LOCUS       NM_001017919            2675 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens RCC1 domain containing 1 (RCCD1), transcript variant
            2, mRNA.
ACCESSION   NM_001017919 XM_370908
VERSION     NM_001017919.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2675)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2675)
  AUTHORS   Cheng,Z., Hou,S., Wu,Y., Wang,X., Sun,Y., Liu,B. and Yuan,M.
  TITLE     LINC01419 promotes cell proliferation and metastasis in lung
            adenocarcinoma via sponging miR-519b-3p to up-regulate RCCD1
  JOURNAL   Biochem Biophys Res Commun 520 (1), 107-114 (2019)
   PUBMED   31582214
  REMARK    GeneRIF: miR-519b-3p binds to LINC01419 and has a role in
            upregulating RCCD1 in lung adenocarcinoma cells
REFERENCE   3  (bases 1 to 2675)
  AUTHORS   Wilkins,S.E., Islam,M.S., Gannon,J.M., Markolovic,S.,
            Hopkinson,R.J., Ge,W., Schofield,C.J. and Chowdhury,R.
  TITLE     JMJD5 is a human arginyl C-3 hydroxylase
  JOURNAL   Nat Commun 9 (1), 1180 (2018)
   PUBMED   29563586
  REMARK    GeneRIF: JMJD5 catalyzes stereoselective C-3 hydroxylation of
            arginine residues in sequences from human RCCD1 and ribosomal
            protein S6.
            Erratum:[Nat Commun. 2018 Apr 23;9(1):1675. doi:
            10.1038/s41467-018-04196-7.. PMID: 29686330]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2675)
  AUTHORS   Wu,J., He,Z., Yang,X.M., Li,K.L., Wang,D.L. and Sun,F.L.
  TITLE     RCCD1 depletion attenuates TGF-beta-induced EMT and cell migration
            by stabilizing cytoskeletal microtubules in NSCLC cells
  JOURNAL   Cancer Lett 400, 18-29 (2017)
   PUBMED   28455245
  REMARK    GeneRIF: RCCD1 as a novel regulator of TGF-beta-induced epithelial
            mesenchymal transformation and cell migration in non-small lung
            carcinoma cells.
REFERENCE   5  (bases 1 to 2675)
  AUTHORS   Hoffman,J.D., Graff,R.E., Emami,N.C., Tai,C.G., Passarelli,M.N.,
            Hu,D., Huntsman,S., Hadley,D., Leong,L., Majumdar,A., Zaitlen,N.,
            Ziv,E. and Witte,J.S.
  TITLE     Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes
            associated with breast cancer risk
  JOURNAL   PLoS Genet 13 (3), e1006690 (2017)
   PUBMED   28362817
  REMARK    GeneRIF: Expression of RCCD1 in whole blood was also suggestively
            associated with disease risk (p-value: 1.2x10-05), as were
            expression of ACAP1 (p-value: 1.9x10-05) and LRRC25 (p-value:
            5.2x10-05). While genome-wide association studies (GWAS) have
            implicated RCCD1 and ANKLE1 in breast cancer risk, they have not
            identified the remaining three genes
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2675)
  AUTHORS   Cai,Q., Zhang,B., Sung,H., Low,S.K., Kweon,S.S., Lu,W., Shi,J.,
            Long,J., Wen,W., Choi,J.Y., Noh,D.Y., Shen,C.Y., Matsuo,K.,
            Teo,S.H., Kim,M.K., Khoo,U.S., Iwasaki,M., Hartman,M.,
            Takahashi,A., Ashikawa,K., Matsuda,K., Shin,M.H., Park,M.H.,
            Zheng,Y., Xiang,Y.B., Ji,B.T., Park,S.K., Wu,P.E., Hsiung,C.N.,
            Ito,H., Kasuga,Y., Kang,P., Mariapun,S., Ahn,S.H., Kang,H.S.,
            Chan,K.Y., Man,E.P., Iwata,H., Tsugane,S., Miao,H., Liao,J.,
            Nakamura,Y., Kubo,M., Delahanty,R.J., Zhang,Y., Li,B., Li,C.,
            Gao,Y.T., Shu,X.O., Kang,D. and Zheng,W.
  CONSRTM   DRIVE GAME-ON Consortium
  TITLE     Genome-wide association analysis in East Asians identifies breast
            cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1
  JOURNAL   Nat Genet 46 (8), 886-890 (2014)
   PUBMED   25038754
REFERENCE   7  (bases 1 to 2675)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
  REMARK    GeneRIF: RCCD1 and KDM8 form a histone demethylase complex.
