LOCUS       NM_016026               2539 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens retinol dehydrogenase 11 (RDH11), transcript variant
            1, mRNA.
ACCESSION   NM_016026
VERSION     NM_016026.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2539)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2539)
  AUTHORS   Tian,J., Liu,J., Li,J., Zheng,J., Chen,L., Wang,Y., Liu,Q. and
            Ni,J.
  TITLE     The interaction of selenoprotein F (SELENOF) with retinol
            dehydrogenase 11 (RDH11) implied a role of SELENOF in vitamin A
            metabolism
  JOURNAL   Nutr Metab (Lond) 15, 7 (2018)
   PUBMED   29410696
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2539)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2539)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 2539)
  AUTHORS   Kummalue,T., Inoue,T., Miura,Y., Narusawa,M., Inoue,H., Komatsu,N.,
            Wanachiwanawin,W., Sugiyama,D. and Tani,K.
  TITLE     Ribosomal protein L11- and retinol dehydrogenase 11-induced
            erythroid proliferation without erythropoietin in UT-7/Epo
            erythroleukemic cells
  JOURNAL   Exp Hematol 43 (5), 414-423 (2015)
   PUBMED   25829192
  REMARK    GeneRIF: Data indicate that ribosomal protein L11
            (RPL11)-expressing cells proliferated more rapidly than the
            ribosomal protein L11 (RPL11)-expressing cells.
REFERENCE   6  (bases 1 to 2539)
  AUTHORS   Li,K., Wang,L., Cheng,J., Lu,Y.Y., Zhang,L.X., Mu,J.S., Hong,Y.,
            Liu,Y., Duan,H.J., Wang,G., Li,L. and Chen,J.M.
  TITLE     Interaction between hepatitis C virus core protein and translin
            protein--a possible molecular mechanism for hepatocellular
            carcinoma and lymphoma caused by hepatitis C virus
  JOURNAL   World J Gastroenterol 9 (2), 300-303 (2003)
   PUBMED   12532453
  REMARK    GeneRIF: The core protein of HCV can interact with translin
            protein. This can partly explain the molecular mechanism for
            hepatocellular carcinoma and lymphoma caused by HCV.
REFERENCE   7  (bases 1 to 2539)
  AUTHORS   Haeseleer,F., Jang,G.F., Imanishi,Y., Driessen,C.A.G.G.,
            Matsumura,M., Nelson,P.S. and Palczewski,K.
  TITLE     Dual-substrate specificity short chain retinol dehydrogenases from
            the vertebrate retina
  JOURNAL   J Biol Chem 277 (47), 45537-45546 (2002)
   PUBMED   12226107
REFERENCE   8  (bases 1 to 2539)
  AUTHORS   Kedishvili,N.Y., Chumakova,O.V., Chetyrkin,S.V., Belyaeva,O.V.,
            Lapshina,E.A., Lin,D.W., Matsumura,M. and Nelson,P.S.
  TITLE     Evidence that the human gene for prostate short-chain
            dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase
            (RalR1)
  JOURNAL   J Biol Chem 277 (32), 28909-28915 (2002)
   PUBMED   12036956
  REMARK    GeneRIF: Prostate short-chain dehydrogenase/reductase (PSDR1)
            encodes a novel retinal reductase (RalR1).
REFERENCE   9  (bases 1 to 2539)
  AUTHORS   Lin,B., White,J.T., Ferguson,C., Wang,S., Vessella,R.,
            Bumgarner,R., True,L.D., Hood,L. and Nelson,P.S.
  TITLE     Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new
            member of the short-chain steroid dehydrogenase/reductase family
            highly expressed in normal and neoplastic prostate epithelium
  JOURNAL   Cancer Res 61 (4), 1611-1618 (2001)
   PUBMED   11245473
REFERENCE   10 (bases 1 to 2539)
  AUTHORS   Hara,T., Harada,N., Mitsui,H., Miura,T., Ishizaka,T. and
            Miyajima,A.
