LOCUS       NM_052960                625 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens retinol binding protein 7 (RBP7), transcript variant
            1, mRNA.
ACCESSION   NM_052960
VERSION     NM_052960.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 625)
  AUTHORS   Liu,Y., Fan,M., Xian,S., Hu,P., Zhang,M., Zhang,X., Zhang,H.,
            Zhang,J., Dai,L., Lin,M., Mei,W., Huang,D., Huang,R., Zhang,J. and
            Huang,Z.
  TITLE     RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte Meiosis
            Pathway in Bone Metastases of Bladder Urothelial Carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 28 (8), 189 (2023)
   PUBMED   37664915
  REMARK    GeneRIF: RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte
            Meiosis Pathway in Bone Metastases of Bladder Urothelial Carcinoma.
REFERENCE   2  (bases 1 to 625)
  AUTHORS   Yan,X., Gao,Z., Zhang,L. and Chen,C.
  TITLE     Reduced Expression of RBP7 is Associated with Resistance to
            Tamoxifen In Luminal A Breast Cancer
  JOURNAL   Anticancer Agents Med Chem 23 (8), 929-937 (2023)
   PUBMED   36537604
  REMARK    GeneRIF: Reduced Expression of RBP7 is Associated with Resistance
            to Tamoxifen In Luminal A Breast Cancer.
REFERENCE   3  (bases 1 to 625)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 625)
  AUTHORS   Folli,C., Calderone,V., Ramazzina,I., Zanotti,G. and Berni,R.
  TITLE     Ligand binding and structural analysis of a human putative cellular
            retinol-binding protein
  JOURNAL   J Biol Chem 277 (44), 41970-41977 (2002)
   PUBMED   12177003
  REMARK    GeneRIF: Human CRBP IV belongs to a clearly distinct CRBP subfamily
            and suggest a relatively different mode of retinol binding for this
            binding protein.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC063013.1 and AL590639.9.
            
            On Nov 23, 2018 this sequence version replaced NM_052960.2.
            
            Summary: The protein encoded by this gene is a member of the
            cellular retinol-binding protein (CRBP) family, whose members are
            required for vitamin A stability and metabolism. The encoded
            protein binds all-trans-retinol and is structurally similar to
            other CRBPs; however, it has a lower binding affinity for retinol
            than other CRBPs. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279839.2117.1, BC063013.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294435.8/ ENSP00000294435.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-624               BC063013.1         32-655
            625-625             AL590639.9         17160-17160
FEATURES             Location/Qualifiers
     source          1..625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..625
                     /gene="RBP7"
                     /gene_synonym="CRABP4; CRBP4; CRBPIV"
                     /note="retinol binding protein 7"
                     /db_xref="GeneID:116362"
                     /db_xref="HGNC:HGNC:30316"
                     /db_xref="MIM:608604"
     exon            1..104
                     /gene="RBP7"
                     /gene_synonym="CRABP4; CRBP4; CRBPIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..436
                     /gene="RBP7"
                     /gene_synonym="CRABP4; CRBP4; CRBPIV"
                     /EC_number="2.7.7.1"
                     /note="putative cellular retinol-binding protein CRBP IV;
                     cellular retinoic acid-binding protein 4; cellular
                     retinoic acid-binding protein IV; retinol binding protein
                     7, cellular; cellular retinol binding protein 7"
                     /codon_start=1
                     /product="retinoid-binding protein 7"
                     /protein_id="NP_443192.1"
                     /db_xref="CCDS:CCDS109.1"
                     /db_xref="GeneID:116362"
                     /db_xref="HGNC:HGNC:30316"
                     /db_xref="MIM:608604"
                     /translation="MPADLSGTWTLLSSDNFEGYMLALGIDFATRKIAKLLKPQKVIE
                     QNGDSFTIHTNSSLRNYFVKFKVGEEFDEDNRGLDNRKCKSLVIWDNDRLTCIQKGEK
                     KNRGWTHWIEGDKLHLEMFCEGQVCKQTFQRA"
     exon            105..283
                     /gene="RBP7"
                     /gene_synonym="CRABP4; CRBP4; CRBPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            284..385
                     /gene="RBP7"
                     /gene_synonym="CRABP4; CRBP4; CRBPIV"
                     /inference="alignment:Splign:2.1.0"
     exon            386..625
                     /gene="RBP7"
                     /gene_synonym="CRABP4; CRBP4; CRBPIV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      606..611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBP7"
                     /gene_synonym="CRABP4; CRBP4; CRBPIV"
                     /note="hexamer: AATAAA"
     polyA_site      625
                     /gene="RBP7"
                     /gene_synonym="CRABP4; CRBP4; CRBPIV"
                     /note="major polyA site"
ORIGIN      
        1 gcccgccggg tttgtcccgc gatccccgac catgcccgcc gacctcagcg gtacttggac
       61 cctgctcagc agcgacaact tcgagggcta catgctggcc ctaggtattg actttgccac
      121 tcgtaaaata gccaagttgc tgaagccaca gaaagtgatt gagcagaatg gggattcttt
      181 taccatccac acgaacagca gcctaaggaa ctactttgtg aaatttaaag ttggagaaga
      241 atttgatgaa gataacagag gcctggacaa cagaaaatgc aagagtttgg ttatctggga
      301 caatgacagg ctcacctgta tccagaaggg agaaaagaag aacagaggct ggacccattg
      361 gatcgaagga gacaaactcc acctggaaat gttctgtgaa ggtcaagtgt gcaaacagac
      421 attccagaga gcctgatcca catccagcag cagagcccac ttgtggctgc agctttatgc
      481 caaattatat tgcagactga acagacgttt atctatccca tttggcgacg aggactcgtg
      541 gctggagaga gccacacagc gtgtaacctg aagtcatcta gattatgggg aaactgctca
      601 gcttcaataa acctgtccaa atgac
//