REFERENCE   8  (bases 1 to 2675)
  AUTHORS   Zody,M.C., Garber,M., Sharpe,T., Young,S.K., Rowen,L., O'Neill,K.,
            Whittaker,C.A., Kamal,M., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Kodira,C.D., Madan,A., Qin,S., Yang,X., Abbasi,N.,
            Abouelleil,A., Arachchi,H.M., Baradarani,L., Birditt,B., Bloom,S.,
            Bloom,T., Borowsky,M.L., Burke,J., Butler,J., Cook,A.,
            DeArellano,K., DeCaprio,D., Dorris,L. 3rd, Dors,M., Eichler,E.E.,
            Engels,R., Fahey,J., Fleetwood,P., Friedman,C., Gearin,G.,
            Hall,J.L., Hensley,G., Johnson,E., Jones,C., Kamat,A., Kaur,A.,
            Locke,D.P., Madan,A., Munson,G., Jaffe,D.B., Lui,A., Macdonald,P.,
            Mauceli,E., Naylor,J.W., Nesbitt,R., Nicol,R., O'Leary,S.B.,
            Ratcliffe,A., Rounsley,S., She,X., Sneddon,K.M., Stewart,S.,
            Sougnez,C., Stone,S.M., Topham,K., Vincent,D., Wang,S.,
            Zimmer,A.R., Birren,B.W., Hood,L., Lander,E.S. and Nusbaum,C.
  TITLE     Analysis of the DNA sequence and duplication history of human
            chromosome 15
  JOURNAL   Nature 440 (7084), 671-675 (2006)
   PUBMED   16572171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ924078.1, BU850147.1, BC008845.2, AL527085.3 and AA564459.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001017919.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140709.1, SRR11853559.11655.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394258.7/ ENSP00000377801.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               BQ924078.1         9-234
            227-829             BU850147.1         35-637
            830-1892            BC008845.2         1048-2110
            1893-2501           AL527085.3         260-868
            2502-2675           AA564459.1         8-181               c
FEATURES             Location/Qualifiers
     source          1..2675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..2675
                     /gene="RCCD1"
                     /note="RCC1 domain containing 1"
                     /db_xref="GeneID:91433"
                     /db_xref="HGNC:HGNC:30457"
                     /db_xref="MIM:617997"
     exon            1..65
                     /gene="RCCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            66..354
                     /gene="RCCD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1319
                     /gene="RCCD1"
                     /codon_start=1
                     /product="RCC1 domain-containing protein 1"
                     /protein_id="NP_001017919.1"
                     /db_xref="CCDS:CCDS32333.1"
                     /db_xref="GeneID:91433"
                     /db_xref="HGNC:HGNC:30457"
                     /db_xref="MIM:617997"
                     /translation="MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRV
                     SASWSYTAFVTRGGRLELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAE
                     SALRGEPLWAQNVVPEAEGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRA
                     RQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAG
                     GWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGA
                     EDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH
                     EDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGKS"
     exon            355..745
                     /gene="RCCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..867
                     /gene="RCCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..966
                     /gene="RCCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1137
                     /gene="RCCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1167
                     /gene="RCCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..2675
                     /gene="RCCD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1755..1760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCCD1"
