LOCUS       NM_001048194            2433 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of chromosome condensation 1 (RCC1),
            transcript variant 1, mRNA.
ACCESSION   NM_001048194
VERSION     NM_001048194.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2433)
  AUTHORS   Zhuang,M., Li,F., Liang,H., Su,Y., Cheng,L., Lin,B., Zhou,J.,
            Deng,R., Chen,L., Lyu,P. and Lu,Z.
  TITLE     Targeting RCC1 to block the human soft-tissue sarcoma by disrupting
            nucleo-cytoplasmic trafficking of Skp2
  JOURNAL   Cell Death Dis 15 (4), 241 (2024)
   PUBMED   38561375
  REMARK    GeneRIF: Targeting RCC1 to block the human soft-tissue sarcoma by
            disrupting nucleo-cytoplasmic trafficking of Skp2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2433)
  AUTHORS   Xu,Z., Wu,Y., Zhao,G., Jin,B. and Jiang,P.
  TITLE     A novel DNA methylation signature revealed GDF6 and RCC1 as
            potential prognostic biomarkers correlated with cell proliferation
            in clear cell renal cell carcinoma
  JOURNAL   Mol Biol Rep 51 (1), 16 (2023)
   PUBMED   38087057
  REMARK    GeneRIF: A novel DNA methylation signature revealed GDF6 and RCC1
            as potential prognostic biomarkers correlated with cell
            proliferation in clear cell renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2433)
  AUTHORS   Wu,Y., Xu,Z., Chen,X., Fu,G., Tian,J. and Jin,B.
  TITLE     RCC1 functions as a tumor facilitator in clear cell renal cell
            carcinoma by dysregulating cell cycle, apoptosis, and EZH2
            stability
  JOURNAL   Cancer Med 12 (19), 19889-19903 (2023)
   PUBMED   37747077
  REMARK    GeneRIF: RCC1 functions as a tumor facilitator in clear cell renal
            cell carcinoma by dysregulating cell cycle, apoptosis, and EZH2
            stability.
REFERENCE   4  (bases 1 to 2433)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2433)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 2433)
  AUTHORS   Hood,F.E. and Clarke,P.R.
  TITLE     RCC1 isoforms differ in their affinity for chromatin, molecular
            interactions and regulation by phosphorylation
  JOURNAL   J Cell Sci 120 (Pt 19), 3436-3445 (2007)
   PUBMED   17855385
  REMARK    GeneRIF: These results show that human RCC1 isoforms have distinct
            chromatin binding properties, different molecular interactions, and
            are selectively regulated by phosphorylation, as determined by
            their different NTRs.
REFERENCE   7  (bases 1 to 2433)
  AUTHORS   Bischoff,F.R. and Ponstingl,H.
  TITLE     Mitotic regulator protein RCC1 is complexed with a nuclear
            ras-related polypeptide
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10830-10834 (1991)
   PUBMED   1961752
REFERENCE   8  (bases 1 to 2433)
  AUTHORS   Bischoff,F.R. and Ponstingl,H.
  TITLE     Catalysis of guanine nucleotide exchange on Ran by the mitotic
            regulator RCC1
  JOURNAL   Nature 354 (6348), 80-82 (1991)
   PUBMED   1944575
REFERENCE   9  (bases 1 to 2433)
  AUTHORS   Furuno,N., Nakagawa,K., Eguchi,U., Ohtsubo,M., Nishimoto,T. and
            Soeda,E.
  TITLE     Complete nucleotide sequence of the human RCC1 gene involved in
            coupling between DNA replication and mitosis
  JOURNAL   Genomics 11 (2), 459-461 (1991)
   PUBMED   1769659
  REMARK    Erratum:[Genomics 1992 Jan;12(1):181. Ohtubo M [corrected to
            Ohtsubo M]]
REFERENCE   10 (bases 1 to 2433)
  AUTHORS   Bischoff,F.R., Maier,G., Tilz,G. and Ponstingl,H.
  TITLE     A 47-kDa human nuclear protein recognized by antikinetochore
            autoimmune sera is homologous with the protein encoded by RCC1, a
            gene implicated in onset of chromosome condensation
  JOURNAL   Proc Natl Acad Sci U S A 87 (21), 8617-8621 (1990)
   PUBMED   2236072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513497.21, X12654.1, BC069198.1 and BF590413.1.
