     NP_005660.4
DBSOURCE    REFSEQ: accession NM_005669.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 189)
  AUTHORS   Li,J., Gui,Q., Liang,F.-X., Sall,J., Zhang,Q., Duan,Y.,
            Dhabaria,A., Askenazi,M., Ueberheide,B., Stapleford,K.A. and
            Pagano,M.
  TITLE     The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus
            replication
  JOURNAL   J Virol 97 (10), e0050723 (2023)
   PUBMED   37768083
  REMARK    GeneRIF: The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes
            virus replication.
REFERENCE   2  (residues 1 to 189)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (residues 1 to 189)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (residues 1 to 189)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 189)
  AUTHORS   Lee,S.H., Hadipour-Lakmehsari,S., Murthy,H.R., Gibb,N., Miyake,T.,
            Teng,A.C.T., Cosme,J., Yu,J.C., Moon,M., Lim,S., Wong,V., Liu,P.,
            Billia,F., Fernandez-Gonzalez,R., Stagljar,I., Sharma,P.,
            Kislinger,T., Scott,I.C. and Gramolini,A.O.
  TITLE     REEP5 depletion causes sarco-endoplasmic reticulum vacuolization
            and cardiac functional defects
  JOURNAL   Nat Commun 11 (1), 965 (2020)
   PUBMED   32075961
  REMARK    GeneRIF: The sarco-endoplasmic reticulum (SR/ER) plays an important
            role in the development and progression of many heart diseases.
            Receptor accessory protein 5 (REEP5), a cardiac enriched,
            sarco-endoplasmic reticulum (SR/ER) membrane protein,is centrally
            involved in regulating SR/ER organization and cellular stress
            responses in cardiac myocytes.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 189)
  AUTHORS   Prieschl,E.E., Pendl,G.G., Harrer,N.E. and Baumruker,T.
  TITLE     The murine homolog of TB2/DP1, a gene of the familial adenomatous
            polyposis (FAP) locus
  JOURNAL   Gene 169 (2), 215-218 (1996)
   PUBMED   8647449
REFERENCE   7  (residues 1 to 189)
  AUTHORS   Spirio,L., Joslyn,G., Nelson,L., Leppert,M. and White,R.
  TITLE     A CA repeat 30-70 KB downstream from the adenomatous polyposis coli
            (APC) gene
  JOURNAL   Nucleic Acids Res 19 (22), 6348 (1991)
   PUBMED   1659692
  REMARK    Erratum:[Nucleic Acids Res. 1992 Feb 11;20(3):642. doi:
            10.1093/nar/20.3.642-a.. PMID: 1312235]
REFERENCE   8  (residues 1 to 189)
  AUTHORS   Joslyn,G., Carlson,M., Thliveris,A., Albertsen,H., Gelbert,L.,
            Samowitz,W., Groden,J., Stevens,J., Spirio,L., Robertson,M. et al.
  TITLE     Identification of deletion mutations and three new genes at the
            familial polyposis locus
  JOURNAL   Cell 66 (3), 601-613 (1991)
   PUBMED   1678319
REFERENCE   9  (residues 1 to 189)
  AUTHORS   Nishisho,I., Nakamura,Y., Miyoshi,Y., Miki,Y., Ando,H., Horii,A.,
            Koyama,K., Utsunomiya,J., Baba,S. and Hedge,P.
  TITLE     Mutations of chromosome 5q21 genes in FAP and colorectal cancer
            patients
  JOURNAL   Science 253 (5020), 665-669 (1991)
   PUBMED   1651563
REFERENCE   10 (residues 1 to 189)
  AUTHORS   Kinzler,K.W., Nilbert,M.C., Su,L.K., Vogelstein,B., Bryan,T.M.,
            Levy,D.B., Smith,K.J., Preisinger,A.C., Hedge,P., McKechnie,D. et
            al.
  TITLE     Identification of FAP locus genes from chromosome 5q21
  JOURNAL   Science 253 (5020), 661-665 (1991)
   PUBMED   1651562
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA807043.1, BC000232.1 and AC008575.7.
            
            On Sep 30, 2006 this sequence version replaced NP_005660.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.41716.1,
                                           SRR1803612.60533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379638.9/ ENSP00000368959.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.2"
     Protein         1..189
                     /product="receptor expression-enhancing protein 5"
                     /note="polyposis locus protein 1; deleted in polyposis 1;
                     polyposis coli region hypothetical protein DP1"
                     /calculated_mol_wt=21362
     Site            35..51
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00765.3)"
     Site            54..74
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00765.3)"
     Region          67..144
                     /region_name="TB2_DP1_HVA22"
                     /note="TB2/DP1, HVA22 family; pfam03134"
                     /db_xref="CDD:460820"
     Site            85..103
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00765.3)"
     Site            106..123
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00765.3)"
     Region          114..185
                     /region_name="Required for dimerization and maintaining
                     endoplasmic reticulum morphology.
                     /evidence=ECO:0000269|PubMed:32075961"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00765.3)"
     CDS             1..189
                     /gene="REEP5"
                     /gene_synonym="C5orf18; D5S346; DP1; POB16; TB2; Yip2e;
                     YOP1"
                     /coded_by="NM_005669.5:38..607"
                     /db_xref="CCDS:CCDS4109.2"
                     /db_xref="GeneID:7905"
                     /db_xref="HGNC:HGNC:30077"
                     /db_xref="MIM:125265"
ORIGIN      
        1 msaamrerfd rflhekncmt dllakleakt gvnrsfialg viglvalylv fgygasllcn
       61 ligfgypayi sikaiespnk eddtqwltyw vvygvfsiae ffsdiflswf pfyymlkcgf
      121 llwcmapsps ngaellykri irpfflkhes qmdsvvkdlk dkaketadai tkeakkatvn
      181 llgeekkst
//
