LOCUS       NM_013441               6863 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens RCAN family member 3 (RCAN3), transcript variant 1,
            mRNA.
ACCESSION   NM_013441
VERSION     NM_013441.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6863)
  AUTHORS   Hu,T., Liu,L., Wang,H., Yang,M., Xu,B., Xie,H., Lin,Z., Jin,X.,
            Wang,P., Liu,Y., Sun,H. and Liu,S.
  TITLE     RCAN family member 3 deficiency contributes to noncompaction of the
            ventricular myocardium
  JOURNAL   J Genet Genomics 51 (5), 543-553 (2024)
   PUBMED   38181896
  REMARK    GeneRIF: RCAN family member 3 deficiency contributes to
            noncompaction of the ventricular myocardium.
REFERENCE   2  (bases 1 to 6863)
  AUTHORS   Bicer,A., Lopez-Henares,P., Molero-Magarino,M., Feu-Llaurado,A.,
            Sabariego-Navarro,M., Bayod,S., Padilla,L., Taco,M.R., Larriba,S.,
            Perez-Riba,M. and Serrano-Candelas,E.
  TITLE     The PxIxIT motif of the RCAN3 inhibits angiogenesis and tumor
            progression in Triple Negative breast cancer in immunocompetent
            mice
  JOURNAL   Carcinogenesis 43 (8), 808-812 (2022)
   PUBMED   35640493
  REMARK    GeneRIF: The PxIxIT motif of the RCAN3 inhibits angiogenesis and
            tumor progression in Triple Negative breast cancer in
            immunocompetent mice.
REFERENCE   3  (bases 1 to 6863)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 6863)
  AUTHORS   Zhang,X.Y., Ma,H., Li,J., Lu,X.R., Li,J.Q., Yuan,N., Zhang,Z.L. and
            Xue,X.Y.
  TITLE     Functional implications of miR-145/RCAN3 axis in the progression of
            cervical cancer
  JOURNAL   Reprod Biol 20 (2), 140-146 (2020)
   PUBMED   32345470
  REMARK    GeneRIF: Functional implications of miR-145/RCAN3 axis in the
            progression of cervical cancer.
REFERENCE   5  (bases 1 to 6863)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6863)
  AUTHORS   Enjuanes,A., Benavente,Y., Bosch,F., Martin-Guerrero,I.,
            Colomer,D., Perez-Alvarez,S., Reina,O., Ardanaz,M.T., Jares,P.,
            Garcia-Orad,A., Pujana,M.A., Montserrat,E., de Sanjose,S. and
            Campo,E.
  TITLE     Genetic variants in apoptosis and immunoregulation-related genes
            are associated with risk of chronic lymphocytic leukemia
  JOURNAL   Cancer Res 68 (24), 10178-10186 (2008)
   PUBMED   19074885
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6863)
  AUTHORS   Facchin,F., Canaider,S., Vitale,L., Frabetti,F., Griffoni,C.,
            Lenzi,L., Casadei,R. and Strippoli,P.
  TITLE     Identification and analysis of human RCAN3 (DSCR1L2) mRNA and
            protein isoforms
  JOURNAL   Gene 407 (1-2), 159-168 (2008)
   PUBMED   18022329
  REMARK    GeneRIF: The interaction between TNNI3 and the new R variants of
            RCAN3, RCAN3-2,3,5 and RCAN3-2,4,5, is reported.
REFERENCE   8  (bases 1 to 6863)
  AUTHORS   Mulero,M.C., Aubareda,A., Schluter,A. and Perez-Riba,M.
  TITLE     RCAN3, a novel calcineurin inhibitor that down-regulates
            NFAT-dependent cytokine gene expression
  JOURNAL   Biochim Biophys Acta 1773 (3), 330-341 (2007)
   PUBMED   17270291
  REMARK    GeneRIF: human RCAN3, encoded by the RCAN3 (also known as DSCR1L2)
            gene, interacts physically and functionally with calcineurin
REFERENCE   9  (bases 1 to 6863)
  AUTHORS   Canaider,S., Facchin,F., Griffoni,C., Casadei,R., Vitale,L.,
            Lenzi,L., Frabetti,F., D'Addabbo,P., Carinci,P., Zannotti,M. and
            Strippoli,P.
