LOCUS       NM_001381865            2551 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of chromosome condensation 1 (RCC1),
            transcript variant 5, mRNA.
ACCESSION   NM_001381865 NR_030725
VERSION     NM_001381865.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2551)
  AUTHORS   Zhuang,M., Li,F., Liang,H., Su,Y., Cheng,L., Lin,B., Zhou,J.,
            Deng,R., Chen,L., Lyu,P. and Lu,Z.
  TITLE     Targeting RCC1 to block the human soft-tissue sarcoma by disrupting
            nucleo-cytoplasmic trafficking of Skp2
  JOURNAL   Cell Death Dis 15 (4), 241 (2024)
   PUBMED   38561375
  REMARK    GeneRIF: Targeting RCC1 to block the human soft-tissue sarcoma by
            disrupting nucleo-cytoplasmic trafficking of Skp2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2551)
  AUTHORS   Xu,Z., Wu,Y., Zhao,G., Jin,B. and Jiang,P.
  TITLE     A novel DNA methylation signature revealed GDF6 and RCC1 as
            potential prognostic biomarkers correlated with cell proliferation
            in clear cell renal cell carcinoma
  JOURNAL   Mol Biol Rep 51 (1), 16 (2023)
   PUBMED   38087057
  REMARK    GeneRIF: A novel DNA methylation signature revealed GDF6 and RCC1
            as potential prognostic biomarkers correlated with cell
            proliferation in clear cell renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2551)
  AUTHORS   Wu,Y., Xu,Z., Chen,X., Fu,G., Tian,J. and Jin,B.
  TITLE     RCC1 functions as a tumor facilitator in clear cell renal cell
            carcinoma by dysregulating cell cycle, apoptosis, and EZH2
            stability
  JOURNAL   Cancer Med 12 (19), 19889-19903 (2023)
   PUBMED   37747077
  REMARK    GeneRIF: RCC1 functions as a tumor facilitator in clear cell renal
            cell carcinoma by dysregulating cell cycle, apoptosis, and EZH2
            stability.
REFERENCE   4  (bases 1 to 2551)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2551)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 2551)
  AUTHORS   Hood,F.E. and Clarke,P.R.
  TITLE     RCC1 isoforms differ in their affinity for chromatin, molecular
            interactions and regulation by phosphorylation
  JOURNAL   J Cell Sci 120 (Pt 19), 3436-3445 (2007)
   PUBMED   17855385
  REMARK    GeneRIF: These results show that human RCC1 isoforms have distinct
            chromatin binding properties, different molecular interactions, and
            are selectively regulated by phosphorylation, as determined by
            their different NTRs.
REFERENCE   7  (bases 1 to 2551)
  AUTHORS   Bischoff,F.R. and Ponstingl,H.
  TITLE     Mitotic regulator protein RCC1 is complexed with a nuclear
            ras-related polypeptide
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10830-10834 (1991)
   PUBMED   1961752
REFERENCE   8  (bases 1 to 2551)
  AUTHORS   Bischoff,F.R. and Ponstingl,H.
  TITLE     Catalysis of guanine nucleotide exchange on Ran by the mitotic
            regulator RCC1
  JOURNAL   Nature 354 (6348), 80-82 (1991)
   PUBMED   1944575
REFERENCE   9  (bases 1 to 2551)
  AUTHORS   Furuno,N., Nakagawa,K., Eguchi,U., Ohtsubo,M., Nishimoto,T. and
            Soeda,E.
  TITLE     Complete nucleotide sequence of the human RCC1 gene involved in
            coupling between DNA replication and mitosis
  JOURNAL   Genomics 11 (2), 459-461 (1991)
   PUBMED   1769659
  REMARK    Erratum:[Genomics 1992 Jan;12(1):181. Ohtubo M [corrected to
            Ohtsubo M]]
REFERENCE   10 (bases 1 to 2551)
  AUTHORS   Bischoff,F.R., Maier,G., Tilz,G. and Ponstingl,H.
  TITLE     A 47-kDa human nuclear protein recognized by antikinetochore
            autoimmune sera is homologous with the protein encoded by RCC1, a
            gene implicated in onset of chromosome condensation
  JOURNAL   Proc Natl Acad Sci U S A 87 (21), 8617-8621 (1990)
   PUBMED   2236072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513497.21.
            
            On May 20, 2020 this sequence version replaced NM_001381865.1.
