LOCUS       NM_014248               1169 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens ring-box 1 (RBX1), mRNA.
ACCESSION   NM_014248
VERSION     NM_014248.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1169)
  AUTHORS   Monshizadeh,K., Tajamolian,M., Anbari,F., Mehrjardi,M.Y.V.,
            Kalantar,S.M. and Dehghani,M.
  TITLE     The association of RBX1 and BAMBI gene expression with oocyte
            maturation in PCOS women
  JOURNAL   BMC Med Genomics 17 (1), 24 (2024)
   PUBMED   38238750
  REMARK    GeneRIF: The association of RBX1 and BAMBI gene expression with
            oocyte maturation in PCOS women.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1169)
  AUTHORS   Bao,E., Zhou,Y., He,S., Tang,J., He,Y., Zhu,M., Cheng,C. and
            Wang,Y.
  TITLE     RING box protein-1(RBX1), a key component of SCF E3 ligase, induced
            multiple myeloma cell drug-resistance though suppressing p27
  JOURNAL   Cancer Biol Ther 24 (1), 2231670 (2023)
   PUBMED   37639640
  REMARK    GeneRIF: RING box protein-1(RBX1), a key component of SCF E3
            ligase, induced multiple myeloma cell drug-resistance though
            suppressing p27.
REFERENCE   3  (bases 1 to 1169)
  AUTHORS   Teng,F., Wang,Y., Liu,M., Tian,S., Stjepanovic,G. and Su,M.Y.
  TITLE     Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric
            metabolic enzyme
  JOURNAL   Structure 31 (11), 1431-1440 (2023)
   PUBMED   37788672
REFERENCE   4  (bases 1 to 1169)
  AUTHORS   Lee,S.H., Lee,Y.J., Jung,S. and Chung,K.C.
  TITLE     E3 ligase adaptor FBXO7 contributes to ubiquitination and
            proteasomal degradation of SIRT7 and promotes cell death in
            response to hydrogen peroxide
  JOURNAL   J Biol Chem 299 (3), 102909 (2023)
   PUBMED   36646384
REFERENCE   5  (bases 1 to 1169)
  AUTHORS   Nardone,C., Palanski,B.A., Scott,D.C., Timms,R.T., Barber,K.W.,
            Gu,X., Mao,A., Leng,Y., Watson,E.V., Schulman,B.A., Cole,P.A. and
            Elledge,S.J.
  TITLE     A central role for regulated protein stability in the control of
            TFE3 and MITF by nutrients
  JOURNAL   Mol Cell 83 (1), 57-73 (2023)
   PUBMED   36608670
REFERENCE   6  (bases 1 to 1169)
  AUTHORS   Kamura,T., Conrad,M.N., Yan,Q., Conaway,R.C. and Conaway,J.W.
  TITLE     The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1
            modification of cullins Cdc53 and Cul2
  JOURNAL   Genes Dev 13 (22), 2928-2933 (1999)
   PUBMED   10579999
REFERENCE   7  (bases 1 to 1169)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   8  (bases 1 to 1169)
  AUTHORS   Kamura,T., Koepp,D.M., Conrad,M.N., Skowyra,D., Moreland,R.J.,
            Iliopoulos,O., Lane,W.S., Kaelin,W.G. Jr., Elledge,S.J.,
            Conaway,R.C., Harper,J.W. and Conaway,J.W.
  TITLE     Rbx1, a component of the VHL tumor suppressor complex and SCF
            ubiquitin ligase
  JOURNAL   Science 284 (5414), 657-661 (1999)
   PUBMED   10213691
REFERENCE   9  (bases 1 to 1169)
  AUTHORS   Ohta,T., Michel,J.J., Schottelius,A.J. and Xiong,Y.
  TITLE     ROC1, a homolog of APC11, represents a family of cullin partners
            with an associated ubiquitin ligase activity
  JOURNAL   Mol Cell 3 (4), 535-541 (1999)
   PUBMED   10230407
REFERENCE   10 (bases 1 to 1169)
  AUTHORS   Tan,P., Fuchs,S.Y., Chen,A., Wu,K., Gomez,C., Ronai,Z. and Pan,Z.Q.
  TITLE     Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to
            catalyze the ubiquitination of I kappa B alpha
  JOURNAL   Mol Cell 3 (4), 527-533 (1999)
   PUBMED   10230406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA353856.1, AF140598.1,
            DN602016.1 and AL080242.11.
            
            On May 17, 2019 this sequence version replaced NM_014248.3.
            
            Summary: This locus encodes a RING finger-like domain-containing
            protein. The encoded protein interacts with cullin proteins and
            likely plays a role in ubiquitination processes necessary for cell
            cycle progression. This protein may also affect protein turnover.