  TITLE     Proteins encoded by human Down syndrome critical region gene 1-like
            2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with
            cardiac troponin I (TNNI3)
  JOURNAL   Gene 372, 128-136 (2006)
   PUBMED   16516408
  REMARK    GeneRIF: The yeast cotransformation and GST fusion protein assay
            demonstrated the interaction between this new DSCR1L2 variant and
            the human cardiac troponin I.
REFERENCE   10 (bases 1 to 6863)
  AUTHORS   Strippoli,P., Lenzi,L., Petrini,M., Carinci,P. and Zannotti,M.
  TITLE     A new gene family including DSCR1 (Down Syndrome Candidate Region
            1) and ZAKI-4: characterization from yeast to human and
            identification of DSCR1-like 2, a novel human member (DSCR1L2)
  JOURNAL   Genomics 64 (3), 252-263 (2000)
   PUBMED   10756093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL034582.11, BC035854.1, EF431960.1 and AI697154.1.
            
            On May 17, 2019 this sequence version replaced NM_013441.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1-4 encode the same isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.203613.1, BC035854.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374395.9/ ENSP00000363516.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AL034582.11        2909-2969
            62-787              BC035854.1         1-726
            788-1180            EF431960.1         266-658
            1181-1975           BC035854.1         1120-1914
            1976-2405           AL034582.11        36226-36655
            2406-2843           AI697154.1         6-443               c
            2844-6863           AL034582.11        37094-41113
FEATURES             Location/Qualifiers
     source          1..6863
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..6863
                     /gene="RCAN3"
                     /gene_synonym="DSCR1L2; hRCN3; MCIP3; RCN3"
                     /note="RCAN family member 3"
                     /db_xref="GeneID:11123"
                     /db_xref="HGNC:HGNC:3042"
                     /db_xref="MIM:605860"
     exon            1..315
                     /gene="RCAN3"
                     /gene_synonym="DSCR1L2; hRCN3; MCIP3; RCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            316..569
                     /gene="RCAN3"
                     /gene_synonym="DSCR1L2; hRCN3; MCIP3; RCN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..1100
                     /gene="RCAN3"
                     /gene_synonym="DSCR1L2; hRCN3; MCIP3; RCN3"
                     /note="isoform 1 is encoded by transcript variant 1; Down
                     syndrome candidate region 1-like 2; Down syndrome critical
                     region gene 1-like 2; calcipressin-3; down syndrome
                     candidate region 1-like protein 2; myocyte-enriched
                     calcineurin-interacting protein 3"
                     /codon_start=1
                     /product="calcipressin-3 isoform 1"
                     /protein_id="NP_038469.1"
                     /db_xref="CCDS:CCDS254.1"
                     /db_xref="GeneID:11123"
                     /db_xref="HGNC:HGNC:3042"
                     /db_xref="MIM:605860"
                     /translation="MLRDTMKSWNDSQSDLCSTDQEEEEEMIFGENEDDLDEMMDLSD
                     LPTSLFACSVHEAVFEAREQKERFEALFTIYDDQVTFQLFKSFRRVRINFSKPEAAAR
