LOCUS       NM_001286832            2453 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens RCC1 and BTB domain containing protein 2 (RCBTB2),
            transcript variant 4, mRNA.
ACCESSION   NM_001286832
VERSION     NM_001286832.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2453)
  AUTHORS   Wiphakphongpakorn,P., Juengsomjit,R., Poomsawat,S., Meesakul,O.,
            Bhattarai,B.P., Klongnoi,B., Buajeeb,W. and Khovidhunkit,S.P.
  TITLE     Expression of CLLD7 and CHC1L Proteins in Oral Epithelial Dysplasia
            in a Group of Thai Patients
  JOURNAL   Asian Pac J Cancer Prev 25 (4), 1257-1264 (2024)
   PUBMED   38679985
  REMARK    GeneRIF: Expression of CLLD7 and CHC1L Proteins in Oral Epithelial
            Dysplasia in a Group of Thai Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2453)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2453)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2453)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2453)
  AUTHORS   Legartova,S., Harnicarova-Horakova,A., Bartova,E., Hajek,R.,
            Pour,L. and Kozubek,S.
  TITLE     Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma
            patients and in myeloma cell lines treated with HDAC and Dnmts
            inhibitors
  JOURNAL   Neoplasma 57 (5), 482-487 (2010)
   PUBMED   20568903
REFERENCE   6  (bases 1 to 2453)
  AUTHORS   Armellini,A., Sarasquete,M.E., Garcia-Sanz,R., Chillon,M.C.,
            Balanzategui,A., Alcoceba,M., Fuertes,M., Lopez,R., Hernandez,J.M.,
            Fernandez-Calvo,J., Sierra,M., Megido,M., Orfao,A., Gutierrez,N.C.,
            Gonzalez,M. and San Miguel,J.F.
  TITLE     Low expression of ZHX2, but not RCBTB2 or RAN, is associated with
            poor outcome in multiple myeloma
  JOURNAL   Br J Haematol 141 (2), 212-215 (2008)
   PUBMED   18353163
REFERENCE   7  (bases 1 to 2453)
  AUTHORS   Latil,A., Chene,L., Mangin,P., Fournier,G., Berthon,P. and
            Cussenot,O.
  TITLE     Extensive analysis of the 13q14 region in human prostate tumors:
            DNA analysis and quantitative expression of genes lying in the
            interval of deletion
  JOURNAL   Prostate 57 (1), 39-50 (2003)
   PUBMED   12886522
REFERENCE   8  (bases 1 to 2453)
  AUTHORS   Manome,Y., Saeki,N., Yoshinaga,H., Watanabe,M. and Mizuno,S.
  TITLE     A culture device demonstrates that hydrostatic pressure increases
            mRNA of RGS5 in neuroblastoma and CHC1-L in lymphocytic cells
  JOURNAL   Cells Tissues Organs 174 (4), 155-161 (2003)
   PUBMED   14504426
REFERENCE   9  (bases 1 to 2453)
  AUTHORS   Latil,A., Morant,P., Fournier,G., Mangin,P., Berthon,P. and
            Cussenot,O.
  TITLE     CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is
            frequently affected by loss of heterozygosity and underexpressed in
            human prostate cancer
  JOURNAL   Int J Cancer 99 (5), 689-696 (2002)
   PUBMED   12115502
  REMARK    GeneRIF: decreased expression in prostate cancer associated with
            the difference in frequency of variant isoforms between normal and
            neoplastic prostate tissues places it in a pivotal role or possibly
            adjacent to a gene with that role in prostate cancer evolution
REFERENCE   10 (bases 1 to 2453)
  AUTHORS   Devilder,M.C., Cadoret,E., Cherel,M., Moreau,I., Rondeau,G.,
            Bezieau,S. and Moisan,J.P.
  TITLE     cDNA cloning, gene characterization and 13q14.3 chromosomal
            assignment of CHC1-L, a chromosome condensation regulator-like
            guanine nucleotide exchange factor
  JOURNAL   Genomics 54 (1), 99-106 (1998)
   PUBMED   9806834
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK304598.1, AB209543.1 and
            BC029052.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001286832.1.
