LOCUS       NM_001008710            2874 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RNA binding protein, mRNA processing factor (RBPMS),
            transcript variant 1, mRNA.
ACCESSION   NM_001008710
VERSION     NM_001008710.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2874)
  AUTHORS   Gan,P., Wang,Z., Bezprozvannaya,S., McAnally,J.R., Tan,W., Li,H.,
            Bassel-Duby,R., Liu,N. and Olson,E.N.
  TITLE     RBPMS regulates cardiomyocyte contraction and cardiac function
            through RNA alternative splicing
  JOURNAL   Cardiovasc Res 120 (1), 56-68 (2024)
   PUBMED   37890031
  REMARK    GeneRIF: RBPMS regulates cardiomyocyte contraction and cardiac
            function through RNA alternative splicing.
REFERENCE   2  (bases 1 to 2874)
  AUTHORS   Gong,T.T., Liu,F.H., Xiao,Q., Li,Y.Z., Wei,Y.F., Xu,H.L., Cao,F.,
            Sun,M.L., Jiang,F.L., Tao,T., Ma,Q.P., Qin,X., Song,Y., Gao,S.,
            Wu,L., Zhao,Y.H., Huang,D.H. and Wu,Q.J.
  TITLE     SH3RF2 contributes to cisplatin resistance in ovarian cancer cells
            by promoting RBPMS degradation
  JOURNAL   Commun Biol 7 (1), 67 (2024)
   PUBMED   38195842
  REMARK    GeneRIF: SH3RF2 contributes to cisplatin resistance in ovarian
            cancer cells by promoting RBPMS degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2874)
  AUTHORS   Yang,Y., Lee,G.C., Nakagaki-Silva,E., Huang,Y., Peacey,M.,
            Partridge,R., Gooding,C. and Smith,C.W.J.
  TITLE     Cell-type specific regulator RBPMS switches alternative splicing
            via higher-order oligomerization and heterotypic interactions with
            other splicing regulators
  JOURNAL   Nucleic Acids Res 51 (18), 9961-9982 (2023)
   PUBMED   37548402
  REMARK    GeneRIF: Cell-type specific regulator RBPMS switches alternative
            splicing via higher-order oligomerization and heterotypic
            interactions with other splicing regulators.
REFERENCE   4  (bases 1 to 2874)
  AUTHORS   Bartsch,D., Kalamkar,K., Ahuja,G., Lackmann,J.W., Hescheler,J.,
            Weber,T., Bazzi,H., Clamer,M., Mendjan,S., Papantonis,A. and
            Kurian,L.
  TITLE     mRNA translational specialization by RBPMS presets the competence
            for cardiac commitment in hESCs
  JOURNAL   Sci Adv 9 (13), eade1792 (2023)
   PUBMED   36989351
  REMARK    GeneRIF: mRNA translational specialization by RBPMS presets the
            competence for cardiac commitment in hESCs.
REFERENCE   5  (bases 1 to 2874)
  AUTHORS   Rabelo-Fernandez,R.J., Noriega Rivera,R.A., Rivera,Y.S.,
            Tous-Beveraggi,J., Valiyeva,F. and Vivas-Mejia,P.E.
  TITLE     Increased Expression of the RBPMS Splice Variants Inhibits Cell
            Proliferation in Ovarian Cancer Cells
  JOURNAL   Int J Mol Sci 23 (23), 14742 (2022)
   PUBMED   36499073
  REMARK    GeneRIF: Increased Expression of the RBPMS Splice Variants Inhibits
            Cell Proliferation in Ovarian Cancer Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2874)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 2874)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 2874)
  AUTHORS   Sun,Y., Ding,L., Zhang,H., Han,J., Yang,X., Yan,J., Zhu,Y., Li,J.,
            Song,H. and Ye,Q.
  TITLE     Potentiation of Smad-mediated transcriptional activation by the
            RNA-binding protein RBPMS
  JOURNAL   Nucleic Acids Res 34 (21), 6314-6326 (2006)
   PUBMED   17099224
REFERENCE   9  (bases 1 to 2874)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   10 (bases 1 to 2874)
  AUTHORS   Shimamoto,A., Kitao,S., Ichikawa,K., Suzuki,N., Yamabe,Y.,
            Imamura,O., Tokutake,Y., Satoh,M., Matsumoto,T., Kuromitsu,J.,
            Kataoka,H., Sugawara,K., Sugawara,M., Sugimoto,M., Goto,M. and
            Furuichi,Y.
