LOCUS       NM_025232               1666 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens receptor accessory protein 4 (REEP4), transcript
            variant 1, mRNA.
ACCESSION   NM_025232
VERSION     NM_025232.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1666)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 1666)
  AUTHORS   Golchoubian,B., Brunner,A., Bragulat-Teixidor,H., Neuner,A.,
            Akarlar,B.A., Ozlu,N. and Schlaitz,A.L.
  TITLE     Reticulon-like REEP4 at the inner nuclear membrane promotes nuclear
            pore complex formation
  JOURNAL   J Cell Biol 221 (2) (2022)
   PUBMED   34874453
  REMARK    GeneRIF: Reticulon-like REEP4 at the inner nuclear membrane
            promotes nuclear pore complex formation.
REFERENCE   3  (bases 1 to 1666)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1666)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1666)
  AUTHORS   Kumar,D., Golchoubian,B., Belevich,I., Jokitalo,E. and
            Schlaitz,A.L.
  TITLE     REEP3 and REEP4 determine the tubular morphology of the endoplasmic
            reticulum during mitosis
  JOURNAL   Mol Biol Cell 30 (12), 1377-1389 (2019)
   PUBMED   30995177
  REMARK    GeneRIF: the endoplasmic reticulum (ER) membrane proteins REEP3 and
            REEP4 as major determinants of ER morphology in metaphase cells.
REFERENCE   6  (bases 1 to 1666)
  AUTHORS   Weissglas-Volkov,D., Aguilar-Salinas,C.A., Nikkola,E., Deere,K.A.,
            Cruz-Bautista,I., Arellano-Campos,O., Munoz-Hernandez,L.L.,
            Gomez-Munguia,L., Ordonez-Sanchez,M.L., Reddy,P.M., Lusis,A.J.,
            Matikainen,N., Taskinen,M.R., Riba,L., Cantor,R.M.,
            Sinsheimer,J.S., Tusie-Luna,T. and Pajukanta,P.
  TITLE     Genomic study in Mexicans identifies a new locus for triglycerides
            and refines European lipid loci
  JOURNAL   J Med Genet 50 (5), 298-308 (2013)
   PUBMED   23505323
REFERENCE   7  (bases 1 to 1666)
  AUTHORS   Clark,A.J., Metherell,L.A., Cheetham,M.E. and Huebner,A.
  TITLE     Inherited ACTH insensitivity illuminates the mechanisms of ACTH
            action
  JOURNAL   Trends Endocrinol Metab 16 (10), 451-457 (2005)
   PUBMED   16271481
  REMARK    Review article
REFERENCE   8  (bases 1 to 1666)
  AUTHORS   Benzinger,A., Muster,N., Koch,H.B., Yates,J.R. 3rd and Hermeking,H.
  TITLE     Targeted proteomic analysis of 14-3-3 sigma, a p53 effector
            commonly silenced in cancer
  JOURNAL   Mol Cell Proteomics 4 (6), 785-795 (2005)
   PUBMED   15778465
REFERENCE   9  (bases 1 to 1666)
  AUTHORS   Saito,H., Kubota,M., Roberts,R.W., Chi,Q. and Matsunami,H.
  TITLE     RTP family members induce functional expression of mammalian
            odorant receptors
  JOURNAL   Cell 119 (5), 679-691 (2004)
   PUBMED   15550249
REFERENCE   10 (bases 1 to 1666)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC013048.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025232.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013048.1, SRR3476690.1073890.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306306.8/ ENSP00000303482.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1666              BC013048.1         29-1694
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..1666
                     /gene="REEP4"
                     /gene_synonym="C8orf20; PP432; Yip2c"
                     /note="receptor accessory protein 4"
                     /db_xref="GeneID:80346"
                     /db_xref="HGNC:HGNC:26176"
                     /db_xref="MIM:609349"
     exon            1..457
                     /gene="REEP4"
                     /gene_synonym="C8orf20; PP432; Yip2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..1199
                     /gene="REEP4"
                     /gene_synonym="C8orf20; PP432; Yip2c"
                     /note="isoform 1 is encoded by transcript variant 1;
                     receptor expression-enhancing protein 4"
                     /codon_start=1
                     /product="receptor expression-enhancing protein 4 isoform
                     1"
                     /protein_id="NP_079508.2"
