LOCUS       NM_021111               4412 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens reversion inducing cysteine rich protein with kazal
            motifs (RECK), transcript variant 1, mRNA.
ACCESSION   NM_021111
VERSION     NM_021111.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4412)
  AUTHORS   Wang,X., Jia,Y., Li,Q., Yang,Q., Liu,Y., Wei,B., Niu,X., Zhang,Y.,
            Luo,X., Zhao,Z. and Wang,P.
  TITLE     miR-200b-3p accelerates progression of pituitary adenomas by
            negatively regulating expression of RECK
  JOURNAL   Oncol Res 32 (5), 933-941 (2024)
   PUBMED   38686051
  REMARK    GeneRIF: miR-200b-3p accelerates progression of pituitary adenomas
            by negatively regulating expression of RECK.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4412)
  AUTHORS   Wang,J., Su,Y., Liu,H., Li,Y., Fang,X., Yu,X., Li,Q. and Han,W.
  TITLE     Association between the Reduced Expression of RECK and Neutrophilic
            Inflammation in Chronic Obstructive Pulmonary Disease
  JOURNAL   Int Arch Allergy Immunol 185 (5), 480-488 (2024)
   PUBMED   38387446
  REMARK    GeneRIF: Association between the Reduced Expression of RECK and
            Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease.
REFERENCE   3  (bases 1 to 4412)
  AUTHORS   Qi,F., Wang,Y., Yu,B. and Li,F.
  TITLE     Identification of RECK as a protective prognostic indicator and a
            tumor suppressor through regulation of the ERK/MAPK signaling
            pathway in gastric cancer
  JOURNAL   J Transl Med 21 (1), 766 (2023)
   PUBMED   37904179
  REMARK    GeneRIF: Identification of RECK as a protective prognostic
            indicator and a tumor suppressor through regulation of the ERK/MAPK
            signaling pathway in gastric cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4412)
  AUTHORS   Liu,C., Zhao,F., Sun,P., Han,W., Hong,M., Wu,J. and Zhang,X.
  TITLE     [miR-181c promotes the migration and angiogenesis of human A549
            cells via targeting inhibition of reversion-inducing cysteine-rich
            protein with Kazal motifs (RECK)]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 38 (12), 1084-1090 (2022)
   PUBMED   36585230
  REMARK    GeneRIF: [miR-181c promotes the migration and angiogenesis of human
            A549 cells via targeting inhibition of reversion-inducing
            cysteine-rich protein with Kazal motifs (RECK)].
REFERENCE   5  (bases 1 to 4412)
  AUTHORS   Said,E.M., Salem,A.A., Shousha,H.I., Ahmad,E.S., Alazzouny,M.A.,
            Ahmed,I.A., Elfeky,H.M. and Abdelsalam,F.M.
  TITLE     RECK gene polymorphisms in hepatitis B-related hepatocellular
            carcinoma: A case-control study
  JOURNAL   Arab J Gastroenterol 23 (3), 201-205 (2022)
   PUBMED   35941073
  REMARK    GeneRIF: RECK gene polymorphisms in hepatitis B-related
            hepatocellular carcinoma: A case-control study.
REFERENCE   6  (bases 1 to 4412)
  AUTHORS   Masui,T., Doi,R., Koshiba,T., Fujimoto,K., Tsuji,S., Nakajima,S.,
            Koizumi,M., Toyoda,E., Tulachan,S., Ito,D., Kami,K., Mori,T.,
            Wada,M., Noda,M. and Imamura,M.
  TITLE     RECK expression in pancreatic cancer: its correlation with lower
            invasiveness and better prognosis
  JOURNAL   Clin Cancer Res 9 (5), 1779-1784 (2003)
   PUBMED   12738734
  REMARK    GeneRIF: High RECK protein is associated with invasiveness of
            pancreatic cancer by MMP-2 activation
REFERENCE   7  (bases 1 to 4412)
  AUTHORS   Eisenberg,I., Hochner,H., Sadeh,M., Argov,Z. and
            Mitrani-Rosenbaum,S.
  TITLE     Establishment of the genomic structure and identification of
            thirteen single-nucleotide polymorphisms in the human RECK gene
  JOURNAL   Cytogenet Genome Res 97 (1-2), 58-61 (2002)
   PUBMED   12438739
  REMARK    GeneRIF: Four SNPs were identified in the coding region of the gene
            (exons 1, 9, 13 and 15), and the remaining nine in introns 5, 8,
            10, 12, 15 and 17.