  TITLE     A unique human gene that spans over 230 kb in the human chromosome
            8p11-12 and codes multiple family proteins sharing RNA-binding
            motifs
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 10913-10917 (1996)
   PUBMED   8855282
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CX165198.1, BC003608.2,
            D84107.1, CX781149.1, CN360712.1 and BX097929.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001008710.2.
            
            Summary: This gene encodes a member of the RNA recognition motif
            family of RNA-binding proteins. The RNA recognition motif is
            between 80-100 amino acids in length and family members contain one
            to four copies of the motif. The RNA recognition motif consists of
            two short stretches of conserved sequence, as well as a few highly
            conserved hydrophobic residues. The encoded protein has a single,
            putative RNA recognition motif in its N-terminus. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (1) encodes isoform A. Variants 1
            and 4 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.54264.1,
                                           SRR1660809.128176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397323.9/ ENSP00000380486.4
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                CX165198.1         41-132
            93-300              BC003608.2         74-281
            301-1278            D84107.1           315-1292
            1279-2019           CX781149.1         111-851
            2020-2531           CN360712.1         285-796
            2532-2874           BX097929.1         19-361              c
FEATURES             Location/Qualifiers
     source          1..2874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..2874
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /note="RNA binding protein, mRNA processing factor"
                     /db_xref="GeneID:11030"
                     /db_xref="HGNC:HGNC:19097"
                     /db_xref="MIM:601558"
     exon            1..618
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /inference="alignment:Splign:2.1.0"
     CDS             553..1143
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /note="isoform A is encoded by transcript variant 1; heart
                     and RRM expressed sequence; RNA binding protein with
                     multiple splicing"
                     /codon_start=1
                     /product="RNA-binding protein with multiple splicing
                     isoform A"
                     /protein_id="NP_001008710.1"
                     /db_xref="CCDS:CCDS6077.1"
                     /db_xref="GeneID:11030"
                     /db_xref="HGNC:HGNC:19097"
                     /db_xref="MIM:601558"
                     /translation="MNNGGKAEKENTPSEANLQEEEVRTLFVSGLPLDIKPRELYLLF
                     RPFKGYEGSLIKLTSKQPVGFVSFDSRSEAEAAKNALNGIRFDPEIPQTLRLEFAKAN
                     TKMAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAP
                     ALPPPAFTYPASLHAQMRWLPPSEATSQGWKSRQFC"
     exon            619..696
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /inference="alignment:Splign:2.1.0"
     exon            697..735
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /inference="alignment:Splign:2.1.0"
     exon            736..798
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /inference="alignment:Splign:2.1.0"
     exon            799..949
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1080
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1150
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1254
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..2874
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1347..1352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /note="hexamer: AATAAA"
     polyA_site      1376
