LOCUS       NM_001032279            1458 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens Ras converting CAAX endopeptidase 1 (RCE1), transcript
            variant 2, mRNA.
ACCESSION   NM_001032279
VERSION     NM_001032279.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1458)
  AUTHORS   Ma,C., Yang,Y., Xu,L., Tu,W., Chen,F. and Wang,J.
  TITLE     Rce1 suppresses invasion and metastasis of hepatocellular carcinoma
            via epithelial-mesenchymal transition induced by the
            TGF-beta1/H-Ras signaling pathway
  JOURNAL   J Cell Physiol 235 (3), 2506-2520 (2020)
   PUBMED   31506952
  REMARK    GeneRIF: Rce1 suppresses invasion and metastasis of hepatocellular
            carcinoma via epithelial-mesenchymal transition induced by the
            TGF-beta1/H-Ras signaling pathway.
REFERENCE   2  (bases 1 to 1458)
  AUTHORS   Shi,B., Zhou,X., He,L., Liang,M., Luo,Y. and Jiang,P.
  TITLE     Reduced RCE1 expression predicts poor prognosis of colorectal
            carcinoma
  JOURNAL   BMC Cancer 17 (1), 414 (2017)
   PUBMED   28615075
  REMARK    GeneRIF: RCE1 acts as a tumor suppressor in CRC, as its reduced
            expression may increase CRC cell invasion and independently predict
            an unsatisfactory prognosis in CRC patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1458)
  AUTHORS   Li,J., Wang,D., Liu,J., Qin,Y., Huang,L., Zeng,Q., Xiao,M., Hu,J.,
            Yang,Q., He,J., Mai,L., Li,Y. and Liu,W.
  TITLE     Rce1 expression in renal cell carcinoma and its regulatory effect
            on 786-O cell apoptosis through endoplasmic reticulum stress
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 49 (3), 254-261 (2017)
   PUBMED   28159979
  REMARK    GeneRIF: High expression of Rce1 is associated with renal cell
            carcinoma.
REFERENCE   4  (bases 1 to 1458)
  AUTHORS   Huang,L., Li,M., Wang,D., He,J., Wu,W., Zeng,Q., Li,J., Xiao,M.,
            Hu,J., He,Y., Li,Y., Mai,L. and Liu,W.
  TITLE     Overexpressed Rce1 is positively correlated with tumor progression
            and predicts poor prognosis in prostate cancer
  JOURNAL   Hum Pathol 47 (1), 109-114 (2016)
   PUBMED   26546252
  REMARK    GeneRIF: Suggests that expression of Rce1 can serve as an
            independent biomarker for the prognosis of prostate carcinoma
            patients.
REFERENCE   5  (bases 1 to 1458)
  AUTHORS   Jaworski,J., Govender,U., McFarlane,C., de la Vega,M., Greene,M.K.,
            Rawlings,N.D., Johnston,J.A., Scott,C.J. and Burrows,J.F.
  TITLE     A novel RCE1 isoform is required for H-Ras plasma membrane
            localization and is regulated by USP17
  JOURNAL   Biochem J 457 (2), 289-300 (2014)
   PUBMED   24134311
  REMARK    GeneRIF: A novel RCE1 isoform is required for H-Ras plasma membrane
            localization regulated by ubiquitin specific peptidase (USP)17.
REFERENCE   6  (bases 1 to 1458)
  AUTHORS   Maske,C.P., Hollinshead,M.S., Higbee,N.C., Bergo,M.O., Young,S.G.
            and Vaux,D.J.
  TITLE     A carboxyl-terminal interaction of lamin B1 is dependent on the
            CAAX endoprotease Rce1 and carboxymethylation
  JOURNAL   J Cell Biol 162 (7), 1223-1232 (2003)
   PUBMED   14504265
  REMARK    GeneRIF: CAAX endoprotease Rce1 is required for lamin B1
            endoproteolysis
REFERENCE   7  (bases 1 to 1458)
  AUTHORS   Hollander,I.J., Frommer,E., Aulabaugh,A. and Mallon,R.
  TITLE     Human Ras converting enzyme endoproteolytic specificity at the P2'
            and P3' positions of K-Ras-derived peptides
  JOURNAL   Biochim Biophys Acta 1649 (1), 24-29 (2003)
   PUBMED   12818187
  REMARK    GeneRIF: We found that an 8-aa K-Ras-derived 'CAA' peptide,
            KSKTKC(farnesyl)VI, was a better substrate for hRCE1 than a
            KSKTKC(f)VIM 'CAAX' peptide, hRCE1 has important interaction with
            the P2' and P3' substrate positions in addition to the farnesylated
            cysteine
REFERENCE   8  (bases 1 to 1458)
  AUTHORS   Hollander,I., Frommer,E. and Mallon,R.
  TITLE     Human ras-converting enzyme (hRCE1) endoproteolytic activity on
            K-ras-derived peptides
  JOURNAL   Anal Biochem 286 (1), 129-137 (2000)
   PUBMED   11038283
REFERENCE   9  (bases 1 to 1458)
  AUTHORS   Freije,J.M., Blay,P., Pendas,A.M., Cadinanos,J., Crespo,P. and
            Lopez-Otin,C.
  TITLE     Identification and chromosomal location of two human genes encoding
            enzymes potentially involved in proteolytic maturation of
            farnesylated proteins
  JOURNAL   Genomics 58 (3), 270-280 (1999)
   PUBMED   10373325
REFERENCE   10 (bases 1 to 1458)
  AUTHORS   Otto,J.C., Kim,E., Young,S.G. and Casey,P.J.
