LOCUS       NM_005133               1462 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens Ras converting CAAX endopeptidase 1 (RCE1), transcript
            variant 1, mRNA.
ACCESSION   NM_005133 XM_001129665
VERSION     NM_005133.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1462)
  AUTHORS   Ma,C., Yang,Y., Xu,L., Tu,W., Chen,F. and Wang,J.
  TITLE     Rce1 suppresses invasion and metastasis of hepatocellular carcinoma
            via epithelial-mesenchymal transition induced by the
            TGF-beta1/H-Ras signaling pathway
  JOURNAL   J Cell Physiol 235 (3), 2506-2520 (2020)
   PUBMED   31506952
  REMARK    GeneRIF: Rce1 suppresses invasion and metastasis of hepatocellular
            carcinoma via epithelial-mesenchymal transition induced by the
            TGF-beta1/H-Ras signaling pathway.
REFERENCE   2  (bases 1 to 1462)
  AUTHORS   Shi,B., Zhou,X., He,L., Liang,M., Luo,Y. and Jiang,P.
  TITLE     Reduced RCE1 expression predicts poor prognosis of colorectal
            carcinoma
  JOURNAL   BMC Cancer 17 (1), 414 (2017)
   PUBMED   28615075
  REMARK    GeneRIF: RCE1 acts as a tumor suppressor in CRC, as its reduced
            expression may increase CRC cell invasion and independently predict
            an unsatisfactory prognosis in CRC patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1462)
  AUTHORS   Li,J., Wang,D., Liu,J., Qin,Y., Huang,L., Zeng,Q., Xiao,M., Hu,J.,
            Yang,Q., He,J., Mai,L., Li,Y. and Liu,W.
  TITLE     Rce1 expression in renal cell carcinoma and its regulatory effect
            on 786-O cell apoptosis through endoplasmic reticulum stress
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 49 (3), 254-261 (2017)
   PUBMED   28159979
  REMARK    GeneRIF: High expression of Rce1 is associated with renal cell
            carcinoma.
REFERENCE   4  (bases 1 to 1462)
  AUTHORS   Huang,L., Li,M., Wang,D., He,J., Wu,W., Zeng,Q., Li,J., Xiao,M.,
            Hu,J., He,Y., Li,Y., Mai,L. and Liu,W.
  TITLE     Overexpressed Rce1 is positively correlated with tumor progression
            and predicts poor prognosis in prostate cancer
  JOURNAL   Hum Pathol 47 (1), 109-114 (2016)
   PUBMED   26546252
  REMARK    GeneRIF: Suggests that expression of Rce1 can serve as an
            independent biomarker for the prognosis of prostate carcinoma
            patients.
REFERENCE   5  (bases 1 to 1462)
  AUTHORS   Jaworski,J., Govender,U., McFarlane,C., de la Vega,M., Greene,M.K.,
            Rawlings,N.D., Johnston,J.A., Scott,C.J. and Burrows,J.F.
  TITLE     A novel RCE1 isoform is required for H-Ras plasma membrane
            localization and is regulated by USP17
  JOURNAL   Biochem J 457 (2), 289-300 (2014)
   PUBMED   24134311
  REMARK    GeneRIF: A novel RCE1 isoform is required for H-Ras plasma membrane
            localization regulated by ubiquitin specific peptidase (USP)17.
REFERENCE   6  (bases 1 to 1462)
  AUTHORS   Maske,C.P., Hollinshead,M.S., Higbee,N.C., Bergo,M.O., Young,S.G.
            and Vaux,D.J.
  TITLE     A carboxyl-terminal interaction of lamin B1 is dependent on the
            CAAX endoprotease Rce1 and carboxymethylation
  JOURNAL   J Cell Biol 162 (7), 1223-1232 (2003)
   PUBMED   14504265
  REMARK    GeneRIF: CAAX endoprotease Rce1 is required for lamin B1
            endoproteolysis
REFERENCE   7  (bases 1 to 1462)
  AUTHORS   Hollander,I.J., Frommer,E., Aulabaugh,A. and Mallon,R.
  TITLE     Human Ras converting enzyme endoproteolytic specificity at the P2'
            and P3' positions of K-Ras-derived peptides
  JOURNAL   Biochim Biophys Acta 1649 (1), 24-29 (2003)
   PUBMED   12818187
  REMARK    GeneRIF: We found that an 8-aa K-Ras-derived 'CAA' peptide,
            KSKTKC(farnesyl)VI, was a better substrate for hRCE1 than a
            KSKTKC(f)VIM 'CAAX' peptide, hRCE1 has important interaction with
            the P2' and P3' substrate positions in addition to the farnesylated
            cysteine
REFERENCE   8  (bases 1 to 1462)
  AUTHORS   Hollander,I., Frommer,E. and Mallon,R.
  TITLE     Human ras-converting enzyme (hRCE1) endoproteolytic activity on
            K-ras-derived peptides
  JOURNAL   Anal Biochem 286 (1), 129-137 (2000)
   PUBMED   11038283
REFERENCE   9  (bases 1 to 1462)
  AUTHORS   Freije,J.M., Blay,P., Pendas,A.M., Cadinanos,J., Crespo,P. and
            Lopez-Otin,C.
  TITLE     Identification and chromosomal location of two human genes encoding
            enzymes potentially involved in proteolytic maturation of
            farnesylated proteins
  JOURNAL   Genomics 58 (3), 270-280 (1999)
   PUBMED   10373325
REFERENCE   10 (bases 1 to 1462)
  AUTHORS   Otto,J.C., Kim,E., Young,S.G. and Casey,P.J.
