LOCUS       NM_018715               4040 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens regulator of chromosome condensation 2 (RCC2),
            transcript variant 1, mRNA.
ACCESSION   NM_018715
VERSION     NM_018715.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4040)
  AUTHORS   Xu,X., Huang,Y., Yang,F., Sun,X., Lin,R., Feng,J., Yang,M.,
            Shao,J., Liu,X., Zhou,T., Xie,S. and Yang,Y.
  TITLE     NudCL2 is required for cytokinesis by stabilizing RCC2 with Hsp90
            at the midbody
  JOURNAL   Protein Cell 15 (10), 766-782 (2024)
   PUBMED   38801297
  REMARK    GeneRIF: NudCL2 is required for cytokinesis by stabilizing RCC2
            with Hsp90 at the midbody.
REFERENCE   2  (bases 1 to 4040)
  AUTHORS   Wang,S., Lei,Z., Liu,W., Xiong,J., Shi,Y., Yang,L., Gao,Q., Le,K.
            and Zhang,B.
  TITLE     RCC2 promotes prostate cancer cell proliferation and migration
            through Hh/GLI1 signaling pathway and cancer stem-like cells
  JOURNAL   Biol Direct 18 (1), 80 (2023)
   PUBMED   38008751
  REMARK    GeneRIF: RCC2 promotes prostate cancer cell proliferation and
            migration through Hh/GLI1 signaling pathway and cancer stem-like
            cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4040)
  AUTHORS   Buranjiang,G., Abuduwanke,A., Li,X. and Abulizi,G.
  TITLE     LncRNA HOTAIR enhances RCC2 to accelerate cervical cancer
            progression by sponging miR-331-3p
  JOURNAL   Clin Transl Oncol 25 (6), 1650-1660 (2023)
   PUBMED   36593385
  REMARK    GeneRIF: LncRNA HOTAIR enhances RCC2 to accelerate cervical cancer
            progression by sponging miR-331-3p.
REFERENCE   4  (bases 1 to 4040)
  AUTHORS   Liu,T., Wang,Y., Wang,Y., Cheung,S.K., Or,P.M., Wong,C.W., Guan,J.,
            Li,Z., Yang,W., Tu,Y., Wang,J., Ho,W.L., Gu,H., Cheng,A.S.,
            Tsui,S.K. and Chan,A.M.
  TITLE     The mitotic regulator RCC2 promotes glucose metabolism through
            BACH1-dependent transcriptional upregulation of hexokinase II in
            glioma
  JOURNAL   Cancer Lett 549, 215914 (2022)
   PUBMED   36116740
  REMARK    GeneRIF: The mitotic regulator RCC2 promotes glucose metabolism
            through BACH1-dependent transcriptional upregulation of hexokinase
            II in glioma.
REFERENCE   5  (bases 1 to 4040)
  AUTHORS   Yu,H., Zhang,S., Ibrahim,A.N., Wang,J., Deng,Z. and Wang,M.
  TITLE     RCC2 promotes proliferation and radio-resistance in glioblastoma
            via activating transcription of DNMT1
  JOURNAL   Biochem Biophys Res Commun 516 (3), 999-1006 (2019)
   PUBMED   31277942
  REMARK    GeneRIF: RCC2 promotes proliferation and radio-resistance in
            glioblastoma via activating transcription of DNMT1.
REFERENCE   6  (bases 1 to 4040)
  AUTHORS   Grigera,P.R., Ma,L., Borgman,C.A., Pinto,A.F., Sherman,N.E.,
            Parsons,J.T. and Fox,J.W.
  TITLE     Mass spectrometric analysis identifies a cortactin-RCC2/TD60
            interaction in mitotic cells
  JOURNAL   J Proteomics 75 (7), 2153-2159 (2012)
   PUBMED   22282019
  REMARK    GeneRIF: a complex containing cortactin and RCC2/TD60 complex that
            may play a functional role in cells undergoing mitosis.
