LOCUS       NP_066934                971 aa            linear   PRI 27-MAY-2024
DEFINITION  reversion-inducing cysteine-rich protein with Kazal motifs isoform
            1 precursor [Homo sapiens].
ACCESSION   NP_066934
VERSION     NP_066934.1
DBSOURCE    REFSEQ: accession NM_021111.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 971)
  AUTHORS   Wang,X., Jia,Y., Li,Q., Yang,Q., Liu,Y., Wei,B., Niu,X., Zhang,Y.,
            Luo,X., Zhao,Z. and Wang,P.
  TITLE     miR-200b-3p accelerates progression of pituitary adenomas by
            negatively regulating expression of RECK
  JOURNAL   Oncol Res 32 (5), 933-941 (2024)
   PUBMED   38686051
  REMARK    GeneRIF: miR-200b-3p accelerates progression of pituitary adenomas
            by negatively regulating expression of RECK.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 971)
  AUTHORS   Wang,J., Su,Y., Liu,H., Li,Y., Fang,X., Yu,X., Li,Q. and Han,W.
  TITLE     Association between the Reduced Expression of RECK and Neutrophilic
            Inflammation in Chronic Obstructive Pulmonary Disease
  JOURNAL   Int Arch Allergy Immunol 185 (5), 480-488 (2024)
   PUBMED   38387446
  REMARK    GeneRIF: Association between the Reduced Expression of RECK and
            Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease.
REFERENCE   3  (residues 1 to 971)
  AUTHORS   Qi,F., Wang,Y., Yu,B. and Li,F.
  TITLE     Identification of RECK as a protective prognostic indicator and a
            tumor suppressor through regulation of the ERK/MAPK signaling
            pathway in gastric cancer
  JOURNAL   J Transl Med 21 (1), 766 (2023)
   PUBMED   37904179
  REMARK    GeneRIF: Identification of RECK as a protective prognostic
            indicator and a tumor suppressor through regulation of the ERK/MAPK
            signaling pathway in gastric cancer.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 971)
  AUTHORS   Liu,C., Zhao,F., Sun,P., Han,W., Hong,M., Wu,J. and Zhang,X.
  TITLE     [miR-181c promotes the migration and angiogenesis of human A549
            cells via targeting inhibition of reversion-inducing cysteine-rich
            protein with Kazal motifs (RECK)]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 38 (12), 1084-1090 (2022)
   PUBMED   36585230
  REMARK    GeneRIF: [miR-181c promotes the migration and angiogenesis of human
            A549 cells via targeting inhibition of reversion-inducing
            cysteine-rich protein with Kazal motifs (RECK)].
REFERENCE   5  (residues 1 to 971)
  AUTHORS   Said,E.M., Salem,A.A., Shousha,H.I., Ahmad,E.S., Alazzouny,M.A.,
            Ahmed,I.A., Elfeky,H.M. and Abdelsalam,F.M.
  TITLE     RECK gene polymorphisms in hepatitis B-related hepatocellular
            carcinoma: A case-control study
  JOURNAL   Arab J Gastroenterol 23 (3), 201-205 (2022)
   PUBMED   35941073
  REMARK    GeneRIF: RECK gene polymorphisms in hepatitis B-related
            hepatocellular carcinoma: A case-control study.
REFERENCE   6  (residues 1 to 971)
  AUTHORS   Masui,T., Doi,R., Koshiba,T., Fujimoto,K., Tsuji,S., Nakajima,S.,
            Koizumi,M., Toyoda,E., Tulachan,S., Ito,D., Kami,K., Mori,T.,
            Wada,M., Noda,M. and Imamura,M.
  TITLE     RECK expression in pancreatic cancer: its correlation with lower
            invasiveness and better prognosis
  JOURNAL   Clin Cancer Res 9 (5), 1779-1784 (2003)
   PUBMED   12738734
  REMARK    GeneRIF: High RECK protein is associated with invasiveness of
            pancreatic cancer by MMP-2 activation
REFERENCE   7  (residues 1 to 971)
  AUTHORS   Eisenberg,I., Hochner,H., Sadeh,M., Argov,Z. and
            Mitrani-Rosenbaum,S.
  TITLE     Establishment of the genomic structure and identification of
            thirteen single-nucleotide polymorphisms in the human RECK gene
  JOURNAL   Cytogenet Genome Res 97 (1-2), 58-61 (2002)
   PUBMED   12438739
  REMARK    GeneRIF: Four SNPs were identified in the coding region of the gene
            (exons 1, 9, 13 and 15), and the remaining nine in introns 5, 8,
            10, 12, 15 and 17.
REFERENCE   8  (residues 1 to 971)
  AUTHORS   Oh,J., Takahashi,R., Kondo,S., Mizoguchi,A., Adachi,E.,
            Sasahara,R.M., Nishimura,S., Imamura,Y., Kitayama,H.,
            Alexander,D.B., Ide,C., Horan,T.P., Arakawa,T., Yoshida,H.,
            Nishikawa,S., Itoh,Y., Seiki,M., Itohara,S., Takahashi,C. and
            Noda,M.