  TITLE     Cloning and characterization of a mammalian prenyl protein-specific
            protease
  JOURNAL   J Biol Chem 274 (13), 8379-8382 (1999)
   PUBMED   10085068
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF121951.1, BC052622.1 and
            AP000485.5.
            
            On May 17, 2019 this sequence version replaced NM_005133.2.
            
            Summary: This gene encodes an integral membrane protein which is
            classified as a member of the metalloproteinase family.  This
            enzyme is thought to function in the maintenance and processing of
            CAAX-type prenylated proteins. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant represents the longer transcript
            and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.874020.1, Y13835.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309657.8/ ENSP00000309163.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1018              AF121951.1         30-1047
            1019-1442           BC052622.1         1005-1428
            1443-1462           AP000485.5         120259-120278
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1462
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /note="Ras converting CAAX endopeptidase 1"
                     /db_xref="GeneID:9986"
                     /db_xref="HGNC:HGNC:13721"
                     /db_xref="MIM:605385"
     exon            1..200
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1005
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /EC_number="3.4.26.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     farnesylated protein-converting enzyme 2; prenyl
                     protein-specific endoprotease 2; CAAX prenyl protease 2;
                     farnesylated proteins-converting enzyme 2; RCE1 homolog,
                     prenyl protein peptidase"
                     /codon_start=1
                     /product="CAAX prenyl protease 2 isoform 1"
                     /protein_id="NP_005124.1"
                     /db_xref="CCDS:CCDS8151.1"
                     /db_xref="GeneID:9986"
                     /db_xref="HGNC:HGNC:13721"
                     /db_xref="MIM:605385"
                     /translation="MAALGGDGLRLLSVSRPERPPESAALGGLGPGLCCWVSVFSCLS
                     LACSYVGSLYVWKSELPRDHPAVIKRRFTSVLVVSSLSPLCVLLWRELTGIQPGTSLL
                     TLMGFRLEGIFPAALLPLLLTMILFLGPLMQLSMDCPCDLADGLKVVLAPRSWARCLT
                     DMRWLRNQVIAPLTEELVFRACMLPMLAPCMGLGPAVFTCPLFFGVAHFHHIIEQLRF
                     RQSSVGNIFLSAAFQFSYTAVFGAYTAFLFIRTGHLIGPVLCHSFCNYMGFPAVCAAL
                     EHPQRRPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCVLLERAGDSEAPLCS"
     exon            201..303
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            304..387
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            388..466
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            467..634
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            635..706
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            707..769
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1462
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1413..1418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /note="hexamer: ATTAAA"
     polyA_site      1436
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /note="major polyA site"
ORIGIN      
        1 gcgggtcagg gcgcaatggc ggcgctgggc ggggatgggc tgcgactgct gtcggtgtcg
       61 cggccggagc ggccgcccga gtcggcggcg ctgggcggcc tgggccccgg gctgtgctgc
      121 tgggtgtcag tgttctcctg cctcagcctc gcctgctcct acgtgggcag cctctacgtc
      181 tggaagagcg aactgcccag ggaccatccc gcggtcatca agcgacgctt caccagcgtc
      241 ctggtggtgt ccagtctctc acccctgtgc gtgctgctct ggagggaact cacaggcatc
      301 cagccaggca catccctgct caccctgatg ggcttcaggc tggagggcat tttcccagcg
      361 gcgctgctgc ccctgttgct gaccatgatt cttttcctgg gcccactgat gcagctctct
      421 atggattgcc cttgtgacct ggcagatggg ctgaaggttg tcctggcccc ccgctcctgg
      481 gcccgctgcc tcacagacat gcgttggctg cggaaccaag tgatcgcccc gctgacagag
      541 gagctggtgt tccgggcctg tatgctgccc atgttagcac cgtgcatggg cctgggccct
      601 gctgtgttca cctgcccgct cttttttgga gttgcccatt ttcaccatat tattgagcag
      661 ctgcgtttcc gccagagcag cgtggggaac atcttcttgt ctgctgcgtt ccagttctcc
      721 tacacagctg tcttcggtgc ctacactgct ttcctcttca tccgcacagg acacctgatt
      781 gggccggttc tctgccattc cttctgcaat tacatgggtt tcccagctgt ttgcgcggcc
      841 ttggagcacc cacagaggcg gcccctgctg gcaggctatg ccctgggtgt gggactcttc
      901 ctgcttctgc tccagcccct cacggacccc aagctctacg gcagccttcc cctttgtgtg
      961 cttttggagc gggcagggga ctcagaggct cccctgtgct cctgacctat gctcctggat
     1021 acgctatgaa ctctcaccgg ctccccagcc ctccccacca aggggtactg caggggaagg
     1081 gctggctggg gtccccgaga tctcaggaat ttttgtaggg gattgaagcc agagctagtt
     1141 gcgtcccagg gaccaagaga aagaagcaga tatccaaagg gtgcagcccc ttttgaaagg
     1201 ggtgtttacg agcagctgtg agtgagggga caaggggcag gtcccaggag ccacacactc
     1261 ccttcctcac tttggactgc tgcttctctt agctcctctg cctctgaaaa gctgctcggg
     1321 gttttttatt tataaaacct ctccccaccc cccacccccc aacttcctgg gttttctcat
     1381 tgtctttttg catcagtact ttgtattggg atattaaaga gatttaactt gggtaacatg
     1441 gccttgggcc tttgggaatc gg
//