                     /db_xref="CCDS:CCDS6024.1"
                     /db_xref="GeneID:80346"
                     /db_xref="HGNC:HGNC:26176"
                     /db_xref="MIM:609349"
                     /translation="MVSWMICRLVVLVFGMLCPAYASYKAVKTKNIREYVRWMMYWIV
                     FALFMAAEIVTDIFISWFPFYYEIKMAFVLWLLSPYTKGASLLYRKFVHPSLSRHEKE
                     IDAYIVQAKERSYETVLSFGKRGLNIAASAAVQAATKSQGALAGRLRSFSMQDLRSIS
                     DAPAPAYHDPLYLEDQVSHRRPPIGYRAGGLQDSDTEDECWSDTEAVPRAPARPREKP
                     LIRSQSLRVVKRKPPVREGTSRSLKVRTRKKTVPSDVDS"
     exon            458..530
                     /gene="REEP4"
                     /gene_synonym="C8orf20; PP432; Yip2c"
                     /inference="alignment:Splign:2.1.0"
     exon            531..607
                     /gene="REEP4"
                     /gene_synonym="C8orf20; PP432; Yip2c"
                     /inference="alignment:Splign:2.1.0"
     exon            608..728
                     /gene="REEP4"
                     /gene_synonym="C8orf20; PP432; Yip2c"
                     /inference="alignment:Splign:2.1.0"
     exon            729..842
                     /gene="REEP4"
                     /gene_synonym="C8orf20; PP432; Yip2c"
                     /inference="alignment:Splign:2.1.0"
     exon            843..978
                     /gene="REEP4"
                     /gene_synonym="C8orf20; PP432; Yip2c"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1133
                     /gene="REEP4"
                     /gene_synonym="C8orf20; PP432; Yip2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1666
                     /gene="REEP4"
                     /gene_synonym="C8orf20; PP432; Yip2c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REEP4"
                     /gene_synonym="C8orf20; PP432; Yip2c"
                     /note="hexamer: AATAAA"
     polyA_site      1666
                     /gene="REEP4"
                     /gene_synonym="C8orf20; PP432; Yip2c"
                     /note="major polyA site"
ORIGIN      
        1 actcggttcc gtgcaacttt caagtgagtt gcgaactccg ccctgtaggc cggtgctggt
       61 ggcccggcgc gctggaaccg cggcgacccg ctccagcgcg ggaccagcag caagggccga
      121 gcgccaggtt ctccgcggca gaaagggcgg gtgggagctg taactgcccc ggccgcgggg
      181 cgcgcccgct cccaagtcgg cttcctcccc gccggggccg ctttgcctcg ggtctcccca
      241 ttctccaggt cccctgaact gcacagtcgg aggccgtggg cggcgggctc tgcctccgcc
      301 gagggacagc cggatcgccc ctctgcttcc cgcaactgcc ctgatcaccc cccgtcccag
      361 cccttgagtg aacgtccttc tgagcggctt cctggggtcc tccccacgtc ccaaaggccg
      421 gcaagatggt gtcctggatg atctgtcgcc tggtggtgct ggtgtttggg atgctgtgtc
      481 cagcttatgc ttcctataag gctgtgaaga ccaagaacat tcgtgaatat gtgcggtgga
      541 tgatgtactg gattgttttt gcactcttca tggcagcaga gatcgttaca gacattttta
      601 tctcctggtt ccctttctac tatgagatca agatggcctt cgtgctgtgg ctgctctcac
      661 cctacaccaa gggcgccagc ctgctttacc gcaagtttgt ccacccgtcc ctgtcccgcc
      721 atgagaagga gatcgacgcg tacatcgtgc aggccaagga gcgcagctac gagaccgtgc
      781 tcagcttcgg gaagcggggc ctcaacattg ccgcctccgc tgctgtgcag gctgccacca
      841 agagtcaggg ggcgctggcc ggcaggctgc ggagcttctc catgcaggac ctgcgctcca
      901 tctctgacgc acctgcccct gcctaccatg accccctcta cctggaggac caggtgtccc
      961 accggaggcc acccattggg taccgggccg ggggcctgca ggacagcgac accgaggatg
     1021 agtgttggtc agatactgag gcagtccccc gggcgccagc ccggccccga gagaagcccc
     1081 taatccgcag ccagagcctg cgtgtggtca agaggaagcc accggtgcgg gagggcacct
     1141 cgcgctccct gaaggttcgg acgaggaaaa agactgtgcc ctcagacgtg gacagctagg
     1201 gtctgctgca tctgccccct tcttacctcg tgccctgcag ggctccaggg ctatttggag
     1261 ggaccttggg ctgcacatct ggcctgcctg caccagctgc ctgggcccca ccctcctgac
     1321 tcctgctgat ggttaagggc cgggagcaga tgctgccaag gccacatgca gggatgcacc
     1381 cacaatgtac caaagcaggc tgggcccagg gttctattta ttgccttgct ctgccctctc
     1441 ccttccccgg ttgtgggaca agagccctcc ctgaacccct gcaaccctcc ctgaacccct
     1501 gcaaatgaaa ccaaacgtcc acctgggtgt gttcattcct tcctgtcctt caaagtactt
     1561 gatagccttt cataaggcct ggcacatgtg tcctggttgt gtgtgtgtgt gttggtgagt
     1621 gaggtcaggt ttgcgagtgt tttgataaat aaatacataa aggggc
//
