LOCUS       NM_015874               5395 bp    mRNA    linear   PRI 18-MAR-2025
DEFINITION  Homo sapiens recombination signal binding protein for
            immunoglobulin kappa J region (RBPJ), transcript variant 2, mRNA.
ACCESSION   NM_015874
VERSION     NM_015874.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5395)
  AUTHORS   Chen,J.H., Li,J.J., Yuan,Y., Tian,Q., Feng,D.D., Zhuang,L.L.,
            Cao,Q., Zhou,G.P. and Jin,R.
  TITLE     ETS1 and RBPJ transcriptionally regulate METTL14 to suppress
            TGF-beta1-induced epithelial-mesenchymal transition in human
            bronchial epithelial cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167349 (2024)
   PUBMED   39002703
  REMARK    GeneRIF: ETS1 and RBPJ transcriptionally regulate METTL14 to
            suppress TGF-beta1-induced epithelial-mesenchymal transition in
            human bronchial epithelial cells.
REFERENCE   2  (bases 1 to 5395)
  AUTHORS   Ng,C., Qin,Y., Xia,Y., Hu,X. and Zhao,B.
  TITLE     Jagged1 Acts as an RBP-J Target and Feedback Suppresses
            TNF-Mediated Inflammatory Osteoclastogenesis
  JOURNAL   J Immunol 211 (9), 1340-1347 (2023)
   PUBMED   37756541
  REMARK    GeneRIF: Jagged1 Acts as an RBP-J Target and Feedback Suppresses
            TNF-Mediated Inflammatory Osteoclastogenesis.
REFERENCE   3  (bases 1 to 5395)
  AUTHORS   Adhicary,S., Fanelli,K., Nakisli,S., Ward,B., Pearce,I. and
            Nielsen,C.M.
  TITLE     Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin
            and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous
            Malformation
  JOURNAL   Stroke 54 (6), 1593-1605 (2023)
   PUBMED   37051908
  REMARK    GeneRIF: Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal
            Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain
            Arteriovenous Malformation.
REFERENCE   4  (bases 1 to 5395)
  AUTHORS   Mao,Z., Lin,D. and Xu,J.
  TITLE     Hsa_circ_0001535 Regulates Colorectal Cancer Progression via the
            miR-433-3p/RBPJ Axis
  JOURNAL   Biochem Genet 61 (3), 861-878 (2023)
   PUBMED   36208372
  REMARK    GeneRIF: Hsa_circ_0001535 Regulates Colorectal Cancer Progression
            via the miR-433-3p/RBPJ Axis.
REFERENCE   5  (bases 1 to 5395)
  AUTHORS   Hall,D., Giaimo,B.D., Park,S.S., Hemmer,W., Friedrich,T.,
            Ferrante,F., Bartkuhn,M., Yuan,Z., Oswald,F., Borggrefe,T.,
            Rual,J.F. and Kovall,R.A.
  TITLE     The structure, binding and function of a Notch transcription
            complex involving RBPJ and the epigenetic reader protein L3MBTL3
  JOURNAL   Nucleic Acids Res 50 (22), 13083-13099 (2022)
   PUBMED   36477367
  REMARK    GeneRIF: The structure, binding and function of a Notch
            transcription complex involving RBPJ and the epigenetic reader
            protein L3MBTL3.
REFERENCE   6  (bases 1 to 5395)
  AUTHORS   Tong,X., Drapkin,R., Yalamanchili,R., Mosialos,G. and Kieff,E.
  TITLE     The Epstein-Barr virus nuclear protein 2 acidic domain forms a
            complex with a novel cellular coactivator that can interact with
            TFIIE
  JOURNAL   Mol Cell Biol 15 (9), 4735-4744 (1995)
   PUBMED   7651391
REFERENCE   7  (bases 1 to 5395)
  AUTHORS   Oka,C. and Kawaichi,M.
  TITLE     V(D)J recombination of immunoglobulin genes
  JOURNAL   Adv Biophys 31, 163-180 (1995)
   PUBMED   7625272
  REMARK    Review article
REFERENCE   8  (bases 1 to 5395)
  AUTHORS   Amakawa,R., Jing,W., Ozawa,K., Matsunami,N., Hamaguchi,Y.,
            Matsuda,F., Kawaichi,M. and Honjo,T.
  TITLE     Human Jk recombination signal binding protein gene (IGKJRB):
            comparison with its mouse homologue
  JOURNAL   Genomics 17 (2), 306-315 (1993)
   PUBMED   8406481
REFERENCE   9  (bases 1 to 5395)
  AUTHORS   Lehman,A., Wuyts,W. and Patel,M.S.
