LOCUS       NM_001268               3075 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RCC1 and BTB domain containing protein 2 (RCBTB2),
            transcript variant 2, mRNA.
ACCESSION   NM_001268
VERSION     NM_001268.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3075)
  AUTHORS   Wiphakphongpakorn,P., Juengsomjit,R., Poomsawat,S., Meesakul,O.,
            Bhattarai,B.P., Klongnoi,B., Buajeeb,W. and Khovidhunkit,S.P.
  TITLE     Expression of CLLD7 and CHC1L Proteins in Oral Epithelial Dysplasia
            in a Group of Thai Patients
  JOURNAL   Asian Pac J Cancer Prev 25 (4), 1257-1264 (2024)
   PUBMED   38679985
  REMARK    GeneRIF: Expression of CLLD7 and CHC1L Proteins in Oral Epithelial
            Dysplasia in a Group of Thai Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3075)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3075)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3075)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3075)
  AUTHORS   Legartova,S., Harnicarova-Horakova,A., Bartova,E., Hajek,R.,
            Pour,L. and Kozubek,S.
  TITLE     Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma
            patients and in myeloma cell lines treated with HDAC and Dnmts
            inhibitors
  JOURNAL   Neoplasma 57 (5), 482-487 (2010)
   PUBMED   20568903
REFERENCE   6  (bases 1 to 3075)
  AUTHORS   Armellini,A., Sarasquete,M.E., Garcia-Sanz,R., Chillon,M.C.,
            Balanzategui,A., Alcoceba,M., Fuertes,M., Lopez,R., Hernandez,J.M.,
            Fernandez-Calvo,J., Sierra,M., Megido,M., Orfao,A., Gutierrez,N.C.,
            Gonzalez,M. and San Miguel,J.F.
  TITLE     Low expression of ZHX2, but not RCBTB2 or RAN, is associated with
            poor outcome in multiple myeloma
  JOURNAL   Br J Haematol 141 (2), 212-215 (2008)
   PUBMED   18353163
REFERENCE   7  (bases 1 to 3075)
  AUTHORS   Latil,A., Chene,L., Mangin,P., Fournier,G., Berthon,P. and
            Cussenot,O.
  TITLE     Extensive analysis of the 13q14 region in human prostate tumors:
            DNA analysis and quantitative expression of genes lying in the
            interval of deletion
  JOURNAL   Prostate 57 (1), 39-50 (2003)
   PUBMED   12886522
REFERENCE   8  (bases 1 to 3075)
  AUTHORS   Manome,Y., Saeki,N., Yoshinaga,H., Watanabe,M. and Mizuno,S.
  TITLE     A culture device demonstrates that hydrostatic pressure increases
            mRNA of RGS5 in neuroblastoma and CHC1-L in lymphocytic cells
  JOURNAL   Cells Tissues Organs 174 (4), 155-161 (2003)
   PUBMED   14504426
REFERENCE   9  (bases 1 to 3075)
  AUTHORS   Latil,A., Morant,P., Fournier,G., Mangin,P., Berthon,P. and
            Cussenot,O.
  TITLE     CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is
            frequently affected by loss of heterozygosity and underexpressed in
            human prostate cancer
  JOURNAL   Int J Cancer 99 (5), 689-696 (2002)
   PUBMED   12115502
  REMARK    GeneRIF: decreased expression in prostate cancer associated with
            the difference in frequency of variant isoforms between normal and
            neoplastic prostate tissues places it in a pivotal role or possibly
            adjacent to a gene with that role in prostate cancer evolution
REFERENCE   10 (bases 1 to 3075)
  AUTHORS   Devilder,M.C., Cadoret,E., Cherel,M., Moreau,I., Rondeau,G.,
            Bezieau,S. and Moisan,J.P.
  TITLE     cDNA cloning, gene characterization and 13q14.3 chromosomal
            assignment of CHC1-L, a chromosome condensation regulator-like
            guanine nucleotide exchange factor
  JOURNAL   Genomics 54 (1), 99-106 (1998)
   PUBMED   9806834
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG772479.1, BC029052.1 and
            AF060219.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001268.3.
