LOCUS       NM_052862               5443 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RCSD domain containing 1 (RCSD1), transcript variant
            1, mRNA.
ACCESSION   NM_052862
VERSION     NM_052862.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5443)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 5443)
  AUTHORS   Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
            Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
  TITLE     Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
            genetic association with bone mineral density variation
  JOURNAL   Hum Mol Genet 18 (4), 679-687 (2009)
   PUBMED   19064610
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 5443)
  AUTHORS   De Braekeleer,E., Douet-Guilbert,N., Le Bris,M.J., Berthou,C.,
            Morel,F. and De Braekeleer,M.
  TITLE     A new partner gene fused to ABL1 in a t(1;9)(q24;q34)-associated
            B-cell acute lymphoblastic leukemia
  JOURNAL   Leukemia 21 (10), 2220-2221 (2007)
   PUBMED   17541395
  REMARK    GeneRIF: CapZIP is fused to ABL1 in a t(1;9)(q24;q34)-associated
            B-cell acute lymphoblastic leukemia
REFERENCE   4  (bases 1 to 5443)
  AUTHORS   Eyers,C.E., McNeill,H., Knebel,A., Morrice,N., Arthur,S.J.,
            Cuenda,A. and Cohen,P.
  TITLE     The phosphorylation of CapZ-interacting protein (CapZIP) by
            stress-activated protein kinases triggers its dissociation from
            CapZ
  JOURNAL   Biochem J 389 (Pt 1), 127-135 (2005)
   PUBMED   15850461
  REMARK    GeneRIF: The structure and function of CapZ-interacting protein are
            reported.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031733.3, DR006615.1, BC101562.1, BC013186.1 and AL356532.9.
            
            On Nov 22, 2018 this sequence version replaced NM_052862.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.215302.1,
                                           SRR1803611.82931.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367854.8/ ENSP00000356828.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL031733.3         68962-68966         c
            6-168               DR006615.1         28-190
            169-1533            BC101562.1         1-1365
            1534-2996           BC013186.1         578-2040
            2997-5443           AL356532.9         7153-9599
FEATURES             Location/Qualifiers
     source          1..5443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..5443
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
                     /note="RCSD domain containing 1"
                     /db_xref="GeneID:92241"
                     /db_xref="HGNC:HGNC:28310"
                     /db_xref="MIM:610579"
     exon            1..198
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1443
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CapZ-interacting protein; protein kinase substrate MK2S4;
                     protein kinase substrate CapZIP; RCSD domain-containing
                     protein 1"
                     /codon_start=1
                     /product="capZ-interacting protein isoform 1"
                     /protein_id="NP_443094.3"
                     /db_xref="CCDS:CCDS1263.1"
                     /db_xref="GeneID:92241"
                     /db_xref="HGNC:HGNC:28310"
                     /db_xref="MIM:610579"
                     /translation="MEERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTR
                     RKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLP
                     GASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVR
                     TRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPL
                     SSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHP
                     AQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQ
                     ETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLET
                     SSEVQSEPAVPKPEDDTPVQDTKM"
     exon            199..300
