LOCUS       NM_001251974            3416 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens regulator of calcineurin 2 (RCAN2), transcript variant
            2, mRNA.
ACCESSION   NM_001251974
VERSION     NM_001251974.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3416)
  AUTHORS   Xu,Y.J., Lai,Z.C., Kan,A., Liu,H., Huang,Y., Lai,Y.Y., Weng,J.F.,
            Wu,Z.F., Shi,M., Gu,W.L., Zhang,S. and He,M.K.
  TITLE     TMB Signature-Related RCAN2 Promotes Apoptosis by Upregulating
            EHF/DR5 Pathway in Hepatocellular Carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 29 (7), 243 (2024)
   PUBMED   39082336
  REMARK    GeneRIF: TMB Signature-Related RCAN2 Promotes Apoptosis by
            Upregulating EHF/DR5 Pathway in Hepatocellular Carcinoma.
REFERENCE   2  (bases 1 to 3416)
  AUTHORS   Chang,Y., Chen,L., Tang,J., Chen,G., Ji,J. and Xu,M.
  TITLE     USP7-mediated JUND suppresses RCAN2 transcription and elevates
            NFATC1 to enhance stem cell property in colorectal cancer
  JOURNAL   Cell Biol Toxicol 39 (6), 3121-3140 (2023)
   PUBMED   37535148
  REMARK    GeneRIF: USP7-mediated JUND suppresses RCAN2 transcription and
            elevates NFATC1 to enhance stem cell property in colorectal cancer.
REFERENCE   3  (bases 1 to 3416)
  AUTHORS   Huang,X., Wang,Z., Song,M., Huan,H., Cai,Z., Wu,B., Shen,J.,
            Zhou,Y.L. and Shi,J.
  TITLE     CircIQGAP1 regulates RCAN1 and RCAN2 through the mechanism of ceRNA
            and promotes the growth of malignant glioma
  JOURNAL   Pharmacol Res 197, 106979 (2023)
   PUBMED   37918583
  REMARK    GeneRIF: CircIQGAP1 regulates RCAN1 and RCAN2 through the mechanism
            of ceRNA and promotes the growth of malignant glioma.
            Erratum:[Pharmacol Res. 2024 Jan;199:107021. doi:
            10.1016/j.phrs.2023.107021.. PMID: 38042685]
REFERENCE   4  (bases 1 to 3416)
  AUTHORS   Wang,H., Fang,X., Ren,Q., Zeng,Y., Tan,X., Ye,T., Fan,J. and Xu,Y.
  TITLE     Association Between Circulating Regulator of Calcineurin 2
            Concentrations With Overweight and Obesity
  JOURNAL   Front Endocrinol (Lausanne) 13, 857841 (2022)
   PUBMED   35733783
  REMARK    GeneRIF: Association Between Circulating Regulator of Calcineurin 2
            Concentrations With Overweight and Obesity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3416)
  AUTHORS   Gollogly,L.K., Ryeom,S.W. and Yoon,S.S.
  TITLE     Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the
            inhibitory effects of DSCR1 on calcineurin signaling in endothelial
            cells and inhibits angiogenesis
  JOURNAL   J Surg Res 142 (1), 129-136 (2007)
   PUBMED   17610901
  REMARK    GeneRIF: DSCR1-L1 is constitutively expressed in endothelial cells
            and acts similar to DSCR1 in inhibiting calcineurin activity and
            restraining VEGF-mediated angiogenesis.
REFERENCE   6  (bases 1 to 3416)
  AUTHORS   Cao,X., Kambe,F., Miyazaki,T., Sarkar,D., Ohmori,S. and Seo,H.
  TITLE     Novel human ZAKI-4 isoforms: hormonal and tissue-specific
            regulation and function as calcineurin inhibitors
  JOURNAL   Biochem J 367 (Pt 2), 459-466 (2002)
   PUBMED   12102656
  REMARK    GeneRIF: the expression of ZAKI-4 isoforms is subjected to distinct
            hormonal as well as tissue-specific regulation, constituting a
            complex signalling network through inhibition of calcineurin.
