LOCUS       NM_002901               2369 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens reticulocalbin 1 (RCN1), mRNA.
ACCESSION   NM_002901
VERSION     NM_002901.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2369)
  AUTHORS   Guo,H., Shu,J., Hu,G., Liu,B., Li,J., Sun,J., Wang,X., Liu,H.,
            Xiong,S., Tang,Y., Yin,Y. and Wang,X.
  TITLE     Downregulation of RCN1 inhibits esophageal squamous cell carcinoma
            progression and M2 macrophage polarization
  JOURNAL   PLoS One 19 (5), e0302780 (2024)
   PUBMED   38713738
  REMARK    GeneRIF: Downregulation of RCN1 inhibits esophageal squamous cell
            carcinoma progression and M2 macrophage polarization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2369)
  AUTHORS   Liu,H., Guo,H., Wu,Y., Hu,Q., Hu,G., He,H., Yin,Y., Nan,X., Lin,G.,
            Han,J., Zhao,R. and Liu,Y.
  TITLE     RCN1 deficiency inhibits oral squamous cell carcinoma progression
            and THP-1 macrophage M2 polarization
  JOURNAL   Sci Rep 13 (1), 21488 (2023)
   PUBMED   38057406
  REMARK    GeneRIF: RCN1 deficiency inhibits oral squamous cell carcinoma
            progression and THP-1 macrophage M2 polarization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2369)
  AUTHORS   Deng,S., Pan,Y., An,N., Chen,F., Chen,H., Wang,H., Xu,X., Liu,R.,
            Yang,L., Wang,X., Du,X. and Zhang,Q.
  TITLE     Downregulation of RCN1 promotes pyroptosis in acute myeloid
            leukemia cells
  JOURNAL   Mol Oncol 17 (12), 2584-2602 (2023)
   PUBMED   37746742
  REMARK    GeneRIF: Downregulation of RCN1 promotes pyroptosis in acute
            myeloid leukemia cells.
REFERENCE   4  (bases 1 to 2369)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   5  (bases 1 to 2369)
  AUTHORS   Ueda,S., Hashimoto,K., Miyabe,S., Hasegawa,S., Goto,M., Shimizu,D.,
            Oh-Iwa,I., Shimozato,K., Nagao,T. and Nomoto,S.
  TITLE     Salivary NUS1 and RCN1 Levels as Biomarkers for Oral Squamous Cell
            Carcinoma Diagnosis
  JOURNAL   In Vivo 34 (5), 2353-2361 (2020)
   PUBMED   32871760
  REMARK    GeneRIF: Salivary NUS1 and RCN1 Levels as Biomarkers for Oral
            Squamous Cell Carcinoma Diagnosis.
REFERENCE   6  (bases 1 to 2369)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 2369)
  AUTHORS   Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
            Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
            Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
            FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
            Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
            Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
            Lander,E.S. and Sakaki,Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
REFERENCE   8  (bases 1 to 2369)
  AUTHORS   Kent,J., Lee,M., Schedl,A., Boyle,S., Fantes,J., Powell,M.,
            Rushmere,N., Abbott,C., van Heyningen,V. and Bickmore,W.A.
  TITLE     The reticulocalbin gene maps to the WAGR region in human and to the
            Small eye Harwell deletion in mouse
  JOURNAL   Genomics 42 (2), 260-267 (1997)
   PUBMED   9192846
REFERENCE   9  (bases 1 to 2369)
  AUTHORS   Ozawa,M.
  TITLE     Cloning of a human homologue of mouse reticulocalbin reveals
            conservation of structural domains in the novel endoplasmic
            reticulum resident Ca(2+)-binding protein with multiple EF-hand
            motifs
  JOURNAL   J Biochem 117 (5), 1113-1119 (1995)
   PUBMED   8586628
REFERENCE   10 (bases 1 to 2369)
  AUTHORS   Ozawa,M. and Muramatsu,T.