            
            Summary: This gene encodes a protein containing two C-terminal
            BTB/POZ domains that is related to regulator of chromosome
            condensation (RCC). The encoded protein may act as a guanine
            nucleotide exchange factor. This gene is observed to be lost or
            underexpressed in prostate cancers. There is a pseudogene of this
            gene on chromosome 10. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 5' coding region and initiates translation at an alternate
            start codon, compared to variant 1. The encoded isoform (2) has a
            distinct N-terminus and is shorter than isoform 1. Variants 2, 5,
            and 6 all encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029052.1, SRR1803614.99086.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344532.8/ ENSP00000345144.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BG772479.1         227-246             c
            21-2723             BC029052.1         1-2703
            2724-3073           AF060219.1         2681-3030
            3074-3075           BC029052.1         3054-3055
FEATURES             Location/Qualifiers
     source          1..3075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..3075
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /note="RCC1 and BTB domain containing protein 2"
                     /db_xref="GeneID:1102"
                     /db_xref="HGNC:HGNC:1914"
                     /db_xref="MIM:603524"
     exon            1..53
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            54..152
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            153..248
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            249..313
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1927
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RCC1-like G exchanging factor RLG; regulator of chromosome
                     condensation (RCC1) and BTB (POZ) domain containing
                     protein 2"
                     /codon_start=1
                     /product="RCC1 and BTB domain-containing protein 2 isoform
                     2"
                     /protein_id="NP_001259.1"
                     /db_xref="CCDS:CCDS9411.1"
                     /db_xref="GeneID:1102"
                     /db_xref="HGNC:HGNC:1914"
                     /db_xref="MIM:603524"
                     /translation="MEEELPLFSGDSGKPVQATLSSLKMLDVGKWPIFSLCSEEELQL
                     IRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIAC
                     LSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACG
                     SYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCM
                     AVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEG
                     QVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMW
                     GQCRGQSVILPHLTHFSCTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPD
                     TADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYT
                     DSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYDAQDLE
                     EFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN"
     exon            314..469
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            470..620
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            621..787
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            788..946
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1054
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1197
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1388
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1515
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1655
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1786
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..3075
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3047..3052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /note="hexamer: AATAAA"