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
                     /inference="alignment:Splign:2.1.0"
     exon            301..390
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
                     /inference="alignment:Splign:2.1.0"
     exon            391..462
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
                     /inference="alignment:Splign:2.1.0"
     exon            463..666
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
                     /inference="alignment:Splign:2.1.0"
     exon            667..1410
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..5443
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2966..2971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
                     /note="hexamer: GATAAA"
     polyA_site      2989
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
                     /note="major polyA site"
     regulatory      5420..5425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
                     /note="hexamer: AATAAA"
     polyA_site      5443
                     /gene="RCSD1"
                     /gene_synonym="CAPZIP; MK2S4"
ORIGIN      
        1 ctctcgcgca gggcccccgc ggccggggca gtcccgcagc cgagcgcagc cgggcgcgcg
       61 ccaccgccca ctcgccctgt gcccgccgca gcccgaaact ggccacggcc gggagcggag
      121 gggacagcgg ggatcgtgag ctccggcccg ggcgagcggg tgcgtctgcc gcagagtcgg
      181 cacctgaagg acatggagga aagaccggca gagaccaatg ccaatgtgga caactcggcg
      241 tccccctcgg tggcccagct ggccgggcgg tttagggagc aggcggctgc agccaaggag
      301 acaccagcca gtaaaccaac ccgaaggaaa ccgccctgtt ccctccccct gttccccccc
      361 aaggtagacc tgggccagaa tggtgaggag aaatcaccac ccaatgcgag ccaccctcct
      421 aaattcaagg tcaagagctc gcctctgatt gagaagcttc aggccaattt aacctttgac
      481 ccagctgctc tactgcctgg ggcctcaccc aagagtcctg gactcaaggc tatggtgtcg
      541 ccatttcaca gcccaccttc tacccccagc agccctggtg tgcgatctag gcccagcgag
      601 gcagaggagg tgcctgtcag cttcgaccag ccccctgaag gcagtcatct gccctgttac
      661 aacaaggtgc ggacgagggg ctcaataaaa aggcgccctc cctccaggcg attccgaagg
      721 tcacagtcag actgtggaga acttggagat ttcagggcgg tggagtcatc tcagcagaac
      781 ggtgctaagg aagaggatgg ggatgaagtg ttgccatcca agagcaaggc cccaggatcc
      841 cctttgtcca gtgagggagc agcgggagag ggagtgagaa ccctgggacc tgctgaaaag
      901 cctcctctga ggaggtcacc cagcaggaca gagaagcagg aggaggacag ggccacagag
      961 gaagccaaga acggtgaaaa ggccaggcgg agttcagagg aggtggacgg ccagcacccg
     1021 gcccaagagg aggtcccgga atcgccccag acctctggcc cagaggcaga aaataggtgt
     1081 gggagcccca gggaggaaaa gccagctgga gaggaagcag agatggaaaa ggctacagag
     1141 gtgaaggggg agagggtgca aaatgaagag gtgggacctg aacatgacag ccaagaaaca
     1201 aagaagctgg aggagggagc tgcagtgaag gagacccccc acagtccccc tggaggagtg
     1261 aagggcggag atgtccccaa gcaggaaaaa ggcaaggaaa aacaacagga gggggcagtg
     1321 ctcgagccag gctgcagccc ccagaccggc cctgcccagc tggagaccag cagtgaggtc
     1381 cagagcgagc cagcagtccc caagccggag gatgacactc ctgtccagga cactaaaatg
     1441 tgaagaacag ctcattgtgc cccagtgatg aagttgctgg acacatctct ttgcaggtag
     1501 cagcaacagt tgtagcagca gcagacgaag ccattgcaga ggcagaatat gctgagtgtc
     1561 tggagtcagc ctgaagacac agggtggatt atttcctggc ctccacacca aacgttccct
     1621 tgcagatgga gactgaatct gagggcagca gacttttatc agcttgagtt tatgtcattt
     1681 gatggacttg gttcaacaac aagaacttac ttaaaacaat gtactgtggt gatgagtccc
     1741 aggggcactg gtcagcctgt ggagccctgg atgctatcca cacccaccta tccctgcagc
     1801 taatttagct gatctctaat ttaactgagc tctaatttag ctgatcagat tttgcttggg
     1861 taaagttcct ttttaatgtt ctaaagtgtt tacggttctc aaatatcagt taaaaactaa
     1921 ttttaggtgg ccataaacat aaaatagaaa ccctgtaagt tacagaagac cctaaattgt
     1981 atcaaaaccc tagagacaac ttttcaattt gatccaaatt tgaactggcc aaccagtctt
     2041 taaaacactg gactagaaga gataatgatt gaaacattta aaaaaaaaaa gtgctccatt
     2101 cgcaggagct tttcctgtcc tgtggttttc cagttggtga ccaccatggg aggtcgctgg
     2161 ctcggctcac tcccttctcc cacccttgag aatgtggaga actcccatgg agaggcagaa
     2221 tggcaggagg tttcatgtcc cgcgttgcat ctcctcctga aagaaaagca gtgatacctg