  TITLE     Characterization of cell phenotype by a novel cDNA library
            subtraction system: expression of CD8 alpha in a mast cell-derived
            interleukin-4-dependent cell line
  JOURNAL   Blood 84 (1), 189-199 (1994)
   PUBMED   8018917
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC355364.1, BC011727.2 and
            AF167438.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016026.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF167438.1, SRR5189658.217098.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381346.9/ ENSP00000370750.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                DC355364.1         30-85
            57-1975             BC011727.2         1-1919
            1976-2539           AF167438.1         1956-2519
FEATURES             Location/Qualifiers
     source          1..2539
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.1"
     gene            1..2539
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
                     /note="retinol dehydrogenase 11"
                     /db_xref="GeneID:51109"
                     /db_xref="HGNC:HGNC:17964"
                     /db_xref="MIM:607849"
     exon            1..135
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1018
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
                     /EC_number="1.1.1.300"
                     /note="isoform 1 is encoded by transcript variant 1;
                     androgen-regulated short-chain dehydrogenase/reductase 1;
                     short chain dehydrogenase/reductase family 7C, member 1;
                     prostate short-chain dehydrogenase reductase 1; retinal
                     reductase 1; HCV core-binding protein HCBP12; retinol
                     dehydrogenase 11 (all-trans/9-cis/11-cis)"
                     /codon_start=1
                     /product="retinol dehydrogenase 11 isoform 1"
                     /protein_id="NP_057110.3"
                     /db_xref="CCDS:CCDS32104.1"
                     /db_xref="GeneID:51109"
                     /db_xref="HGNC:HGNC:17964"
                     /db_xref="MIM:607849"
                     /translation="MVELMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVV
                     VVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLS
                     DTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLL
                     LEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELAR
                     RLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGL
                     EILSGNHFSDCHVAWVSAQARNETIARRLWDVSCDLLGLPID"
     exon            136..254
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..410
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..515
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..725
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..915
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..2539
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2459..2464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
                     /note="hexamer: AATAAA"
     polyA_site      2479
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
                     /note="major polyA site"
     regulatory      2515..2520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
                     /note="hexamer: ATTAAA"
     polyA_site      2539
                     /gene="RDH11"
                     /gene_synonym="ARSDR1; CGI82; HCBP12; MDT1; PSDR1; RALR1;
                     RDJCSS; SCALD; SDR7C1"
ORIGIN      
        1 aagccatagt cggcgagcaa cgctggagca tcccgctctg gtgccgctgc agccggcaga
       61 gatggttgag ctcatgttcc cgctgttgct cctccttctg cccttccttc tgtatatggc
      121 tgcgccccaa atcaggaaaa tgctgtccag tggggtgtgt acatcaactg ttcagcttcc
      181 tgggaaagta gttgtggtca caggagctaa tacaggtatc gggaaggaga cagccaaaga
      241 gctggctcag agaggagctc gagtatattt agcttgccgg gatgtggaaa agggggaatt
      301 ggtggccaaa gagatccaga ccacgacagg gaaccagcag gtgttggtgc ggaaactgga
      361 cctgtctgat actaagtcta ttcgagcttt tgctaagggc ttcttagctg aggaaaagca
      421 cctccacgtt ttgatcaaca atgcaggagt gatgatgtgt ccgtactcga agacagcaga
      481 tggctttgag atgcacatag gagtcaacca cttgggtcac ttcctcctaa cccatctgct
      541 gctagagaaa ctaaaggaat cagccccatc aaggatagta aatgtgtctt ccctcgcaca
      601 tcacctggga aggatccact tccataacct gcagggcgag aaattctaca atgcaggcct
      661 ggcctactgt cacagcaagc tagccaacat cctcttcacc caggaactgg cccggagact
      721 aaaaggctct ggcgttacga cgtattctgt acaccctggc acagtccaat ctgaactggt
      781 tcggcactca tctttcatga gatggatgtg gtggcttttc tcctttttca tcaagactcc
      841 tcagcaggga gcccagacca gcctgcactg tgccttaaca gaaggtcttg agattctaag
      901 tgggaatcat ttcagtgact gtcatgtggc atgggtctct gcccaagctc gtaatgagac
      961 tatagcaagg cggctgtggg acgtcagttg tgacctgctg ggcctcccaa tagactaaca
     1021 ggcagtgcca gttggaccca agagaagact gcagcagact acacagtact tcttgtcaaa
     1081 atgattctcc ttcaaggttt tcaaaacctt tagcacaaag agagcaaaac cttccagcct
     1141 tgcctgcttg gtgtccagtt aaaactcagt gtactgccag attcgtctaa atgtctgtca
     1201 tgtccagatt tactttgctt ctgttactgc cagagttact agagatatca taataggata
     1261 agaagaccct catatgacct gcacagctca ttttccttct gaaagaaact actacctagg
     1321 agaatctaag ctatagcagg gatgatttat gcaaatttga actagcttct ttgttcacaa
     1381 ttcagttcct cccaaccaac cagtcttcac ttcaagaggg ccacactgca acctcagctt
     1441 aacatgaata acaaagactg gctcaggagc agggcttgcc caggcatggt ggatcaccgg
     1501 aggtcagtag ttcaagacca gcctggccaa catggtgaaa ccccacctct actaaaaatt
     1561 gtgtatatct ttgtgtgtct tcctgtttat gtgtgccaag ggagtatttt cacaaagttc
     1621 aaaacagcca caataatcag agatggagca aaccagtgcc atccagtctt tatgcaaatg
     1681 aaatgctgca aagggaagca gattctgtat atgttggtaa ctacccacca agagcacatg
     1741 ggtagcaggg aagaagtaaa aaaagagaag gagaatactg gaagataatg cacaaaatga
     1801 agggactagt taaggattaa ctagcccttt aaggattaac tagttaagga ttaatagcaa
     1861 aagatattaa atatgctaac atagctatgg aggaattgag ggcaagcacc caggactgat
     1921 gaggtcttaa caaaaaccag tgtggcaaaa aaaaaaaaaa aaaaaaaaaa aaaaatccta
     1981 aaaacaaaca aacaaaaaaa acaattcttc attcagaaaa attatcttag ggactgatat
     2041 tggtaattat ggtcaattta ataatatttt ggggcatttc cttacattgt cttgacaaga
     2101 ttaaaatgtc tgtgccaaaa ttttgtattt tatttggaga cttcttatca aaagtaatgc
     2161 tgccaaagga agtctaagga attagtagtg ttcccatcac ttgtttggag tgtgctattc
     2221 taaaagattt tgatttcctg gaatgacaat tatattttaa ctttggtggg ggaaagagtt
     2281 ataggaccac agtcttcact tctgatactt gtaaattaat cttttattgc acttgttttg
     2341 accattaagc tatatgttta gaaatggtca ttttacggaa aaattagaaa aattctgata
     2401 atagtgcaga ataaatgaat taatgtttta cttaatttat attgaactgt caatgacaaa
     2461 taaaaattct ttttgattat tttttgtttt catttaccag aataaaaact aagaattaaa
     2521 agtttgatta cagtcaaaa
//