            
            On May 20, 2020 this sequence version replaced NM_001048194.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069198.1, SRR14038192.1905920.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL513497.21        17722-17728
            8-42                X12654.1           98-132
            43-1608             BC069198.1         1-1566
            1609-2423           X12654.1           1606-2420
            2424-2433           BF590413.1         208-217             c
FEATURES             Location/Qualifiers
     source          1..2433
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..2433
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /note="regulator of chromosome condensation 1"
                     /db_xref="GeneID:1104"
                     /db_xref="HGNC:HGNC:1913"
                     /db_xref="MIM:179710"
     exon            1..83
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            84..165
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1451
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /note="isoform a is encoded by transcript variant 1;
                     guanine nucleotide-releasing protein; cell cycle
                     regulatory protein"
                     /codon_start=1
                     /product="regulator of chromosome condensation isoform a"
                     /protein_id="NP_001041659.1"
                     /db_xref="CCDS:CCDS41295.1"
                     /db_xref="GeneID:1104"
                     /db_xref="HGNC:HGNC:1913"
                     /db_xref="MIM:179710"
                     /translation="MSPKRIAKRRSPPADAIPKSKKVKDTRAAASRRVPGARSCQGAC
                     GPSPPDQKTRPVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQ
                     AEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDS
                     HTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVML
                     TADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDA
                     FCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQ
                     HHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVT
                     KDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKE
                     QS"
     exon            166..258
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            259..446
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            447..626
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            627..723
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            724..846
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1002
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1122
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1275
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..2433
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2409..2414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /note="hexamer: AATAAA"
     polyA_site      2433
                     /gene="RCC1"
                     /gene_synonym="CHC1; RCC1-I"
                     /note="major polyA site"
ORIGIN      
        1 agaggcctgc agagcgcatg ctctggggca gttcgcggcc cggcggggag cgccggagtt
       61 ccttgtggcc gacgtgcacc aaggacagga agatgtcacc caagcgcata gctaaaagaa
      121 ggtccccccc agcagatgcc atccccaaaa gcaagaaggt gaaggacacg agggccgctg
      181 cctcccgccg cgttcctggc gcccgctcct gccaaggtgc ctgcgggccg agccctcctg
      241 accagaaaac ccgaccagtc tcacacaggt cccacagcac agaacccggc ttggtgctga
      301 cactaggcca gggcgacgtg ggccagctgg ggctgggtga gaatgtgatg gagaggaaga
      361 agccggccct ggtatccatt ccggaggatg ttgtgcaggc tgaggctggg ggcatgcaca
      421 ccgtgtgtct aagcaaaagt ggccaggtct attccttcgg ctgcaatgat gagggtgccc
      481 tgggaaggga cacatcagtg gagggctcgg agatggtccc tgggaaagtg gagctgcaag
      541 agaaggtggt acaggtgtca gcaggagaca gtcacacagc agccctcacc gatgatggcc
      601 gtgtcttcct ctggggctcc ttccgggaca ataacggtgt gattggactg ttggagccca
      661 tgaagaagag catggtgcct gtgcaggtgc agctggatgt gcctgtggta aaggtggcct
      721 caggaaacga ccacttggtg atgctgacag ctgatggtga cctctacacc ttgggctgcg
      781 gggaacaggg ccagctaggc cgtgtgcctg agttatttgc caaccgtggt ggccggcaag
      841 gcctcgaacg actcctggtc cccaagtgtg tgatgctgaa atccagggga agccggggcc
      901 acgtgagatt ccaggatgcc ttttgtggtg cctatttcac ctttgccatc tcccatgagg
      961 gccacgtgta cggcttcggc ctctccaact accatcagct tggaactccg ggcacagaat
     1021 cttgcttcat accccagaac ctaacatcct tcaagaattc caccaagtcc tgggtgggct
     1081 tctctggtgg ccagcaccat acagtctgca tggattcgga aggaaaagca tacagcctgg
     1141 gccgggctga gtatgggcgg ctgggccttg gagagggtgc tgaggagaag agcataccca
     1201 ccctcatctc caggctgcct gctgtctcct cggtggcttg tggggcctct gtggggtatg
     1261 ctgtgaccaa ggatggtcgt gttttcgcct ggggcatggg caccaactac cagctgggca
     1321 cagggcagga tgaggacgcc tggagccctg tggagatgat gggcaaacag ctggagaacc
     1381 gtgtggtctt atctgtgtcc agcgggggcc agcatacagt cttattagtc aaggacaaag
     1441 aacagagctg atgaagcctc tgagggcctg gcttctgtcc tgcacaacct ccctcacaga
     1501 acagggaagc agtgacagct gcagatggca gcgggcctct ccccagccct gagcactgtg
     1561 tcagttcctg ccttttctca tcagcagaac agaatccttt tcctcttttc cttcctcctc
     1621 tttggaattt tcctgggacc tacagaataa agggggggat ggacaggggg ttttcaaaag
     1681 gaacatggct cactcagagc tatatggtta gacgtttctc cccttttccc taccttccat
     1741 ggtcctggtt ggccctggct ttgcctacta gaaaaccaaa acttcccccc tggggttttg
     1801 tgcccactct ctgagaagtt ggggctccat caagccccat tctagtcatg tgcccctttc
     1861 ctgtccctaa cagtccacag gcaaacaaat ggtacagtca taagagccat ctgtcacgga
     1921 cccacgccca gaggaacgtg cagaaaaaag cagagctaca tggctgtggg caactataag
     1981 ccaaatattt ggctcagaac aggtgtccat gggacaaaaa agaacgatcc tccacttgac
     2041 caagaaaaaa gtgattctcc cagaagcaca aagcatactc ttgcccctca ggtgttgctt
     2101 gtgtacatcg tacccatcca ttcggcttca cctgcagcca acggcctgga atcgcaaaga
     2161 gacaccactc tgggcagagc agagcagggt atggggtggg gagagagggt ggagggtttt
     2221 ataaacaaac ttaacagcaa tattgaaagg aggtggggga ttgagggagg gacagagtgt
     2281 tggagggcca gagactagtc ctgagatgga aacagcaact tgtacagtgg ctgagaaaat
     2341 aggatatagt tttgattttt ttaattgtaa aatattttgg agggagaaca aaatctttta
     2401 acattttgaa taaatttaga gttttataaa ata
//