     2281 aataatgctg gctctccgat tgatcctgtg aggatgaatt tgcatttcca gaatccttga
     2341 gcatggatta gatgtttcct gggaggtgcc ttgagtacca ttatgtgcaa gctacataat
     2401 taaaacattt ttcttagttt ccctgggaag cttttcttga ctcacagccc aggttcttct
     2461 gcccaacaca aaaggagtga gttggggtct ttagtctctt cttattgggt agctcttgct
     2521 ttaatattct gtttggtgag tgtaagggat tctgcaaggg acagggggcc tgactaccca
     2581 gtctttgact tgtatcctct cccctcttca tacactcctg ctgaaaaatg ttaatccaaa
     2641 tacacattta aacttagggt cggtccttat tctgatttga gtattttaat gtctcagtgt
     2701 gctgatttgg tagttggaag aattattctt ctggaggtct gttagactac atcctacact
     2761 gacttcagaa aacagtctgt cagacaaaaa ggccttatgt caccactggt acctcagttt
     2821 cctcatccca tttacagttt ttctaactcc agggtagtgt ttagtgttaa tatttgggat
     2881 atattttttt tcaaaactgt ttttaagtag tttgtaattt gtaacaaact tgtaacctgg
     2941 ttgggactga tattgtcata gctatgataa actttggata ttagcagaat ttgggagatg
     3001 tgtgtgtcaa ttattttgag atctataaac ttgtctgtct atctatctag ctggctagct
     3061 tgctatcaat ctagctacca tccatttatt gacagagaag tctaccccta aacaatactt
     3121 ggttttattt atatatgtct ttgggttgtt tatacacatg cactatctgg gcaagtactt
     3181 tgtgaatatg tgcatgattg tgaatgtgtg atgaaaaggg ccactttact tgaggaaggc
     3241 atggaacaga aagtatgggg tttagatatg aaaaatgaaa ctgcattttt cttctggagg
     3301 gtctaaacat agtagcagac gagagagggg cagtaaaaat gacaagaatg tgacattgcg
     3361 gcaccatgct tgtgggcatc agaatacctt tctatccccc aagtctcctg ttagtcacat
     3421 tatttggtgt attttgtgaa aaaaatagag gccccattcc cagggcttgt tcattaataa
     3481 agggggctct tggcagggaa ctcatgaagt acagggactg atttttgttg gtgctgcagc
     3541 cccactgctt aaaactctcc tttctcaaag caaccatgat caggtgtttt atttgcatgg
     3601 ttgatactgg aacttctaaa tttgggatta aagaaattca tctgtgtctt aggtagcaca
     3661 aagttattaa caggccagga agaccttgtt tctttcaggc ttccataatg ggtttgaaag
     3721 aaaacacgga ttcttctaca gcaacagagt taaagaaata gtcatagtca ttcttccacg
     3781 atctttgtag tctagcttga atttcaaact gtgtccttcc ttactccaga gagggagcaa
     3841 gaaaaaaaac ctggatgctt tgaagggatc tgccactatt taaaagggga ttaggattct
     3901 gtttcagctg catgtggaac taggtaagct tcagtggcct cagaactcca ggcccctcac
     3961 ggagatcacc ctgaacaatg cccagttttt catgcaggtt ttgtcctatg accagttaac
     4021 tacatgttca ataaataaat gtcaaagaaa taaatgcgtg aaaaggcaac cagttcatca
     4081 tcttatgatt aggttttctt gattagggat gtgtttagta cagctgaatg aacaagttca
     4141 cccagctgct ggtgacagaa acccaactca aactagctga tgaaaaacag aactatacag
     4201 atcaatgaat ctctccccct ttttcagcct catagaactg aaaaaaacaa acctaaatac
     4261 agtcacccaa gtgatgtcag gaatctctca tggtattggt ctctgctttc cctcgtattg
     4321 gccatattct tttttttttc ttttttaaaa acttatttaa ttagttttcc ttaatagttg
     4381 cagccaaggc tgtctctttt ttctcttctt ttctcttctt tttttttgaa tgagacagag
     4441 tctcgcgctg tcactcaggc tggagtgcag tggcacaatc acagttcact gcaacctctg
     4501 cctcctgcat tcaagcgatt ctcgtgcctc agcctcccaa gtactgcagt tacttttgca
     4561 ccaacctaat agctcggatt acaagtatgc accaccatgc ccagctaatt tttgtatttt
     4621 ttagtagaga ccaggtttca ctatgttggc caggctggtc tcaaactcct ggcctctagt
     4681 gatctgcctg cctcggtctc ccaaagtggg attacaggca tgaaccacca cgtccagcca
     4741 gtcattttct taagtaggtt cttcccagcc tgcaaaccca gtgaaagggc ttattctttc
     4801 accattactg tggggaaaaa gtcctgtaga ggctttccat aggccctgtg tgactcacgt
     4861 gtctatacct gaatcaactg ttacaaccaa gcagatgcag agactgcgtg ccctctcctg
     4921 gagctaggag ctaggtgagt caatcctgca ctttctctac aaggcttgca aaggtgagca
     4981 agaagattcc ccaaagtgaa atcagggtgc tgttaccaaa agaagctatg ctggcaggca
     5041 aaaaacaaca gctgtttccc atagggcaaa acctgaaaca cccaattact atcccattgt
     5101 ttgcttcaaa attaaatttt gtttgacccc aactagttct agtcaagttt ttgctcgatg
     5161 gaccacgtga aaaaaggata aacaatgtct ctatataatg catgatcagg tggtttatga
     5221 agatgtcaag agcactgaac aaaatccaaa tgctcacata aaatgggatt aggtttcata
     5281 agccacccaa gaaaatcagt ctcattattt tatgtaataa tgtattactg tgcccagagc
     5341 taacctgtag ctctagggga gtacaatgtg tttgtattat tcttcattgt acacagtgcc
     5401 tcagacatag taggtattca ataaatattt gttaaatcat gaa
//
