LOCUS       NM_001001330            5172 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens receptor accessory protein 3 (REEP3), mRNA.
ACCESSION   NM_001001330
VERSION     NM_001001330.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5172)
  AUTHORS   Liu,G.H., Tan,X.Y., Xu,Z.Y., Li,J.X., Zhong,G.H., Zhai,J.W. and
            Li,M.Y.
  TITLE     REEP3 is a potential diagnostic and prognostic biomarker correlated
            with immune infiltration in pancreatic cancer
  JOURNAL   Sci Rep 14 (1), 13834 (2024)
   PUBMED   38879709
  REMARK    GeneRIF: REEP3 is a potential diagnostic and prognostic biomarker
            correlated with immune infiltration in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5172)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 5172)
  AUTHORS   Wei,H., Yan,S., Hui,Y., Liu,Y., Guo,H., Li,Q., Li,J. and Chang,Z.
  TITLE     CircFAT1 promotes hepatocellular carcinoma progression via
            miR-30a-5p/REEP3 pathway
  JOURNAL   J Cell Mol Med 24 (24), 14561-14570 (2020)
   PUBMED   33179443
  REMARK    GeneRIF: CircFAT1 promotes hepatocellular carcinoma progression via
            miR-30a-5p/REEP3 pathway.
REFERENCE   4  (bases 1 to 5172)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5172)
  AUTHORS   Kumar,D., Golchoubian,B., Belevich,I., Jokitalo,E. and
            Schlaitz,A.L.
  TITLE     REEP3 and REEP4 determine the tubular morphology of the endoplasmic
            reticulum during mitosis
  JOURNAL   Mol Biol Cell 30 (12), 1377-1389 (2019)
   PUBMED   30995177
  REMARK    GeneRIF: the endoplasmic reticulum (ER) membrane proteins REEP3 and
            REEP4 as major determinants of ER morphology in metaphase cells.
REFERENCE   6  (bases 1 to 5172)
  AUTHORS   Yuan,X., Waterworth,D., Perry,J.R., Lim,N., Song,K., Chambers,J.C.,
            Zhang,W., Vollenweider,P., Stirnadel,H., Johnson,T., Bergmann,S.,
            Beckmann,N.D., Li,Y., Ferrucci,L., Melzer,D., Hernandez,D.,
            Singleton,A., Scott,J., Elliott,P., Waeber,G., Cardon,L.,
            Frayling,T.M., Kooner,J.S. and Mooser,V.
  TITLE     Population-based genome-wide association studies reveal six loci
            influencing plasma levels of liver enzymes
  JOURNAL   Am J Hum Genet 83 (4), 520-528 (2008)
   PUBMED   18940312
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 5172)
  AUTHORS   Castermans,D., Vermeesch,J.R., Fryns,J.P., Steyaert,J.G., Van de
            Ven,W.J., Creemers,J.W. and Devriendt,K.
  TITLE     Identification and characterization of the TRIP8 and REEP3 genes on
            chromosome 10q21.3 as novel candidate genes for autism
  JOURNAL   Eur J Hum Genet 15 (4), 422-431 (2007)
   PUBMED   17290275
  REMARK    GeneRIF: Receptor Expression-Enhancing Proteins (REEP) 3 is one of
            the six human homologs of yeast Yop1p, a probable regulator of
            cellular vesicle trafficking between the endoplasmatic reticulum
            and the Golgi network. Positional candidate gene for autism.
REFERENCE   8  (bases 1 to 5172)
  AUTHORS   Clark,A.J., Metherell,L.A., Cheetham,M.E. and Huebner,A.
  TITLE     Inherited ACTH insensitivity illuminates the mechanisms of ACTH
            action
  JOURNAL   Trends Endocrinol Metab 16 (10), 451-457 (2005)
   PUBMED   16271481
  REMARK    Review article
REFERENCE   9  (bases 1 to 5172)
  AUTHORS   Benzinger,A., Muster,N., Koch,H.B., Yates,J.R. 3rd and Hermeking,H.