            
            Transcript Variant: This variant (5), as well as variants 3, 4, and
            6, encodes isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4529907.1,
                                           SRR14038197.1580446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683442.1/ ENSP00000508074.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL513497.21        5539-5580
            43-75               AL513497.21        7624-7656
            76-151              AL513497.21        8326-8401
            152-294             AL513497.21        16221-16363
            295-376             AL513497.21        29354-29435
            377-564             AL513497.21        31299-31486
            565-744             AL513497.21        31667-31846
            745-841             AL513497.21        34546-34642
            842-964             AL513497.21        34754-34876
            965-1120            AL513497.21        35367-35522
            1121-1240           AL513497.21        35758-35877
            1241-1393           AL513497.21        36243-36395
            1394-2551           AL513497.21        37328-38485
FEATURES             Location/Qualifiers
     source          1..2551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..2551
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /note="regulator of chromosome condensation 1"
                     /db_xref="GeneID:1104"
                     /db_xref="HGNC:HGNC:1913"
                     /db_xref="MIM:179710"
     exon            1..42
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            43..75
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            76..151
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            152..294
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            295..376
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..1569
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /note="isoform c is encoded by transcript variant 5;
                     guanine nucleotide-releasing protein; cell cycle
                     regulatory protein"
                     /codon_start=1
                     /product="regulator of chromosome condensation isoform c"
                     /protein_id="NP_001368794.1"
                     /db_xref="GeneID:1104"
                     /db_xref="HGNC:HGNC:1913"
                     /db_xref="MIM:179710"
                     /translation="MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGD
                     VGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRD
                     TSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMK
                     KSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQ
                     GLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG
                     TESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEE
                     KSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMM
                     GKQLENRVVLSVSSGGQHTVLLVKDKEQS"
     exon            377..564
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            565..744
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            745..841
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            842..964
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1120
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1240
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1393
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..2551
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2527..2532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /note="hexamer: AATAAA"
     polyA_site      2551
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /note="major polyA site"
ORIGIN      
        1 cctttttgga gacagattcg cagtggtcgc ttcttctcct tggatttgtt aaggattcca
       61 agtaactctt atttggagag aagacgatct gcacttcgca ttttggcatt gacatttaat
      121 tttagggtcc tttatataga agggagagta gctacatgaa tgtgtaagat cttggaggaa
      181 gacagcagag agagagagag agatcagaga tcccagggtt aaaagttgga gaaatttcac
      241 agtacatcat ccaaaagagg agtccatgat ggaggcagag gtaaacttgg agaggacagg
      301 aagatgtcac ccaagcgcat agctaaaaga aggtcccccc cagcagatgc catccccaaa
      361 agcaagaagg tgaaggtctc acacaggtcc cacagcacag aacccggctt ggtgctgaca
      421 ctaggccagg gcgacgtggg ccagctgggg ctgggtgaga atgtgatgga gaggaagaag
      481 ccggccctgg tatccattcc ggaggatgtt gtgcaggctg aggctggggg catgcacacc
      541 gtgtgtctaa gcaaaagtgg ccaggtctat tccttcggct gcaatgatga gggtgccctg
      601 ggaagggaca catcagtgga gggctcggag atggtccctg ggaaagtgga gctgcaagag
      661 aaggtggtac aggtgtcagc aggagacagt cacacagcag ccctcaccga tgatggccgt
      721 gtcttcctct ggggctcctt ccgggacaat aacggtgtga ttggactgtt ggagcccatg
      781 aagaagagca tggtgcctgt gcaggtgcag ctggatgtgc ctgtggtaaa ggtggcctca
      841 ggaaacgacc acttggtgat gctgacagct gatggtgacc tctacacctt gggctgcggg
      901 gaacagggcc agctaggccg tgtgcctgag ttatttgcca accgtggtgg ccggcaaggc
      961 ctcgaacgac tcctggtccc caagtgtgtg atgctgaaat ccaggggaag ccggggccac
     1021 gtgagattcc aggatgcctt ttgtggtgcc tatttcacct ttgccatctc ccatgagggc
     1081 cacgtgtacg gcttcggcct ctccaactac catcagcttg gaactccggg cacagaatct
     1141 tgcttcatac cccagaacct aacatccttc aagaattcca ccaagtcctg ggtgggcttc
     1201 tctggtggcc agcaccatac agtctgcatg gattcggaag gaaaagcata cagcctgggc
     1261 cgggctgagt atgggcggct gggccttgga gagggtgctg aggagaagag catacccacc
     1321 ctcatctcca ggctgcctgc tgtctcctcg gtggcttgtg gggcctctgt ggggtatgct
     1381 gtgaccaagg atggtcgtgt tttcgcctgg ggcatgggca ccaactacca gctgggcaca
     1441 gggcaggatg aggacgcctg gagccctgtg gagatgatgg gcaaacagct ggagaaccgt
     1501 gtggtcttat ctgtgtccag cgggggccag catacagtct tattagtcaa ggacaaagaa
     1561 cagagctgat gaagcctctg agggcctggc ttctgtcctg cacaacctcc ctcacagaac
     1621 agggaagcag tgacagctgc agatggcagc gggcctctcc ccagccctga gcactgtgtc
     1681 agttcctgcc ttttctcatc agcagaacag aatccttttc ctcttttcct tcctcctctt
     1741 tggaattttc ctgggaccta cagaataaag ggggggatgg acagggggtt ttcaaaagga
     1801 acatggctca ctcagagcta tatggttaga cgtttctccc cttttcccta ccttccatgg
     1861 tcctggttgg ccctggcttt gcctactaga aaaccaaaac ttcccccctg gggttttgtg
     1921 cccactctct gagaagttgg ggctccatca agccccattc tagtcatgtg cccctttcct
     1981 gtccctaaca gtccacaggc aaacaaatgg tacagtcata agagccatct gtcacggacc
     2041 cacgcccaga ggaacgtgca gaaaaaagca gagctacatg gctgtgggca actataagcc
     2101 aaatatttgg ctcagaacag gtgtccatgg gacaaaaaag aacgatcctc cacttgacca
     2161 agaaaaaagt gattctccca gaagcacaaa gcatactctt gcccctcagg tgttgcttgt
     2221 gtacatcgta cccatccatt cggcttcacc tgcagccaac ggcctggaat cgcaaagaga
     2281 caccactctg ggcagagcag agcagggtat ggggtgggga gagagggtgg agggttttat
     2341 aaacaaactt aacagcaata ttgaaaggag gtgggggatt gagggaggga cagagtgttg
     2401 gagggccaga gactagtcct gagatggaaa cagcaacttg tacagtggct gagaaaatag
     2461 gatatagttt tgattttttt aattgtaaaa tattttggag ggagaacaaa atcttttaac
     2521 attttgaata aatttagagt tttataaaat a
//
