LOCUS       NM_001136223            4474 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens REST corepressor 3 (RCOR3), transcript variant 1,
            mRNA.
ACCESSION   NM_001136223
VERSION     NM_001136223.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4474)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4474)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4474)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4474)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 4474)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 4474)
  AUTHORS   Xue,J.H., Zheng,M., Xu,X.W., Wu,S.S., Chen,Z. and Chen,F.
  TITLE     Involvement of REST corepressor 3 in prognosis of human hepatitis B
  JOURNAL   Acta Pharmacol Sin 32 (8), 1019-1024 (2011)
   PUBMED   21765449
  REMARK    GeneRIF: The serum RCOR3 levels in SHB, cirrhosis and liver cancer
            patients were significantly lower than those in the patients with
            moderate chronic hepatitis B and with mild chronic hepatitis B.
REFERENCE   7  (bases 1 to 4474)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 4474)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4474)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   10 (bases 1 to 4474)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY024910.1, AK302664.1, AL590101.9 and BU689437.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001136223.2.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302664.1, SRR1660809.240179.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419091.7/ ENSP00000413929.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                HY024910.1         91-157
            68-2095             AK302664.1         1-2028
            2096-3934           AL590101.9         35274-37112
            3935-4474           BU689437.1         13-552              c
FEATURES             Location/Qualifiers
     source          1..4474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2-q32.3"
     gene            1..4474
                     /gene="RCOR3"
                     /note="REST corepressor 3"
                     /db_xref="GeneID:55758"
                     /db_xref="HGNC:HGNC:25594"
                     /db_xref="MIM:620464"
     exon            1..361
                     /gene="RCOR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1857
                     /gene="RCOR3"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="REST corepressor 3 isoform a"
                     /protein_id="NP_001129695.1"
                     /db_xref="CCDS:CCDS44312.1"
                     /db_xref="GeneID:55758"
                     /db_xref="HGNC:HGNC:25594"
                     /db_xref="MIM:620464"
                     /translation="MPGMMEKGPELLGKNRSANGSAKSPAGGGGSGASSTNGGLHYSE
                     PESGCSSDDEHDVGMRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLD
                     EYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFS
                     FHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDV
                     EETHPMDGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPP
                     KGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEE
                     FKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRR
                     FNLEEVLQEWEAEQGTQASNGDASTLGEETKSASNVPSGKSTDEEEEAQTPQAPRTLG
                     PSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRPTLNQ
                     PPPPLIRPANSMPPRLNPRPVLSTVGGQQPPSLIGIQTDSQSSLH"
     exon            362..418
                     /gene="RCOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            419..496