  TITLE     Adams-Oliver Syndrome - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27077170
REFERENCE   10 (bases 1 to 5395)
  AUTHORS   Matsunami,N., Hamaguchi,Y., Yamamoto,Y., Kuze,K., Kangawa,K.,
            Matsuo,H., Kawaichi,M. and Honjo,T.
  TITLE     A protein binding to the J kappa recombination sequence of
            immunoglobulin genes contains a sequence related to the integrase
            motif
  JOURNAL   Nature 342 (6252), 934-937 (1989)
   PUBMED   2556644
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097109.4 and AC093637.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 2, 2020 this sequence version replaced NM_015874.5.
            
            Summary: The protein encoded by this gene is a transcriptional
            regulator important in the Notch signaling pathway. The encoded
            protein acts as a repressor when not bound to Notch proteins and an
            activator when bound to Notch proteins. It is thought to function
            by recruiting chromatin remodeling complexes containing histone
            deacetylase or histone acetylase proteins to Notch signaling
            pathway genes. Several transcript variants encoding different
            isoforms have been found for this gene, and several pseudogenes of
            this gene exist on chromosome 9. [provided by RefSeq, Oct 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2612081.1,
                                           SRR11853564.20756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355476.8/ ENSP00000347659.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC097109.4         53996-54030
            36-74               AC097109.4         119335-119373
            75-170              AC093637.5         16328-16423
            171-336             AC093637.5         25628-25793
            337-511             AC093637.5         30704-30878
            512-649             AC093637.5         34495-34632
            650-762             AC093637.5         34784-34896
            763-903             AC093637.5         38873-39013
            904-1059            AC093637.5         40051-40206
            1060-1163           AC093637.5         40572-40675
            1164-5395           AC093637.5         40845-45076
FEATURES             Location/Qualifiers
     source          1..5395
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.2"
     gene            1..5395
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /note="recombination signal binding protein for
                     immunoglobulin kappa J region"
                     /db_xref="GeneID:3516"
                     /db_xref="HGNC:HGNC:5724"
                     /db_xref="MIM:147183"
     exon            1..35
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1479
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /note="isoform 2 is encoded by transcript variant 2;
                     immunoglobulin kappa J region recombination signal binding
                     protein 1; suppressor of hairless homolog; H-2K binding
                     factor-2; renal carcinoma antigen NY-REN-30; recombining
                     binding protein suppressor of hairless; CSL family DNA
                     binding factor 1"
                     /codon_start=1
                     /product="recombining binding protein suppressor of
                     hairless isoform 2"
                     /protein_id="NP_056958.3"
                     /db_xref="CCDS:CCDS43219.1"
                     /db_xref="GeneID:3516"
                     /db_xref="HGNC:HGNC:5724"
                     /db_xref="MIM:147183"
                     /translation="MAPVVTGKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQ
                     KSYGNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQL
                     NLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQS
                     LKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESE
                     GEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFY
                     LKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPV
                     LAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVV
