LOCUS       NM_194272               2017 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RNA binding protein, mRNA processing factor 2
            (RBPMS2), transcript variant 1, mRNA.
ACCESSION   NM_194272 XM_496072
VERSION     NM_194272.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2017)
  AUTHORS   Cheng,M., Zhan,X., Xu,Y., Wang,S., Zhang,H., Fang,L., Jin,H. and
            Chen,W.
  TITLE     DNA methylation of RNA-binding protein for multiple splicing 2
            functions as diagnosis biomarker in gastric cancer pathogenesis and
            its potential clinical significance
  JOURNAL   Bioengineered 13 (2), 4347-4360 (2022)
   PUBMED   35137653
  REMARK    GeneRIF: DNA methylation of RNA-binding protein for multiple
            splicing 2 functions as diagnosis biomarker in gastric cancer
            pathogenesis and its potential clinical significance.
REFERENCE   2  (bases 1 to 2017)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2017)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2017)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2017)
  AUTHORS   Sagnol,S., Yang,Y., Bessin,Y., Allemand,F., Hapkova,I.,
            Notarnicola,C., Guichou,J.F., Faure,S., Labesse,G. and de Santa
            Barbara,P.
  TITLE     Homodimerization of RBPMS2 through a new RRM-interaction motif is
            necessary to control smooth muscle plasticity
  JOURNAL   Nucleic Acids Res 42 (15), 10173-10184 (2014)
   PUBMED   25064856
  REMARK    GeneRIF: The study shows that RBPMS2 homodimerizes through a
            particular sequence motif located in its RNA recognition motif
            domain.
REFERENCE   6  (bases 1 to 2017)
  AUTHORS   Farazi,T.A., Leonhardt,C.S., Mukherjee,N., Mihailovic,A., Li,S.,
            Max,K.E., Meyer,C., Yamaji,M., Cekan,P., Jacobs,N.C.,
            Gerstberger,S., Bognanni,C., Larsson,E., Ohler,U. and Tuschl,T.
  TITLE     Identification of the RNA recognition element of the RBPMS family
            of RNA-binding proteins and their transcriptome-wide mRNA targets
  JOURNAL   RNA 20 (7), 1090-1102 (2014)
   PUBMED   24860013
REFERENCE   7  (bases 1 to 2017)
  AUTHORS   Hapkova,I., Skarda,J., Rouleau,C., Thys,A., Notarnicola,C.,
            Janikova,M., Bernex,F., Rypka,M., Vanderwinden,J.M., Faure,S.,
            Vesely,J. and de Santa Barbara,P.
  TITLE     High expression of the RNA-binding protein RBPMS2 in
            gastrointestinal stromal tumors
  JOURNAL   Exp Mol Pathol 94 (2), 314-321 (2013)
   PUBMED   23295309
  REMARK    GeneRIF: RBPMS2 is up-regulated in Gastrointestinal stromal tumors
            compared to normal adult gastrointestinal tissues, indicating that
            RBPMS2 might represent a new diagnostic marker for GISTs and a
            potential target for cancer therapy.
REFERENCE   8  (bases 1 to 2017)
  AUTHORS   Notarnicola,C., Rouleau,C., Le Guen,L., Virsolvy,A., Richard,S.,
            Faure,S. and De Santa Barbara,P.
  TITLE     The RNA-binding protein RBPMS2 regulates development of
            gastrointestinal smooth muscle
  JOURNAL   Gastroenterology 143 (3), 687-697 (2012)
   PUBMED   22683258
  REMARK    GeneRIF: RBPMS3 transcripts are up-regulation in colons of patients
            with chronic psuedo obstruction syndrome.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091582.17, AK127873.1 and
            AI274305.1.
            
            On Nov 23, 2018 this sequence version replaced NM_194272.2.
