LOCUS       NM_001145971            1870 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens retinol dehydrogenase 13 (RDH13), transcript variant
            1, mRNA.
ACCESSION   NM_001145971
VERSION     NM_001145971.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1870)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1870)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1870)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   4  (bases 1 to 1870)
  AUTHORS   Belyaeva,O.V., Korkina,O.V., Stetsenko,A.V. and Kedishvili,N.Y.
  TITLE     Human retinol dehydrogenase 13 (RDH13) is a mitochondrial
            short-chain dehydrogenase/reductase with a retinaldehyde reductase
            activity
  JOURNAL   FEBS J 275 (1), 138-147 (2008)
   PUBMED   18039331
  REMARK    GeneRIF: RDH13 exhibits a wide tissue distribution and, by contrast
            with other members of the RDH11-like group of short-chain
            dehydrogenases/reductases, is a mitochondrial rather than a
            microsomal protein.
REFERENCE   5  (bases 1 to 1870)
  AUTHORS   Haeseleer,F., Jang,G.F., Imanishi,Y., Driessen,C.A.G.G.,
            Matsumura,M., Nelson,P.S. and Palczewski,K.
  TITLE     Dual-substrate specificity short chain retinol dehydrogenases from
            the vertebrate retina
  JOURNAL   J Biol Chem 277 (47), 45537-45546 (2002)
   PUBMED   12226107
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB273341.1, AY358473.1,
            BC009881.2, AK122764.1 and AC011476.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001145971.1.
            
            Summary: This gene encodes a mitochondrial short-chain
            dehydrogenase/reductase, which catalyzes the reduction and
            oxidation of retinoids. The encoded enzyme may function in retinoic
            acid production and may also protect the mitochondria against
            oxidative stress. Alternatively spliced transcript variants have
            been described. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.352756.1,
                                           SRR3476690.382351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155974 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18039331; reported by
                                                  MitoCarta
            MANE Ensembl match                 :: ENST00000415061.8/
                                                  ENSP00000391121.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-388               DB273341.1         29-416
            389-1294            AY358473.1         354-1259
            1295-1847           BC009881.2         1440-1992
            1848-1862           AK122764.1         3041-3055
            1863-1870           AC011476.8         147062-147069       c
FEATURES             Location/Qualifiers
     source          1..1870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1870
                     /gene="RDH13"
                     /gene_synonym="SDR7C3"
                     /note="retinol dehydrogenase 13"
                     /db_xref="GeneID:112724"
                     /db_xref="HGNC:HGNC:19978"
     exon            1..181
                     /gene="RDH13"
                     /gene_synonym="SDR7C3"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1112
                     /gene="RDH13"
                     /gene_synonym="SDR7C3"
                     /EC_number="1.1.1.300"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; retinol dehydrogenase 13 (all-trans and 9-cis);
                     short chain dehydrogenase/reductase family 7C member 3;
                     retinol dehydrogenase 13 (all-trans/9-cis)"
                     /codon_start=1
                     /product="retinol dehydrogenase 13 isoform 1 precursor"
                     /protein_id="NP_001139443.1"
                     /db_xref="CCDS:CCDS54320.1"
                     /db_xref="GeneID:112724"
                     /db_xref="HGNC:HGNC:19978"
                     /translation="MSRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVT
