LOCUS       NM_020650               1469 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens reticulocalbin 3 (RCN3), mRNA.
ACCESSION   NM_020650
VERSION     NM_020650.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1469)
  AUTHORS   Riveros-Mckay,F., Roberts,D., Di Angelantonio,E., Yu,B.,
            Soranzo,N., Danesh,J., Selvin,E., Butterworth,A.S. and Barroso,I.
  TITLE     An Expanded Genome-Wide Association Study of Fructosamine Levels
            Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the
            Effector Transcript
  JOURNAL   Diabetes 71 (2), 359-364 (2022)
   PUBMED   34753797
  REMARK    GeneRIF: An Expanded Genome-Wide Association Study of Fructosamine
            Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT
            as the Effector Transcript.
REFERENCE   2  (bases 1 to 1469)
  AUTHORS   Zhang,Q., Wang,T., Jin,J., Shi,X., Huang,A., Ma,Z., Li,J., Wang,S.,
            Z Ma,R. and Fang,Q.
  TITLE     Rcn3 Suppression Was Responsible for Partial Relief of Emphysema as
            Shown by Specific Type II Alveolar Epithelial Cell Rcn3 CKO Mouse
            Model
  JOURNAL   Int J Chron Obstruct Pulmon Dis 16, 147-158 (2021)
   PUBMED   33531801
  REMARK    GeneRIF: Rcn3 Suppression Was Responsible for Partial Relief of
            Emphysema as Shown by Specific Type II Alveolar Epithelial Cell
            Rcn3 CKO Mouse Model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1469)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1469)
  AUTHORS   Loomis,S.J., Li,M., Maruthur,N.M., Baldridge,A.S., North,K.E.,
            Mei,H., Morrison,A., Carson,A.P., Pankow,J.S., Boerwinkle,E.,
            Scharpf,R., Rasmussen-Torvik,L.J., Coresh,J., Duggal,P., Kottgen,A.
            and Selvin,E.
  TITLE     Genome-Wide Association Study of Serum Fructosamine and Glycated
            Albumin in Adults Without Diagnosed Diabetes: Results From the
            Atherosclerosis Risk in Communities Study
  JOURNAL   Diabetes 67 (8), 1684-1696 (2018)
   PUBMED   29844224
  REMARK    GeneRIF: genome-wide association study in US: Data suggest, among
            white subjects, an SNP in RCN3 (rs34459162) and a missense mutation
            in GCKR (rs1260236) are associated with serum levels of glycated
            albumin; among black subjects, an intergenic SNP in PRKCA
            (rs2438321) is associated with fructosamine levels and intronic
            variant in PRKCA (rs59443763) is associated with glycated albumin
            levels. (GCKR = glucokinase regulatory protein)
REFERENCE   5  (bases 1 to 1469)
  AUTHORS   Martinez-Martinez,E., Ibarrola,J., Fernandez-Celis,A.,
            Santamaria,E., Fernandez-Irigoyen,J., Rossignol,P., Jaisser,F. and
            Lopez-Andres,N.
  TITLE     Differential Proteomics Identifies Reticulocalbin-3 as a Novel
            Negative Mediator of Collagen Production in Human Cardiac
            Fibroblasts
  JOURNAL   Sci Rep 7 (1), 12192 (2017)
   PUBMED   28939891
  REMARK    GeneRIF: Study identified reticulocalbin-3 (RCN-3) as a common
            molecule down-regulated by aldosterone (Aldo), galectin-3 and
            cardiotrophin-1 - key factors in the cardiac remodeling induced by
            Aldo associated with cardiac hypertrophy and fibrosis. Moreover,
            RCN-3 emerges as a new potential negative regulator of collagen
            production.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1469)
  AUTHORS   Balanescu,P., Ladaru,A., Balanescu,E., Pompilian,V., Gologanu,D.,
            Caraiola,S., Baicus,C. and Dan,G.A.
  TITLE     Circulating Reticulocalbin 1 and Reticulocalbin 3 in Systemic
            Sclerosis Patients: Results of a Case Control Study
  JOURNAL   Clin Lab 62 (6), 1109-1116 (2016)
   PUBMED   27468573
  REMARK    GeneRIF: RCN3 expression in systemic sclerosis was not
            statistically significantly different to healthy controls.
REFERENCE   7  (bases 1 to 1469)
  AUTHORS   Tsuji,A., Kikuchi,Y., Sato,Y., Koide,S., Yuasa,K., Nagahama,M. and
            Matsuda,Y.