REFERENCE   8  (bases 1 to 4412)
  AUTHORS   Oh,J., Takahashi,R., Kondo,S., Mizoguchi,A., Adachi,E.,
            Sasahara,R.M., Nishimura,S., Imamura,Y., Kitayama,H.,
            Alexander,D.B., Ide,C., Horan,T.P., Arakawa,T., Yoshida,H.,
            Nishikawa,S., Itoh,Y., Seiki,M., Itohara,S., Takahashi,C. and
            Noda,M.
  TITLE     The membrane-anchored MMP inhibitor RECK is a key regulator of
            extracellular matrix integrity and angiogenesis
  JOURNAL   Cell 107 (6), 789-800 (2001)
   PUBMED   11747814
REFERENCE   9  (bases 1 to 4412)
  AUTHORS   Takahashi,C., Sheng,Z., Horan,T.P., Kitayama,H., Maki,M.,
            Hitomi,K., Kitaura,Y., Takai,S., Sasahara,R.M., Horimoto,A.,
            Ikawa,Y., Ratzkin,B.J., Arakawa,T. and Noda,M.
  TITLE     Regulation of matrix metalloproteinase-9 and inhibition of tumor
            invasion by the membrane-anchored glycoprotein RECK
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13221-13226 (1998)
   PUBMED   9789069
REFERENCE   10 (bases 1 to 4412)
  AUTHORS   Gerstein,M.
  TITLE     Measurement of the effectiveness of transitive sequence comparison,
            through a third 'intermediate' sequence
  JOURNAL   Bioinformatics 14 (8), 707-714 (1998)
   PUBMED   9789096
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292653.1, D50406.1 and
            BC050306.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021111.2.
            
            Summary: The protein encoded by this gene is a cysteine-rich,
            extracellular protein with protease inhibitor-like domains whose
            expression is suppressed strongly in many tumors and cells
            transformed by various kinds of oncogenes. In normal cells, this
            membrane-anchored glycoprotein may serve as a negative regulator
            for matrix metalloproteinase-9, a key enzyme involved in tumor
            invasion and metastasis. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.68219.1, D50406.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377966.4/ ENSP00000367202.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AK292653.1         1-6
            7-4117              D50406.1           30-4140
            4118-4412           BC050306.1         4244-4538
FEATURES             Location/Qualifiers
     source          1..4412
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..4412
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /note="reversion inducing cysteine rich protein with kazal
                     motifs"
                     /db_xref="GeneID:8434"
                     /db_xref="HGNC:HGNC:11345"
                     /db_xref="MIM:605227"
     exon            1..186
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..3002
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; suppression of tumorigenicity 5
                     (reversion-inducing-cysteine-rich protein with kazal
                     motifs); membrane-anchored glycoprotein (metastasis and
                     invasion); suppression of tumorigenicity 15
                     (reversion-inducing-cysteine-rich protein with kazal
                     motifs); reversion-inducing cysteine-rich protein with
                     Kazal motifs; suppressor of tumorigenicity 15 protein"
                     /codon_start=1
                     /product="reversion-inducing cysteine-rich protein with
                     Kazal motifs isoform 1 precursor"
                     /protein_id="NP_066934.1"
                     /db_xref="CCDS:CCDS6597.1"
                     /db_xref="GeneID:8434"
                     /db_xref="HGNC:HGNC:11345"
                     /db_xref="MIM:605227"
                     /translation="MATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDN
                     QMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGL
                     GCCELAIALECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTN
                     CREYCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCD
                     RAEDHACQNACKRILMSKKTEMEIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVT
                     VHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGNTQSWQEFDRFCEYNPVEVS
                     MLTCLADVREPCQLGCRNLTYCTNFNNRPTELFRSCNAQSDQGAMNDMKLWEKGSIKM
                     PFINIPVLDIKKCQPEMWKAIACSLQIKPCHSKSRGSIICKSDCVEILKKCGDQNKFP
                     EDHTAESICELLSPTDDLKNCIPLDTYLRPSTLGNIVEEVTHPCNPNPCPANELCEVN
                     RKGCPSGDPCLPYFCVQGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLL
                     ENCMEMHCIDLQKSCIVGGKRKSHGTSFSIDCNVCSCFAGNLVCSTRLCLSEHSSEDD
                     RRTFTGLPCNCADQFVPVCGQNGRTYPSACIARCVGLQDHQFEFGSCMSKDPCNPNPC
                     QKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLACDQVQDPVCDTDHMEHNNLCTLYQR
                     GKSLSYKGPCQPFCRATEPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSS
                     VAECASVKCPSLLAAGCKPIIPPGACCPLCAGMLRVLFDKEKLDTIAKVTNKKPITVL
                     EILQKIRMHVSVPQCDVFGYFSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLIN
                     SDSPTLASHVPLSALIISQVQVSSSVPSAGVRARPSCHSLLLPLSLGLALHLLWTYN"
     exon            187..245
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            246..320
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            321..357
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            358..443
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            444..491
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            492..525
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            526..723
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            724..991
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1171
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1384
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1521
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1662
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1851
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1974
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2146
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2339
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2550
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2624
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2780
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..4412
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4362..4367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /note="hexamer: AATATA"
     regulatory      4388..4393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /note="hexamer: AATAAA"
     polyA_site      4395
                     /gene="RECK"
                     /gene_synonym="ST15"
     polyA_site      4412
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgagcgg cggcggtagc ggcggcagcg gctgcggcca agctgggtcc gagcatcccg
       61 cggctctgga gccgcccggc ccggacatgg cgaccgtccg ggcctctctg cgaggtgcgc
      121 tgctccttct gctggccgtg gcgggggtcg cggaggtggc agggggcctg gctccgggca
      181 gtgcgggtgc attgtgttgt aatcattcaa aggataacca aatgtgccgt gatgtatgtg
      241 aacagatttt ctcctcaaaa agtgaatccc gactaaaaca tctgttgcag cgagccccag
      301 attattgccc agagacaatg gttgaaattt ggaattgtat gaattcatct ttgccaggtg
      361 tgtttaagaa gtctgatggc tgggttggct taggctgctg tgaactggct attgccttgg
      421 agtgtcgaca ggcatgcaag caggcatctt caaagaatga tatttccaaa gtttgcagaa
      481 aagaatatga gaatgctctt ttcagttgca ttagcagaaa tgaaatgggc tcggtttgtt
      541 gcagttatgc aggtcatcac acaaactgcc gagaatactg tcaagccatt tttcgaacag
      601 actcttctcc tggtccatct cagataaaag cagtggaaaa ttattgcgcc tctattagtc
      661 cacaattaat acattgtgtg aacaattata ctcaatctta tccaatgagg aacccaacgg
      721 atagtttata ttgctgtgac agagctgaag accatgcttg ccaaaatgcc tgcaagagaa
      781 tcctgatgtc caagaaaacg gaaatggaga ttgttgatgg tctcatcgag ggttgtaaga
      841 cccagccctt gcctcaagat cctctttggc aatgttttct tgaaagctca caatctgttc
      901 accctggagt cactgtacac cctcctccct ctacaggcct cgatggggct aaattgcatt
      961 gttgttctaa agcaaacact tcaacatgta gggaactctg cactaaactt tacagcatga
     1021 gctggggcaa tacacagagt tggcaagagt ttgatcgctt ttgtgaatat aatccagtgg
     1081 aagtgtccat gttgacctgt ttagcggatg tccgggaacc ttgccagttg ggctgtagaa
