LOCUS       NM_173587               2915 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens REST corepressor 2 (RCOR2), transcript variant 1,
            mRNA.
ACCESSION   NM_173587
VERSION     NM_173587.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2915)
  AUTHORS   Rivera,C., Verbel-Vergara,D., Arancibia,D., Lappala,A.,
            Gonzalez,M., Guzman,F., Merello,G., Lee,J.T. and Andres,M.E.
  TITLE     Revealing RCOR2 as a regulatory component of nuclear speckles
  JOURNAL   Epigenetics Chromatin 14 (1), 51 (2021)
   PUBMED   34819154
  REMARK    GeneRIF: Revealing RCOR2 as a regulatory component of nuclear
            speckles.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2915)
  AUTHORS   Hiramatsu,H., Kobayashi,K., Kobayashi,K., Haraguchi,T., Ino,Y.,
            Todo,T. and Iba,H.
  TITLE     The role of the SWI/SNF chromatin remodeling complex in maintaining
            the stemness of glioma initiating cells
  JOURNAL   Sci Rep 7 (1), 889 (2017)
   PUBMED   28420882
  REMARK    Erratum:[Sci Rep. 2018 Oct 25;8(1):16079. doi:
            10.1038/s41598-018-31444-z.. PMID: 30356171]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2915)
  AUTHORS   Monaghan,C.E., Nechiporuk,T., Jeng,S., McWeeney,S.K., Wang,J.,
            Rosenfeld,M.G. and Mandel,G.
  TITLE     REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate
            the proliferation-differentiation balance in the developing brain
  JOURNAL   Proc Natl Acad Sci U S A 114 (3), E406-E415 (2017)
   PUBMED   28049845
REFERENCE   4  (bases 1 to 2915)
  AUTHORS   Suva,M.L., Rheinbay,E., Gillespie,S.M., Patel,A.P., Wakimoto,H.,
            Rabkin,S.D., Riggi,N., Chi,A.S., Cahill,D.P., Nahed,B.V.,
            Curry,W.T., Martuza,R.L., Rivera,M.N., Rossetti,N., Kasif,S.,
            Beik,S., Kadri,S., Tirosh,I., Wortman,I., Shalek,A.K.,
            Rozenblatt-Rosen,O., Regev,A., Louis,D.N. and Bernstein,B.E.
  TITLE     Reconstructing and reprogramming the tumor-propagating potential of
            glioblastoma stem-like cells
  JOURNAL   Cell 157 (3), 580-594 (2014)
   PUBMED   24726434
REFERENCE   5  (bases 1 to 2915)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2915)
  AUTHORS   Yang,P., Wang,Y., Chen,J., Li,H., Kang,L., Zhang,Y., Chen,S.,
            Zhu,B. and Gao,S.
  TITLE     RCOR2 is a subunit of the LSD1 complex that regulates ESC property
            and substitutes for SOX2 in reprogramming somatic cells to
            pluripotency
  JOURNAL   Stem Cells 29 (5), 791-801 (2011)
   PUBMED   21433225
  REMARK    GeneRIF: Ectopic expression of Rcor2 in both mouse and human
            somatic cells effectively substituted the requirement for exogenous
            Sox2 expression in somatic cell reprogramming.
REFERENCE   7  (bases 1 to 2915)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003780.3 and BC023587.2.
            
            On Nov 23, 2018 this sequence version replaced NM_173587.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023587.2, AB593132.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301459.5/ ENSP00000301459.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AP003780.3         77841-78160         c
            321-1511            BC023587.2         1-1191
            1512-1512           AP003780.3         75037-75037         c
            1513-2247           BC023587.2         1193-1927
            2248-2248           AP003780.3         72893-72893         c
            2249-2915           BC023587.2         1929-2595
FEATURES             Location/Qualifiers
     source          1..2915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2915
                     /gene="RCOR2"
                     /note="REST corepressor 2"
                     /db_xref="GeneID:283248"
                     /db_xref="HGNC:HGNC:27455"
                     /db_xref="MIM:616019"
     exon            1..835
                     /gene="RCOR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             709..2280
                     /gene="RCOR2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="REST corepressor 2 isoform 1"
                     /protein_id="NP_775858.2"
                     /db_xref="CCDS:CCDS8052.1"
                     /db_xref="GeneID:283248"
                     /db_xref="HGNC:HGNC:27455"
                     /db_xref="MIM:616019"
                     /translation="MPSVMEKPSAGSGILSRSRAKTVPNGGQPHSEDDSSEEEHSHDS
                     MIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGY
                     NIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQM
                     LPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGGVSEGEPD
                     PADPKREPLPSRPLNARPGPGKKEVQVSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGS
                     PDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTT
                     DEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDG
                     APGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPP
                     PLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAAPRHSARPGPQPP
                     PTLIGTPLEPPAPSL"
     exon            836..892
                     /gene="RCOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..973
                     /gene="RCOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1026
                     /gene="RCOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1188
                     /gene="RCOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1313
                     /gene="RCOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1383
                     /gene="RCOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1599
                     /gene="RCOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1677
                     /gene="RCOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1735
                     /gene="RCOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1965
                     /gene="RCOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2915
                     /gene="RCOR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2895..2900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCOR2"
                     /note="hexamer: ATTAAA"
     polyA_site      2915
                     /gene="RCOR2"
                     /note="major polyA site"
ORIGIN      
        1 attgtgtgcg cgaggagcga gcggcggcgg agagcgggcg agcaagcggc atcccgagcg
       61 cggcggggag agcgagcgcg ccggggaggg tgcgaggcgg cacccgcggc tgcgctccgc
      121 ccgcctcccg gcaactctgc ccagcgccgc gcgccgtgcg cgccgtcccg ccgccgtcgc
      181 cgccgccgcc gccgccggtg ccccggccgg ctgccgtcgc gggcaggggt ctgcttagga
      241 cacgggtccc cgcccgggga ctggggcatc cccggcgcag ctgagaggcg cagagcccgg
      301 ggggcgcaga ttgcgctcca gcgcccagcc gctgaacggc gtgggcaggt gggcggtggg
      361 gttccagggc gccccgagga cagggggccc cgacttcagg ggaaccccaa ccctgagggg
      421 cgtacatagt aatcacgccc cagccgcacc ggaccttgcg ctcatccctt gcgtccccca
      481 cttctgcaca aacttttctg acgccctggc tcgtgggggt cgtggagagc gctggggcta
      541 ccaggtgggc tcccaccccg ccggacccta gccacgctga cctcctgcct ctcctaacct
      601 cagtggcgac ctctccaggc cgggccgggc tcggcactcg gagcgagtgc ggcaaccact
      661 gtcgctctcc gaaggctcct gcgccccccg gggcagctgg gcggggtaat gccctcagtg
      721 atggagaagc cgagcgcggg ctctgggatc ctgtcccgta gccgggccaa gacggtgccc
      781 aacggcggac agccccactc ggaggatgac agcagcgagg aggagcactc gcacgacagc
      841 atgatccgcg ttggaaccaa ttaccaggcc gtaattccgg agtgcaagcc tgagagcccc
      901 gcacgctaca gcaacaagga gctgaagggg atgctggtgt ggtcacccaa ccactgtgtg
      961 tcagatgcca agcttgacaa gtacattgcg atggccaagg agaagcatgg ctacaacatt
     1021 gagcaggcgc tgggcatgct tctgtggcat aagcacgatg tggagaagtc gctggccgac
     1081 ctggccaact tcaccccatt ccctgacgag tggacagtag aggacaaggt gctgtttgaa
     1141 caggcctttg gcttccatgg caaatgcttc cagcggatcc agcagatgct gcctgacaag
     1201 ttgattccca gcctggtgaa atactactac tcttggaaga agacccgcag ccgaactagt
     1261 gtgatggaca gacaggcccg gcggctgggg ggccgcaagg acaaagaaga cagtgatgag
     1321 ctcgaagagg gtcgaggagg cgtgagtgag ggagagcccg atcctgcaga tcccaagaga
     1381 gagcctctac cctctcggcc cctgaatgca cgcccaggcc ctgggaaaaa ggaggtccag
     1441 gtgtctcagt accgccacca tcccttgcga acccggcgtc gcccacccaa gggcatgtac
     1501 ctgagccctg aaggcctcac ggcagtgtca ggaagcccgg accttgccaa cctcacgctc
     1561 cgaggtcttg actctcagct catctccctc aagcgccagg tacagagcat gaagcagacg
     1621 aacagcagcc tgcgccaagc cctggagggc ggtattgatc cactacgccc cccggaggcc
     1681 aacaccaagt tcaactcccg ctggaccaca gatgagcagc ttttggctgt tcaagccatc
     1741 cgtaggtatg gcaaagactt tggggctatt gcagaggtga ttgggaacaa gactctgacc
     1801 caggtgaaga ctttctttgt gagctaccgg cgccgcttca atctggagga ggtgctgcag
     1861 gaatgggagg ctgagcagga tggggcccct ggagccccag tccccatgga ggaggctagg
     1921 agaggggctc cattgccagc cccagcccta gaggaagatg atgaggtcca gattacatcg
     1981 gtctccacgt ccgtgccccg atcagtgccc cctgcgccac caccccctcc acctcccacc
     2041 tcgctgtccc agccaccccc gctgctgagg ccacctttgc ccacggctcc cactctgctc
     2101 cgacagccac ccccactgca gcagggccgc ttcctccagc cccggctggc ccccaaccag
     2161 cccccaccgc ctctcatccg ccccgctctg gctgcccccc gccacagcgc ccgccctggc
     2221 cctcagcccc cacccaccct gattggaacc cctctggagc ccccagcacc ctcactctga
     2281 gccctgacgt cctccaccaa ccacgggctc caggacccct ttgctggcca tccccaggca
     2341 tctctggtgt cactgaggac agaagggact agggctctgg cggggtcttt gtaagaccag
     2401 agtttcggac agcccagccc cgccctttgg gttctgcatg tgttcctggc agctgggcct
     2461 gtctcctggg gccatggccg ggctcagggg cctttgagct ggcctgaggg cactttcgct
     2521 tcctggccgg tactggaatg gctgtgtcct agtctgctgg ggcttggcct ctgggtcctg
     2581 ccctttgtgt gtccggggta gtgaccttag cgtggagtgg ggagagggca gttgggtgtg
     2641 ctggctgttc tcattcctct ttcccttctt ttagcaataa gtctggggtg aggtggggag
     2701 ggaggctgca gggggggagg tgggcagagg ggccttacag cagcagaggc tggaagagaa
     2761 gctctgtctt caggggccag ctgggaaatg ctaaggagct gagggtgccc accaagccca
     2821 ccttccagaa acttggagaa atgggggttg ggaacttatg cagacatgga tttatttttc
     2881 aacatttttt aaaaattaaa aaaaataaaa tctaa
//