                     PDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHCSAAGAILRA
                     NSSQVPPNESNTNSEGSYTNASTNSTSVTSSTATVVS"
     exon            36..74
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /inference="alignment:Splign:2.1.0"
     exon            75..170
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /inference="alignment:Splign:2.1.0"
     exon            171..336
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /inference="alignment:Splign:2.1.0"
     exon            337..511
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /inference="alignment:Splign:2.1.0"
     exon            512..649
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /inference="alignment:Splign:2.1.0"
     exon            650..762
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /inference="alignment:Splign:2.1.0"
     exon            763..903
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1059
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1163
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..5395
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5366..5371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /note="hexamer: AATAAA"
     polyA_site      5395
                     /gene="RBPJ"
                     /gene_synonym="AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1;
                     KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH"
                     /note="major polyA site"
ORIGIN      
        1 gagagtttgt ggaagatggc gcctgttgtg acagggaaat ttggtgagcg gcctccacct
       61 aaacgactta ctagggaagc tatgcgaaat tatttaaaag agcgagggga tcaaacagta
      121 cttattcttc atgcaaaagt tgcacagaag tcatatggaa atgaaaaaag gtttttttgc
      181 ccacctcctt gtgtatatct tatgggcagt ggatggaaga aaaaaaaaga acaaatggaa
      241 cgcgatggtt gttctgaaca agagtctcaa ccgtgtgcat ttattgggat aggaaatagt
      301 gaccaagaaa tgcagcagct aaacttggaa ggaaagaact attgcacagc caaaacattg
      361 tatatatctg actcagacaa gcgaaagcac ttcatgttgt ctgtaaagat gttctatggc
      421 aacagtgatg acattggtgt gttcctcagc aagcggataa aagtcatctc caaaccttcc
      481 aaaaagaagc agtcattgaa aaatgctgac ttatgcattg cctcaggaac aaaggtggct
      541 ctgtttaatc gactacgatc ccagacagtt agtaccagat acttgcatgt agaaggaggt
      601 aattttcatg ccagttcaca gcagtgggga gcctttttta ttcatctctt ggatgatgat
      661 gaatcagaag gagaagaatt cacagtccga gatggctaca tccattatgg acaaacagtc
      721 aaacttgtgt gctcagttac tggcatggca ctcccaagat tgataattag gaaagttgat
      781 aagcagaccg cattattgga tgcagatgat cctgtgtcac aactccataa atgtgcattt
      841 taccttaagg atacagaaag aatgtatttg tgcctttctc aagaaagaat aattcaattt
      901 caggccactc catgtccaaa agaaccaaat aaagagatga taaatgatgg cgcttcctgg
      961 acaatcatta gcacagataa ggcagagtat acattttatg agggaatggg ccctgtcctt
     1021 gccccagtca ctcctgtgcc tgtggtagag agccttcagt tgaatggcgg tggggacgta
     1081 gcaatgcttg aacttacagg acagaatttc actccaaatt tacgagtgtg gtttggggat
     1141 gtagaagctg aaactatgta caggtgtgga gagagtatgc tctgtgtcgt cccagacatt
     1201 tctgcattcc gagaaggttg gagatgggtc cggcaaccag tccaggttcc agtaactttg
     1261 gtccgaaatg atggaatcat ttattccacc agccttacct ttacctacac accagaacca
     1321 gggccgcggc cacattgcag tgcagcagga gcaatccttc gagccaattc aagccaggtg
     1381 ccccctaacg aatcaaacac aaacagcgag ggaagttaca caaacgccag cacaaattca
     1441 accagtgtca catcatctac agccacagtg gtatcctaac taccgtcttt ttgctaggac
     1501 ttaaactgac ttgagtgtgg caaaaagtta acaaaaaagg agaaaaaatg aacaatcgtt
     1561 tgtggtttct tgggaaaact tttcatacca ggtgatacta ttcaaaaacc ccgttgtctc
     1621 cctgcaagtg ctgatttgaa atgcagaagc cacagtaaaa aaaaaaaaaa aaaaaaaaaa
     1681 aaagaaaaaa aaatcaaaat gtataaatat tggaaatcaa gtttttcagc tgttttgttg
     1741 gttggttggt tggtttttgt ttggttttgt ttaaatgggc aagaagtaaa taatgtggct
     1801 ggaatacaag ttgaacaaac tagaagacac aaatctaaca tagtttttat ggaccaagga
     1861 acttgtatat tgtataagct ttagtaaaag gtacattttc accatacctt tttttatatc
     1921 acggtattat agtacacctt gttaccaaat aggttgttct cttccccacc cacctttgag
     1981 cttttgctct aaaatacatt caggttccaa gcctgaccat ccttgtttaa tctatcatac
     2041 tcttccaggt tttttttttt tggtctaagg ctggaacttt tttctttttt ttcagctgaa
