LOCUS       NM_006744               1070 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens retinol binding protein 4 (RBP4), transcript variant
            1, mRNA.
ACCESSION   NM_006744
VERSION     NM_006744.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1070)
  AUTHORS   Fan,J. and Hu,J.
  TITLE     Retinol binding protein 4 and type 2 diabetes: from insulin
            resistance to pancreatic beta-cell function
  JOURNAL   Endocrine 85 (3), 1020-1034 (2024)
   PUBMED   38520616
  REMARK    GeneRIF: Retinol binding protein 4 and type 2 diabetes: from
            insulin resistance to pancreatic beta-cell function.
            Review article
REFERENCE   2  (bases 1 to 1070)
  AUTHORS   Wang,H., Zhang,Z., Xie,L., Lu,K., Zhang,S. and Xing,S.
  TITLE     Retinol and retinol binding protein 4 levels and COVID-19: a
            Mendelian randomization study
  JOURNAL   BMC Pulm Med 24 (1), 206 (2024)
   PUBMED   38671384
  REMARK    GeneRIF: Retinol and retinol binding protein 4 levels and COVID-19:
            a Mendelian randomization study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1070)
  AUTHORS   Rychter,A.M., Skrzypczak-Zielinska,M., Naskret,D., Michalak,M.,
            Zawada,A., Walczak,M., Slomski,R., Dobrowolska,A. and
            Krela-Kazmierczak,I.
  TITLE     Are variants of the RBP4 gene associated with serum retinol-binding
            protein 4 concentrations and carotid intima-media thickness values
            in women with obesity?
  JOURNAL   Gene 893, 147909 (2024)
   PUBMED   37858746
  REMARK    GeneRIF: Are variants of the RBP4 gene associated with serum
            retinol-binding protein 4 concentrations and carotid intima-media
            thickness values in women with obesity?
REFERENCE   4  (bases 1 to 1070)
  AUTHORS   Oluwamodupe,C. and Adeleye,A.O.
  TITLE     Targeting Retinol-Binding Protein 4 (RBP4) in the Management of
            Cardiometabolic Diseases
  JOURNAL   Cardiovasc Toxicol 23 (9-10), 285-294 (2023)
   PUBMED   37587250
  REMARK    GeneRIF: Targeting Retinol-Binding Protein 4 (RBP4) in the
            Management of Cardiometabolic Diseases.
            Review article
REFERENCE   5  (bases 1 to 1070)
  AUTHORS   Kiuchi,S., Ihara,H., Sega,M., Tani,A., Nishiguchi,Y. and
            Hashizume,N.
  TITLE     Does Retinol-Binding Protein 4 (holo- and apo-RBP4) Increase or
            Remain Constant in Sera from Patients with Hypothyroidism?
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 69 (6), 412-419 (2023)
   PUBMED   38171813
  REMARK    GeneRIF: Does Retinol-Binding Protein 4 (holo- and apo-RBP4)
            Increase or Remain Constant in Sera from Patients with
            Hypothyroidism?
REFERENCE   6  (bases 1 to 1070)
  AUTHORS   Monaco,H.L. and Zanotti,G.
  TITLE     Three-dimensional structure and active site of three hydrophobic
            molecule-binding proteins with significant amino acid sequence
            similarity
  JOURNAL   Biopolymers 32 (4), 457-465 (1992)
   PUBMED   1623143
REFERENCE   7  (bases 1 to 1070)
  AUTHORS   Fex,G., Albertsson,P.A. and Hansson,B.
  TITLE     Interaction between prealbumin and retinol-binding protein studied
            by affinity chromatography, gel filtration and two-phase partition
  JOURNAL   Eur J Biochem 99 (2), 353-360 (1979)
   PUBMED   574085
REFERENCE   8  (bases 1 to 1070)
  AUTHORS   Rask,L., Anundi,H. and Peterson,P.A.
  TITLE     The primary structure of the human retinol-binding protein
  JOURNAL   FEBS Lett 104 (1), 55-58 (1979)
   PUBMED   573217
REFERENCE   9  (bases 1 to 1070)
  AUTHORS   Fex,G. and Hansson,B.
  TITLE     Retinol-binding protein from human urine and its interaction with
            retinol and prealbumin
  JOURNAL   Eur J Biochem 94 (1), 307-313 (1979)
   PUBMED   571335
REFERENCE   10 (bases 1 to 1070)
  AUTHORS   Kopelman,M., Cogan,U., Mokady,S. and Shinitzky,M.