REFERENCE   7  (bases 1 to 3416)
  AUTHORS   Fuentes,J.J., Genesca,L., Kingsbury,T.J., Cunningham,K.W.,
            Perez-Riba,M., Estivill,X. and de la Luna,S.
  TITLE     DSCR1, overexpressed in Down syndrome, is an inhibitor of
            calcineurin-mediated signaling pathways
  JOURNAL   Hum Mol Genet 9 (11), 1681-1690 (2000)
   PUBMED   10861295
REFERENCE   8  (bases 1 to 3416)
  AUTHORS   Rothermel,B., Vega,R.B., Yang,J., Wu,H., Bassel-Duby,R. and
            Williams,R.S.
  TITLE     A protein encoded within the Down syndrome critical region is
            enriched in striated muscles and inhibits calcineurin signaling
  JOURNAL   J Biol Chem 275 (12), 8719-8725 (2000)
   PUBMED   10722714
REFERENCE   9  (bases 1 to 3416)
  AUTHORS   Strippoli,P., Lenzi,L., Petrini,M., Carinci,P. and Zannotti,M.
  TITLE     A new gene family including DSCR1 (Down Syndrome Candidate Region
            1) and ZAKI-4: characterization from yeast to human and
            identification of DSCR1-like 2, a novel human member (DSCR1L2)
  JOURNAL   Genomics 64 (3), 252-263 (2000)
   PUBMED   10756093
REFERENCE   10 (bases 1 to 3416)
  AUTHORS   Miyazaki,T., Kanou,Y., Murata,Y., Ohmori,S., Niwa,T., Maeda,K.,
            Yamamura,H. and Seo,H.
  TITLE     Molecular cloning of a novel thyroid hormone-responsive gene,
            ZAKI-4, in human skin fibroblasts
  JOURNAL   J Biol Chem 271 (24), 14567-14571 (1996)
   PUBMED   8662924
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359633.15, DA113879.1,
            AK090990.1, BP264912.1 and BU069906.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_001251974.1.
            
            Summary: This gene encodes a member of the regulator of calcineurin
            (RCAN) protein family. These proteins play a role in many
            physiological processes by binding to the catalytic domain of
            calcineurin A, inhibiting calcineurin-mediated nuclear
            translocation of the transcription factor NFATC1. Expression of
            this gene in skin fibroblasts is upregulated by thyroid hormone,
            and the encoded protein may also play a role in endothelial cell
            function and angiogenesis. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (2, also known as beta-1) differs
            in the 5' UTR and uses an alternate start codon, compared to
            variant 1. Variants 2 and 3 encode the same isoform (2, also known
            as beta), which is longer and has a distinct N-terminus, compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090990.1, AY034086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371374.6/ ENSP00000360425.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AL359633.15        51484-51609
            127-155             DA113879.1         1-29
            156-2551            AK090990.1         1-2396
            2552-3003           BP264912.1         187-638
            3004-3416           BU069906.1         22-434              c
FEATURES             Location/Qualifiers
     source          1..3416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..3416
                     /gene="RCAN2"
                     /gene_synonym="CSP2; DSCR1L1; MCIP2; RCN2; ZAKI-4; ZAKI4"
                     /note="regulator of calcineurin 2"
                     /db_xref="GeneID:10231"
                     /db_xref="HGNC:HGNC:3041"
                     /db_xref="MIM:604876"
     exon            1..277