                     ARIELHETDFNGQKLKLYFAQVQMSGEVRDKSYLLPPQPVKQFLISPPASPPVGWKQS
                     EDAMPVINYDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEETKNPKQKI
                     AQTRRPDPPTAALNEPQTFDCAL"
     exon            570..743
                     /gene="RCAN3"
                     /gene_synonym="DSCR1L2; hRCN3; MCIP3; RCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            744..915
                     /gene="RCAN3"
                     /gene_synonym="DSCR1L2; hRCN3; MCIP3; RCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            916..6863
                     /gene="RCAN3"
                     /gene_synonym="DSCR1L2; hRCN3; MCIP3; RCN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2815..2820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCAN3"
                     /gene_synonym="DSCR1L2; hRCN3; MCIP3; RCN3"
                     /note="hexamer: AATAAA"
     polyA_site      2839
                     /gene="RCAN3"
                     /gene_synonym="DSCR1L2; hRCN3; MCIP3; RCN3"
                     /note="major polyA site"
     regulatory      6836..6841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCAN3"
                     /gene_synonym="DSCR1L2; hRCN3; MCIP3; RCN3"
                     /note="hexamer: AATAAA"
     polyA_site      6863
                     /gene="RCAN3"
                     /gene_synonym="DSCR1L2; hRCN3; MCIP3; RCN3"
                     /note="major polyA site"
ORIGIN      
        1 agaacaggag gggacgaggc gggcgcgcgg cgccggcagc ctagctcagc cgggacaccg
       61 ccctagtccc agcccagggg gccgctctcg ccggcgtcga gggcgtggcg gcgaggctgc
      121 tgctgcaggc ggctcccggc tctgccttcg gccccgcccg ccgcccacca ggctcccaga
      181 ggccccgcag ctcgcgccgt ccggctcccc gcagccccgt cgggcagccc gggcccgtcc
      241 gctgccctcc cggctcccgt cctgcggcgg cggggcgtgc aggtgaggcc ccacggcgcc
      301 cggcctctcc agcagtgggt gcctgataga catcctagga ctatacagaa ggaaaaggcc
      361 cactttgggg gataatgctg agggacacta tgaaatcttg gaatgatagc cagtcagatc
      421 tgtgtagcac tgaccaagaa gaggaagaag agatgatttt tggtgaaaat gaagatgatt
      481 tggatgagat gatggattta agtgatctgc ctacctcact ttttgcttgc agcgtccatg
      541 aagcagtgtt tgaggcacga gagcagaagg aaagatttga agcactcttc accatctatg
      601 atgaccaggt tacttttcag ctgtttaaaa gctttagaag agtcagaata aatttcagca
      661 aacctgaagc ggcagcaaga gcgcgaatag aactccacga aacagacttc aatgggcaga
      721 agctaaagct atattttgca caggtgcaga tgtccggcga agtgcgggac aagtcctatc
      781 tcctgccgcc ccagcctgtc aagcagttcc tcatctcccc tccagcctct cccccggtgg
      841 ggtggaagca gagcgaagat gcgatgcctg ttataaatta tgatttactc tgtgctgttt
      901 ccaaattggg accaggagag aaatatgaac ttcacgcggg aacagagtcg acacccagcg
      961 tggtggttca tgtctgtgaa agtgaaactg aagaggaaga agagacaaaa aaccccaaac
     1021 agaaaattgc ccagacgagg cgccccgacc ctccgaccgc agcgttgaat gagccccaga
     1081 cctttgattg cgcgctgtga ggcccttggt tgtggtgcga ggcggctgcc ctggtgggct
     1141 ctggccatgg cgctctgtgc ctgcggccga tgcgttgctg cgaacagcat aggtgagact
     1201 ctgccgagtg aggtataggt cttctcacca cgcctgtact gcagacacgg tcgtgtagag
     1261 tagcagctga tttgacctgt cccagatttt aagtgatatt ccaaaaggga ctttacatta
     1321 aaggagaagc ccccaagatg tggccaccct taaccatttt taaatagtaa caaattagga
     1381 aaacagctcc cctcccctcc agccatgtaa gtcctcctga ttctgtatca catgagacac
     1441 caaaaactgg aaatgtagtc acacccagta cagtaccatt tttatgaatt taaaaatagt