  TITLE     The membrane-anchored MMP inhibitor RECK is a key regulator of
            extracellular matrix integrity and angiogenesis
  JOURNAL   Cell 107 (6), 789-800 (2001)
   PUBMED   11747814
REFERENCE   9  (residues 1 to 971)
  AUTHORS   Takahashi,C., Sheng,Z., Horan,T.P., Kitayama,H., Maki,M.,
            Hitomi,K., Kitaura,Y., Takai,S., Sasahara,R.M., Horimoto,A.,
            Ikawa,Y., Ratzkin,B.J., Arakawa,T. and Noda,M.
  TITLE     Regulation of matrix metalloproteinase-9 and inhibition of tumor
            invasion by the membrane-anchored glycoprotein RECK
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13221-13226 (1998)
   PUBMED   9789069
REFERENCE   10 (residues 1 to 971)
  AUTHORS   Gerstein,M.
  TITLE     Measurement of the effectiveness of transitive sequence comparison,
            through a third 'intermediate' sequence
  JOURNAL   Bioinformatics 14 (8), 707-714 (1998)
   PUBMED   9789096
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292653.1, D50406.1 and
            BC050306.1.
            
            Summary: The protein encoded by this gene is a cysteine-rich,
            extracellular protein with protease inhibitor-like domains whose
            expression is suppressed strongly in many tumors and cells
            transformed by various kinds of oncogenes. In normal cells, this
            membrane-anchored glycoprotein may serve as a negative regulator
            for matrix metalloproteinase-9, a key enzyme involved in tumor
            invasion and metastasis. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.68219.1, D50406.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377966.4/ ENSP00000367202.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..971
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     Protein         1..971
                     /product="reversion-inducing cysteine-rich protein with
                     Kazal motifs isoform 1 precursor"
                     /note="suppression of tumorigenicity 5
                     (reversion-inducing-cysteine-rich protein with kazal
                     motifs); membrane-anchored glycoprotein (metastasis and
                     invasion); suppression of tumorigenicity 15
                     (reversion-inducing-cysteine-rich protein with kazal
                     motifs); reversion-inducing cysteine-rich protein with
                     Kazal motifs; suppressor of tumorigenicity 15 protein"
                     /calculated_mol_wt=103953
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2523
     mat_peptide     27..971
                     /product="reversion-inducing cysteine-rich protein with
                     Kazal motifs isoform 1"
                     /calculated_mol_wt=103953
     Region          <633..699
                     /region_name="MFS"
                     /note="Major Facilitator Superfamily; cl28910"
                     /db_xref="CDD:475125"
     Region          <802..>886
                     /region_name="Amnionless"
                     /note="pfam14828"
                     /db_xref="CDD:464340"
     CDS             1..971
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /coded_by="NM_021111.3:87..3002"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS6597.1"
                     /db_xref="GeneID:8434"
                     /db_xref="HGNC:HGNC:11345"
                     /db_xref="MIM:605227"
ORIGIN      
        1 matvraslrg alllllavag vaevagglap gsagalccnh skdnqmcrdv ceqifsskse
       61 srlkhllqra pdycpetmve iwncmnsslp gvfkksdgwv glgccelaia lecrqackqa
      121 sskndiskvc rkeyenalfs cisrnemgsv ccsyaghhtn creycqaifr tdsspgpsqi
      181 kavenycasi spqlihcvnn ytqsypmrnp tdslyccdra edhacqnack rilmskktem
      241 eivdgliegc ktqplpqdpl wqcflessqs vhpgvtvhpp pstgldgakl hccskantst
      301 crelctklys mswgntqswq efdrfceynp vevsmltcla dvrepcqlgc rnltyctnfn
      361 nrptelfrsc naqsdqgamn dmklwekgsi kmpfinipvl dikkcqpemw kaiacslqik
      421 pchsksrgsi icksdcveil kkcgdqnkfp edhtaesice llsptddlkn cipldtylrp
      481 stlgniveev thpcnpnpcp anelcevnrk gcpsgdpclp yfcvqgcklg easdfivrqg
      541 tliqvpssag evgcykicsc gqsgllencm emhcidlqks civggkrksh gtsfsidcnv
      601 cscfagnlvc strlclsehs seddrrtftg lpcncadqfv pvcgqngrty psaciarcvg
      661 lqdhqfefgs cmskdpcnpn pcqknqrcip kpqvclttfd kfgcsqyecv prqlacdqvq
      721 dpvcdtdhme hnnlctlyqr gkslsykgpc qpfcratepv cghngetyss vcaaysdrva
      781 vdyygdcqav gvlsehssva ecasvkcpsl laagckpiip pgaccplcag mlrvlfdkek
      841 ldtiakvtnk kpitvleilq kirmhvsvpq cdvfgyfsie seiviliipv dhypkalqie
      901 acnkeaekie slinsdsptl ashvplsali isqvqvsssv psagvrarps chslllplsl
      961 glalhllwty n
//
