LOCUS       NM_145654               1163 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RAD52 motif containing 1 (RDM1), transcript variant 1,
            mRNA.
ACCESSION   NM_145654
VERSION     NM_145654.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1163)
  AUTHORS   Qiu,C., Li,Z., Cao,W., Cai,X., Ye,L., Zhang,C., Ma,Y., Wang,X. and
            Yang,Y.
  TITLE     Correlation analysis of RDM1 gene with immune infiltration and
            clinical prognosis of hepatocellular carcinoma
  JOURNAL   Biosci Rep 41 (9) (2021)
   PUBMED   34435618
  REMARK    GeneRIF: Correlation analysis of RDM1 gene with immune infiltration
            and clinical prognosis of hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1163)
  AUTHORS   Sheng,J., Liu,K., Sun,D., Nie,P., Mu,Z., Chen,H. and Zhang,Z.
  TITLE     Association of RDM1 with osteosarcoma progression via cell cycle
            and MEK/ERK signalling pathway regulation
  JOURNAL   J Cell Mol Med 25 (16), 8039-8046 (2021)
   PUBMED   34264012
  REMARK    GeneRIF: Association of RDM1 with osteosarcoma progression via cell
            cycle and MEK/ERK signalling pathway regulation.
REFERENCE   3  (bases 1 to 1163)
  AUTHORS   Tong,L., Cao,W., Sheng,J., Zhu,E., Yu,Y., Zhong,T., Chen,Y. and
            Wang,L.
  TITLE     RDM1 plays an oncogenic role in human ovarian carcinoma cells
  JOURNAL   Artif Cells Nanomed Biotechnol 48 (1), 885-892 (2020)
   PUBMED   32501118
  REMARK    GeneRIF: RDM1 plays an oncogenic role in human ovarian carcinoma
            cells.
REFERENCE   4  (bases 1 to 1163)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1163)
  AUTHORS   Chen,S.L., Liu,L.L., Wang,C.H., Lu,S.X., Yang,X., He,Y.F.,
            Zhang,C.Z. and Yun,J.P.
  TITLE     Loss of RDM1 enhances hepatocellular carcinoma progression via p53
            and Ras/Raf/ERK pathways
  JOURNAL   Mol Oncol 14 (2), 373-386 (2020)
   PUBMED   31670863
  REMARK    GeneRIF: Loss of RDM1 enhances hepatocellular carcinoma progression
            via p53 and Ras/Raf/ERK pathways.
REFERENCE   6  (bases 1 to 1163)
  AUTHORS   Tong,L., Liu,J., Yan,W., Cao,W., Shen,S., Li,K., Li,L. and Niu,G.
  TITLE     RDM1 plays an oncogenic role in human lung adenocarcinoma cells
  JOURNAL   Sci Rep 8 (1), 11525 (2018)
   PUBMED   30069034
  REMARK    GeneRIF: Knockdown of RDM1 in lung adenocarcinoma cells reduces
            cell proliferation and promotes apoptosis, consistent with the role
            RDM1 in the overexpression experiments. Xenograft mouse model shows
            stable knockdown of RDM1 significantly inhibits lung adenocarcinoma
            tumor growth. These in vitro and in vivo results conclude that RDM1
            plays an oncogenic role in human lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1163)
  AUTHORS   Xu,G., Du,J., Wang,F., Zhang,F., Hu,R., Sun,D. and Shen,J.
  TITLE     RAD52 motif-containing protein 1 promotes non-small cell lung
            cancer cell proliferation and survival via cell cycle regulation
  JOURNAL   Oncol Rep 40 (2), 833-840 (2018)
   PUBMED   29845285
  REMARK    GeneRIF: Due to its similarity to RAD52, we hypothesized that RDM1
            potentially repairs DNA doublestrand breaks arising through DNA
            replication.
REFERENCE   8  (bases 1 to 1163)
  AUTHORS   Messaoudi,L., Yang,Y.G., Kinomura,A., Stavreva,D.A., Yan,G.,
            Bortolin-Cavaille,M.L., Arakawa,H., Buerstedde,J.M., Hainaut,P.,
            Cavaille,J., Takata,M. and Van Dyck,E.
  TITLE     Subcellular distribution of human RDM1 protein isoforms and their
            nucleolar accumulation in response to heat shock and proteotoxic
            stress
  JOURNAL   Nucleic Acids Res 35 (19), 6571-6587 (2007)
   PUBMED   17905820
  REMARK    GeneRIF: The identification of 11 human cDNAs encoding RDM1 protein
            isoforms which is generated by alternative pre-mRNA splicing and
            differential usage of two translational start sites.
REFERENCE   9  (bases 1 to 1163)
  AUTHORS   Hamimes,S., Arakawa,H., Stasiak,A.Z., Kierzek,A.M., Hirano,S.,
            Yang,Y.G., Takata,M., Stasiak,A., Buerstedde,J.M. and Van Dyck,E.
  TITLE     RDM1, a novel RNA recognition motif (RRM)-containing protein
            involved in the cell response to cisplatin in vertebrates
  JOURNAL   J Biol Chem 280 (10), 9225-9235 (2005)
   PUBMED   15611051
  REMARK    GeneRIF: RDM1 recognizes DNA distortions induced by cisplatin-DNA
            adducts in vitro; possible role in spermatogenesis
REFERENCE   10 (bases 1 to 1163)
  AUTHORS   Baynton,K., Otterlei,M., Bjoras,M., von Kobbe,C., Bohr,V.A. and
            Seeberg,E.
  TITLE     WRN interacts physically and functionally with the recombination
            mediator protein RAD52
  JOURNAL   J Biol Chem 278 (38), 36476-36486 (2003)
   PUBMED   12750383
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU599050.1, AB080728.1 and
            BX376188.2.