  TITLE     Targeted proteomic analysis of 14-3-3 sigma, a p53 effector
            commonly silenced in cancer
  JOURNAL   Mol Cell Proteomics 4 (6), 785-795 (2005)
   PUBMED   15778465
REFERENCE   10 (bases 1 to 5172)
  AUTHORS   Saito,H., Kubota,M., Roberts,R.W., Chi,Q. and Matsunami,H.
  TITLE     RTP family members induce functional expression of mammalian
            odorant receptors
  JOURNAL   Cell 119 (5), 679-691 (2004)
   PUBMED   15550249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC068557.1 and AC022387.8.
            
            On Nov 23, 2018 this sequence version replaced NM_001001330.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.449631.1,
                                           SRR1660803.112087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373758.5/ ENSP00000362863.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2023              BC068557.1         39-2061
            2024-2024           AC022387.8         183500-183500       c
            2025-2256           BC068557.1         2063-2294
            2257-5172           AC022387.8         180352-183267       c
FEATURES             Location/Qualifiers
     source          1..5172
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.3"
     gene            1..5172
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /note="receptor accessory protein 3"
                     /db_xref="GeneID:221035"
                     /db_xref="HGNC:HGNC:23711"
                     /db_xref="MIM:609348"
     exon            1..177
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..913
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /codon_start=1
                     /product="receptor expression-enhancing protein 3"
                     /protein_id="NP_001001330.1"
                     /db_xref="CCDS:CCDS44411.1"
                     /db_xref="GeneID:221035"
                     /db_xref="HGNC:HGNC:23711"
                     /db_xref="MIM:609348"
                     /translation="MVSWMISRAVVLVFGMLYPAYYSYKAVKTKNVKEYVRWMMYWIV
                     FALYTVIETVADQTVAWFPLYYELKIAFVIWLLSPYTKGASLIYRKFLHPLLSSKERE
                     IDDYIVQAKERGYETMVNFGRQGLNLAATAAVTAAVKSQGAITERLRSFSMHDLTTIQ
                     GDEPVGQRPYQPLPEAKKKSKPAPSESAGYGIPLKDGDEKTDEEAEGPYSDNEMLTHK
                     GLRRSQSMKSVKTTKGRKEVRYGSLKYKVKKRPQVYF"
     exon            178..250
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /inference="alignment:Splign:2.1.0"
     exon            251..327
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /inference="alignment:Splign:2.1.0"
     exon            328..448
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /inference="alignment:Splign:2.1.0"
     exon            449..562
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /inference="alignment:Splign:2.1.0"
     exon            563..710
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /inference="alignment:Splign:2.1.0"
     exon            711..856
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /inference="alignment:Splign:2.1.0"
     exon            857..5172
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      998..1003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /note="hexamer: ATTAAA"
     polyA_site      1016
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /note="major polyA site"
     regulatory      4597..4602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /note="hexamer: AATAAA"
     polyA_site      4621
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /note="major polyA site"