            Related pseudogenes exist on chromosomes 2 and 5.[provided by
            RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.60101.1,
                                           SRR1803614.52727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216225.9/ ENSP00000216225.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA353856.1         32-47
            17-395              AF140598.1         2-380
            396-875             DN602016.1         105-584
            876-1169            AL080242.11        43688-43981
FEATURES             Location/Qualifiers
     source          1..1169
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..1169
                     /gene="RBX1"
                     /gene_synonym="BA554C12.1; RNF75; ROC1"
                     /note="ring-box 1"
                     /db_xref="GeneID:9978"
                     /db_xref="HGNC:HGNC:9928"
                     /db_xref="MIM:603814"
     exon            1..99
                     /gene="RBX1"
                     /gene_synonym="BA554C12.1; RNF75; ROC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..348
                     /gene="RBX1"
                     /gene_synonym="BA554C12.1; RNF75; ROC1"
                     /EC_number="2.3.2.27"
                     /EC_number="2.3.2.32"
                     /note="regulator of cullins 1; ZYP protein; RING-box
                     protein 1; RING finger protein 75; ring-box 1, E3
                     ubiquitin protein ligase; E3 ubiquitin-protein transferase
                     RBX1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RBX1"
                     /protein_id="NP_055063.1"
                     /db_xref="CCDS:CCDS14009.1"
                     /db_xref="GeneID:9978"
                     /db_xref="HGNC:HGNC:9928"
                     /db_xref="MIM:603814"
                     /translation="MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAI
                     CRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWE
                     FQKYGH"
     exon            100..178
                     /gene="RBX1"
                     /gene_synonym="BA554C12.1; RNF75; ROC1"
                     /inference="alignment:Splign:2.1.0"
     exon            179..249
                     /gene="RBX1"
                     /gene_synonym="BA554C12.1; RNF75; ROC1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..335
                     /gene="RBX1"
                     /gene_synonym="BA554C12.1; RNF75; ROC1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..1169
                     /gene="RBX1"
                     /gene_synonym="BA554C12.1; RNF75; ROC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      500..505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBX1"
                     /gene_synonym="BA554C12.1; RNF75; ROC1"
                     /note="hexamer: AATAAA"
     polyA_site      524
                     /gene="RBX1"
                     /gene_synonym="BA554C12.1; RNF75; ROC1"
                     /note="major polyA site"
     regulatory      564..569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBX1"
                     /gene_synonym="BA554C12.1; RNF75; ROC1"
                     /note="hexamer: AATGAA"
     polyA_site      594
                     /gene="RBX1"
                     /gene_synonym="BA554C12.1; RNF75; ROC1"
     polyA_site      967
                     /gene="RBX1"
                     /gene_synonym="BA554C12.1; RNF75; ROC1"
ORIGIN      
        1 gacagaccgt gtgtttccaa aatggcggca gcgatggatg tggatacccc gagcggcacc
       61 aacagcggcg cgggcaagaa gcgctttgaa gtgaaaaagt ggaatgcagt agccctctgg
      121 gcctgggata ttgtggttga taactgtgcc atctgcagga accacattat ggatctttgc
      181 atagaatgtc aagctaacca ggcgtccgct acttcagaag agtgtactgt cgcatgggga
      241 gtctgtaacc atgcttttca cttccactgc atctctcgct ggctcaaaac acgacaggtg
      301 tgtccattgg acaacagaga gtgggaattc caaaagtatg ggcactagga aaagacttct
      361 tccatcaagc ttaattgttt tgttattcat ttaatgactt tccctgctgt tacctaatta
      421 caaattggat ggaactgtgt ttttttctgc tttgtttttt cagtttgctg tttctgtagc
      481 catattgtat tctgtgtcaa ataaagtcca gttggattct ggaacggatg ctctctcttg
      541 tgtatgtgaa caaagtgaac ataaatgaag agtctcccct tccaaggctg aaaactcagc
      601 ttttgaaagt gaaatgtttg ttcatcgggg ccagagcagg gttgtcctct gagcgcatca
      661 cttagtgacg aggaatccaa cagctcaagg cagagtgtgg atcaccggct cccgaaaaca
      721 gcagtcagcc cttctttctc ctgtgtgaca gcagtgggca gctgaaagag ggaagaatgt
      781 gggattcagt catcaaaccc agttctgagt cctggttcca cagcttgggt actgatggca
      841 atcttggcca agttgtctct ctactctgaa ctttcctcct ctgtactgtg ggcttctgag
      901 gactaagtgg catcatgtgg gcacagagag aagctttgta aaatgtaaaa ccgctataca
      961 aatgtgacct ttggttgtgt atgacagcag tccccaacct ttttgccacc agggattggt
     1021 ttcatggaag acgatttttc catggaccgg gggtggggcg ggggtgtgct tggggatggt
     1081 tttggaactg ttccacctga gatcatgagg cagtagatgg accgcgcaac ctagatccct
     1141 cacatgcacg gttcgccaat agggttgaa
//