     1141 accttactta ctgtactaat tttaacaaca ggccaacaga acttttcagg agttgtaatg
     1201 cacagtcaga tcaaggagcc atgaatgaca tgaagttgtg ggagaaagga agcataaaga
     1261 tgccatttat caatatacct gttcttgata ttaaaaagtg ccagccagag atgtggaaag
     1321 caatagcttg ttcactgcag attaaacctt gtcatagtaa atctcgggga agtattattt
     1381 gcaaatcaga ttgtgtggag attcttaaaa aatgtggaga ccagaacaaa ttccctgaag
     1441 accacacagc tgaaagtatt tgtgagcttc tgtcacctac agatgatctg aagaattgta
     1501 tacctttgga tacatacctc aggccaagta ctttaggtaa cattgtagaa gaagtgactc
     1561 atccctgtaa cccaaatcct tgccctgcca atgagctctg tgaagtaaac cgaaaaggat
     1621 gtccatctgg agatccctgt cttccatact tttgtgttca aggttgcaaa ctgggagaag
     1681 cttctgattt cattgtccgt caagggacac taatccaggt gccatcatct gcaggggaag
     1741 ttggttgtta taaaatctgt tcatgtggac aaagtggact cttagaaaac tgtatggaaa
     1801 tgcactgtat agacctccag aagtcttgta ttgttggagg aaaaagaaaa agtcatggaa
     1861 catcctttag tattgactgc aatgtctgtt cttgttttgc tggcaatttg gtgtgctcta
     1921 cccgcctttg cctcagtgag cacagttcag aagatgaccg tcgtaccttc acaggtctgc
     1981 cctgtaactg tgcagatcag tttgtccctg tatgtgggca gaatgggcgc acttacccca
     2041 gtgcctgcat tgctcgctgt gtgggcctcc aagaccatca gtttgagttt ggatcatgca
     2101 tgtcaaagga tccatgtaat cctaatccct gccaaaaaaa ccaaaggtgc atacccaaac
     2161 cacaggtctg cctgacgact tttgataaat ttggatgtag ccagtatgag tgtgtaccaa
     2221 gacagctcgc gtgtgaccag gtccaagatc ctgtttgtga cacagaccac atggagcaca
     2281 acaatctctg cactttatac caaagaggaa aaagcctctc ttacaaaggt ccctgccagc
     2341 ccttttgcag agcaaccgag cccgtatgtg ggcacaatgg tgagacctac agcagtgtgt
     2401 gtgctgccta ctcggatcgc gtggcagtcg attactatgg ggactgccag gccgtcggag
     2461 tcctctcaga gcacagctcc gtcgccgagt gtgcttctgt caagtgtcct tcgctcttgg
     2521 cagctggatg caaacccatc atcccaccgg gtgcttgttg cccattatgt gctgggatgt
     2581 taagagtttt atttgacaaa gaaaaactgg atactattgc taaggtaaca aataaaaagc
     2641 caataacagt tctggaaata cttcagaaaa tccgcatgca cgtgtctgtc ccacagtgtg
     2701 atgtgtttgg atacttcagc attgaatcag aaattgtgat cctgatcatt cccgtcgatc
     2761 actatccaaa agctctgcag attgaagcct gcaataaaga agcagagaag attgagtccc
     2821 ttatcaactc tgacagcccg actttggcgt cccatgtccc tctctctgcc ctcatcattt
     2881 cccaggtaca ggtctccagc agtgtgccat cggccggtgt cagggccagg ccttcttgcc
     2941 actccctcct ccttcccctc agcttgggcc ttgccttgca cttgctctgg acatataact
     3001 gactgcccac ggaaagtgca gaatgctcct ccacctcact ctcctgcctt gaaaaagaca
     3061 ttcaggactg ctggtttgta gttgaatatt ggccaaggaa aggcacatgt cacctctatt
     3121 cgccacacag tatttttttt tttaatccgc caatattagt aggatttttg ttttgttttt
     3181 acaaatgtta aaatgtgttg ttccaaatac taatgaaaac agaatgtctc ttcctggtag
     3241 accactgcca tatgatttac atttcctcac cataagggtc ccccactcta aagcaaattt
     3301 atcgctggga aatgagatga ccacttttta gaaagataat tcactgtact atcaggttca
     3361 caaacttcat ttcagagttc tttttgaagt atttaaggtt cccgttgcat ttgttttgtt
     3421 tacagataat tacctactct ggctagaagc taggggtccc agtgaagagc cactgccatt
     3481 aaagaatatg aaacatagat aaaacatctt tgaaattatg taaattatgt aaattatcag
     3541 gcaaatttgc attaaattac agaaatttaa ttcagaaccc caactactgt gttatgcaaa
     3601 agcaagctga ttaaatgaca ctcatataat tatatgttgt aagcaacagg ctcactggtc
     3661 acggatttgt gtctgtgact tttgtgaaag ggagaagtga cattgcatca aagcatcttg
     3721 cattatgcaa tttttatatt aaccagatat atattcatcg gtattcatcc aagttaaatg
     3781 tagagttttt aaacatcaat ctttaaacca attgctgcta cttatataat tgccaaaaag
     3841 tgaaataatg tgtagttcat gtaaataata cattatattt ctattttatt atgaagaagg
     3901 tgaatagcca tatttgtaaa atgacaatca tgtgtgttaa cccagtgctt tccattcgtg
     3961 aaaacacatt tgctttttgt gatatgcaca atgtagataa gtgttctgtc tgactttctt
     4021 ttttgatata gaagtataaa gaattgtggt ttatatattt aaaagtgtca agctgagtat
     4081 taaaatgtat gcatgttgtc taagaaattg aatactttga atgtgtttca cagtttgaaa
     4141 taagctattt gatgtaatac ttcttgtgtg tatgcacatg aacttagatt ttacatgaag
     4201 tattttttca gtattatatg taccctctga aatacatagg gatatgcgta ttataccaaa
     4261 atgttgctga aaaatgggca cttaaagctt tcagaatatg tcagtgctga tgtagcatgc
     4321 ttgttgcaat tgcctttttt ctgtataaat gtctttaatg caatatactg gaaagctttt
     4381 ctattttaat aaaaataatt tttatatgat ca
//
