LOCUS       NM_002902               6218 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens reticulocalbin 2 (RCN2), transcript variant 1, mRNA.
ACCESSION   NM_002902
VERSION     NM_002902.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6218)
  AUTHORS   Yao,H., Zhang,S., Xie,H., Fan,Y., Miao,M., Zhu,R., Yuan,L., Gu,M.,
            You,Y. and You,B.
  TITLE     RCN2 promotes Nasopharyngeal carcinoma progression by curbing
            Calcium flow and Mitochondrial apoptosis
  JOURNAL   Cell Oncol (Dordr) 46 (4), 1031-1048 (2023)
   PUBMED   36952101
  REMARK    GeneRIF: RCN2 promotes Nasopharyngeal carcinoma progression by
            curbing Calcium flow and Mitochondrial apoptosis.
REFERENCE   2  (bases 1 to 6218)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   3  (bases 1 to 6218)
  AUTHORS   Li,J., Taylor,A.M., Manichaikul,A., Angle,J.F. and Shi,W.
  TITLE     Reticulocalbin 2 as a Potential Biomarker and Therapeutic Target
            for Atherosclerosis
  JOURNAL   Cells 11 (7), 1107 (2022)
   PUBMED   35406670
  REMARK    GeneRIF: Reticulocalbin 2 as a Potential Biomarker and Therapeutic
            Target for Atherosclerosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6218)
  AUTHORS   Gu,J., Liu,Y., Qi,T., Qian,W., Hu,D. and Feng,W.
  TITLE     Long non-coding RNA DUXAP8 elevates RCN2 expression and facilitates
            cell malignant behaviors and angiogenesis in cervical cancer via
            sponging miR-1297
  JOURNAL   Diagn Pathol 16 (1), 105 (2021)
   PUBMED   34774078
  REMARK    GeneRIF: Long non-coding RNA DUXAP8 elevates RCN2 expression and
            facilitates cell malignant behaviors and angiogenesis in cervical
            cancer via sponging miR-1297.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6218)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6218)
  AUTHORS   Kirkpatrick,L.L., Matzuk,M.M., Dodds,D.C. and Perin,M.S.
  TITLE     Biochemical interactions of the neuronal pentraxins. Neuronal
            pentraxin (NP) receptor binds to taipoxin and taipoxin-associated
            calcium-binding protein 49 via NP1 and NP2
  JOURNAL   J Biol Chem 275 (23), 17786-17792 (2000)
   PUBMED   10748068
REFERENCE   7  (bases 1 to 6218)
  AUTHORS   Dodds,D.C., Omeis,I.A., Cushman,S.J., Helms,J.A. and Perin,M.S.
  TITLE     Neuronal pentraxin receptor, a novel putative integral membrane
            pentraxin that interacts with neuronal pentraxin 1 and 2 and
            taipoxin-associated calcium-binding protein 49
  JOURNAL   J Biol Chem 272 (34), 21488-21494 (1997)
   PUBMED   9261167
REFERENCE   8  (bases 1 to 6218)
  AUTHORS   Wang,J.Y., Zhen,D.K., Bianchi,D.W., Androphy,E.J. and Chen,J.J.
  TITLE     Assignment of the gene for ERC-55 (RCN2) to human chromosome band
            15q22.33-->q24.1 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 60-61 (1997)
   PUBMED   9533013
REFERENCE   9  (bases 1 to 6218)
  AUTHORS   Chen,J.J., Reid,C.E., Band,V. and Androphy,E.J.
  TITLE     Interaction of papillomavirus E6 oncoproteins with a putative
            calcium-binding protein
  JOURNAL   Science 269 (5223), 529-531 (1995)
   PUBMED   7624774
REFERENCE   10 (bases 1 to 6218)
  AUTHORS   Weis,K., Griffiths,G. and Lamond,A.I.
  TITLE     The endoplasmic reticulum calcium-binding protein of 55 kDa is a
            novel EF-hand protein retained in the endoplasmic reticulum by a
            carboxyl-terminal His-Asp-Glu-Leu motif
  JOURNAL   J Biol Chem 269 (29), 19142-19150 (1994)
   PUBMED   8034671
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB452318.1, AK313833.1 and
            AC051643.5.
            
            On Nov 24, 2018 this sequence version replaced NM_002902.2.