                     GANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLK
                     SIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDK
                     LKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRL
                     QGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAV
                     AEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLVGLEAPSVREQPLPR"
     exon            182..300
                     /gene="RDH13"
                     /gene_synonym="SDR7C3"
                     /inference="alignment:Splign:2.1.0"
     exon            301..456
                     /gene="RDH13"
                     /gene_synonym="SDR7C3"
                     /inference="alignment:Splign:2.1.0"
     exon            457..561
                     /gene="RDH13"
                     /gene_synonym="SDR7C3"
                     /inference="alignment:Splign:2.1.0"
     exon            562..774
                     /gene="RDH13"
                     /gene_synonym="SDR7C3"
                     /inference="alignment:Splign:2.1.0"
     exon            775..876
                     /gene="RDH13"
                     /gene_synonym="SDR7C3"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1870
                     /gene="RDH13"
                     /gene_synonym="SDR7C3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RDH13"
                     /gene_synonym="SDR7C3"
                     /note="hexamer: AAGAAA"
     polyA_site      1870
                     /gene="RDH13"
                     /gene_synonym="SDR7C3"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctccgc tcgcctgtgg ctgcgtcgcg cgctcttcct cggagctacc caggcggctg
       61 gtgtgcagca agctccgcgc cgacccctga cgcctgacgc ctgtccccgg cccggcatga
      121 gccgctacct gctgccgctg tcggcgctgg gcacggtagc aggcgccgcc gtgctgctca
      181 aggactatgt caccggtggg gcttgcccca gcaaggccac catccctggg aagacggtca
      241 tcgtgacggg tgccaacaca ggcatcggga agcagaccgc cttggaactg gccaggagag
      301 gaggcaacat catcctggcc tgccgagaca tggagaagtg tgaggcggca gcaaaggaca
      361 tccgcgggga gaccctcaat caccatgtca acgcccggca cctggacttg gcttccctca
      421 agtctatccg agagtttgca gcaaagatca ttgaagagga ggagcgagtg gacattctaa
      481 tcaacaacgc gggtgtgatg cggtgccccc actggaccac cgaggacggc ttcgagatgc
      541 agtttggcgt taaccacctg ggtcactttc tcttgacaaa cttgctgctg gacaagctga
      601 aagcctcagc cccttcgcgg atcatcaacc tctcgtccct ggcccatgtt gctgggcaca
      661 tagactttga cgacttgaac tggcagacga ggaagtataa caccaaagcc gcctactgcc
      721 agagcaagct cgccatcgtc ctcttcacca aggagctgag ccggcggctg caaggctctg
      781 gtgtgactgt caacgccctg caccccggcg tggccaggac agagctgggc agacacacgg
      841 gcatccatgg ctccaccttc tccagcacca cactcgggcc catcttctgg ctgctggtca
      901 agagccccga gctggccgcc cagcccagca catacctggc cgtggcggag gaactggcgg
      961 atgtttccgg aaagtacttc gatggactca aacagaaggc cccggccccc gaggctgagg
     1021 atgaggaggt ggcccggagg ctttgggctg aaagtgcccg cctggtgggc ttagaggctc
     1081 cctctgtgag ggagcagccc ctccccagat aacctctgga gcagatttga aagccaggat
     1141 ggcgcctcca gaccgaggac agctgtccgc catgcccgca gcttcctggc actacctgag
     1201 ccgggagacc caggactggc ggccgccatg cccgcagtag gttctagggg gcggtgctgg
     1261 ccgcagtgga ctggcctgca ggtgagcact gccctgggct ctggctggtt ccgtctgctc
     1321 tgctgccagc aggggagagg ggccatctga tgcttcccct gggaatctaa actgggaatg
     1381 gccgaggagg aaggggctcc gtgcacttgc aggccacgtc aggagagcca gcggtgcctg
     1441 tcggggaggg ttccaaggtg ctccgtgaag agcatgggca agttgtctga cacttggtgg
     1501 attcttgggt ccctgtggga ccttgtgcat gcatggtcct ctctgagcct tggtttcttc
     1561 agcagtgaga tgctcagaat aactgctgtc tcccatgatg gtgtggtaca gcgagctgtt
     1621 gtctggctat ggcatggctg tgccgggggt gtttgctgag ggcttcctgt gccagagccc
     1681 agccagagag caggtgcagg tgtcatcctg agttcaggct ctgcacggca tggagtggga
     1741 accccaccag ctgctgctac aggacctggg attgcctggg actcccacct tcctatcaat
     1801 tctcatggta gtccaaactg cagactctca aacttgctca tttaaaagaa aaaaaaaaga
     1861 agaaaatgta
//