                     /gene="RCAN2"
                     /gene_synonym="CSP2; DSCR1L1; MCIP2; RCN2; ZAKI-4; ZAKI4"
                     /inference="alignment:Splign:2.1.0"
     exon            278..504
                     /gene="RCAN2"
                     /gene_synonym="CSP2; DSCR1L1; MCIP2; RCN2; ZAKI-4; ZAKI4"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1011
                     /gene="RCAN2"
                     /gene_synonym="CSP2; DSCR1L1; MCIP2; RCN2; ZAKI-4; ZAKI4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     thyroid hormone-responsive (skin fibroblasts); Down
                     syndrome critical region gene 1-like 1; calcipressin-2;
                     myocyte-enriched calcineurin-interacting protein 2; Down
                     syndrome candidate region 1-like 1; thyroid
                     hormone-responsive protein ZAKI-4"
                     /codon_start=1
                     /product="calcipressin-2 isoform 2"
                     /protein_id="NP_001238903.1"
                     /db_xref="CCDS:CCDS59023.1"
                     /db_xref="GeneID:10231"
                     /db_xref="HGNC:HGNC:3041"
                     /db_xref="MIM:604876"
                     /translation="MRGESYFIGMRSPGQQGHVPEDGGLFLLCCIDRDWAVTRCFAEE
                     AFQAITDFNDLPNSLFACNVHQSVFEGEESKEKFEGLFRTYDDCVTFQLFKSFRRVRI
                     NFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPP
                     SSPPVGWQPINDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEE
                     EDPKTSPKPKIIQTRRPGLPPSVSN"
     exon            505..678
                     /gene="RCAN2"
                     /gene_synonym="CSP2; DSCR1L1; MCIP2; RCN2; ZAKI-4; ZAKI4"
                     /inference="alignment:Splign:2.1.0"
     exon            679..850
                     /gene="RCAN2"
                     /gene_synonym="CSP2; DSCR1L1; MCIP2; RCN2; ZAKI-4; ZAKI4"
                     /inference="alignment:Splign:2.1.0"
     exon            851..3416
                     /gene="RCAN2"
                     /gene_synonym="CSP2; DSCR1L1; MCIP2; RCN2; ZAKI-4; ZAKI4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3398..3403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RCAN2"
                     /gene_synonym="CSP2; DSCR1L1; MCIP2; RCN2; ZAKI-4; ZAKI4"
                     /note="hexamer: AATATA"
     polyA_site      3416
                     /gene="RCAN2"
                     /gene_synonym="CSP2; DSCR1L1; MCIP2; RCN2; ZAKI-4; ZAKI4"
                     /note="major polyA site"
ORIGIN      
        1 ggagccgctt tgtcccgggt gacggcggcg gaggttgcgg ggaggagcgg gcagcaggca
       61 gaatcccact gacccacggc ggcagagaga gggaggcggg gcgcgccgcg ccgcgtacgg
      121 ccccacgcaa aggcccgcgg gcaccgcgcc gcccccacgc gctcgcaccg gcgggcaggt
      181 gagcaggcag cgccgcgcgc tagcagctgg cccccgtaga cgccccagcc gccgcctccg
      241 cctccgcctc cgccggcgca tcgcggacgc ccagcaggaa tgaggggaga atcatacttc
      301 atcggaatga ggagcccagg gcagcaggga cacgtccctg aagatggagg acttttctta
      361 ctgtgctgca tagacaggga ctgggctgtc actcgttgtt ttgcagaaga agcctttcaa
      421 gcaatcactg acttcaatga cctccccaac tcgttgtttg cgtgcaatgt tcaccagtca
      481 gtgtttgaag gagaagagag caaggaaaaa tttgagggac tgtttcggac ttatgatgac
      541 tgtgtgacgt tccagctatt taagagtttc agacgtgtcc gtataaactt cagcaatcct
      601 aaatctgcag cccgagctag gatagagctt catgaaaccc aattcagagg gaaaaaatta
      661 aagctctact ttgcacaggt tcagactcca gagacagatg gagacaaact gcacttggct