     regulatory      5146..5151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /note="hexamer: TATAAA"
     regulatory      5150..5155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
                     /note="hexamer: AATAAA"
     polyA_site      5164
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
     polyA_site      5172
                     /gene="REEP3"
                     /gene_synonym="C10orf74; Yip2b"
ORIGIN      
        1 acacaccggg cccggctcct gagggcgcca gcgcggcccc ggggagcgcg aggagccggc
       61 gaagcgcgcg gcctgccgtt ggcggcctgg tccgcagcgc cctgcgccca cccgccccgg
      121 acgtggggcc caagcccccg tgaagatggt gtcctggatg atctccagag ccgtggtgct
      181 ggtgtttgga atgctttatc ctgcatatta ttcatacaaa gctgtgaaaa caaaaaacgt
      241 gaaggaatat gttcgatgga tgatgtactg gattgttttt gctctctata ctgtgattga
      301 aacagtagcc gatcaaacag ttgcttggtt tcccctgtac tatgagctga agattgcttt
      361 tgtcatatgg ctgctttctc cctataccaa aggagcaagt ttaatatata gaaaattcct
      421 tcatccactt ctttcttcaa aggaaaggga gattgatgat tatattgtac aagcaaagga
      481 acgaggctat gaaaccatgg taaactttgg acggcaaggt ttaaaccttg cagctactgc
      541 tgctgttact gcagcagtaa agagccaagg agcaataact gaacgtttaa gaagcttcag
      601 tatgcatgat ttaacaacta tccaaggtga tgagcctgtg ggacaaagac cataccaacc
      661 tctaccagaa gcaaaaaaga aaagtaaacc agcccccagt gaatcagcag gttatggaat
      721 tccactgaaa gacggagatg agaaaacaga tgaagaagca gaggggccat attcagataa
      781 tgagatgtta acacacaaag ggcttcgaag atcgcaaagc atgaaatctg tgaaaaccac
      841 caaaggccgc aaagaggtgc ggtacgggtc actaaaatac aaagtgaaga aacgaccaca
      901 agtgtatttt tagtcatcta cacgtcaaat atcccaagac agattatgct aaatacatcg
      961 acttcatctt ctaacatgat atattcagga tttacacatt aaaatgatta tttaaattgt
     1021 ggcagtgatg gggtttactt tcatgaattt aaattgtttt tatttctgta acaattgctt
     1081 ccaaatattg actactaaag gcagttctgc aagatgtact aaatatgtat attagaaatt
     1141 atagaaaatc atgttgtccg ttttcaaatt catcaacagc ctagagtgcc tgagatataa
     1201 gatgaaacac aaatccacag tatacttgaa aggagccttt ttacggttca ggataaatca
     1261 gcctttgtga tgtactgtgt ttacctcctt ttgtgttgta tctggtaatt aaataggcct
     1321 cagattcagc agtgacataa caaggacata atgtaagata ataaagtagg ttttatatat
     1381 tctttaaatt tttacttata taatactttc tagtttttcc accatcagct gaaagttttt
     1441 gaaacaaata tttgaaaacc aggtatccac acatagcact tttattcctg actagttttg
     1501 cacacttgaa aattgtttac ttattttaca actgttttac tgatgctatc tttattgttt
     1561 ttgccgtatt ctgacatgtc aaatctatgc cttgaattat atcatctctt ttcctgtggg
     1621 tttcatttgt taaattcatt ggattttaat aatataaaag tatagctaat tgttcagttt
     1681 taactatttt taattatctt cttaacaaat aagaagttgc tttaaacatt aaccaatttt
     1741 ctatatttag ctatacagag taattgaact taacatgttt ttgtcaacac caattacatt
     1801 ttcagctttt aaaaatggta gcttttgtga aatagaatca gtgaccagta tagcacttag
     1861 atcccttcta actcatataa tttttctcag ccaatccatt cacaagcttg gcattgacat
     1921 gtgctgctag tttataaact ggcattgacg aaaatcattt gaatctcttc tggctgagat
     1981 aatttgccaa tgcaaaatac agttgtcatt aatcctgcac attagaaatt attagaaaca
     2041 tattactttt taactttaaa tctcaaagag attttgagtt attgaattct taaggctttc
     2101 ttagcttgaa ctgataacta tgcattatga accctaagtc aatatatttt tggtggtttt
     2161 agtgatcagt aatcaaattt gtacttatta tgcttgttca ggtaatttac ttgactgttc
     2221 tatttgtttg tccaaaagat aaaatgatga gagagattcg agaggtcttt gatctgtctc
     2281 ccttttaaga aatgaagcca gctggtaatg tatattcagg acttcctcag agtattggcc
     2341 aagaacataa tgtttacaca ggagtacctt ggtataatgc atacattgtc tcatgatact