                     /gene="RCOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            497..549
                     /gene="RCOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            550..711
                     /gene="RCOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            712..836
                     /gene="RCOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            837..915
                     /gene="RCOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1134
                     /gene="RCOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1212
                     /gene="RCOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1270
                     /gene="RCOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1512
                     /gene="RCOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..4474
                     /gene="RCOR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2653..2658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCOR3"
                     /note="hexamer: AATATA"
     polyA_site      2680
                     /gene="RCOR3"
                     /note="major polyA site"
     regulatory      4089..4094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCOR3"
                     /note="hexamer: ATTAAA"
     polyA_site      4108
                     /gene="RCOR3"
     regulatory      4297..4302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCOR3"
                     /note="hexamer: AATAAA"
     polyA_site      4332
                     /gene="RCOR3"
     regulatory      4452..4457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCOR3"
                     /note="hexamer: AATAAA"
     polyA_site      4474
                     /gene="RCOR3"
ORIGIN      
        1 gttgttgtga ggcgactgcg ctactgccgg agcggggcgg ttatggcggc tccatattaa
       61 cagcctcctc ctcctccgcc gccgccgccg tctcctcctc ctcctccttt ccctcccgcc
      121 cgcgctctaa gccatctccg ccttcaccct gacgcctgcc tcttcccctc acctttcccc
      181 ctcccctgtt ctaccatgcc cggcatgatg gagaaagggc ccgagttact ggggaagaac
      241 cgatcggcca acggcagcgc caagagcccg gcaggcggcg gcggcagcgg cgcctcgtcc
      301 accaacggcg ggctgcacta ctcagagccc gagagcggct gcagcagcga cgacgagcac
      361 gatgttggga tgagagtcgg agccgaatac caagctcgga tccctgaatt tgatccaggt
      421 gctacaaagt acacagataa agacaatgga gggatgcttg tatggtctcc atatcacagt
      481 atcccagatg ccaaattgga tgaatacatt gcaattgcaa aggaaaagca tggctacaat
      541 gtggaacagg cacttggcat gttgttctgg cataaacata acattgagaa gtcccttgct
      601 gatctcccta atttcactcc ctttccggat gagtggacag tggaagataa agtcctattt
      661 gaacaagcct ttagttttca tggaaagagc tttcacagga ttcagcaaat gcttccagat
      721 aagacaattg caagccttgt aaaatattac tattcttgga aaaaaactcg ctctaggaca
      781 agtttgatgg atcgccaggc tcgtaaacta gctaatagac ataatcaggg tgacagtgat
      841 gatgatgtag aagaaacaca tccaatggat gggaatgata gtgattatga tcccaaaaaa
      901 gaagccaaaa aagagggtaa tactgaacaa cctgtccaaa ctagcaagat tggacttgga
      961 agaagagagt atcagagttt acaacatcgc catcattctc agcgttctaa gtgccgtcca
     1021 cctaagggca tgtatttaac ccaggaagat gtggtagcag tttcctgtag tcccaatgca
     1081 gccaacacca tcctgaggca actggacatg gagttgatct ctctaaaacg tcaggttcag
     1141 aatgctaagc aagtaaacag tgcacttaaa cagaaaatgg aaggtggaat tgaagaattc
     1201 aaacctcctg agtcaaatca gaaaattaat gcccgttgga ccacagagga gcagcttcta
     1261 gcagtgcaag gtgtccgcaa atatggtaaa gattttcaag ctattgcaga tgtaattggc
     1321 aacaagactg ttggccaagt gaagaacttc tttgtaaact acaggcgtcg gtttaactta
     1381 gaggaggtat tgcaggagtg ggaagcagaa caaggaaccc aggcttctaa tggtgatgct
     1441 tctactttag gggaggagac aaaaagtgct tctaatgtgc catcagggaa gagcactgat
     1501 gaagaagagg aggcacagac cccacaggct cctcggacac tgggtccatc acctcctgcc
