LOCUS       NM_002906               4392 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens radixin (RDX), transcript variant 3, mRNA.
ACCESSION   NM_002906
VERSION     NM_002906.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4392)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 4392)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4392)
  AUTHORS   Kruse,T., Benz,C., Garvanska,D.H., Lindqvist,R., Mihalic,F.,
            Coscia,F., Inturi,R., Sayadi,A., Simonetti,L., Nilsson,E., Ali,M.,
            Kliche,J., Moliner Morro,A., Mund,A., Andersson,E., McInerney,G.,
            Mann,M., Jemth,P., Davey,N.E., Overby,A.K., Nilsson,J. and
            Ivarsson,Y.
  TITLE     Large scale discovery of coronavirus-host factor protein
            interaction motifs reveals SARS-CoV-2 specific mechanisms and
            vulnerabilities
  JOURNAL   Nat Commun 12 (1), 6761 (2021)
   PUBMED   34799561
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4392)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4392)
  AUTHORS   Prasad,S., Vona,B., Dineiro,M., Costales,M., Gonzalez-Aguado,R.,
            Fontalba,A., Diego-Perez,C., Subasioglu,A., Bademci,G., Tekin,M.,
            Cabanillas,R., Cadinanos,J. and Fridberger,A.
  TITLE     Radixin modulates the function of outer hair cell stereocilia
  JOURNAL   Commun Biol 3 (1), 792 (2020)
   PUBMED   33361775
  REMARK    GeneRIF: Radixin modulates the function of outer hair cell
            stereocilia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4392)
  AUTHORS   Stemmer-Rachamimov,A.O., Gonzalez-Agosti,C., Xu,L., Burwick,J.A.,
            Beauchamp,R., Pinney,D., Louis,D.N. and Ramesh,V.
  TITLE     Expression of NF2-encoded merlin and related ERM family proteins in
            the human central nervous system
  JOURNAL   J Neuropathol Exp Neurol 56 (6), 735-742 (1997)
   PUBMED   9184664
REFERENCE   7  (bases 1 to 4392)
  AUTHORS   Hirao,M., Sato,N., Kondo,T., Yonemura,S., Monden,M., Sasaki,T.,
            Takai,Y., Tsukita,S. and Tsukita,S.
  TITLE     Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma
            membrane association: possible involvement of phosphatidylinositol
            turnover and Rho-dependent signaling pathway
  JOURNAL   J Cell Biol 135 (1), 37-51 (1996)
   PUBMED   8858161
REFERENCE   8  (bases 1 to 4392)
  AUTHORS   Wilgenbus,K.K., Milatovich,A., Francke,U. and Furthmayr,H.
  TITLE     Molecular cloning, cDNA sequence, and chromosomal assignment of the
            human radixin gene and two dispersed pseudogenes
  JOURNAL   Genomics 16 (1), 199-206 (1993)
   PUBMED   8486357
REFERENCE   9  (bases 1 to 4392)
  AUTHORS   Shearer,A.E., Hildebrand,M.S., Odell,A.M. and Smith,R.J.H.
  TITLE     Genetic Hearing Loss Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301607
REFERENCE   10 (bases 1 to 4392)
  AUTHORS   Sato,N., Funayama,N., Nagafuchi,A., Yonemura,S., Tsukita,S. and
            Tsukita,S.
  TITLE     A gene family consisting of ezrin, radixin and moesin. Its specific
            localization at actin filament/plasma membrane association sites
  JOURNAL   J Cell Sci 103 (Pt 1), 131-143 (1992)
   PUBMED   1429901
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002788.3 and AP000901.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 27, 2019 this sequence version replaced NM_002906.3.