     2401 agtcataaaa tattttatgg attatttcac attcttcata tataacaagt aaaattaatt
     2461 cagttttctt ctcccaacgt ttaattctga ataactctat ctactttacc ctaattttta
     2521 gcctcttaat ttctggaagg actctaattt ctattccaaa tttctatgaa ttctaattgt
     2581 aaattatcgg aacagagttt tatttatatg acctggtact agacttctta atataactgt
     2641 tacactgtcc ttgtctttcc tactcaaaga cagtatcatc tgaagttgcc taataaggtc
     2701 atgtgagtca agaactttat ctgtgggagc tgatttgcac cattttacct tttttttttt
     2761 tttttttttg agacggagtc ttgctctgtc accaggctgg agtgcagtgg cgcgatctcg
     2821 gctcactaca acctctgcct cccgggttcg agcgattctc ctgcctcggc ctcccgagta
     2881 actgggtcta caggcccgtg ctaccacgcc cagctaattt ttgtcttttt agtagagaca
     2941 gggtttaacc atgttgccca ggatggtctc catctcttga cctcgtgatc cgcccgcctc
     3001 ggcctcccaa acttctggga ttacaggcgt gagccaccgc acccagccac cattttatct
     3061 ctctaaagtc tggtcccagt attaaaccta ttctttagta aactcatatt actgttctaa
     3121 attgaagaaa ttatttatta ctctgtactt ctagactcaa aattctttat caaagatagt
     3181 ctcaaagagg tagtacaagt cctgtttaac tgcacttttt cacattcaca gtgcttcctc
     3241 tgatatcttt ccttacatca ttatacactg ttgatatcat tttactcttc tttctcttct
     3301 acatttctta aattttggtt cttttcctgt acatgtgttt tagcggggcc cttttctttg
     3361 aactttgtct aattagcctg tacatttttg tttcttttaa ggtagaacag atcttttttt
     3421 gtttctcctt ttaagtctac tggttttaaa agaggtaaat gtatccatag accacagtgc
     3481 cttgcttttt cctctgccag cacatggagc acgggattag atgcacaaac ctatttaggg
     3541 aactattttg gtagatgttt gagtttatac agaaattgca gctggtattt tattttgctg
     3601 tacatttact caacttgtcc attagtattt aactatttcc agagtttgtt taggagtaag
     3661 aattgaccca ttcgttagtt taccatattt tttcctggta taaaaaggag ccagaaataa
     3721 gccttattgc taaataatta attatgtaag cccacctagg tcctgcataa gatccccctc
     3781 acatacttca caatatatat gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3841 gtatttggct aaaaaattat actgccaaaa ttactgatta taaatacttg actacactga
     3901 ttgatgggac aaaatgatta aagtattttc agggatctta ttccatatgt caccaccaaa
     3961 gatttctaca gtgttataaa gtatataaat attccaaatt tctgtggtta aatatttttt
     4021 tctttttttt ccttttttag aataacacag tctgtgcttt ccaaaaatgc ttgaactttt
     4081 atgttgttaa gaaatatata atgatatctt acattaagca tgagtctaat ttgtattaat
     4141 tgggatggac taaattttca tttgattatc aggaaaatta aggagttata tatttaaaag
     4201 caattttctg tgttttcttc tttgtaagtt gactcatttg tgaagcaatt aggcaaattt
     4261 tgagaagatc attgttattg tggtttgcag tatatatttc ttagtaaata tcacttaaga
     4321 ttaaattttt cagaaagaaa attatagctt ttttcccaaa atatttttaa gatttaatct
     4381 ttttgtagta tgctacagat ttaattatat taactctttt ttaagacatt gaccatgact
     4441 taacattttg ccttctaaca ccttttaaat ctatgtactt taatagttaa gagaaaataa
     4501 gtttgcagat ttttaataat ctgtttgtaa aaggctatct ctaagcctag tatgtgggta
     4561 attttacagg tgtgtttttt gataacttta atataaaata aactcatttt atttgtggca
     4621 attcgcgttt ctttttttat gccagagtac atatgttgga ttccatgaat tggtattact
     4681 tattattatg tgttgattaa atatatgcac acacttagga ttacagatca cagagcaaat
     4741 tatgaaaatc ataaacattc tggtatggtc atccatagga ttatgaaaaa gaaatactga
     4801 attgttaaat ttggatgtta gaaaggaaag ataggaaaaa caatgagtac agaaatcctc
     4861 accatcaatt tggatgggtt agctgtctca ggcataaaat gtaacacaaa attcagattt
     4921 atgtatcctg gaaatgttct ggggttccat ctgttttaaa gttagacgtc tgtctgcctc
     4981 acatttaagc tttagagaga aatcctatgt tttaagaagt ttctttgtgt tacttcatta
     5041 tgacacataa tgcgtgttaa ggtctttcta gatagcattt taaatggaat tattttcatt
     5101 ttcattatga ggtatatact tgtaatgatc taaagaggtt agaaatataa ataaaaattc
     5161 aaaagaacac aa
//