            
            Summary: The protein encoded by this gene is a calcium-binding
            protein located in the lumen of the ER. The protein contains six
            conserved regions with similarity to a high affinity Ca(+2)-binding
            motif, the EF-hand. This gene maps to the same region as type 4
            Bardet-Biedl syndrome, suggesting a possible causative role for
            this gene in the disorder. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) is a predominant transcript
            and encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.133488.1,
                                           SRR3476690.466817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394885.8/ ENSP00000378349.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB452318.1         129-129
            2-1047              AK313833.1         1-1046
            1048-6218           AC051643.5         12040-17210         c
FEATURES             Location/Qualifiers
     source          1..6218
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.3"
     gene            1..6218
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /note="reticulocalbin 2"
                     /db_xref="GeneID:5955"
                     /db_xref="HGNC:HGNC:9935"
                     /db_xref="MIM:602584"
     exon            1..237
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1047
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; reticulocalbin 2, EF-hand calcium binding
                     domain (endoplasmic reticulum calcium-binding protein,
                     55kD); E6-binding protein; calcium-binding protein ERC-55"
                     /codon_start=1
                     /product="reticulocalbin-2 isoform a precursor"
                     /protein_id="NP_002893.1"
                     /db_xref="CCDS:CCDS10291.1"
                     /db_xref="GeneID:5955"
                     /db_xref="HGNC:HGNC:9935"
                     /db_xref="MIM:602584"
                     /translation="MRLGPRTAALGLLLLCAAAAGAGKAEELHYPLGERRSDYDREAL
                     LGVQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEA
                     KQQFVEYDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKLHLKDKKRFEK
                     ANQDSGPGLSLEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWD
                     PTANEDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMD
                     LNGDKKLSEEEILENPDLFLTSEATDYGRQLHDDYFYHDEL"
     exon            238..343
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /inference="alignment:Splign:2.1.0"
     exon            344..540
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /inference="alignment:Splign:2.1.0"
     exon            541..654
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /inference="alignment:Splign:2.1.0"
     exon            655..751
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /inference="alignment:Splign:2.1.0"
     exon            752..894
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /inference="alignment:Splign:2.1.0"
     exon            895..6218
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /note="hexamer: ATTAAA"
     polyA_site      1729
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /note="major polyA site"
     regulatory      1759..1764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /note="hexamer: GATAAA"
     polyA_site      1780
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
     regulatory      1903..1908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /note="hexamer: AATATA"
     polyA_site      1938
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
     regulatory      2063..2068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /note="hexamer: ATTAAA"
     polyA_site      2091
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
     regulatory      6201..6206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
                     /note="hexamer: AATAAA"
     polyA_site      6218