  TITLE     Reticulocalbin, a novel endoplasmic reticulum resident
            Ca(2+)-binding protein with multiple EF-hand motifs and a
            carboxyl-terminal HDEL sequence
  JOURNAL   J Biol Chem 268 (1), 699-705 (1993)
   PUBMED   8416973
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP253627.1, BC010120.2,
            AK126419.1, CA449220.1 and BG109024.1.
            
            On Nov 30, 2019 this sequence version replaced NM_002901.3.
            
            Summary: Reticulocalbin 1 is a calcium-binding protein located in
            the lumen of the ER. The protein contains six conserved regions
            with similarity to a high affinity Ca(+2)-binding motif, the
            EF-hand. High conservation of amino acid residues outside of these
            motifs, in comparison to mouse reticulocalbin, is consistent with a
            possible biochemical function besides that of calcium binding. In
            human endothelial and prostate cancer cell lines this protein
            localizes to the plasma membrane.[provided by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129791.1, FJ224346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000054950.4/ ENSP00000054950.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-407               BP253627.1         144-550
            408-1416            BC010120.2         420-1428
            1417-2178           AK126419.1         1891-2652
            2179-2365           CA449220.1         17-203              c
            2366-2369           BG109024.1         393-396
FEATURES             Location/Qualifiers
     source          1..2369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..2369
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /note="reticulocalbin 1"
                     /db_xref="GeneID:5954"
                     /db_xref="HGNC:HGNC:9934"
                     /db_xref="MIM:602735"
     exon            1..377
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1119
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /note="proliferation-inducing gene 20; epididymis
                     secretory protein Li 84; reticulocalbin 1, EF-hand calcium
                     binding domain"
                     /codon_start=1
                     /product="reticulocalbin-1 precursor"
                     /protein_id="NP_002892.1"
                     /db_xref="CCDS:CCDS7876.1"
                     /db_xref="GeneID:5954"
                     /db_xref="HGNC:HGNC:9934"
                     /db_xref="MIM:602735"
                     /translation="MARGGRGRRLGLALGLLLALVLAPRVLRAKPTVRKERVVRPDSE
                     LGERPPEDNQSFQYDHEAFLGKEDSKTFDQLTPDESKERLGKIVDRIDNDGDGFVTTE
                     ELKTWIKRVQKRYIFDNVAKVWKDYDRDKDDKISWEEYKQATYGYYLGNPAEFHDSSD
                     HHTFKKMLPRDERRFKAADLNGDLTATREEFTAFLHPEEFEHMKEIVVLETLEDIDKN
                     GDGFVDQDEYIADMFSHEENGPEPDWVLSEREQFNEFRDLNKDGKLDKDEIRHWILPQ
                     DYDHAQAEARHLVYESDKNKDEKLTKEEILENWNMFVGSQATNYGEDLTKNHDEL"
     exon            378..571
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /inference="alignment:Splign:2.1.0"
     exon            572..750
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /inference="alignment:Splign:2.1.0"
     exon            751..811
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1011
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..2369
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /note="hexamer: ATTAAA"
     polyA_site      1421