  TITLE     A proteomic approach reveals transient association of
            reticulocalbin-3, a novel member of the CREC family, with the
            precursor of subtilisin-like proprotein convertase, PACE4
  JOURNAL   Biochem J 396 (1), 51-59 (2006)
   PUBMED   16433634
  REMARK    GeneRIF: Autoactivation & secretion of rat PACE4 was increased upon
            co-expression with recombinant human RCN-3. Selective and transient
            association of RCN-3 with the precursor of PACE4 plays an important
            role in the biosynthesis of PACE4.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY195859.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020650.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY195859.1, SRR3476690.101050.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270645.8/ ENSP00000270645.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1469              AY195859.1         386-1854
FEATURES             Location/Qualifiers
     source          1..1469
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1469
                     /gene="RCN3"
                     /gene_synonym="RLP49"
                     /note="reticulocalbin 3"
                     /db_xref="GeneID:57333"
                     /db_xref="HGNC:HGNC:21145"
                     /db_xref="MIM:619032"
     exon            1..56
                     /gene="RCN3"
                     /gene_synonym="RLP49"
                     /inference="alignment:Splign:2.1.0"
     exon            57..304
                     /gene="RCN3"
                     /gene_synonym="RLP49"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1049
                     /gene="RCN3"
                     /gene_synonym="RLP49"
                     /note="reticulocabin; EF-hand calcium-binding protein
                     RLP49; reticulocalbin 3, EF-hand calcium binding domain"
                     /codon_start=1
                     /product="reticulocalbin-3 precursor"
                     /protein_id="NP_065701.2"
                     /db_xref="CCDS:CCDS12771.1"
                     /db_xref="GeneID:57333"
                     /db_xref="HGNC:HGNC:21145"
                     /db_xref="MIM:619032"
                     /translation="MMWRPSVLLLLLLLRHGAQGKPSPDAGPHGQGRVHQAAPLSDAP
                     HDDAHGNFQYDHEAFLGREVAKEFDQLTPEESQARLGRIVDRMDRAGDGDGWVSLAEL
                     RAWIAHTQQRHIRDSVSAAWDTYDTDRDGRVGWEELRNATYGHYAPGEEFHDVEDAET
                     YKKMLARDERRFRVADQDGDSMATREELTAFLHPEEFPHMRDIVIAETLEDLDRNKDG
                     YVQVEEYIADLYSAEPGEEEPAWVQTERQQFRDFRDLNKDGHLDGSEVGHWVLPPAQD
                     QPLVEANHLLHESDTDKDGRLSKAEILGNWNMFVGSQATNYGEDLTRHHDEL"
     exon            305..507
                     /gene="RCN3"
                     /gene_synonym="RLP49"
                     /inference="alignment:Splign:2.1.0"
     exon            508..680
                     /gene="RCN3"
                     /gene_synonym="RLP49"
                     /inference="alignment:Splign:2.1.0"
     exon            681..741
                     /gene="RCN3"
                     /gene_synonym="RLP49"
                     /inference="alignment:Splign:2.1.0"
     exon            742..941
                     /gene="RCN3"
                     /gene_synonym="RLP49"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1469
                     /gene="RCN3"
                     /gene_synonym="RLP49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1450..1455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCN3"
                     /gene_synonym="RLP49"
                     /note="hexamer: AATAAA"
     polyA_site      1469
                     /gene="RCN3"
                     /gene_synonym="RLP49"
                     /note="major polyA site"
ORIGIN      
        1 acatttgcgg gaacgcagag cggagcgtgg agagcggagc gaagctggat aacaggggac
       61 cgatgatgtg gcgaccatca gttctgctgc ttctgttgct actgaggcac ggggcccagg
      121 ggaagccatc cccagacgca ggccctcatg gccaggggag ggtgcaccag gcggcccccc
      181 tgagcgacgc tccccatgat gacgcccacg ggaacttcca gtacgaccat gaggctttcc
      241 tgggacggga agtggccaag gaattcgacc aactcacccc agaggaaagc caggcccgtc
      301 tggggcggat cgtggaccgc atggaccgcg cgggggacgg cgacggctgg gtgtcgctgg
      361 ccgagcttcg cgcgtggatc gcgcacacgc agcagcggca catacgggac tcggtgagcg
      421 cggcctggga cacgtacgac acggaccgcg acgggcgtgt gggttgggag gagctgcgca
      481 acgccaccta tggccactac gcgcccggtg aagaatttca tgacgtggag gatgcagaga
      541 cctacaaaaa gatgctggct cgggacgagc ggcgtttccg ggtggccgac caggatgggg
      601 actcgatggc cactcgagag gagctgacag ccttcctgca ccccgaggag ttccctcaca
      661 tgcgggacat cgtgattgct gaaaccctgg aggacctgga cagaaacaaa gatggctatg
      721 tccaggtgga ggagtacatc gcggatctgt actcagccga gcctggggag gaggagccgg
      781 cgtgggtgca gacggagagg cagcagttcc gggacttccg ggatctgaac aaggatgggc
      841 acctggatgg gagtgaggtg ggccactggg tgctgccccc tgcccaggac cagcccctgg
      901 tggaagccaa ccacctgctg cacgagagcg acacggacaa ggatgggcgg ctgagcaaag
      961 cggaaatcct gggtaattgg aacatgtttg tgggcagtca ggccaccaac tatggcgagg
     1021 acctgacccg gcaccacgat gagctgtgag caccgcgcac ctgccacagc ctcagaggcc
     1081 cgcacaatga ccggaggagg ggccgctgtg gtctggcccc ctccctgtcc aggccccgca
     1141 ggaggcagat gcagtcccag gcatcctcct gcccctgggc tctcagggac cccctgggtc
     1201 ggcttctgtc cctgtcacac ccccaacccc agggaggggc tgtcatagtc ccagaggata
     1261 agcaatacct atttctgact gagtctccca gcccagaccc agggaccctt ggccccaagc
     1321 tcagctctaa gaaccgcccc aacccctcca gctccaaatc tgagcctcca ccacatagac
     1381 tgaaactccc ctggccccag ccctctcctg cctggcctgg cctgggacac ctcctctctg
     1441 ccaggaggca ataaaagcca gcgccggga
//
