LOCUS       NM_172037               3959 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens retinol dehydrogenase 10 (RDH10), mRNA.
ACCESSION   NM_172037
VERSION     NM_172037.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3959)
  AUTHORS   Zhao,Z., Song,Z., Wang,Z., Zhang,F., Ding,Z., Zhao,Z., Liu,L. and
            Fan,T.
  TITLE     Retinol dehydrogenase 10 promotes epithelial-mesenchymal transition
            in spinal cord gliomas via PI3K/AKT pathway
  JOURNAL   Int J Immunopathol Pharmacol 38, 3946320241276336 (2024)
   PUBMED   39180753
  REMARK    GeneRIF: Retinol dehydrogenase 10 promotes epithelial-mesenchymal
            transition in spinal cord gliomas via PI3K/AKT pathway.
REFERENCE   2  (bases 1 to 3959)
  AUTHORS   Murakami,A., Amano,T., Yoshino,F., Kita,H., Moritani,S.,
            Murakami,T. and Chano,T.
  TITLE     Retinol dehydrogenase 10 contributes to cancer stemness and
            intracellular carbohydrate storage in ovarian clear cell carcinomas
  JOURNAL   Cancer Biomark 34 (4), 673-679 (2022)
   PUBMED   35634847
  REMARK    GeneRIF: Retinol dehydrogenase 10 contributes to cancer stemness
            and intracellular carbohydrate storage in ovarian clear cell
            carcinomas.
REFERENCE   3  (bases 1 to 3959)
  AUTHORS   Klyuyeva,A.V., Belyaeva,O.V., Goggans,K.R., Krezel,W., Popov,K.M.
            and Kedishvili,N.Y.
  TITLE     Changes in retinoid metabolism and signaling associated with
            metabolic remodeling during fasting and in type I diabetes
  JOURNAL   J Biol Chem 296, 100323 (2021)
   PUBMED   33485967
  REMARK    GeneRIF: Changes in retinoid metabolism and signaling associated
            with metabolic remodeling during fasting and in type I diabetes.
REFERENCE   4  (bases 1 to 3959)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3959)
  AUTHORS   Guan,F., Kang,Z., Wang,L., Wang,K., Mao,B.B., Peng,W.C.,
            Zhang,B.L., Lin,Z.Y., Zhang,J.T. and Hu,Z.Q.
  TITLE     Retinol dehydrogenase 10 promotes metastasis of glioma cells via
            the transforming growth factor-beta/SMAD signaling pathway
  JOURNAL   Chin Med J (Engl) 132 (20), 2430-2437 (2019)
   PUBMED   31613821
  REMARK    GeneRIF: RDH10 regulated the migration and invasion of glioma cells
            via the TGF-beta/SMAD signaling pathway.
REFERENCE   6  (bases 1 to 3959)
  AUTHORS   Belyaeva,O.V., Johnson,M.P. and Kedishvili,N.Y.
  TITLE     Kinetic analysis of human enzyme RDH10 defines the characteristics
            of a physiologically relevant retinol dehydrogenase
  JOURNAL   J Biol Chem 283 (29), 20299-20308 (2008)
   PUBMED   18502750
  REMARK    GeneRIF: dual physiological role for RDH10: in the biosynthesis of
            11-cis-retinaldehyde for vision as well as the biosynthesis of
            all-trans-retinoic acid for differentiation and development
REFERENCE   7  (bases 1 to 3959)
  AUTHORS   Rossi,E., Picozzi,P., Bodega,B., Lavazza,C., Carlo-Stella,C.,
            Marozzi,A. and Ginelli,E.
  TITLE     Forced expression of RDH10 gene retards growth of HepG2 cells
  JOURNAL   Cancer Biol Ther 6 (2), 238-244 (2007)
   PUBMED   17218779
  REMARK    GeneRIF: Forced over-expression of the RDH10 gene causes growth
            arrest of HepG2 cells and could be a possible curative strategy for
            hepatocellular carcinoma.