REFERENCE   7  (bases 1 to 4040)
  AUTHORS   Zhou,F., Cardoza,J.D., Ficarro,S.B., Adelmant,G.O., Lazaro,J.B. and
            Marto,J.A.
  TITLE     Online nanoflow RP-RP-MS reveals dynamics of multicomponent Ku
            complex in response to DNA damage
  JOURNAL   J Proteome Res 9 (12), 6242-6255 (2010)
   PUBMED   20873769
  REMARK    GeneRIF: Studies indicated that DDX21, HNRNPC, and RCC2 were
            isolated from Ku86 multicomponent complex in response to DNA
            damage.
REFERENCE   8  (bases 1 to 4040)
  AUTHORS   Humphries,J.D., Byron,A., Bass,M.D., Craig,S.E., Pinney,J.W.,
            Knight,D. and Humphries,M.J.
  TITLE     Proteomic analysis of integrin-associated complexes identifies RCC2
            as a dual regulator of Rac1 and Arf6
  JOURNAL   Sci Signal 2 (87), ra51 (2009)
   PUBMED   19738201
  REMARK    GeneRIF: Dysregulation of Rac1 and Arf6 function by RCC2 knockdown
            also abolished persistent migration along fibronectin fibers,
            indicating a functional role for RCC2 in directional cell movement.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4040)
  AUTHORS   Mollinari,C., Reynaud,C., Martineau-Thuillier,S., Monier,S.,
            Kieffer,S., Garin,J., Andreassen,P.R., Boulet,A., Goud,B.,
            Kleman,J.P. and Margolis,R.L.
  TITLE     The mammalian passenger protein TD-60 is an RCC1 family member with
            an essential role in prometaphase to metaphase progression
  JOURNAL   Dev Cell 5 (2), 295-307 (2003)
   PUBMED   12919680
  REMARK    GeneRIF: Data show that TD-60 is a member of the RCC1 family and
            that it binds preferentially the nucleotide-free form of the small
            G protein Rac1.
REFERENCE   10 (bases 1 to 4040)
  AUTHORS   Martineau-Thuillier,S., Andreassen,P.R. and Margolis,R.L.
  TITLE     Colocalization of TD-60 and INCENP throughout G2 and mitosis:
            evidence for their possible interaction in signalling cytokinesis
  JOURNAL   Chromosoma 107 (6-7), 461-470 (1998)
   PUBMED   9914378
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB040903.1, BC004933.1 and
            BQ774471.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018715.3.
            
            Summary: The protein encoded by this gene is a guanine exchange
            factor that is active on RalA, a small GTPase. The encoded protein
            and RalA are both essential for proper kinetochore-microtubule
            function in early mitosis. This protein has been shown to be a
            biomarker for colorectal cancer. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040903.1, AJ421269.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375436.9/ ENSP00000364585.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1436              AB040903.1         9-1444
            1437-3141           BC004933.1         785-2489
            3142-3731           AB040903.1         3153-3742
            3732-4040           BQ774471.1         23-331              c
FEATURES             Location/Qualifiers
     source          1..4040
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..4040
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /note="regulator of chromosome condensation 2"
                     /db_xref="GeneID:55920"
                     /db_xref="HGNC:HGNC:30297"
                     /db_xref="MIM:609587"
     exon            1..133
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     exon            134..426
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1710
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /note="RCC1-like protein TD-60; telophase disk protein of