            
            Summary: Radixin is a cytoskeletal protein that may be important in
            linking actin to the plasma membrane. It is highly similar in
            sequence to both ezrin and moesin. The radixin gene has been
            localized by fluorescence in situ hybridization to 11q23. A
            truncated version representing a pseudogene (RDXP2) was assigned to
            Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was
            mapped to 11p by Southern and PCR analyses. Multiple alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (3) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The resulting isoform (2)
            has a shorter C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047109.1, AK312903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000645495.2/ ENSP00000496503.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AP002788.3         37785-37932         c
            149-224             AP002788.3         20999-21074         c
            225-308             AP002788.3         13854-13937         c
            309-404             AP002788.3         6097-6192           c
            405-679             AP002788.3         5278-5552           c
            680-763             AP000901.5         109880-109963       c
            764-910             AP000901.5         109541-109687       c
            911-1007            AP000901.5         107063-107159       c
            1008-1171           AP000901.5         105720-105883       c
            1172-1302           AP000901.5         99477-99607         c
            1303-1463           AP000901.5         89266-89426         c
            1464-1556           AP000901.5         87873-87965         c
            1557-1799           AP000901.5         85011-85253         c
            1800-4392           AP000901.5         81215-83807         c
FEATURES             Location/Qualifiers
     source          1..4392
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..4392
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /note="radixin"
                     /db_xref="GeneID:5962"
                     /db_xref="HGNC:HGNC:9944"
                     /db_xref="MIM:179410"
     exon            1..148
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     exon            149..224
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1964
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="radixin isoform 2"
                     /protein_id="NP_002897.1"
                     /db_xref="CCDS:CCDS8343.1"
                     /db_xref="GeneID:5962"
                     /db_xref="HGNC:HGNC:9944"
                     /db_xref="MIM:179410"
                     /translation="MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWF
                     FGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLF
                     FLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQ
                     HKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWL
                     GVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRI
                     NKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAE
                     KEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKE
                     RRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAF
                     AAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNH
                     RSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLR
                     QIRQGNTKQRIDEFEAM"
     exon            225..308
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     exon            309..404
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     exon            405..679
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     exon            680..763
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     exon            764..910
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1007
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1171
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1302
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1463
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1556
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1799
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..4392
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3630..3635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /note="hexamer: ATTAAA"
     polyA_site      3669
                     /gene="RDX"
                     /gene_synonym="DFNB24"
     regulatory      4364..4369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /note="hexamer: AATAAA"
     polyA_site      4392
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /note="major polyA site"
ORIGIN      
        1 atattgcgga gctgtctgcg gtggcggcgg cgcctctcgt ctcccgcggg ccagcgctcg
       61 caccaccgct tctccctccc tgtcgcagcc gcgccgccgc gcagcgcccc agccacacgc
      121 cggcgggcag aagccgcccg ctctccggaa agtgataaca gaattcattg aagtggagaa
      181 tttttaaaga aggtaacaaa aagagaaaga aaatgccgaa accaatcaac gtaagagtaa
      241 ctacaatgga tgctgagctg gaatttgcca ttcagcccaa tacaactggc aaacaacttt