REFERENCE   8  (bases 1 to 3959)
  AUTHORS   Picozzi,P., Marozzi,A., Fornasari,D., Benfante,R., Barisani,D.,
            Meneveri,R. and Ginelli,E.
  TITLE     Genomic organization and transcription of the human retinol
            dehydrogenase 10 (RDH10) gene
  JOURNAL   FEBS Lett 554 (1-2), 59-66 (2003)
   PUBMED   14596915
  REMARK    GeneRIF: organization of the gene includes a unique transcriptional
            start site, a coding region with six translated exons and a 3' UTR
            containing at least two used polyadenylation sites.
REFERENCE   9  (bases 1 to 3959)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 3959)
  AUTHORS   Wu,B.X., Chen,Y., Chen,Y., Fan,J., Rohrer,B., Crouch,R.K. and
            Ma,J.X.
  TITLE     Cloning and characterization of a novel all-trans retinol
            short-chain dehydrogenase/reductase from the RPE
  JOURNAL   Invest Ophthalmol Vis Sci 43 (11), 3365-3372 (2002)
   PUBMED   12407145
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD110145.1, AF456765.1,
            BC067131.1, AC111149.4, BM472905.1, BM804062.1 and BM979260.1.
            
            On Nov 22, 2018 this sequence version replaced NM_172037.4.
            
            Summary: This gene encodes a retinol dehydrogenase, which converts
            all-trans-retinol to all-trans-retinal, with preference for NADP as
            a cofactor. Studies in mice suggest that this protein is essential
            for synthesis of embryonic retinoic acid and is required for limb,
            craniofacial, and organ development. [provided by RefSeq, Dec
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067131.1, SRR1660805.173060.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240285.10/ ENSP00000240285.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               CD110145.1         55-482
            429-1869            AF456765.1         1-1441
            1870-2350           BC067131.1         1370-1850
            2351-2423           AC111149.4         69933-70005         c
            2424-2812           BC067131.1         1926-2314
            2813-3130           BM472905.1         86-403
            3131-3483           BM804062.1         256-608
            3484-3959           BM979260.1         23-498              c
FEATURES             Location/Qualifiers
     source          1..3959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.11"
     gene            1..3959
                     /gene="RDH10"
                     /gene_synonym="SDR16C4"
                     /note="retinol dehydrogenase 10"
                     /db_xref="GeneID:157506"
                     /db_xref="HGNC:HGNC:19975"
                     /db_xref="MIM:607599"
     exon            1..977
                     /gene="RDH10"
                     /gene_synonym="SDR16C4"
                     /inference="alignment:Splign:2.1.0"
     CDS             689..1714
                     /gene="RDH10"
                     /gene_synonym="SDR16C4"
                     /EC_number="1.1.1.300"
                     /note="short chain dehydrogenase/reductase family 16C
                     member 4; retinol dehydrogenase 10 (all-trans)"
                     /codon_start=1
                     /product="retinol dehydrogenase 10"
                     /protein_id="NP_742034.1"
                     /db_xref="CCDS:CCDS6213.1"
                     /db_xref="GeneID:157506"
                     /db_xref="HGNC:HGNC:19975"
