LOCUS       NM_031491                957 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens retinol binding protein 5 (RBP5), transcript variant
            1, mRNA.
ACCESSION   NM_031491
VERSION     NM_031491.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 957)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 957)
  AUTHORS   Ho,J.C., Cheung,S.T., Poon,W.S., Lee,Y.T., Ng,I.O. and Fan,S.T.
  TITLE     Down-regulation of retinol binding protein 5 is associated with
            aggressive tumor features in hepatocellular carcinoma
  JOURNAL   J Cancer Res Clin Oncol 133 (12), 929-936 (2007)
   PUBMED   17497168
  REMARK    GeneRIF: Our study revealed that RBP5 down-regulation in HCC was
            associated with aggressive tumor features, suggesting an
REFERENCE   3  (bases 1 to 957)
  AUTHORS   Folli,C., Calderone,V., Ottonello,S., Bolchi,A., Zanotti,G.,
            Stoppini,M. and Berni,R.
  TITLE     Identification, retinoid binding, and x-ray analysis of a human
            retinol-binding protein
  JOURNAL   Proc Natl Acad Sci U S A 98 (7), 3710-3715 (2001)
   PUBMED   11274389
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC029355.1 and AA912830.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031491.3.
            
            Summary: The protein encoded by this gene is a cellular
            retinol-binding protein expressed highly in kidney and liver.
            Down-regulation of the encoded protein in hepatocellular carcinoma
            was associated with large tumor size and poor patient survival
            rates. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223378.1, SRR5189664.38728.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159080, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266560.8/ ENSP00000266560.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-956               BC029355.1         3-958
            957-957             AA912830.1         23-23               c
FEATURES             Location/Qualifiers
     source          1..957
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..957
                     /gene="RBP5"
                     /gene_synonym="CRBP-III; CRBP3; CRBPIII; HRBPiso"
                     /note="retinol binding protein 5"
                     /db_xref="GeneID:83758"
                     /db_xref="HGNC:HGNC:15847"
                     /db_xref="MIM:611866"
     exon            1..187
                     /gene="RBP5"
                     /gene_synonym="CRBP-III; CRBP3; CRBPIII; HRBPiso"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..522
                     /gene="RBP5"
                     /gene_synonym="CRBP-III; CRBP3; CRBPIII; HRBPiso"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative cellular retinol-binding protein CRBP III;
                     cellular retinol-binding protein III; retinol binding
                     protein 5, cellular"
                     /codon_start=1
                     /product="retinol-binding protein 5 isoform 1"
                     /protein_id="NP_113679.1"
                     /db_xref="CCDS:CCDS8574.1"
                     /db_xref="GeneID:83758"
                     /db_xref="HGNC:HGNC:15847"
                     /db_xref="MIM:611866"
                     /translation="MPPNLTGYYRFVSQKNMEDYLQALNISLAVRKIALLLKPDKEIE
                     HQGNHMTVRTLSTFRNYTVQFDVGVEFEEDLRSVDGRKCQTIVTWEEEHLVCVQKGEV
                     PNRGWRHWLEGEMLYLELTARDAVCEQVFRKVR"
     exon            188..366
                     /gene="RBP5"
                     /gene_synonym="CRBP-III; CRBP3; CRBPIII; HRBPiso"
                     /inference="alignment:Splign:2.1.0"
     exon            367..468
                     /gene="RBP5"
                     /gene_synonym="CRBP-III; CRBP3; CRBPIII; HRBPiso"
                     /inference="alignment:Splign:2.1.0"
     exon            469..957
                     /gene="RBP5"
                     /gene_synonym="CRBP-III; CRBP3; CRBPIII; HRBPiso"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      957
                     /gene="RBP5"
                     /gene_synonym="CRBP-III; CRBP3; CRBPIII; HRBPiso"
                     /note="major polyA site"
ORIGIN      
        1 acatcctgtc tctgtgtgtg gagctggctg gaatctctca gcctcacctg ccagacaaca
       61 ccccctcctt cctcaccctg tctcctgcat tctcctgaaa ccttcatcca cacaatgcct
      121 cccaacctca ctggctacta ccgctttgtc tcgcagaaga acatggagga ctacctgcaa
      181 gccctaaaca tcagcttggc tgtgcggaag atcgcgctgc tgctgaagcc ggacaaggag
      241 atcgaacacc agggcaacca catgacggtg aggacgctca gcaccttccg aaactacact
      301 gtgcagtttg atgtgggagt ggagtttgag gaggacctca ggagcgtgga cggacgaaaa
      361 tgccagacca tagtaacctg ggaggaggag cacctggtgt gtgtgcagaa aggggaggtc
      421 cccaaccggg gctggagaca ctggctggag ggagagatgc tgtatctgga actgactgca
      481 agggatgcag tgtgcgagca ggtcttcagg aaggtcagat agccggagag gagccaagat
      541 ccctccagac agcaccagct cacagacgct cttgttgtgc ccccttcaag cccagattgt
      601 gccaggtcag ctgtcccttc ctctggccac ctttcctccc tctgggtccc tcctcacccc
      661 tccccgtgtt aatctgtaac ttgcagcccc caggccaaag tcctttctca cactccactg
      721 cccaatagtg acctcacttc caggtcaagg tctggcgtcc caaatgaaag aagcaggcaa
      781 agggaaggag cccctgagaa caaccaatct ccgctctctc ctgtccattt gacctcttct
      841 tttccttcta agaaagaact aagctttggg catttggcga ttagtgaaaa ttctatcctg
      901 atggacttct ggaaaactgt gactggggtt caagagttta aacaggggct actggca
//