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /note="major polyA site"
     regulatory      2159..2164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /note="hexamer: AATAAA"
     polyA_site      2184
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /note="major polyA site"
     regulatory      2347..2352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
                     /note="hexamer: AATAAA"
     polyA_site      2369
                     /gene="RCN1"
                     /gene_synonym="HEL-S-84; PIG20; RCAL; RCN"
ORIGIN      
        1 agtcccctcc tccgcgccgg ccccaaccct gtcgctgccg ccgcgctccg agtccccatt
       61 cccgagctgc cgctgttgtc gctcgctcag cgtctccctc tcggccgccc tctcctcggg
      121 acgatggcgc gcggtggccg cggccgccgc ctggggttag ccctggggct gctgctggcg
      181 ctggtgctgg cgccgcgggt tctgcgggcc aagcccacgg tgcgcaaaga gcgcgtggtg
      241 cggcccgact cggagctggg cgagcggccc cctgaggaca accagagctt ccagtacgac
      301 cacgaggcct tcctgggcaa ggaggactcc aagaccttcg accagctcac cccggacgag
      361 agcaaggaga ggctagggaa gattgttgat cgaatcgaca atgatgggga tggctttgtc
      421 actactgagg agctgaaaac ctggatcaaa cgggtgcaga aaagatacat ctttgataat
      481 gtcgccaaag tctggaagga ttatgatagg gacaaggatg ataaaatttc ctgggaagaa
      541 tacaaacaag ccacctatgg ttactaccta ggaaaccccg cagagtttca tgattcttca
      601 gatcatcaca cctttaaaaa gatgctgcca cgtgatgaga gaagattcaa agctgcagac
      661 ctcaatggtg acctgacagc tactcgggag gagttcactg cctttctgca tcctgaagag
      721 tttgaacata tgaaggaaat tgtggttttg gaaaccctgg aggacatcga caagaacggg
      781 gatgggtttg tggatcagga tgagtatatt gcggatatgt tttcccatga ggagaatggc
      841 cctgagccag actgggtttt atcagaacgg gagcagttta acgaattccg ggatctgaac
      901 aaggacggga agttagacaa agatgagatt cgccactgga tcctccctca agattatgat
      961 catgcacagg ctgaggccag gcatctggta tatgaatcag acaaaaacaa ggatgagaag
     1021 ctaactaaag aggaaatatt ggagaactgg aacatgtttg tcggaagcca agctaccaat
     1081 tacggggaag atctcacaaa aaatcatgat gagctttgat agacactcac cagaatatgg
     1141 cagactgtca taggcattct gttattgtct tggattgttg ctacaattgt ctaatttaca
     1201 gcagttgtga tcccacaaaa agcaagttta tacctcagat tggggtataa aaattgtttt
     1261 tcgctcagta tttactggaa aatggacatc actagtcttt cagtaagatt tctctcaaaa
     1321 cacgtgaaaa ccttggtaaa ttgcaattct ttctggggat atattggtac aacatgactt
     1381 aaaacttttt tttttctatt aaaacttaaa ggggaacaaa acttgaaaaa gccctgttct
     1441 tcagaaggtg agtgggttga gggaggcagt aatatgaagt gactgctgtg tattttaact
     1501 accagatttt ttatatttgc cactgttaaa tagttggaaa ggggaaattc tgattaagcg
     1561 aaagtggtat catcctaggt aagcttattt cagaacaagt ctaatatttc agattctttc
     1621 ttttcgactt tatactctga gttattactt actgtaagtg gtgtatatga aacctccatg
     1681 cattttccag tatggatctg ctaatatgca cagtaaatcc atgtctttgt ttgtttttct
     1741 attaaaaagc aatcaagaaa gataatgtga aaaagaaagg aatttagagg tagggaaaag
     1801 atgaatgtca gacatttgaa gaactatagt aaaatgataa acactaaata tacttgagaa
     1861 aactttctta atatgccaat gaggtaggcc tgatctttga aatagtgaat aggaatacaa
     1921 tgcatttcct cagtgatcac tgattagaat gagttggtgg gatccttggg aagccaaacg
     1981 gagcggagtt ctggatcatg tcccatccag tccagtgaat ccacgacccg cagacctgtc
     2041 cccccgcaac agcttatacc atggaatgag gacaaggtga tactctgagc tgtggactga
     2101 actggcagac acaacctgta cagattgaaa tttcaccttg taaggaggaa gtgaatgaaa
     2161 taaaggatcc ccctaaggat tttctactgt gtcctgtggt gtttgacttc acagatgcta
     2221 tttgtgacat tattcatata gcataaaaca gtggggttgg atcccatgaa taacattata
     2281 aaggttctgg ggtttttttt catccaatta ctagaatgtt cagaatagac tcatatttac
     2341 taatttaata aatgtatgta cttaatgcc
//