     polyA_site      3075
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /note="major polyA site"
ORIGIN      
        1 gcagtaaccg ctacccagga ggcggagcgg acaaggctcc ggcctgcgag gagtcacatt
       61 aactttgctc tagaagacaa ctttacaagg atctaaaagg aacaggatta aagatgactg
      121 aatactgggt tccagaaatt taaaacaatc agcttagcaa atcatatatt cttctgtgga
      181 gctgagaatt gatgtccgct cttccccgtg atttggaact ttccaatccc agagaaaagt
      241 tgacaaaggg actgcccagg actgagtcca tatggaagaa gaacttcctc ttttctctgg
      301 agacagtggc aagccagtac aggctactct gtcatctttg aagatgttag atgtgggaaa
      361 gtggccaatt ttttcccttt gttctgaaga agaactacag ttaattcgtc aggcttgtgt
      421 ctttggcagt gctggcaatg aagttttata cactacagta aatgatgaga tttttgtgct
      481 tggcacaaac tgctgtggct gtttggggtt aggtgacgtc cagagcacca ttgaacctcg
      541 gagactggat tctttaaatg gcaaaaaaat agcctgcctc agctatggga gtggtccaca
      601 tattgtcctt gcaacaacag aaggagaagt ctttacctgg ggtcataatg cttatagcca
      661 gctgggcaat gggacaacta atcatggttt agtgccctgt catatctcta ctaatctgtc
      721 aaacaaacaa gtcattgaag ttgcctgtgg gtcttaccat tctttggtgc taacatctga
      781 tggagaggta tttgcctggg gttataataa ctctgggcag gtaggatctg gatcaacagt
      841 taatcagcca atccctcgaa gagtcactgg ctgcctacaa aataaagtag ttgtgaccat
      901 agcatgtggg cagatgtgct gcatggcagt agtagacacg ggggaggtct atgtctgggg
      961 ttacaacgga aacgggcagc ttggactcgg caacagtggc aaccagccaa ccccttgcag
     1021 agtggcagct ttgcaaggca tccgtgtcca gagggtcgcc tgtggctacg cacacacatt
     1081 agtattaaca gatgaaggcc aagtgtatgc ttggggcgcc aattcttatg ggcagttggg
     1141 cactggcaat aaaagcaacc agtcctatcc tactcctgtc actgtggaaa aggacaggat
     1201 tatcgagatt gcagcctgtc actccacaca cacgtctgcg gccaagacgc agggtgggca
     1261 cgtgtacatg tggggccagt gccggggtca gtccgtgatc ctcccgcacc tcacccactt
     1321 ctcctgcact gacgacgtgt ttgcctgctt tgccacgccc gccgtcacgt ggcgcctcct
     1381 ctccgtggaa cctgatgacc acctcacagt ggctgagtca ctgaagaggg aatttgacaa
     1441 cccggacact gcagacctga agtttctagt tgatggaaag tacatttatg cacataaagt
     1501 ccttctcaag attcgatgtg agcattttcg ttcgtcattg gaagataacg aggatgatat
     1561 tgtagaaatg agtgaatttt catatcctgt ttaccgggcc ttcctggaat acctatacac
     1621 agacagcatc agcctttctc ctgaggaggc agtaggactg ctagacttgg ctacatttta
     1681 tagagaaaat cgtttgaaaa agctctgcca acaaactatc aagcaaggca tctgcgagga
     1741 gaatgccatc gctctgctct cggctgcggt gaagtatgat gcacaggatt tagaagaatt
     1801 ctgcttcagg ttttgcataa accatctgac tgtagtaaca caaacatcag gttttgcaga
     1861 aatggaccat gatctcctga agaactttat cagcaaagca agcagagttg gagcctttaa
     1921 aaattgatcc catctgcagg aaagtttttg agcctttcca tttcccctgc aaaagccaga
     1981 gatgaatcac ttctctttaa ttaatagtat gtatgatgag ctatgtttgg ctgagtactt
     2041 gtaactgtca gaagaaggat ggtggtgagt ggtctttgtc tgcctaaacc cagagtttat
     2101 gtagaaagca ttgaatgttc tgatcagatg tgactaaggt caaggaaaaa aaattgaaat
     2161 atcttattta ccatttcctc tttttgagtc acttaaattg gacacctttg gtaccctggt
     2221 ctcagtatat gctattctgg cccaaatgtt ccattattca gctggctgat accacataga
     2281 tagcttgaca aggagtgctg tctgtcctta ccacattttc agcactcagc acagtgcctt
     2341 gtgtataata ggcactcaat ttattataaa tcttcagtat gtcctgagaa cagctttagt
     2401 catggaatac tgggagaagg aataactttc acaaaataaa cttaaaacag cctgtaatta
     2461 ttgaggttca tattcttctg gtatatcatt ctgagaaatt gtggctaatt tagaacattg
     2521 tttagaattg acaaaaggcc ctggcaatta aattgtcaag gcccaagggc taattttaat
     2581 tttcttttta cttggagtca ttcattaatt tctcacatgg gattatggag tatgaagtat
     2641 tatctttgaa tgaaattcct gggctgatct gccttacata atcacataag gtcctttgct
     2701 tttctttgtg ttaagaggga cttgcctctg taaatgaaaa tgacaatgtg cttttcttgt
     2761 agttgacttt catgtcactc actataaaat aggtctctta acctggcacc agtataacta
     2821 taaagcacta gctgagaagg aactgatact tacatttcat ggacagcatt aacaagaatg
     2881 agataaattt gtacttttta gatcaaaaca aattacctaa ttgcaaaaga gaaactgaaa
     2941 tggaacatag tctcagattc ttctaatgtg tatctcacaa tgtcatgtaa tgtaaaggaa
     3001 acccttttgg aattagaatt cttgttctga tgctgaacta tttggtaata aagtgcttat
     3061 ttgcagataa cagaa
//