                     /note="hexamer: GATAAA"
     polyA_site      1774
                     /gene="RCCD1"
                     /note="major polyA site"
     regulatory      1872..1877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCCD1"
                     /note="hexamer: AATAAT"
     polyA_site      1897
                     /gene="RCCD1"
     regulatory      2649..2654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCCD1"
                     /note="hexamer: AACAAA"
     polyA_site      2675
                     /gene="RCCD1"
ORIGIN      
        1 gcttcctgtt ggggcatgag tccggcgcgt gtcgggtttt gagctgccgc ggtcccggga
       61 ctgagataag gcagctccag cccctggaag gccagagact tgccagtgtc ccactagcgg
      121 gctcttcgca agaatccccc cgggcccgcc gcagccaggc ggcggccggc agagggcgct
      181 gctcgggcat ggcggaggag cggccggggg cctggttcgg cttcggtttc tgcggcttcg
      241 ggcaggagct gggctccgga cgcgggcgcc aggtgcacag ccccagtccg ctgcgggcgg
      301 gcgtcgacat ctgccgcgtg agcgcgagct ggagctacac cgctttcgtg acccgtggag
      361 gccgcttgga gctgtcgggc tcagccagcg gcgcggcggg ccgctgcaag gacgcgtggg
      421 cctcggaggg gctcctcgcg gtgctgcgcg ccgggccggg gccggaggcg ttactgcagg
      481 tctgggcggc cgaatcggcg ctgcgtgggg agccattgtg ggcccagaat gtggtgcccg
      541 aggccgaagg ggaagacgat ccggccggtg aggcccaggc tgggaggcta cccctgctgc
      601 cctgcgcccg tgcctacgtg agcccgcggg cgcccttcta ccggcctctg gctccggagc
      661 tgcgggcacg ccagctggag ctgggcgccg agcacgcgtt gctgctggac gctgctggcc
      721 aggtgttctc ctggggcggg ggcaggcatg gacagctggg ccatgggacc ctggaggcag
      781 agctggagcc acggctgttg gaggcgttgc agggcctagt catggctgag gtggccgcgg
      841 ggggctggca ttctgtgtgt gtgagtgaga ctggggatat ttatatctgg ggctggaatg
      901 aatcagggca gctggccctg cccaccagga acctggcaga ggatggagag actgtcgcaa
      961 gggaagccac agaactgaat gaagatggtt ctcaggtgaa gagaacgggt ggggctgagg
     1021 atggagcccc tgcccccttc atagctgtcc agcccttccc ggcattactg gatctcccca
     1081 tgggctcaga tgcagtcaag gccagctgtg gatcccggca cacagctgtg gtgacacgaa
     1141 caggggagct ctacacctgg ggctggggta aatatggaca gctgggccac gaggacacca
     1201 ccagcttgga tcggcctcgc cgtgtggaat actttgtaga taagcaactc caagtaaagg
     1261 ctgtcacctg tgggccgtgg aacacctacg tgtatgctgt ggagaaaggg aagagctgac
     1321 atgtgtacgt atatgtatat gcaacacctg tgagaccccc attcaggtca aggaaaacca
     1381 ttgcctgcac cccaagggcc ccatatttgc ccctccccat cacagtcctg cccttcaccc
     1441 tcaagcacgg tcctaaactt gtctgcactt tagaaacacc tggagagcat tgaaaactct
     1501 gctgcctaag gtcagcatca atcaaaacaa tgaaatcaat gaaacaatga aaccagagct
     1561 tctaggtgtg tggcctggat agtggtagat tcaaagctcc acccacctca tcccaggtac
     1621 atttgatgtg cagctgagat tggggcacat tccaggtcat cgtcttctgt cagtcatttc
     1681 cctgctttcg tttgaatttt accattcttg tatgcagcct tatacgacat agttgtgttt
     1741 gcttttgagt gttagataaa tggaatcctg tgtatgtgct tttgtgtcgt ttttgtcact
     1801 cagcattgta taatccatcc ttgttgggtc ctggagttca tttttaatgc tatatggtgt
     1861 tctgttgtat gaataatacc tcaagtgata cagccttgtt gatggtcatt tttattgttt
     1921 ctgattttgg tcattccaca taattctttg tgcagtcttc tgcacatgtg cacaagttcc
     1981 tttgcagaac attgagttga attgctaagt caggagatac ctttaatttt actagataac
     2041 tgttgccccc agcagggtgg ggtctactgt ggctaaaatg tcaggtagat gcacactggt
     2101 tttaattggc atttccctgg atactgatga ggttgagtag cttttcattt gttttggatg
     2161 gctgggcatg gtggctcaca cctgtagtcc cagcactttg ggaggctaag cagggagatt
     2221 gcttgaggcg aagagttcat atgtttattg gccacttgga gtttttctgt tgtcaagtgc
     2281 ctgttcaagt tttctggcct tttaaaatgt tctgtatttt ccttagtgat ttttcttttg
     2341 gatatttcag atacaagtct tttgagagtt agtattcaga gtatcttctg ctacaatgta
     2401 gtttgtttca gtctctcttg gtattaccaa ttttaatact taggtgatgc ttactccatg
     2461 ccaggtaagg ctcaaagtgc tttacaagta tcaacttatt ttgataaaat aagcttatca
     2521 gtagttttct ttatagttaa attctatttg tgcatgtgtg tgtctgtggt ttagcaaatg
     2581 tttcccaccc atggggtctt ttttattgtg gtaaaatata ctgaacataa aatttatgtt
     2641 caataaaaaa caaaaattgt ttttaaccat tttaa
//