                     /gene="RCN2"
                     /gene_synonym="E6BP; ERC-55; ERC55; TCBP49"
ORIGIN      
        1 ctctctgtag ccgcccgcgg agcatcgcag ccggcccggg cccccgccag cctccctcct
       61 cgcgtccctc ggtgtcctcc gcgggccggc gcgatgcggc tgggcccgag gaccgcggcg
      121 ttggggctgc tgctgctgtg cgccgccgcg gccggcgccg gcaaggccga ggagctgcac
      181 tacccgctgg gcgagcgccg cagcgactac gaccgcgagg cgctgctggg cgtccaggaa
      241 gatgtggatg aatatgttaa actcggccac gaagagcagc aaaaaagact gcaggcgatc
      301 ataaagaaaa tcgacttgga ctcagatggc tttctcactg aaagtgaact cagttcatgg
      361 attcagatgt cttttaagca ttatgctatg caagaagcaa aacaacagtt tgttgaatat
      421 gataaaaaca gtgatgatac tgtgacttgg gatgaatata acattcagat gtatgatcgt
      481 gtgattgact ttgatgagaa cactgctctg gatgatgcag aagaggagtc ctttaggaag
      541 cttcacttaa aggacaagaa gcgatttgaa aaagctaacc aggattcagg tcccggtttg
      601 agtcttgaag aatttattgc ttttgagcat cctgaagaag ttgattatat gacggaattt
      661 gtcattcaag aagctttaga agaacatgac aaaaatggtg atggatttgt tagtttggaa
      721 gaatttcttg gtgattacag gtgggatcca actgcaaatg aagatccaga atggatactt
      781 gttgagaaag acagattcgt gaatgattat gacaaagata acgatggcag gcttgatccc
      841 caagagctgt taccttgggt agtacctaat aatcagggca ttgcacaaga ggaggcgctt
      901 catctaattg atgaaatgga tttgaatggt gacaaaaagc tctctgaaga agagattctg
      961 gaaaacccgg acttgtttct caccagtgaa gccacagatt atggcagaca gctccatgat
     1021 gactatttct atcatgatga gctttaatct ctgagcctgt ctcagtagag tactggctcc
     1081 ttttataatt tgttaccagc tttacttttg tgataaaata ttgatgttgt attttacact
     1141 cttaagtctt aaccacagtc agaattatct taatgtagat tataattttg gtcttttagg
     1201 aaaaaaaaac aaaaatctga tatttatttc aaaatgtatt gaagcaacaa aatattaata
     1261 ttgtgccata tgacaacaaa gtctttccta aatactccat ctgtttagta ctgtattgtg
     1321 gaatatttga gttctatttc catacttgaa aacatggagg attttagaga tgcctgaaca
     1381 atattattta agtagtatgt gaccgagcta taaatttttg tttttgttct aagtagattt
     1441 aatttgggaa ctgacaggac aatgttttta ggtttagcat tttgtttaaa aacctttaaa
     1501 gaaaccttta gaaggactta gacctcacat attaatgttg agaagttctg cttaatttta
     1561 aaatggtttc tataaagggt tttattgtat gaaatagaac tttatatttt tgcatatgta
     1621 tagatagtaa ttatatttaa tgtataacta tagcattatg gtgagtggaa tttgacattg
     1681 tccaaacctt tttcattttt gagtgattaa aaatgaaatg tcctttgtat atgtttgttt
     1741 gcttttcttt aactttcaga taaatattga atttagcata ggttttgtgg tattgtacat
     1801 tatcttgcct catccattcc tttatgtgga tagttcccaa aactgtcaaa ttattcttgc
     1861 tgcattttct tatttttttt ttaaataaga gaatcatgtt ataatataat tgaatgtgca
     1921 cctgacacat tttaataatt ggtgttgtag caaatgtggt tttgctcttt ggggctataa
     1981 ataatcttga gtaacgcagg ttggaattac caatagagct ggtcagttat caacagtaga
     2041 gctcagtatc aattttactg aaattaaaat catacttgat aagcatgata atcaatttta
     2101 acctaattca gcaggtcaac ttatttaact ttggtggagg tgggataggg aaaagtgaag
     2161 ggaggaatta atttttttct agttctgatg tacagagatt gtttttcatt cttttttttt
     2221 tttttttttt tgtgacagag tcttgctctg tggcccaggc tggagtgcag gggcactatc
     2281 tcggctcact gcaagctctg cctcctgggt tcacgccatt ctcctgcctc agcctcccga
     2341 gtagctggga ctacaggcgc ctgccaccac acccggctaa tttttttgta tttttagtag
     2401 agaccgggtt tcaccgtgtt agccaggatg gtttcgatct cctgacctca tgatcagccc
     2461 acctcggcct cccaaggtgc tggaattaca ggcgtgagcc aacgcgcacg gcctctagtt
     2521 tttcattctt taaatcactt ttatttgtgg gtgaagaggt cagctatgca ttctcttaat
     2581 cactttccag cctaaagttg tctcatatac agcacactgg gggctcaaca agtacctatg
     2641 actatttgag aagacatgaa actcttctct gatagaatcg actgcaccta tatacctctc
     2701 tactgccgca tctttgctga tgtgaggtgt gcttgcaaat tgtaagcttc cacaccttaa
     2761 tgactgcttg cttgggtatc tacatggttt tcattttaac ctacactata tgtctggcta
     2821 tagcagtttt agaattacag atttaccact atcactcatc tgtcatttgt cagactcact
     2881 gaagctggca tatttgaaat caccagtttg actagttaac tatttgtttt tctctctagc
     2941 ttctccaaaa tctatgccag aatagatcat cagatatgga ttatatttca atcctttgca
     3001 gaaatgcaat gtctgtacta ctttccttcc tagcataaag aaaactacac ttcccagccc