            
            On Nov 23, 2018 this sequence version replaced NM_145654.3.
            
            Summary: This gene encodes a protein involved in the cellular
            response to cisplatin, a drug commonly used in chemotherapy. The
            protein encoded by this gene contains two motifs: a motif found in
            RAD52, a protein that functions in DNA double-strand breaks and
            homologous recombination, and an RNA recognition motif (RRM) that
            is not found in RAD52. The RAD52 motif region in RAD52 is important
            for protein function and may be involved in DNA binding or
            oligomerization. Alternatively spliced transcript variants encoding
            different isoforms have been reported. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1, also known as isoform alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.63611.1,
                                           SRR5189667.336538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620284.5/ ENSP00000483549.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BU599050.1         6-24
            20-976              AB080728.1         1-957
            977-1163            BX376188.2         469-655
FEATURES             Location/Qualifiers
     source          1..1163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..1163
                     /gene="RDM1"
                     /gene_synonym="RAD52B"
                     /note="RAD52 motif containing 1"
                     /db_xref="GeneID:201299"
                     /db_xref="HGNC:HGNC:19950"
                     /db_xref="MIM:612896"
     exon            1..142
                     /gene="RDM1"
                     /gene_synonym="RAD52B"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..901
                     /gene="RDM1"
                     /gene_synonym="RAD52B"
                     /note="isoform 1 is encoded by transcript variant 1; RAD52
                     homolog B; RAD52 motif 1"
                     /codon_start=1
                     /product="RAD52 motif-containing protein 1 isoform 1"
                     /protein_id="NP_663629.1"
                     /db_xref="CCDS:CCDS11301.1"
                     /db_xref="GeneID:201299"
                     /db_xref="HGNC:HGNC:19950"
                     /db_xref="MIM:612896"
                     /translation="MAELVPFAVPIESDKTLLVWELSSGPTAEALHHSLFTAFSQFGL
                     LYSVRVFPNAAVAHPGFYAVIKFYSARAAHRAQKACDRKQLFQKSPVKVRLGTRHKAV
                     QHQALALNSSKCQELANYYFGFNGCSKRIIKLQELSDLEERENEDSMVPLPKQSLKFF
                     CALEVVLPSCDCRSPGIGLVEEPMDKVEEGPLSFLMKRKTAQKLAIQKALSDAFQKLL
                     IVVLESGKIAVEYRPSEDIVGVRCEEELHGLIQVPCSPWKQYGQEEEGYLSDFSLEEE
                     EFRLPELD"
     exon            143..322
                     /gene="RDM1"
                     /gene_synonym="RAD52B"
                     /inference="alignment:Splign:2.1.0"
     exon            323..445
                     /gene="RDM1"
                     /gene_synonym="RAD52B"
                     /inference="alignment:Splign:2.1.0"
     exon            446..614
                     /gene="RDM1"
                     /gene_synonym="RAD52B"
                     /inference="alignment:Splign:2.1.0"
     exon            615..713
                     /gene="RDM1"
                     /gene_synonym="RAD52B"
                     /inference="alignment:Splign:2.1.0"
     exon            714..799
                     /gene="RDM1"
                     /gene_synonym="RAD52B"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1163
                     /gene="RDM1"
                     /gene_synonym="RAD52B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1143..1148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RDM1"
                     /gene_synonym="RAD52B"
                     /note="hexamer: AATAAA"
     polyA_site      1163
                     /gene="RDM1"
                     /gene_synonym="RAD52B"
                     /note="major polyA site"
ORIGIN      
        1 gcaatgctgg ggcgagggtt agccgcgcag gtgcggtgaa gggaggatgg cggagttggt
       61 accttttgcg gttcccatcg agagtgacaa aaccttgcta gtgtgggagc tgagctccgg
      121 acccacggcc gaggctttgc atcattctct gttcacagca ttttctcagt ttggccttct
      181 gtattcagtc cgggtcttcc caaatgctgc agtggcccat cctggtttct atgccgtcat
      241 taagttttat tctgcaaggg ctgcccacag agcccaaaag gcatgcgacc ggaagcagct
      301 ttttcagaaa tctccagtca aggttcgtct tggcaccaga cataaggcag ttcaacatca
      361 agcccttgcc ctgaacagtt ccaaatgcca agaactggcg aattactact ttggtttcaa
      421 tgggtgttcc aaaaggatca tcaagcttca ggagctttct gaccttgaag aaagggaaaa
      481 tgaagatagc atggtgccac ttccgaagca aagcctgaag ttcttctgtg ctttagaagt
      541 ggtgttgcca tcctgtgatt gcaggagtcc tggcattggc ttggtggagg agcctatgga
      601 taaggtggag gaaggaccat tatcattcct tatgaaaagg aagacagccc agaagcttgc
      661 tattcagaag gctttgtcag atgcattcca gaaactgttg attgttgttc tagaaagtgg
      721 taaaatagct gtggagtaca gacccagtga agacatcgta ggtgtcagat gcgaagaaga
      781 actacacggt ttaattcaag tcccttgctc tccctggaag cagtatggcc aagaggagga
      841 agggtatctc tcggatttca gcttggagga ggaagagttc aggctgccag aacttgacta
      901 gcatttctga atatcccaag gcgaggtcat gtaacttcct tgggaagctc tgtcgtgccc
      961 ctaccccacg ccgccccacc actataggct gctggagtcc tggaaccacc tgggtcggcc
     1021 gcccaaatct ttcctggcga aggggaggga aggggtgttc tggtggagtg ggaagggagg
     1081 cttgggtagg attgtgggat aagatcgccc tggtgacgag gagcggatct cgaacggaac
     1141 ttaataaagg ttgcctagat aaa
//