                     /db_xref="MIM:607599"
                     /translation="MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGA
                     GSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEE
                     EILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDE
                     LIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVV
                     GFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQA
                     MKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNN
                     NEAKNGI"
     exon            978..1213
                     /gene="RDH10"
                     /gene_synonym="SDR16C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1312
                     /gene="RDH10"
                     /gene_synonym="SDR16C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1458
                     /gene="RDH10"
                     /gene_synonym="SDR16C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1590
                     /gene="RDH10"
                     /gene_synonym="SDR16C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..3959
                     /gene="RDH10"
                     /gene_synonym="SDR16C4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3218..3223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RDH10"
                     /gene_synonym="SDR16C4"
                     /note="hexamer: ATTAAA"
     polyA_site      3240
                     /gene="RDH10"
                     /gene_synonym="SDR16C4"
     regulatory      3941..3946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RDH10"
                     /gene_synonym="SDR16C4"
                     /note="hexamer: AATAAA"
     polyA_site      3959
                     /gene="RDH10"
                     /gene_synonym="SDR16C4"
                     /note="major polyA site"
ORIGIN      
        1 agagccggcc cggagcgctc tgacttgcaa gcgggctgcg ctgcggagcc cagtgcccga
       61 gtgacacccg cggagagtgc agggccgggg aacgcgagcc ctcgggggca gctgcaaggc
      121 gttgggcagc gcttgcctgc gccgagcgag tctccccttc ccggcgctcc gccgccccgc
      181 accccactct cccaccctct cgcaacttgg gtcgagttga caactcccgc ggcagcccgc
      241 tggcccgtgc cgcctccgct gcgcacccct cccccggggt gagagggagc cggcgcgccg
      301 gttccgggga cgctcgggcg gcagcagctt ggccatgagg gcagttcgag tagtctaact
      361 cgcggctgtc accgccactg cagcggagcc ggccggccgg gcgctgcggg acgggcgggc
      421 ggctgccggc aggaggcgcc gagccgggtg actgccgcgg cgggcacagt ccggggccac
      481 agcgccgagc ccgggcggga gtggccccgc gcaggcaggg agcggcgccg cgcactccaa
      541 cccggcgggc acctcggggg cgggcgcggg gcgcagcctt ctcgtcccgg cctctgtgac
      601 aagcgccccg gagccgggag cccgattgcc gggctcgggg tgggcgcgga cgcaggcact
      661 gggctcgtgc ggggccccgg gcgtcgcgat gaacatcgtg gtggagttct tcgtggtcac
      721 tttcaaagtg ctctgggcgt tcgtgctggc cgcggcgcgc tggctggtgc ggcccaagga
      781 gaagagcgtg gcgggccagg tgtgcctcat caccggcgcc ggcagcggcc tgggccgcct
      841 cttcgcgctg gagttcgccc ggcgtcgggc gctgctggtg ctgtgggaca tcaacacgca
      901 aagcaacgag gagacggctg gcatggtgcg ccacatctac cgcgacctgg aggcggccga
      961 cgccgctgcg ctgcaagctg ggaatggtga ggaagaaatt ctgccccact gtaacttgca
     1021 ggtttttacc tacacctgtg acgtggggaa gagggagaac gtctacctga cggctgaaag
     1081 agtccgcaag gaggttggcg aagtctcagt cctggtcaat aatgctggtg tggtctctgg
     1141 gcatcacctt ctggaatgtc ctgatgagct cattgagaga accatgatgg tcaattgcca
     1201 tgcacacttc tggaccacta aggcttttct tcctacgatg ctggagatta atcatggtca