      721 ccaccccagc ctgccaaaca gtttctcatc tcgccccctt cctccccacc tgttggctgg
      781 cagcccatca acgatgccac gccagtcctc aactatgacc tcctctatgc tgtggccaaa
      841 ctaggaccag gagagaagta tgagctccat gcagggactg agtccacccc aagtgtcgtc
      901 gtgcacgtgt gcgacagtga catagaggaa gaagaggacc caaagacttc cccaaagcca
      961 aaaatcatcc aaactcggcg tcctggcctg ccaccctccg tgtccaactg agctgcctgc
     1021 tccttctcga taatagccgt ctcctcttta tcatgctttt tccccctgtt gtttgtcaaa
     1081 aaaaattgcc tttaaattcc tgggtgtttg gttgtttgag attccttcct tgttatcaag
     1141 cctctcggac aaaagggcta ggaaaaggtg atatgtctcc tgatcatatc atacccatta
     1201 agtataaccc attatttaga aggttctagg gaaaaaagta gtattttctt attaaacaat
     1261 cagcacagcc tatatctttg ttctctcatg ttgatccaag ccagagacat cagtaacaaa
     1321 tagcacctgt gttgtttgtg agctgtttca gtcccagtcc tgatgtgtgt gcgttgttct
     1381 ctcctggcca cttaaatagg accatatgta aacttgactt tgactgcatg agatatccct
     1441 atctggtctc actcagtcct ctgcatccca acattcccag gacatgcatg atcaccagca
     1501 tttattttca ttatttgagg atatcttata actcacagat tgtcagcatc cagccatgtc
     1561 ctatctagat taggaaaatg atcagaatat tccagctcaa caagtctggg tatattcact
     1621 attgtgagtc aatacaccat agctctgttg aaattcctgg aggcaaaatt gaccttggcc
     1681 ccaaagatat tcctcaatag atttcaaaca ccactcccct gtagaactct cccagcctcg
     1741 ttggggaggc ttgtccaggg tgatagagac tgatttcaga caaacctatt tattacaaaa
     1801 gtttcatggt gtctgaatga ttgttttctc tctttgtata tttgtacaaa tgtttcagct
     1861 gtgcttttaa aaaatctgga tgttttttat ttagtgattg ttcgacaatt agctgcttca
     1921 aaacataatg tgcattgctt atgaatgcct tcatatacta atacagatac tctgataata
     1981 ttacactcta ataaggataa tgctgaattt tgaaaggaca caaaacatct aatgccaata
     2041 tatacatgat tagccaacat ctttgctatc aagaccactt gtttttaaat aaagatgcaa
     2101 gtgtcagttg tagattattg ggatgaagct aaatccccag aatgcagcag cagctgagca
     2161 tgttaaaatg gggaaggatg atagctacat gtatgccggt cctactcacg cgacacccgt
     2221 gtgctcaaaa aagttatttg tttttgttac gtgtgatttt tctatttctc tagcccaaag
     2281 tgcattacag aagatacacc tatagaacca ttaccttctg ctatgtgtgc caggcctcat
     2341 ctactcctgt acattaatga attactttag atgcaaacgc agattacaat ggagtgggga
     2401 agtactttca ttacccaagc ctcagaaaaa cacacaagaa caataacaca gcaaacagat
     2461 tgagggattg ttgtggtttt tgactaaggt gtatgttagt ttcatcagaa acttaaaaca
     2521 tagactgatc actcagaaat taaagtccgt tttactgtga atatagcaat atagtactgg
     2581 acacagtact ggtgaaactg aggagagcat tgcttgtaaa atcctgagtt tccataagga
     2641 aaatgaaaac tccttttaaa aataaaatct gaggagtgta caataagcat atgctttgac
     2701 tttcctttgc tgtggaggtt tttggttttt cattgatgat aaacgactac agacttagta
     2761 gtggagaaat ggtgtcctct agtggaagaa atagtaggct ccgctattca gatgcagagc
     2821 actgcagcat ccagcctttc aaagctgact cttctcaatc atctgtgggt catttgactt
     2881 gattttttaa gctaccctga atttccagaa tgcaggttct aaagaaatct agatgagaga
     2941 aagtatttga aaatgatttt taaatgtttt ttaaaagaca catctgacat ttttaacaac
     3001 ttagtaaaag ttgaaatgac cattctgtgt agtcataaaa gaaacacaat gaagtgtatg
     3061 gcctctggag ttagtcttag taaaacttat tgctctgtgt caatgttaac ctgtctcaga
     3121 tcaagtaatt ctttcactag gttgggtttg gggagggggg aaaagagggg cttttcctag
     3181 gagaacgata agaaatggaa agactccttg aagtgttgca agggaacctc ctagcactgt
     3241 gaaagtcaga atcgcctcag catttccatg acgcacatta tgcaaatctc tttagcacta
     3301 ttttaagttt gaaaacttta acaatgaagg ggaaggggaa gatttccacc aactgaatca
     3361 tttgtgcacg tgtatagctc aaagagctta gacttcaaat atatctggtg aatgac
//