     3061 tcttgtaggt aggcgatggc tagttctgac cagttaaaca tgggtggaag tagtgtgtgt
     3121 cactatcaga ctatctcatg acaaaccctt ttcctctgcc acagcactgt gcaggaggcc
     3181 tcagctgaaa tggtgcagcc acaagatgaa agtggctttg atcttgagtc tgtgtaggtc
     3241 agctggatcc acagtgggct ttgtatgatc aaaaaataag cttttaatta tgttaagcca
     3301 ctgagatttg gttgtgcttt tttgttttta accacagcag agcccatcct gctgtgactg
     3361 agtgaagatt tcacatttaa caataggctt ttaataagca tgcagagaaa aagaatcatc
     3421 tgcttgaaca gagatgctat atctactgct gagtcaaaat agaaaatttt aaggcttttt
     3481 ttagatttga attttaaata agacttttaa aataaagctt ttattttggt tttaatataa
     3541 ttaggataat ttgaatttat ccttgagcat gagagtaaaa atagtttgag actttctgaa
     3601 tcattggctg attctgcctg aaggacttaa tgacttccat tatttgagtt caggtacaac
     3661 ttcaaagggg aaaattgaat gggatgtgca catgttggct catatgtagt tctgattggg
     3721 ccaatttgca ggacagaaaa tgatgtctag attatgatat aaatttaaag gaagccagga
     3781 cgttcagagg aaaagctagc atatcatgtt tgccttactt agttctttcc tttgcagttt
     3841 taaaaatagg cttttttttt ttttagtgta gttttatgtt cacagcaaaa ttgagcaaaa
     3901 agtagtatag agagtttcaa tatgtcccct gccccacata cgtacagcct cccccactat
     3961 cctatcctat atgtcatgag atagtaccta ccagagtggt acatttgtta aaatcgatga
     4021 aactgttaac atatcattgt cacccaaagt gcatagttta cattagggtt cactcttggt
     4081 gctgcacatg ctctgggttt ggacaaatgt ataattacat attcccacca ttgtagtgtg
     4141 gtagaatatt tcccttgccc taaagtcttt ctgctccacc tattcatccc tcccttccct
     4201 gtaaccccaa gcaatactga tctttttact gttcataatt ttttagattg tagtaaaata
     4261 cacataacaa aattcatctt aacagttttt aattgtacag ttcggtggta tggtattaaa
     4321 tacagtcaaa atgtgaaact attaccacct tccatctcca tgaacttcat ttgtaaaacg
     4381 gaaatttata cccattaaac aataaagccc cctttcccct tcccttcagc acctggcaaa
     4441 caccattcta gtttttttgt ttgagatgga gtcttgctct tgttgcccag gctggagtgc
     4501 aatggcatga tttcggctca ctgcaacctc tgtctcttgg ggtcaagcga ttctcctgcc
     4561 tcagcctccc gactaggtgg gattacaggc gggcaccacc atgcccccta attttttgta
     4621 tttagtagaa atggggtttc accatgttgg tcaagctggt ctcgaactcc tgatctcagg
     4681 tgatccacct gcctcagcct cccaaagtgc tggaattaca ggcgtgagcc accgtgccca
     4741 gcctcccatt ctagttttct ttttctttct tttttgagac ggagtctcac tcttgtcatc
     4801 caggctggag tgcagtggtg cgatctcggc tcactgcaac ctccacctcc caggttcaag
     4861 cgattctcct gcctcagcct cccaagtagc tgggattata gatgcccgct accacgcccg
     4921 gctaattttt gtacttttag tagagacggg gtttcgccat gttggcatgg ctggtctcga
     4981 actcttgacc tcaggtgatc cacctgcctc ggcctcccaa agtgctgaga ttacgggcat
     5041 gagccaccgc gcccagcccc attctagttt gtgtctatta aaatagactc atatagtatt
     5101 tgtctttttg tgagtggctt cacttagcat aacgtcccca aagttcaccc atattgttac
     5161 cagaatttct ttcgtcaggc tgaacaatac tttattgttt gcatatacca cattttgctt
     5221 atccattcac cctttgatgg acacaggttg cttccacctt ttattgtgaa taatgctgcc
     5281 atgaatatgg gtgtacaaat atttctttga gatcctgctt ttagttcttt tggatatata
     5341 ttatacatag aagtgggatt gctggatcat atagtaattc tatatatata tatatatata
     5401 tatatatata tatatatatt tttttttttt tttttttttt tttttttttt gagacggagt
     5461 ctcgctctgt cgcccaggct ggagtgcagt ggcgcgatct cggctcactg caggctccgc
     5521 ctcccgggtt cacaccattc tcctgcctca gcctcccgag tagctgggac tataggcgcc
     5581 tgccaccgca cccggctaat tttttgtatt tttagtagag acggggtttc accgtgttag
     5641 ccaggatggt cttgatctgc tgacctcgtg atccgcccgc cttggcctcc caaagtgctg
     5701 ggattacagg cgtgagccac cgcgcccgac tagtaattct atttttaata ttttgaggaa
     5761 ctgccatagt gtttcccaca gcagctgtgc cattttgcat ttccaccaat agtgcacaag
     5821 agttccagtt tctttacatc cttaccaaca cttgctattt tctgtttttt tttttttctt
     5881 tttttttttt aatagtagcc atcctgttgg gtgagacgtg gtatctcgtt gtggctttga
     5941 tttgcatttc cctaatggtc tgtctctaca gttttgcctg ttccagaata tcattccttt
     6001 gcaatttaaa tgtgaggata aatgtatgct attgtttctc aaacgttttt gtgttacaat
     6061 acctcctttt gagtgagaaa tgtcaactca aacttacact ttttcactta ggaagatgat
     6121 ttaggaaagc cacttagagt aaaagttttt aaacaactgt aaaaactaat ttgcttcatt
     6181 gcaacatttg agttctgtcg aataaatatt tggccaga
//