            
            Summary: This gene encodes a protein containing two C-terminal
            BTB/POZ domains that is related to regulator of chromosome
            condensation (RCC). The encoded protein may act as a guanine
            nucleotide exchange factor. This gene is observed to be lost or
            underexpressed in prostate cancers. There is a pseudogene of this
            gene on chromosome 10. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            contains multiple differences in the 5' coding region, and
            initiates translation at an alternate downstream start codon,
            compared to variant 1. The encoded isoform (4) has a distinct
            N-terminus and is shorter than isoform 1. Variants 4, 8, and 9 all
            encode the same isoform (4).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK304598.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1316              AK304598.1         1-1316
            1317-2451           AB209543.1         1821-2955
            2452-2453           BC029052.1         3054-3055
FEATURES             Location/Qualifiers
     source          1..2453
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..2453
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /note="RCC1 and BTB domain containing protein 2"
                     /db_xref="GeneID:1102"
                     /db_xref="HGNC:HGNC:1914"
                     /db_xref="MIM:603524"
     exon            1..53
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            54..209
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            210..360
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            361..467
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            468..575
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..1305
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /note="isoform 4 is encoded by transcript variant 4;
                     RCC1-like G exchanging factor RLG; regulator of chromosome
                     condensation (RCC1) and BTB (POZ) domain containing
                     protein 2"
                     /codon_start=1
                     /product="RCC1 and BTB domain-containing protein 2 isoform
                     4"
                     /protein_id="NP_001273761.1"
                     /db_xref="CCDS:CCDS73570.1"
                     /db_xref="GeneID:1102"
                     /db_xref="HGNC:HGNC:1914"
                     /db_xref="MIM:603524"
                     /translation="MSGVTTETGSLDSATVATSQPLAEWQLCKASVSRGIIEIAACHS
                     THTSAAKTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVTWRLLSVEPDD
                     HLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMS
                     EFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENA
                     IALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFK
                     N"
     exon            576..766
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            767..893
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1033
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1164
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..2453
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2425..2430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /note="hexamer: AATAAA"
     polyA_site      2453
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /note="major polyA site"
ORIGIN      
        1 gcagtaaccg ctacccagga ggcggagcgg acaaggctcc ggcctgcgag gagccagtac
       61 aggctactct gtcatctttg aagatgttag atgtgggaaa gtggccaatt ttttcccttt
      121 gttctgaaga agaactacag ttaattcgtc aggcttgtgt ctttggcagt gctggcaatg
      181 aagttttata cactacagta aatgatgaga tttttgtgct tggcacaaac tgctgtggct
      241 gtttggggtt aggtgacgtc cagagcacca ttgaacctcg gagactggat tctttaaatg
      301 gcaaaaaaat agcctgcctc agctatggga gtggtccaca tattgtcctt gcaacaacag
      361 ttaatcagcc aatccctcga agagtcactg gctgcctaca aaataaagta gttgtgacca
      421 tagcatgtgg gcagatgtgc tgcatggcag tagtagacac gggggaggtc tatgtctggg
      481 gttacaacgg aaacgggcag cttggactcg gcaacagtgg caaccagcca accccttgca
      541 gagtggcagc tttgcaaggc atccgtgtcc agagggatta tcgagattgc agcctgtcac
      601 tccacacaca cgtctgcggc caagacgcag ggtgggcacg tgtacatgtg gggccagtgc
      661 cggggtcagt ccgtgatcct cccgcacctc acccacttct cctgcactga cgacgtgttt
      721 gcctgctttg ccacgcccgc cgtcacgtgg cgcctcctct ccgtggaacc tgatgaccac
      781 ctcacagtgg ctgagtcact gaagagggaa tttgacaacc cggacactgc agacctgaag
      841 tttctagttg atggaaagta catttatgca cataaagtcc ttctcaagat tcgatgtgag
      901 cattttcgtt cgtcattgga agataacgag gatgatattg tagaaatgag tgaattttca
      961 tatcctgttt accgggcctt cctggaatac ctatacacag acagcatcag cctttctcct
     1021 gaggaggcag taggactgct agacttggct acattttata gagaaaatcg tttgaaaaag
     1081 ctctgccaac aaactatcaa gcaaggcatc tgcgaggaga atgccatcgc tctgctctcg
     1141 gctgcggtga agtatgatgc acaggattta gaagaattct gcttcaggtt ttgcataaac
     1201 catctgactg tagtaacaca aacatcaggt tttgcagaaa tggaccatga tctcctgaag
     1261 aactttatca gcaaagcaag cagagttgga gcctttaaaa attgatccca tctgcaggaa
     1321 agtttttgag cctttccatt tcccctgcaa aagccagaga tgaatcactt ctctttaatt
     1381 aatagtatgt atgatgagct atgtttggct gagtacttgt aactgtcaga agaaggatgg
     1441 tggtgagtgg tctttgtctg cctaaaccca gagtttatgt agaaagcatt gaatgttctg
     1501 atcagatgtg actaaggtca aggaaaaaaa attgaaatat cttatttacc atttcctctt
     1561 tttgagtcac ttaaattgga cacctttggt accctggtct cagtatatgc tattctggcc
     1621 caaatgttcc attattcagc tggctgatac cacatagata gcttgacaag gagtgctgtc
     1681 tgtccttacc acattttcag cactcagcac agtgccttgt gtataatagg cactcaattt
     1741 attataaatc ttcagtatgt cctgagaaca gctttagtca tggaatactg ggagaaggaa
     1801 taactttcac aaaataaact taaaacagcc tgtaattatt gaggttcata ttcttctggt
     1861 atatcattct gagaaattgt ggctaattta gaacattgtt tagaattgac aaaaggccct
     1921 ggcaattaaa ttgtcaaggc ccaagggcta attttaattt tctttttact tggagtcatt
     1981 cattaatttc tcacatggga ttatggagta tgaagtatta tctttgaatg aaattcctgg
     2041 gctgatctgc cttacataat cacataaggt cctttgcttt tctttgtgtt aagagggact
     2101 tgcctctgta aatgaaaatg acaatgtgct tttcttgtag ttgactttca tgtcactcac
     2161 tataaaatag gtctcttaac ctggcaccag tataactata aagcactagc tgagaaggaa
     2221 ctgatactta catttcatgg acagcattaa caagaatgag ataaatttgt actttttaga
     2281 tcaaaacaaa ttacctaatt gcaaaagaga aactgaaatg gaacatagtc tcagattctt
     2341 ctaatgtgta tctcacaatg tcatgtaatg taaaggaaac ccttttggaa ttagaattct
     2401 tgttctgatg ctgaactatt tggtaataaa gtgcttattt gcagataaca gaa
//