  TITLE     Cloning and characterization of a mammalian prenyl protein-specific
            protease
  JOURNAL   J Biol Chem 274 (13), 8379-8382 (1999)
   PUBMED   10085068
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF121951.1, BC052622.1 and
            AP000485.5.
            
            On May 31, 2019 this sequence version replaced NM_001032279.1.
            
            Summary: This gene encodes an integral membrane protein which is
            classified as a member of the metalloproteinase family.  This
            enzyme is thought to function in the maintenance and processing of
            CAAX-type prenylated proteins. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant uses an alternate splice site in
            the 5' coding region, compared to variant 1. This difference
            results in translation initiation at a downstream ATG and an
            isoform (2) with a shorter N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.763026.1, BC052622.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AF121951.1         30-39
            11-749              BC052622.1         1-739
            750-750             AF121951.1         783-783
            751-1438            BC052622.1         741-1428
            1439-1458           AP000485.5         120259-120278
FEATURES             Location/Qualifiers
     source          1..1458
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1458
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /note="Ras converting CAAX endopeptidase 1"
                     /db_xref="GeneID:9986"
                     /db_xref="HGNC:HGNC:13721"
                     /db_xref="MIM:605385"
     exon            1..200
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            201..303
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            304..383
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1001
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /EC_number="3.4.26.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     farnesylated protein-converting enzyme 2; prenyl
                     protein-specific endoprotease 2; CAAX prenyl protease 2;
                     farnesylated proteins-converting enzyme 2; RCE1 homolog,
                     prenyl protein peptidase"
                     /codon_start=1
                     /product="CAAX prenyl protease 2 isoform 2"
                     /protein_id="NP_001027450.1"
                     /db_xref="GeneID:9986"
                     /db_xref="HGNC:HGNC:13721"
                     /db_xref="MIM:605385"
                     /translation="MGFRLEGIFPAALLPLLLTMILFLGPLMQLSMDCPCDLADGLKV
                     VLAPRSWARCLTDMRWLRNQVIAPLTEELVFRACMLPMLAPCMGLGPAVFTCPLFFGV
                     AHFHHIIEQLRFRQSSVGNIFLSAAFQFSYTAVFGAYTAFLFIRTGHLIGPVLCHSFC
                     NYMGFPAVCAALEHPQRRPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCVLLERAGD
                     SEAPLCS"
     exon            384..462
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            463..630
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            631..702
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            703..765
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            766..1458
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1409..1414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /note="hexamer: ATTAAA"
     polyA_site      1432
                     /gene="RCE1"
                     /gene_synonym="FACE2; RCE1A; RCE1B"
                     /note="major polyA site"
ORIGIN      
        1 gcgggtcagg gcgcaatggc ggcgctgggc ggggatgggc tgcgactgct gtcggtgtcg
       61 cggccggagc ggccgcccga gtcggcggcg ctgggcggcc tgggccccgg gctgtgctgc
      121 tgggtgtcag tgttctcctg cctcagcctc gcctgctcct acgtgggcag cctctacgtc
      181 tggaagagcg aactgcccag ggaccatccc gcggtcatca agcgacgctt caccagcgtc
      241 ctggtggtgt ccagtctctc acccctgtgc gtgctgctct ggagggaact cacaggcatc
      301 caggcacatc cctgctcacc ctgatgggct tcaggctgga gggcattttc ccagcggcgc
      361 tgctgcccct gttgctgacc atgattcttt tcctgggccc actgatgcag ctctctatgg
      421 attgcccttg tgacctggca gatgggctga aggttgtcct ggccccccgc tcctgggccc
      481 gctgcctcac agacatgcgt tggctgcgga accaagtgat cgccccgctg acagaggagc
      541 tggtgttccg ggcctgtatg ctgcccatgt tagcaccgtg catgggcctg ggccctgctg
      601 tgttcacctg cccgctcttt tttggagttg cccattttca ccatattatt gagcagctgc
      661 gtttccgcca gagcagcgtg gggaacatct tcttgtctgc tgcgttccag ttctcctaca
      721 cagctgtctt cggtgcctac actgctttcc tcttcatccg cacaggacac ctgattgggc
      781 cggttctctg ccattccttc tgcaattaca tgggtttccc agctgtttgc gcggccttgg
      841 agcacccaca gaggcggccc ctgctggcag gctatgccct gggtgtggga ctcttcctgc
      901 ttctgctcca gcccctcacg gaccccaagc tctacggcag ccttcccctt tgtgtgcttt
      961 tggagcgggc aggggactca gaggctcccc tgtgctcctg acctatgctc ctggatacgc
     1021 tatgaactct caccggctcc ccagccctcc ccaccaaggg gtactgcagg ggaagggctg
     1081 gctggggtcc ccgagatctc aggaattttt gtaggggatt gaagccagag ctagttgcgt
     1141 cccagggacc aagagaaaga agcagatatc caaagggtgc agcccctttt gaaaggggtg
     1201 tttacgagca gctgtgagtg aggggacaag gggcaggtcc caggagccac acactccctt
     1261 cctcactttg gactgctgct tctcttagct cctctgcctc tgaaaagctg ctcggggttt
     1321 tttatttata aaacctctcc ccacccccca ccccccaact tcctgggttt tctcattgtc
     1381 tttttgcatc agtactttgt attgggatat taaagagatt taacttgggt aacatggcct
     1441 tgggcctttg ggaatcgg
//