            
            Summary: The protein encoded by this gene is a member of the RNA
            recognition motif (RRM)-containing protein family and is involved
            in the development and dedifferentiation of digestive smooth muscle
            cells. The encoded protein functions as a homodimer and indirectly
            inhibits the bone morphogenetic protein pathway. [provided by
            RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY369207.1, AK127873.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300069.5/ ENSP00000300069.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC091582.17        23845-23846         c
            3-1964              AK127873.1         1-1962
            1965-2017           AI274305.1         9-61                c
FEATURES             Location/Qualifiers
     source          1..2017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..2017
                     /gene="RBPMS2"
                     /note="RNA binding protein, mRNA processing factor 2"
                     /db_xref="GeneID:348093"
                     /db_xref="HGNC:HGNC:19098"
                     /db_xref="MIM:619034"
     exon            1..357
                     /gene="RBPMS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..900
                     /gene="RBPMS2"
                     /note="RNA binding protein with multiple splicing 2"
                     /codon_start=1
                     /product="RNA-binding protein with multiple splicing 2"
                     /protein_id="NP_919248.1"
                     /db_xref="CCDS:CCDS32271.1"
                     /db_xref="GeneID:348093"
                     /db_xref="HGNC:HGNC:19098"
                     /db_xref="MIM:619034"
                     /translation="MSNLKPDGEHGGSTGTGSGAGSGGALEEEVRTLFVSGLPVDIKP
                     RELYLLFRPFKGYEGSLIKLTARQPVGFVIFDSRAGAEAAKNALNGIRFDPENPQTLR
                     LEFAKANTKMAKSKLMATPNPSNVHPALGAHFIARDPYDLMGAALIPASPEAWAPYPL
                     YTTELTPAISHAAFTYPTATAAAAALHAQVRWYPSSDTTQQGWKYRQFC"
     exon            358..435
                     /gene="RBPMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..474
                     /gene="RBPMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..537
                     /gene="RBPMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..688
                     /gene="RBPMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..837
                     /gene="RBPMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            838..907
                     /gene="RBPMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..2017
                     /gene="RBPMS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1997..2002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBPMS2"
                     /note="hexamer: AATAAA"
     polyA_site      2017
                     /gene="RBPMS2"
                     /note="major polyA site"
ORIGIN      
        1 gcactcgccg gtcgcagtga aaaggcggag gcggcggccc ctccggctcc cactgcctcc
       61 cccgccgcac cccctcccca ccttccgcac ccgccaaact tgatgtgacc ctggcccgac
      121 gcggaggctg cccctctcac tgccccgtgg gtcccccgcc acccgctccg cacccgcgag
      181 cgcaccgctc cccgcgcccc ttcccacttc ccgcggggcc ggcgccgcgc tcgccctcgc
      241 gttccttccc gccgccccct cccccgcacc atgagcaacc tgaagccgga cggcgagcac
      301 ggcggcagca ccggcaccgg ctccggcgcg ggctccggcg gcgccctgga ggaggaggtc
      361 cggacactgt ttgtcagcgg cctccctgtg gacattaaac ccagagaact ctacttgctc
      421 ttccggccgt tcaaggggta tgaagggtcc ctgatcaagc tcactgcaag acagcctgtt
      481 ggttttgtga tctttgacag ccgtgcagga gcagaagcgg ccaagaatgc gctgaacggt
      541 attcgctttg atcccgaaaa tccacagact ctgaggctag agtttgccaa agccaacacc
      601 aagatggcca agagcaagct aatggcaact ccaaatccca gcaacgtgca ccccgcccta
      661 ggagcacact tcatcgcacg ggacccctat gacctgatgg gggctgctct gatccctgca
      721 tccccagagg cctgggcccc ctaccctttg tacaccacag agctgacccc agccatctcc
      781 catgctgcgt tcacctaccc aactgccact gccgctgccg ccgccctcca cgctcaggtg
      841 cgctggtacc cttcctctga caccacccag caaggatgga agtaccgtca gttctgttag
      901 tttttcagtc tggtcaccgg ggaggtggtt ctggtaatct gtggtggtgc cgggacaggc
      961 gccccgagtt cccactgccc ccgggcggcc tgcacagagc tgctgccctc cagagactgt
     1021 gaatcccaag cctgactcag tggactgctt cctgttcccc tccctcctct tcctcacctt
     1081 gttctgcacc ctcaagcctt tctccaatgc ctcccaggag gatttgggga ctttctccct
     1141 ggggcgccca gatccagctc ggaggcctca ctgggacctg gcaaggcctg acctcccgcc
     1201 caaacttgct tctgtagctc cccctcgagg aagtgaggtg tttaattttg catgttttct
     1261 ggcatgaatt aagacactta tacttgtata tatgagtgta cagtttgttc tcacactgtc
     1321 accatagcga caggtcctgg ctcccagtgg ttcatcctgc ctgcccctct ctcctcgccc
     1381 cgcccctgca cccaccccgc ttcagggagg cccaagttcc gtggccccac acgcttccag
     1441 gctcagctcc cacctccacc caacagatag atggggtttg ctttttcatt tcacatgggg
     1501 ctcctccgct cctgccttct cggatgggcc aacagtcgta agaaagccct ctctgcccgt
     1561 tctgttcacc tctccacagc gcaccccgcc cgccgctgct cctcattctt tccaaacctc
     1621 gaaaccaacc aaaacgtgag aagtattttt gtaccctgtg taacaaaata tttatgcatc
     1681 ataaaggatt tttcatgtgc gtaccattaa ttattaaagc gacctcgttc gccctgtcag
     1741 ataagtttaa tgtttagttt gaggcatgaa gaagaaaagg gtttccattc ttcagcagta
     1801 cgcctttgtg tctggcattt gtttaagaaa atgaaatgaa ggaaacactg tgcaatgttt
     1861 tttgttttga gcatatcagt gctttactgt cagccgcagc tgtgaccgtc tggccatttc
     1921 agacttggga gatgaggcgg ctgttgtcat tgctgatcct gtgagaatgt gaaactggat
     1981 aatatatgaa atgcaaaata aaacaaaacc aaaatga
//