     1561 ccatcatcca ctccaacacc aacagcccct attgccactc tgaaccagcc tccaccactt
     1621 cttcgtccaa cactgcctgc tgccccggct cttcaccggc agcctcctcc actccagcag
     1681 caggctcggt tcatccagcc ccggccaact ttaaatcagc ctccaccacc tcttattcgc
     1741 cctgctaatt ccatgccacc ccgtctaaac ccaagaccgg tgttgtccac ggttggtggt
     1801 caacagccac catcacttat tggaattcag acagattcac agtcctcact gcactaaaaa
     1861 ttaaattgga cacagctgca gtaacttttc accccatcat tataccagtg ctcatctgac
     1921 tgatgaaaaa gaggaaagaa taatcatttc tagatactga ggctgcgaac tagttctgtg
     1981 gcagtggact agcataagtg gatgtctaag aaatttttca gttcactaga ctaaaatgtt
     2041 ttacaacaaa aagcctccag ttagcctcct ttctagagta tatgttcagc aatgttgatc
     2101 tcataaaagg aaaaacaaaa gatttaagta ttctatatac caagtttttg ttttgttttt
     2161 actgtattta ttttattgag gttctttata ttcctgcctc ttcatagtca aggctcttag
     2221 tacaggaata ttgacttagg aattgtgaaa actccttaag tttcttaagt taaggatgtt
     2281 tggctttttt ctttaatttt ttaaaaacca ttttcctatg ttaggagtgc aagaatagcc
     2341 agcatttccg attttgacat atgttcattt tatgcatatt taagaaatta tagctgcata
     2401 tcccttcttt caaaaaatgt tgcttttttt tttaaaggaa ttttaatata ttcctttaaa
     2461 agaaagcaat ttaatcaatt gcaaagcaat tatataaaac cacaaagaat gtactgaacc
     2521 tactaaccct ttaacataca gtttagggtc ctagcgcaga gtccttgttt aaaggtcatt
     2581 gactcatcat ctgtcagtaa tgagaggatt ggaagaataa ttttgcatac aaatgaggac
     2641 ttaatttgtt gaaatataat ctctttaagt tccttgaaaa tggagttggt tttttttgtt
     2701 tctaaatgct atctgctttt aactagtagt tgcctacatc tggggacttc agagaagaat
     2761 tatattttgt tagttaagta gacacagtgg ttatggaagc atttctttac agtacccttt
     2821 acatgtttgg tttctgaact taaaattgcc ctcatactta ataatatggt ctgcatttaa
     2881 tatgaaaggt gttttattga taaatctatt gtactatttg gatacatttg tgtattcctt
     2941 gcagccaacc tgtattcgtg ggattggtgt agggttaaat catcaacatt atttcataaa
     3001 ataagaattt gttctgtgtt atctaaagat gtatcagtat attgtcacag ttgtgctgtt
     3061 aactaaaaat gctgagaccc ctttttatag aaaaacaaaa agacatcaag tcttcttaat
     3121 tcaacccata atcattaagt acttaacaaa gaatatttta caagtgatag tatttcaaca
     3181 atgtgtaatt aatatttttg atacagtgat ttcatattgg aatcattatt tgtgcaaagg
     3241 gacagacaga tcacttagat tgctatacta gtggacatag gctacatgtt tgcacattca
     3301 cattcttatc acgtgtagaa tacttcacaa aatagtcaac atctaaggcc ctaatttatg
     3361 ttttgaaaga tcatgtgttc ccaaagtatt ccctattgtt ggctccacag ccttaaagtg
     3421 ctatagattt aaattcattg attagtttta atttttaatt ttagactgtg tatttccata
     3481 aataccctac gtactggcat atttgaaact ctttttccag gttaggtcct tttctttctc
     3541 attgaatcat cttaaatagt tcttggccct gaatttagct gatttaaaat tcttaatatt
     3601 caagaattta tacttatttt ttccttaaaa gccacagggg acagttaaat atcttaaaat
     3661 atctaaaaca ttttttaaag cacttagatt gtcttacgta tgtgcatact atacctttac
     3721 agcgtttatt gtcttgtctc ttgtcagtag accttcagta cacagtatgt gggatatgtc
     3781 agtcaagttg gtcagcacca gcatctgtcc agctgttcag tatattgtga ttcattaaaa
     3841 aatctcttct atcccagaca tgggccaagg tgctgtatct gagggatgtg ctgtaatttg
     3901 atttacatgc attagagcac acagtagaaa aactttagct tcattagtaa tatgacacat
     3961 gtatatagtg agatgtcttt attgtgtgct ttgcatattt tgtaaatatt ttgcacgtca
     4021 ttatttttct tttttgttta agcagtgttt ggcctggaag agtgatatgc ttgctgctta
     4081 atcaaaggat taaagattta aagatgtcta tgtcttctat ttttatataa tttcatgttc
     4141 tatgaggaat ttagtacctc ttcactgtga aattcgaaat aatgattttt ataaaagcaa
     4201 aactagaaat cttttaatga caattttcat taatttcagg gttatcattt ttgagaaatc
     4261 tacaccaaag tggtttttta aaattacata actaaaaata aaccacactg tggatacatc
     4321 ttataaaact aatggaaaca atgtttttct atatgattta attctagtgt aatatggatg
     4381 aggtaagagt aagttatgat caaacttttt atgttcttaa taagcttgca attgagtaaa
     4441 atagaatata aaataaaggt gaaataatat aaaa
//