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /note="major polyA site"
     regulatory      2850..2855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /note="hexamer: AATAAA"
     polyA_site      2874
                     /gene="RBPMS"
                     /gene_synonym="HERMES"
                     /note="major polyA site"
ORIGIN      
        1 agagcctgcc tggagcgcgt actcagcggc tctcgggtcc cagcgtccca gccgcggccc
       61 gcgctcctcc gccccgctcc tcctcctcct cttcctcctc ctcctcctct ctaggcaccc
      121 ccgtcccctc cttccagcgg ctgcagcccc cagccccaac tctccgcgct tactcctggg
      181 acgcgcgtcc tcgccccatc ctttgcttcc ttccttcctt ccttcttcct tcctcccctg
      241 gctcccgccc tccctctcca ggtcgccctc ccggggcccg attgtctcgg tgccccgctc
      301 ccggcccgcg ccctgccccg tctctccctt gcacttcctg agtcgcccgc cgccgccgtc
      361 gcagactcgc cgcgggagcc ccagcccaac ccgagcccga cagccactgc cccggctcca
      421 gctccagccc cacagcccgc ggcgcccgcc cgagggagcc ccggcgcccg gggaaggctc
      481 cagtgggcta gcgcgccctc gcccagcccc gcgccccagc cctgcccggc ccggcgagga
      541 aggaccggga agatgaacaa cggcggcaaa gccgagaagg agaacacccc gagcgaggcc
      601 aaccttcagg aggaggaggt ccggacccta tttgtcagtg gccttcctct ggatatcaaa
      661 cctcgggagc tctatctgct tttcagacca tttaagggct atgagggttc tcttataaag
      721 ctcacatcta aacagcctgt aggttttgtc agttttgaca gtcgctcaga agcagaggct
      781 gcaaagaatg ctttgaatgg catccgcttc gatcctgaaa ttccgcaaac actacgacta
      841 gagtttgcta aggcaaacac gaagatggcc aagaacaaac tcgtagggac tccaaacccc
      901 agtactcctc tgcccaacac tgtacctcag ttcattgcca gagagccata tgagctcaca
      961 gtgcctgcac tttaccccag tagccctgaa gtgtgggccc cgtaccctct gtacccagcg
     1021 gagttagcgc ctgctctacc tcctcctgct ttcacctatc ccgcttcact gcatgcccag
     1081 atgcgctggc tccctccctc cgaggctact tctcagggct ggaagtcccg tcagttctgc
     1141 tgaatactat gtcccaggtg tgtgatggcg gctgcaatct gtcttgtggg tattaatgca
     1201 atcttcagtg gtggctactg ttctctagct gttctacaaa actggagcat gctggcttga
     1261 aaaacccttg cccagttttg atcccttcaa gactttgtca cagcctctat cacacatctg
     1321 tttttctcga agaaaaaaat ataattaata aaaatgtttt actcttttac actgtataat
     1381 tgtaagaaat agcgtattat ttgtgaatgc atggtctgaa atttctgtac agtttggaga
     1441 tattttcaaa cgaaacgtaa gagaagtcaa caataaaacc aagaaaagtg agtattttta
     1501 taccaaacat tttaagtatg ctgggatgga cgatcttaca ctggtttgga tcacagtttt
     1561 tgttcttgac ttttgaatgc ttgtaattaa aaatatctat ttttttcctc tgaagtaagt
     1621 tgcatgtttg aggcatgttt ccaaatatta tcaaaatatc ctgaattgta ttgtgaatat
     1681 atagaaatct gtgcctggcc ggagtccagg gtaaattagt agcatggtgt tagatgttag
     1741 aaacagaact gttatttgca gtgttaggtc taggatccca gttctagtag gacagccctg
     1801 caagacaatc aaccagaagc ctccaggagc ttctacctat ggcttattca caactgggca
     1861 agaaaacatc attggtaaga actgctgagt gtgcccttag aaagccctag tagctccagc
     1921 tgtgactata tcaactgtgt gccaagtgtg actttgtaca gttttatgtt tccactctcc
     1981 tgtatgtgta gccactcgat gcctaaccta ccttccacaa gccagccccg catccctgct
     2041 cccgcagtgt aagtgcagag cctgcctcac tggtaaggga aaaccttggc ttgggaggcc
     2101 agccctggcc cttgaagggg ttggctgtgc ccagcccacc tggctgcagt gggcagctca
     2161 tgtctgtatc tccaaagtga tgtttgtttg caaaacaccg gctgaactga gctggtgttg
     2221 ccaactcttg gcagcactgg gccaaaccga ccacatacca tgagctccca aatggcgtgt
     2281 gctcactgtg agacgtcctg ccacacccca caggagacgg aggcagtggg catttggaac
     2341 caattctatt cagacttcgt caaagccaaa gtcagtctgg tgttgtcagt tgacacatct
     2401 ccagagttca tgacagctca acctctcccc ttgtacagaa gccatttttg taaaaccaca
     2461 ctgacctaaa ttcagctgcc aaacacagtc tttcctattg atccgctcgg cttatgttga
     2521 aaatttcaat gtcatgatta cctggttggt ttgggttttt gttttgttat tttccattag
     2581 aaatataaag atgtcaagaa gcttttaaag gtcaacacaa aaaaccaagg ccaggagtga
     2641 ggggctcttt cttaccgtaa ataaggggaa aaggcagtta gctcaaggac ttgtgacgga
     2701 tccactttgg tgttcaagga cctgcttatg ccctcagtgc caatcggctc ttggtgagat
     2761 gactgtactc ctaaggaaaa tagccacttc tgcagtctat tatgctttta taactgttta
     2821 aaggtacttt tctattgtca tttttaaaaa ataaagtgct tattccagct gtca
//