  TITLE     The interaction between retinol-binding proteins and prealbumins
            studied by fluorescence polarization
  JOURNAL   Biochim Biophys Acta 439 (2), 449-460 (1976)
   PUBMED   986177
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020633.1, X00129.1,
            BX495987.1 and AL356214.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006744.3.
            
            Summary:  This protein belongs to the lipocalin family and is the
            specific carrier for retinol (vitamin A alcohol) in the blood. It
            delivers retinol from the liver stores to the peripheral tissues.
            In plasma, the RBP-retinol complex interacts with transthyretin
            which prevents its loss by filtration through the kidney glomeruli.
            A deficiency of vitamin A blocks secretion of the binding protein
            posttranslationally and results in defective delivery and supply to
            the epidermal cells. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) and variant 2 both encode
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.257918.1,
                                           SRR5189664.138123.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371464.8/ ENSP00000360519.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               BC020633.1         2-107
            107-119             X00129.1           75-87
            120-918             BC020633.1         121-919
            919-928             BX495987.1         480-489
            929-1070            AL356214.20        107844-107985       c
FEATURES             Location/Qualifiers
     source          1..1070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..1070
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /note="retinol binding protein 4"
                     /db_xref="GeneID:5950"
                     /db_xref="HGNC:HGNC:9922"
                     /db_xref="MIM:180250"
     exon            1..65
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            66..194
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..689
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; retinol-binding protein 4, interstitial; RBP;
                     PRBP; plasma retinol-binding protein; retinol binding
                     protein 4, plasma"
                     /codon_start=1
                     /product="retinol-binding protein 4 isoform a precursor"
                     /protein_id="NP_006735.2"
                     /db_xref="CCDS:CCDS31249.1"
                     /db_xref="GeneID:5950"
                     /db_xref="HGNC:HGNC:9922"
                     /db_xref="MIM:180250"
                     /translation="MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYA
                     MAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPA
                     KFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPN
                     GLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL"
     exon            195..331
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            332..438
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            439..651
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1070
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      900..905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /note="hexamer: ATTAAA"
     polyA_site      920
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /note="major polyA site"
     regulatory      1049..1054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /note="hexamer: ATTAAA"
     polyA_site      1070
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
ORIGIN      
        1 gcctccctcg ctccacgcgc gcccggactc ggcggccagg cttgcgcgcg gttcccctcc
       61 cggtgggcgg attcctgggc aagatgaagt gggtgtgggc gctcttgctg ttggcggcgc
      121 tgggcagcgg ccgcgcggag cgcgactgcc gagtgagcag cttccgagtc aaggagaact
      181 tcgacaaggc tcgcttctct gggacctggt acgccatggc caagaaggac cccgagggcc
      241 tctttctgca ggacaacatc gtcgcggagt tctccgtgga cgagaccggc cagatgagcg
      301 ccacagccaa gggccgagtc cgtcttttga ataactggga cgtgtgcgca gacatggtgg
      361 gcaccttcac agacaccgag gaccctgcca agttcaagat gaagtactgg ggcgtagcct
      421 cctttctcca gaaaggaaat gatgaccact ggatcgtcga cacagactac gacacgtatg
      481 ccgtgcagta ctcctgccgc ctcctgaacc tcgatggcac ctgtgctgac agctactcct
      541 tcgtgttttc ccgggacccc aacggcctgc ccccagaagc gcagaagatt gtaaggcagc
      601 ggcaggagga gctgtgcctg gccaggcagt acaggctgat cgtccacaac ggttactgcg
      661 atggcagatc agaaagaaac cttttgtagc aatatcaaga atctagtttc atctgagaac
      721 ttctgattag ctctcagtct tcagctctat ttatcttagg agtttaattt gcccttctct
      781 ccccatcttc cctcagttcc cataaaacct tcattacaca taaagataca cgtgggggtc
      841 agtgaatctg cttgcctttc ctgaaagttt ctggggctta agattccaga ctctgattca
      901 ttaaactata gtcacccgtg tcctgtgatt ttagttttca tttgtgttta tgtctgtgct
      961 gcagacggat gggtggggtg cgcttcttta taccaggagc acgtggctct ttctgacctt
     1021 tggcctgttc tagtgcctaa tctccattat taaatactgg cttctcccaa
//