                     60 kDa; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="protein RCC2"
                     /protein_id="NP_061185.1"
                     /db_xref="CCDS:CCDS181.1"
                     /db_xref="GeneID:55920"
                     /db_xref="HGNC:HGNC:30297"
                     /db_xref="MIM:609587"
                     /translation="MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSS
                     SSGGGSSGDEDGLELDGAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKC
                     KGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAA
                     HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALT
                     ETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLY
                     SFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRD
                     VACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAG
                     YTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADEST
                     ISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEK
                     EKIKKLPEYNPRTL"
     exon            427..520
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     exon            521..664
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     exon            665..796
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     exon            797..885
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1000
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1167
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1348
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1454
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1527
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1605
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..4040
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4015..4020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /note="hexamer: AATAAA"
     polyA_site      4040
                     /gene="RCC2"
                     /gene_synonym="TD-60"
                     /note="major polyA site"
ORIGIN      
        1 gtatttacat tttaagtgta tctggtgagt gggctggagc cctcgtctgg gccggaaaaa
       61 aaaaagccct ccgatccgtc ttttagttgc ttctcttcct tttttctctc cggtttctca
      121 tcactccaac cagccgcgac catgcccagg aagaaggcgg cggcggcggc ctgggaggag
      181 ccgagctcgg gcaacggcac tgcccgcgcc gggcccagga aacgcggcgg cccggcgggc
      241 aggaagcgcg agcggcccga gcgctgcagt agcagcagcg gcggcggcag cagcggcgac
      301 gaggacggcc tggagctcga cggggccccc ggcgggggca agcgcgcggc gcggccggcg
      361 acagcaggca aggcgggcgg cgcggccgtg gtcatcaccg aacccgagca caccaaggag
      421 cgcgtcaaac ttgaagggtc aaagtgcaaa gggcagcttt tgatttttgg ggcaaccaac
      481 tgggacttga ttggtcgaaa agaagtgcct aaacagcaag ctgcttaccg caatctcggt
      541 cagaatttgt gggggcccca cagatatggg tgcctggcgg gggtccgggt gcggacagtg
      601 gtctcgggct cgtgtgctgc acacagcctc ctcatcacca cggaagggaa gctgtggagc
      661 tggggtcgaa atgagaaggg gcagctggga catggtgaca ccaagagagt agaagcccct
      721 agactcatcg agggtcttag ccacgaagtg attgtgtctg cagcatgtgg gcggaaccac
      781 accttggcct tgacggaaac gggctccgtg tttgcgtttg gggaaaacaa gatggggcag
      841 ctgggccttg gcaaccagac agacgctgtt cccagccccg cgcagataat gtacaacggc
      901 cagccaatta ccaaaatggc ctgtggggct gaattcagta tgataatgga ctgcaaagga
      961 aacctctatt cctttgggtg ccctgaatat ggtcagctgg gacacaactc agatgggaag
     1021 ttcatcgccc gggcacagcg gatagagtac gactgtgaac tagttccccg gcgagtggcc
     1081 atcttcattg agaagacgaa agatggacag attctgcctg taccaaacgt ggttgtacga
     1141 gacgtggcct gtggcgctaa ccacacgctg gtcctggact cccagaagcg agtcttctcc