     1501 cttataattt taattgtttg tgggtatttt tctactggta taaatagctt ctaattaata
     1561 aatcgatcaa aggttgttac tcagtataca tgaaattttt tgcaggaaaa gaaaccagaa
     1621 atacagaata attcatagaa atcatggttc tcaagtattt gttcaattag ctttggggaa
     1681 gaaatgccaa atccactttg aggatgagtc ttacgacaca gatccaccca catgttgctc
     1741 ttatctggaa tttgggacaa agcaatgcac aggccctcat tcctgatgtg gcgccctcca
     1801 gacatggctg cccaggaagg acggccactt tagaagtggg acgtatcacc agtaagcttg
     1861 aatgattagg atcgcaggtg gctactgcat tctgccgttc gtgaccgtgt tctagcctgt
     1921 agaccaccca gctaccttca ttcaccagtt tttatccttc accttttcca gtatcttgtt
     1981 aaccactagt tcttgagttt tttggctatg atgtgtacgt ttatgtatgt cattcatgga
     2041 ctttcaacta gaaaaggtaa tgataaggtt ttctgaagac catttgtaaa ttgtccattt
     2101 aaccattttt cagcttgctt tgaaacaaaa gtcacaccta ctatttttct atgaattagg
     2161 gaatgagggg gagatcattc agttttactt ttctttttgt tgaaattttg tacccggatt
     2221 gcagttggca cttttcctaa aacagaattg tttcccactt aggtgtcaga atgtaccttt
     2281 gaacttccct aagaagcagc aggatctttt taactctctc tggtctgttt agactttgaa
     2341 gtcccttctg tagaaaagtc tcataactga gaaggctctg ttttgggccg ggtgggtctg
     2401 ctggcctcca ctcactgtgc tgtttccttt gagtggcaca cttgggaagc tccggggcat
     2461 gtgaaggagc tgcaaacatg agaactaatg aaccaaggcg gctgccacca ggaaggaaca
     2521 gaacgcaggc attcaaccat gacgtctgca cagtgttagt aacatgtcat tgtggtttcg
     2581 ttctcactgt ggtaaaattt atttctgagc acttaaactg tgttgcatac ccctaatttt
     2641 ttttttttct gtatcttcct tgccctcaaa taccctgagg tgataaactg ttccagttgt
     2701 agccaactac cactgctagg cctcaatgta aattcagttg aaatttgcaa ttctatcagc
     2761 aatttaatgt attgaattca gatcatcatt tgtcatttta accgacaacc acccaataaa
     2821 tttactctgc agttctgaac tcagcattgt gcccattttt tactgcaaga tggaccctgt
     2881 atgccaggag acatgtatta tcaacaattg ggaatttttt gaatttcctt ttaggtaata
     2941 ttgattcact gtaattttct aagtgatcaa aacccatgag attttgttat ttggcttggc
     3001 tttcattctc tgcctgccca ttaaagaata ttctattcct aacacataaa acattttaca
     3061 gtcaagcagt gcaaattaca gtgcttttct attttttttt tgagagcctt gaataaattg
     3121 aagaaaactt taaaccaaaa ttagagacga gtcatttaag cttttctgaa tggaaagtat
     3181 taatattttc atttttctag tataatataa taaaatgaat ttttttaaaa aagctactaa
     3241 gtacccatca actttttcat attgtgaaat gaaccaggat cttaacagat actatcatcg
     3301 ctgtcctttt ttggctgttt aatatctagt tcatgtaaca aatttacaag agataagtct
     3361 catggttttt tttttctttt aataggcttt tctgcaattt ttttgaaatt gagttattac
     3421 ttggatttaa ccctgatagg accaggtgtg gtggctcaca ccataatccc agcactttgg
     3481 gaggccaagg tgggtggatc cacctgaggt caggagttca agaccagcct gaccaacatg
     3541 gtgaaatcct gtctctactt aaaaaataca aaattagcct ggcatggtgg cacatgcctg
     3601 taatcccagc tacttgggag gctgaggcag gagaatttcc tgaaccggga gacggaggtt
     3661 gcggtgagcc gagatcacgc catcgcactc cagcctcggc aacaagagcg aaactccgtc
     3721 tcaaaaaaaa aagatttaac cctgattgat agtatagtag ccatgttttc tttagaaatc
     3781 ataacctctt catgggaatc aaactatgtt gaaaattgtg aggaaagata atggtgcttt
     3841 gtgttgggaa aaaaacattt gtgaaggatt agaaaaccgt aacacttaac aaggatagtc
     3901 acagaaccga cgctgcattg gctcttaggt tctagatttt tgtagcacac tcacctgatg
     3961 aaaccaaaga caaatccatg taaaaagtgt tccagtgagc atctctgagg tttaaggtac
     4021 taagaggcag aagtggatag caacagttcc attgccttcg agaactaaaa ctcagctgga
     4081 aagcaaatta gtcttttcac attctgcttc ttcaaaatgt tgtactcaaa aacataccag
     4141 taattaagag ccaaagcaaa gcttcaagga acttttaagt tcaacataaa ggtttaaata