      301 ttgaccaggt ggtgaaaaca gttggtttgc gtgaggtctg gttttttggg ctgcagtatg
      361 tagacagcaa aggttattct acatggctta aactaaataa aaaggtaaca cagcaggatg
      421 ttaaaaaaga gaatccttta cagttcaagt ttagagctaa attctttcct gaagatgttt
      481 ctgaggaatt aattcaagaa ataacccaga gactcttctt cttgcaagtt aaagaagcca
      541 tcttaaatga tgagatatat tgcccgccag aaactgcagt tcttttggct tcctatgctg
      601 tccaagccaa gtatggagat tacaataaag agattcataa gccaggctac ctggctaatg
      661 atagactcct accccagcgt gtattggaac aacacaaact aacaaaagaa cagtgggaag
      721 aaagaataca gaactggcat gaagaacata gaggaatgtt aagggaggat tctatgatgg
      781 aatacctgaa gattgcacaa gatctagaaa tgtatggagt caactatttt gaaataaaaa
      841 ataaaaaagg aactgaattg tggctaggtg ttgatgcttt gggtctgaat atttatgagc
      901 atgacgacaa gttaacacct aaaattggtt ttccctggag tgaaatcaga aatatttcat
      961 ttaatgacaa aaaatttgtt ataaagccaa tcgacaaaaa ggcacctgat tttgtgtttt
     1021 atgcacctcg tctgagaatc aataagcgga ttttggcctt atgtatggga aaccatgaac
     1081 tatacatgcg aagaaggaag cctgatacta ttgaagtaca acagatgaag gctcaggcta
     1141 gggaggagaa acatcagaag cagttggaaa gggcacaatt agagaatgaa aagaagaaaa
     1201 gagaaatagc agaaaaggaa aaggaaagaa tagaacgtga aaaggaagag ctaatggaac
     1261 gtctaaaaca aattgaagag cagacaatta aagctcagaa agaactagaa gaacagactc
     1321 gaaaagctct agaactggat caagaacgaa aacgagcaaa agaagaagca gaacgacttg
     1381 aaaaggagcg tcgagctgct gaagaggcaa agtctgccat agcaaaacaa gctgccgacc
     1441 agatgaagaa tcaggagcag ctagcagcag aacttgctga attcactgcc aagattgcac
     1501 ttctagagga agccaagaag aaaaaggaag aggaagctac tgagtggcaa cacaaagctt
     1561 ttgcagccca ggaagacttg gaaaagacca aagaagagtt aaaaactgtg atgtctgccc
     1621 cccctccacc tccaccacca ccagtcattc ctccaacaga aaacgaacat gatgaacacg
     1681 atgagaataa tgctgaagct agtgctgaat tatcaaatga aggggtaatg aaccatagaa
     1741 gcgaggaaga acgtgtaacc gaaacacaga aaaatgagcg tgttaagaag caacttcagg
     1801 cattaagttc agaattagcc caagccagag atgaaaccaa gaaaacacaa aatgatgttc
     1861 ttcatgctga gaatgttaaa gcaggccgtg ataagtacaa gactctgcga cagattcgac
     1921 aaggcaatac aaagcagcgt atcgatgagt ttgaagcaat gtgagagctg ttattttgca
     1981 tatatgttct tcataagctg aaccaccaac agagaaaagc aggcctttgc agatatgatg
     2041 gaatgcatcc caccttgcca aagcacttac accagtttga ctgtgctagc taaaagacaa
     2101 atttaagggg agctcttcaa cattaaggca gtatgatatc atgcttggtt ttcttttttc
     2161 ttttggtcca gggaatggag aatggtgttc cattgcctct tttcacattt tttttctttt
     2221 tctttttttt ttctgttgaa gattaacact aattatcacg tctgacaaat gtgtatgtgt
     2281 ggtttcagtt ctgtgtacat tttaaaggat aatggtgaac attttaatgg gtttcccttg
     2341 ccctttccat atttaaccta tttccacatt ctctctcact cacattttct cagtgtgccc
     2401 ttctcttatc tgccatgtcc atagccataa ttccaccatc atacagatca ggcagtgttt
     2461 aaaatgatgg taggtagcac agtggacagt ctttgatcat catgtagaat atggctatga
     2521 atcaggaaag agattagaac atttaataat gtatgtacag ctggtgctta gttttttttt
     2581 aatctaaatt taattacctt attggatatt tgatatttgg ttatttaatc acagtcatct
     2641 ttaacagctt acactgattg gtgttttatc tcctgtgatc ctttgatggc tttttttgcc
     2701 taccatttca cagaggttta gacagcagta gtagctccct aggagagttt actgatgaaa
     2761 cagcctctgc aagattttaa aagttttgtt cttttataga ctgatttaga aaaacaaatg
     2821 attagttaaa aaaagaaaat atacatttgt tggtaactaa tgttattttt taaaacctgg
     2881 accttttctg gaagggcagc atataaaaac atcagtcccg aggaggggac aacaatacta
     2941 cctcactact acatctgtga tgactggttg ttcaaacaca atggagtgtg taaggtatat
     3001 gttttataat tcataaccat agcctcgatc atcaagaaat actttcgaaa tttcattttc
     3061 cttcagaata tcttaagagt gctaaatttt taactgcctt tttgtcgagt caaactgtgg
     3121 gattctgatt tgtattaaaa ttgtaagctc ctcactggta tactatcatc ctggaggggt
     3181 gttgtatggc tgagcaagag agagagagaa tgagagagag actgtgtgtg tgtgtgtgtg
     3241 tgtgtgtgtg tgtactctgt gtgtgtatga gagagagaaa tgctaacctt gtagcatgtg
     3301 aagaatgtct gtaccttgat acgatagtta cataatcagt atatttggtt tctagatcac
     3361 tgtgcttatt ttgtttcaat ctctgactaa aaatacttaa atttggtttg ttaattctta
     3421 ttttagaaat tataatttta gtttatatta atttcggtta tagcttactg aagaaatctt
     3481 tccagttaga aggaggttct aatattcaca tgttctaata ctttgtttat tgtaaaacag
     3541 ctaaatttgg agatacgtaa agccttgttt tctctgtgtg gttcagctac tttccatttg
     3601 gtattacaca gtcaaattta catttatcta ttaaaattgc cattttatta aacattttca
     3661 tgcacagtag attcaagttg tgtctgaaaa tatctcttgt gcttttttga ttttgctgac
     3721 tttaaaagga ttaatctggg cagacattat gtaaaagaaa ggttgcgttt aatatatttt
     3781 ttgaactttg taggacaaaa catagctggt taaccttgaa gtgactgttg taccatggtt
     3841 gtgcacatgc ttcagaatcc tatggaagag aatattccta cttgcagtac atcaaaggaa
     3901 tggatggtgg accctactat tcatgttttg agacataaat gttcacttta aagcaattgc
     3961 ataatagata aaaacctgaa ctttcattgg atttttgtta attttcctca ttttgaatta
     4021 tgtgcactac catagctaca tcagtttgat acagtattga aaaattatca gttatatttt
     4081 gctgtttatg atctatttgt agattaggat taaaatggat ttaatccatt tttaaggctg
     4141 tgtgaatttt tctaaacaag aaccatttgc aatatggatt tcttagagat taaaccaatt
     4201 ataacttatt agcagtcgcg agcacatgtt catatagtca atgtaaaaat acactaatga
     4261 gtatttggta aatcccagta ggcttttacc attagcataa ttttgtgttg tacaattaag
     4321 ttacaattac atctctaatt ttggataata ttcattggtt aacaataaag tgacaaaagc
     4381 tcatgccttc aa
//