     1201 tggggctttg gtggctatgg ccggctgggc cacgcagagc agaaggatga gatggtcccc
     1261 cgcctggtga agctgtttga cttccctggg cgtggggctt cccagatcta tgctggttac
     1321 acctgctcct ttgctgtcag tgaagtgggt ggtctgtttt tctggggggc caccaacacc
     1381 tcccgtgaat ctaccatgta cccaaaagca gtgcaggacc tctgcggctg gagaatccgg
     1441 agcctggctt gtgggaagag cagcatcatt gtggccgccg atgagagcac catcagctgg
     1501 ggtccgtcac cgacctttgg ggaactgggc tacggggacc acaagcccaa gtcttccact
     1561 gcagcccagg aggtaaagac tctggatggc attttctcag agcaggtcgc catgggctac
     1621 tcacactcct tggtgatagc aagagatgaa agtgagactg agaaagagaa gatcaagaaa
     1681 ctgccagaat acaacccccg aaccctctga tgctcccgga gactcctccg actccacacc
     1741 tctcgcggca gctgtcattt ccatgtgcac tgggacggga agtcaaacga ggaatttaaa
     1801 aaagcaaaag ttgaccgaag gtgcattttt gtttagactc cctgaggttc cgttttacac
     1861 atgatccaac gttaactacc tttttttctg tatgctttcc aaagtccttt tttttccctt
     1921 aatgttgaat taaaatactt gctcatagtt gatttaccat tcctacaaaa gaggcagaaa
     1981 ctttgagcaa tctaggtttt tttttttttt aagttttttc tttcttcctc tcctgaatac
     2041 actccccaaa acaccccttt ccagttacaa ttagcatcgt gatccaagca gatgccacat
     2101 ggaagaggaa tcgccattta ctcagaaaaa atgtccctta caggaaccgg cagcagctag
     2161 gcagtcaccg gcccgcctcc atccaaaatc acgctcgcgt gcttcggaag catccgggtc
     2221 actccttctc cgctttttct tgcagatggg cctaggccgg tgtcggttct gtttctcccc
     2281 ttggctgcct gtacgcccac agccttctgg ctgcgacatt atagaatcgg ccgtgtcccc
     2341 cctggtgggg gattggggat ctgtgtttag ccatttatat ctactttagc tgttaaagag
     2401 gtccaaatga aaatcaggtg attgtggaac catggggact tgggggtggg gcagaggtgg
     2461 gaacatttgt atcagttgag tcagcttggt ggctccctgt ggagccaggg ctgagccttg
     2521 tcacgcgcac tcgccaatta agagatggac cagccagcag tcaagtgcat tctccagtcc
     2581 ttgcaagaag gatcagccct ttctgtgcca gcctcgatcg ccttgtgctt tggtctcttt
     2641 ttctcccccc cgcctggatc ctgcctcgcg cgggccgtcc tgttgctgag actcggggta
     2701 ccgttctgct gacccagctc cctttagtca cgtttgcttg gctctggtac caaatagttg
     2761 ggattaccga agagtcccct tccttgcgtg tcagcacgga tgctgtgact gccacctgcg
     2821 tcctcgtcaa gtgcccgagc tcgccgccgt gtgtgctgcg ctgagtgagt tatgaggtgc
     2881 ctttcccgga accctcctct cgcctggacc caagagaggc gacagctgtg gctggggctc
     2941 ttggtttcca gagggtctgg actggtttgg gtgctttaaa atagatattt agttcagtgg
     3001 tgcttatggg ggagatggga ctagaactta agtgtgagac ttgggtggat gggaaagtta
     3061 aatattggtc tcttcaagtt ttttttttct tttgctttgt taccacttgt cactgtctcc
     3121 atgttaaaat gccaaaaatg atgtagttgt tgttgctttt ttccctattt tccaccccag
     3181 tcgctcctta ccgtgactcc tgcccttgga gggcatgtag cagtgtctgt cctgccagtc
     3241 ccaaggccct gtgggaggag actggcctgc atctctctaa gacttagtct gacgccacgc
     3301 gcatctcttg ttctgtgttc aatcagtagt ccaggggaga agcttctgct acttcagagc
     3361 tttgctaaac taacctaatt tgtccaaatc accccaaaac caccatctct gacgtaagct
     3421 tccatgcgac agcctgatcc gtttccctgg acaggtctct ttcctggaat gcagcccagg
     3481 cacctgtgct cctggcaccc ttgaggtctc tcctttgagc cgtggtcacc gagagggttg
     3541 aggacgcagc acccgaggtc ccagcctttg caggagcctc cctgggctta gctggactta
     3601 gatcttcggt ggcctcatgt aaacgtggca gccagcctct tctagaaccc tagcccaggg
     3661 actggagcag gaaagggacc ttcaaagtga agactgcctt gtcccgcagc tccttctggc
     3721 ttagattgaa aaatgggctt cctaatgggt taaatccttt aaaacaagga gttgtggggg
     3781 aagggtgtcg tgcactccta gagaaaggta cacagttgcc cggttgggaa tgtgcttggc
     3841 gctgaccctg cgggcatctg actggtcttc cagctcagga aaaagaattt gaaagaggct
     3901 tagcgtgaag gggaatcaaa gaggaggttg tgatttggtc gaaggtgcct ggtttagtgc
     3961 tgtaattgtc ttattatttt ttttatatat atatttcttg gagtaaacat tttaaataaa
     4021 caacaacatt gtctactgtc
//