     2101 gtcttatgac ttttcatgag tcaaaattgt ttggatttca gcaagtcaaa tcttgcaaag
     2161 gcctgcatat tttttttaag attatatgaa gtctgtgcaa aagctttaaa aaaatgcctc
     2221 tgccttgcct gcaatacatg caatgtatgt taacttagtc tctcttctca gacactgttg
     2281 gtagttattt ctgtgttttc ctttttttaa aaaaaaatat ggacttattg tggttatctg
     2341 agaggttcta acattcacat gcaatttggt gtggccattt agctattaat gagttaatgg
     2401 cgcagaactt gttgatattt gaagtgttct ctcccctttt cccatgacgt aaatacatag
     2461 gtgtgttcca ggatttgttc aggtttttcc cccctcctaa tcttgtacat aacttgtatt
     2521 atgtgtaagt taaacatttt attttgaact tggaatgttc ccagtgattt cattcagcag
     2581 ggtattttct gccttgttgg caagtgacaa aaaatatggg aagtatttgc taccagttgg
     2641 tagatggtgc ccttaatggt agaatgagga aaatgtccgc aaaagcatgt tttattatct
     2701 ttactttttt ggggggttgg agggggtagc ctagccagaa catcattgta atcttaaaac
     2761 ataagatgct tttattagat gatcaactaa aatagctgga agacagtact ttagaaacag
     2821 atagttgtaa gattataaaa tgcaaatgta acttatgttt tcattttttt ctctgccttt
     2881 tttgtttgtt tgttttctct tttccagtac tgagcatctc cacaaatgtc tcctaactca
     2941 gaaaatgttt cttttctttt cagttgagat ttggttgcat tcagggttgt aggttggcct
     3001 tgcttgctaa ccccgccggt tttaccgtgc tttcattcct gaactttgtt tatgcctttg
     3061 tttggtttct tcgaaattgc agcagactca ttgggctaca tttagtacag gaaccacgtg
     3121 tgtaatgtta tacaacacag tctagtaata caatcatccc tcttagagta aaaactacct
     3181 ctagattgtg gtaagctttt actgtcccat aaaacaggag ccacagtacc ttatgaatgc
     3241 aaaactgtaa cttcctacag tgtttcccta cagaacattg tctttctggt gtcctgggct
     3301 gttttgaaaa agtttccatt aatagacttt ttagaaatta ttattagtag catttttttt
     3361 ccagctttgc tgtcttcatc actcactcta tgctcagact atgccactgt aaatattctt
     3421 cctaacatct ttaaatcgcc ttttcctcag ttttcaaggg gaaggtcatt tgtaaagcac
     3481 gttaggtggt taaatcagtt attgcggttt tctcttactg caagcctttt taatcacccc
     3541 caggctgcat tttattctat atcgcctttt ttcttcaaat ctgctccaat cactcacttc
     3601 tctcttataa gctaatcctg cctcacacct taaatctgtt tcagtgatca agggcagaac
     3661 tcattgtggc cttatctttc tttgttgtaa ttgttcactg tctctttctt acagaccact
     3721 tatttctgag tagtagttat tcctctctat ggagtcatgg caggaatcat tacacagtgc
     3781 ttttgttcag agcatggaca tgttcctagt gctgctttgc tttaacggcc acaagtttcc
     3841 tccacttcct aggtttggta tttagttaag gaatcatatt aaattaacca ataacaaaag
     3901 agatactttt gaagaacaaa ctattcctta cccatttttg tagctcaaaa ataatttttc
     3961 aagttcatga ccttattaaa atgaacttgt gtttttttaa caaacatgta tgttttattt
     4021 tgatagtttc tttccgtaag ataattgaaa tattatactg taaacccttt tcttttcttt
     4081 ttttgaaaag tccaagaatg tacttataca ggcatttttc cccacctatt tttggccatt
     4141 ctcataccac agactaaaga gtgaaatgat ttgtccattg tagcttattg tttatcagta
     4201 gttcttttgt cagctgctta cattttttct ttcatggttt tgtgaatcat tttcagtatg
     4261 taatttatag gaaccttgtc ctctggttat agtagactgt gtgccctcct ccagtgatgg
     4321 cattattaga catgctggtc atttaccctc agaaagactc tcttattaga atggtgagtg
     4381 cttcagttat agtatgtttg aatttttaaa aaattctgtt ttagaaatgt atcttatgct
     4441 ctcatgacta tgcagtttct aaacatacac atagaagctg agtctctgat ccaatatgtt
     4501 tttatttgtt ccatttaatt tatcacatag attgggaagg caagctaaaa gccttaaaaa
     4561 tgccctttat attttgagtg atttcagcgt tgaacactag tatactatct aaatttgctg
     4621 ctcactttct ttaaactgtg gcaattaaag gcatgtttat acatgactta atcgtgaaat
     4681 gtttgtcact cttactgcac agacttatct gcaatcataa ctggttagtt tttttgtttt
     4741 gttttgtttt attgttttta atgaaactgg taccatctgt gctttcacaa aaaacttcca
     4801 atgccatttt tgagaactaa cctaactagt catgctaacc agaaaatcca ctggggagga
     4861 ggttcctttt gaaacaaaat gctgttcagt tagtaaccaa gttactttga ttgcaaaagc
     4921 agctgtgttt ctgataagta ctgaacaaat gtgtgtaatt ttctgtgcca gacttatgac
     4981 tttgttttca agcactgtaa tgtgggatgg atggttagaa acaataatat attagggttt
     5041 ctgtttaacc ctttcaggac tgaactgtat ctccttttgt taattttccc ctgtgttgtg
     5101 ataaatgttt gccagcattc agtactgtgt tggtccagat gtaggtttat atgctcattt
     5161 ttagcttatt tcttgtacct tgcagcatgc tctacgcatt cagtccttaa ggggtttatt
     5221 ttacaaactg tgcgcctgta aggtttatta gcaataagat agaaaattga gcaagtttat
     5281 accataattt tgtagaaaaa aagaatctgc tcagttccat atttcatccg tgaaaaactt
     5341 gcaatacgag cagtttcaag gaataaataa aaaggaaatg taaaccattg taaaa
//