     4201 aaatattttt tattttttat ttttatttat ttatttattt attttgagac agagtctcac
     4261 tctgtcgccc aggctggagc gcagccgcgt gatctcggct cactgcaagc tccgcctccc
     4321 gggttcacgc cattctcctg cctcagcctc ccaagtagct gggactacag gcgcccgctc
     4381 ccacgcccgg ctaatttttt tttttttttt ttttataagt agagacgggg tttcaccacg
     4441 ttagccagga tggtctcgat ctcctgacct agtgatccgc ctgccttggc ctcccaaagt
     4501 gctgggatta accaggcgtg agccactgcg cccggcctta aataaaatat tgtagtcatt
     4561 aatggtgtgt ttgaattgaa gagataccag gagatagagg tgaagtgcag tacttttatt
     4621 ctttaagaat atagtcttta gccaggtgca gtggtgtgtg cctgtagtct cagctatttg
     4681 agaggctgag gtgagaggat cacttgagtt caggagttca agaccagcct gggcaacata
     4741 gcaagtccct ggctcaaaaa aaaaaaagtt tcccattcat attaactcca tcttttaaaa
     4801 atgtcatgat tacaaagtga aaagatttgg ctttcttaga ggctcaatca cagaggtgaa
     4861 agtgaccttg gaaatcatat actctatccc catgttacac agattagaaa aactgaggtt
     4921 atggcactga cttaggcacc cccagcaagg caacccaggg actacaactg gcaatcccaa
     4981 ctcctgggct agggcttttt ctaccttttt ttgcattggc ctcttaaaga ggcaatgaat
     5041 actaattcct ggcatcagaa aaaaaaaaag gcatgaggtg ggaggattct tttttccctg
     5101 atgggaaaca gtgaataaga aaaatctcat cattcgatgg aagaggtgac ttaataattt
     5161 tattaatgaa tttgatgtcc catgttttgt agttttgtta tcattgaacc attggggctg
     5221 gaatctgcct aaataatttt atcttggtag ccagcaatta tgttggtatt ttatgtgggc
     5281 cttcccagat tttcatatta atgaaatgac taatagtcgt acttaagagg taactctact
     5341 aaagcagaat gagatctaat atgttgtgga aataaaagag tttgcagtgg aatgatactc
     5401 tcactccgtg cttgtaaaat tgagttctat tcaagacgga actgctatga ctggcctatt
     5461 caaggcttca tatttttata cagactattt cacagaccat agatttattt taaaagggaa
     5521 aatctcacac ataattaagc agtggaaaat gtgctcaatg ctatggtgcg tcaggccctc
     5581 tgtctaccag gtttctcccc tttctgcaga gctgtggacc ctgtacgtac caaacaggtg
     5641 aacttggtcc atctttcctt cttccttttt ttgcacattt gcatttatat cttcctgtac
     5701 taaaagaaac aaattattta taattggggt gacaatataa aggaacaaaa gatggggcaa
     5761 tagttgcttc ctagctggag ctgtaagtcc atgttacaga aactcactat ttaaaaagtt
     5821 ttaaaagatt tatgaacctt gtcctacaat tcgctgaata cttatttgtc ttttaaactc
     5881 ccctcggtgt atggatcatc ttcgtcagaa tgccgttgtt tcattgtgaa tcaggggaaa
     5941 atgttaatca tttggagact gttttcttat taccaaatgt acaatccata agacaactga
     6001 aagcaacaac tgctgggttc actgacaaag attataaaaa tcatcacgtt caaagtagag
     6061 tttttagcca aggtcaagaa ctaacctggg gctgagtcag cgtctctacc cacttaaata
     6121 acagcgtaaa gatctttcac taaattcgtt atgtggtctg tctggatgta aacctatata
     6181 tttccttttg aaacagaatc atatcctgca gactcttggc actcctgcat agctttgacc
     6241 gaatgttcac tctcatcgta atggaagatt tctatctatg cagataatac atgtttttaa
     6301 atactgtttt ctgtttagtc ctcaatcttc ctaactcaaa ttggggactg aggagagaga
     6361 aaggtggtta cccctgttac cgtgccatat tcttcttgct gcttttcaac cccacgtgat
     6421 tgttgattga cggttctgct ataatgtgcg tgcccttcaa gtttcagaaa actttcccaa
     6481 tcatttcact tcaatcttaa ttgaacccaa gagtcaaagt tattattttc tccgaacgtg
     6541 tttgtgatct tctgttatat tttggggcat gttaccttta tggtatataa gctgtagtgc
     6601 atactctttg tattgcaaaa aactggtcag taatttatgt acatgtattc cacattttag
     6661 tgtgcttgaa gtgacaatcc atagtttgta gtagtttgtt atttgtcaac tttaccctgt
     6721 gttttaagga catctaaaca ttccttgtcc tatcaagatg acaaaagcag aatgtaattt
     6781 ttttttggaa gcttcgtgat tacctgtaac aagttctgtt tttaaaacga atacaaataa
     6841 agttagtaac tatttttaaa tca
//