     1261 tattgtgaca gttgcaagtt ccttgggatt gttcagtact gccggagttg aggattactg
     1321 tgccagtaaa tttggagttg tgggttttca tgaatccctg agccatgaac taaaggctgc
     1381 tgaaaaggat ggaattaaaa caaccttggt ttgcccttat cttgtagaca ctggcatgtt
     1441 cagaggctgc cgaatcagga aagaaattga gccttttctg ccacctctga agcctgatta
     1501 ctgtgtgaag caggccatga aggccatcct cactgaccag cccatgatct gcactccccg
     1561 cctcatgtac atcgtgacct tcatgaagag catcctacca tttgaagcag ttgtgtgcat
     1621 gtatcggttc ctaggagcgg acaagtgtat gtaccccttt attgctcaaa gaaagcaagc
     1681 cacaaacaat aatgaagcaa aaaatggaat ctaagaatct ttttgtatgg aatattactt
     1741 ctatcagaag atgatcaaga tgtttcagtc cagtgcacat cagcattgct gacattttat
     1801 ggattctaaa cttgtgttgt ttctttttta aatcaacttt ttaaaaaaat aaagtgtaaa
     1861 ttaaccgact agagtacttg gaaaatgtga tcagtacaag tgaacttagg ttgttgccaa
     1921 cagggtcctt ttaggcagaa cccagaaacc agtcaaatct gtagagaagc agtgtgacat
     1981 cttcaggtta ccattatttt ttaatgagca ggaagtctag aaatgataac tagactgtat
     2041 gtttcatgtg tgtgattttt cagaattccc agagtttact cattcttgtt attaaactct
     2101 agccagttga catcttcgca atttcaagga ctgatagtgc tgtattttct cacgttttct
     2161 aagtttccgt tttgcaaggc ctaggtgact ttttcatggt gtttgtatgt ttagctcttt
     2221 tgaaaaggaa ttttgaaatc tccatcaact gaagtaaatg atgtctgagt gttacagtaa
     2281 aggtgaccaa gtctctttct taaagtcaca atgactaaag tattagttga attttttttt
     2341 tttttttttt gatggagtct cgctctgtca ccaggctgga gtgcagtagc acaatcacgg
     2401 ctcactgcaa tctctgcctc ccagtttcaa gtgattctgc tgtctcagcc tcccaagtag
     2461 ctgggactac aggcatgcgc caccacgccc agctaatttt tgtattttta gtagagacgg
     2521 ggtttcacca tgttggtcag gatggtctcc atctcttgac attgtgatcc acctgcctcg
     2581 gcctcccaaa gtgctgggat tacaggcatg agccactgca cccagccttg aatttttaat
     2641 tttatctctg atatacttca ttaagtgtct ggagacctaa ttatcctaaa agatcataca
     2701 ttttctacct atgaattttg ctgcatacag aaagtgccct ttcctcagga agttgctgtg
     2761 tttcatttct ttggatggac tcttatctag aatacatagc agctctgcaa aggaacagtt
     2821 tttaaaaatg ggaacttcta cattgaaaag tccccatttt tgtgccaact atgattagtg
     2881 agaggaagaa atcttattct atggcatatg tatggaaggg tgtaaagatt cttttgaaag
     2941 gtttattcac attgtagaac agcaaatgac atttttacag tatttttttg taaagcaaac
     3001 tattttgtgc cttgaatttg gtatatgtgt attagtgaaa cattgtaaag gtgaacttct
     3061 acctctgtat ctaaatgtat accatccact tgtaaatgac tataaactat tatgtgattg
     3121 cttttttttt tagaatgtct tgtttaaata gtggccaatg tttaaggctg ttaaaataag
     3181 ccaactttta ctaattgggg agttttataa atgactgatt aaatttaaag aattaactta
     3241 catgcaattg tgtgattatt agttatcagc agtgttgtaa ggaaaattat tgtgtttttt
     3301 tttatgatca ttatcccact ttaggtaaag aaaaatattg gaatggaata gtgttgggaa
     3361 acagacatta acaacctagg gtgcctgcac tcaaatagcc gatgttactg tccctagatt
     3421 agagacttga ttaagggctt gtttgtacca aaagtgggga aacaatgcca tgacctgtgt
     3481 tttagtttgg ctgcaccaca gatcaaatct gcactgtgtc tacatatagg aaaggtcctg
     3541 gtgtgtgcta atgttcccaa tgcaggactt gaggaagagc tctgttatat gtttccattt
     3601 ctctttatca aagataacca aaccttatgg cccttataac aatggaggca ctggctgcct
     3661 cttaattttc aatcatggac ctaaagaagt actctgaagg gtctcaacaa tgccaggtgg
     3721 ggacagatat actcagagat tatccaggtc tgcctcccag cgagcctgga gtacaccaga
     3781 ccctcctaga gaaatctgtt ataatttaac aacccactta tccaccttaa aactgaggaa
     3841 agtcgtcttt acatctaatt ttattcttgt gtgttataac ttaaacctat ttctattttt
     3901 gtttgttatt gcccttataa gggtgtccat ctccaagttc aataaactaa ttcatttaa
//
