LOCUS       NP_006735                201 aa            linear   PRI 27-APR-2025
DEFINITION  retinol-binding protein 4 isoform a precursor [Homo sapiens].
ACCESSION   NP_006735
VERSION     NP_006735.2
DBSOURCE    REFSEQ: accession NM_006744.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 201)
  AUTHORS   Fan,J. and Hu,J.
  TITLE     Retinol binding protein 4 and type 2 diabetes: from insulin
            resistance to pancreatic beta-cell function
  JOURNAL   Endocrine 85 (3), 1020-1034 (2024)
   PUBMED   38520616
  REMARK    GeneRIF: Retinol binding protein 4 and type 2 diabetes: from
            insulin resistance to pancreatic beta-cell function.
            Review article
REFERENCE   2  (residues 1 to 201)
  AUTHORS   Wang,H., Zhang,Z., Xie,L., Lu,K., Zhang,S. and Xing,S.
  TITLE     Retinol and retinol binding protein 4 levels and COVID-19: a
            Mendelian randomization study
  JOURNAL   BMC Pulm Med 24 (1), 206 (2024)
   PUBMED   38671384
  REMARK    GeneRIF: Retinol and retinol binding protein 4 levels and COVID-19:
            a Mendelian randomization study.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 201)
  AUTHORS   Rychter,A.M., Skrzypczak-Zielinska,M., Naskret,D., Michalak,M.,
            Zawada,A., Walczak,M., Slomski,R., Dobrowolska,A. and
            Krela-Kazmierczak,I.
  TITLE     Are variants of the RBP4 gene associated with serum retinol-binding
            protein 4 concentrations and carotid intima-media thickness values
            in women with obesity?
  JOURNAL   Gene 893, 147909 (2024)
   PUBMED   37858746
  REMARK    GeneRIF: Are variants of the RBP4 gene associated with serum
            retinol-binding protein 4 concentrations and carotid intima-media
            thickness values in women with obesity?
REFERENCE   4  (residues 1 to 201)
  AUTHORS   Oluwamodupe,C. and Adeleye,A.O.
  TITLE     Targeting Retinol-Binding Protein 4 (RBP4) in the Management of
            Cardiometabolic Diseases
  JOURNAL   Cardiovasc Toxicol 23 (9-10), 285-294 (2023)
   PUBMED   37587250
  REMARK    GeneRIF: Targeting Retinol-Binding Protein 4 (RBP4) in the
            Management of Cardiometabolic Diseases.
            Review article
REFERENCE   5  (residues 1 to 201)
  AUTHORS   Kiuchi,S., Ihara,H., Sega,M., Tani,A., Nishiguchi,Y. and
            Hashizume,N.
  TITLE     Does Retinol-Binding Protein 4 (holo- and apo-RBP4) Increase or
            Remain Constant in Sera from Patients with Hypothyroidism?
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 69 (6), 412-419 (2023)
   PUBMED   38171813
  REMARK    GeneRIF: Does Retinol-Binding Protein 4 (holo- and apo-RBP4)
            Increase or Remain Constant in Sera from Patients with
            Hypothyroidism?
REFERENCE   6  (residues 1 to 201)
  AUTHORS   Monaco,H.L. and Zanotti,G.
  TITLE     Three-dimensional structure and active site of three hydrophobic
            molecule-binding proteins with significant amino acid sequence
            similarity
  JOURNAL   Biopolymers 32 (4), 457-465 (1992)
   PUBMED   1623143
REFERENCE   7  (residues 1 to 201)
  AUTHORS   Fex,G., Albertsson,P.A. and Hansson,B.
  TITLE     Interaction between prealbumin and retinol-binding protein studied
            by affinity chromatography, gel filtration and two-phase partition
  JOURNAL   Eur J Biochem 99 (2), 353-360 (1979)
   PUBMED   574085
REFERENCE   8  (residues 1 to 201)
  AUTHORS   Rask,L., Anundi,H. and Peterson,P.A.
  TITLE     The primary structure of the human retinol-binding protein
  JOURNAL   FEBS Lett 104 (1), 55-58 (1979)
   PUBMED   573217
REFERENCE   9  (residues 1 to 201)
  AUTHORS   Fex,G. and Hansson,B.
  TITLE     Retinol-binding protein from human urine and its interaction with
            retinol and prealbumin
  JOURNAL   Eur J Biochem 94 (1), 307-313 (1979)
   PUBMED   571335
REFERENCE   10 (residues 1 to 201)
  AUTHORS   Kopelman,M., Cogan,U., Mokady,S. and Shinitzky,M.
  TITLE     The interaction between retinol-binding proteins and prealbumins
            studied by fluorescence polarization
  JOURNAL   Biochim Biophys Acta 439 (2), 449-460 (1976)
   PUBMED   986177
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020633.1, X00129.1,
            BX495987.1 and AL356214.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 15, 2004 this sequence version replaced NP_006735.1.
            
            Summary:  This protein belongs to the lipocalin family and is the
            specific carrier for retinol (vitamin A alcohol) in the blood. It
            delivers retinol from the liver stores to the peripheral tissues.
            In plasma, the RBP-retinol complex interacts with transthyretin
            which prevents its loss by filtration through the kidney glomeruli.
            A deficiency of vitamin A blocks secretion of the binding protein
            posttranslationally and results in defective delivery and supply to
            the epidermal cells. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) and variant 2 both encode
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.257918.1,
                                           SRR5189664.138123.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371464.8/ ENSP00000360519.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..201
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     Protein         1..201
                     /product="retinol-binding protein 4 isoform a precursor"
                     /note="retinol-binding protein 4, interstitial; RBP; PRBP;
                     plasma retinol-binding protein; retinol binding protein 4,
                     plasma"
                     /calculated_mol_wt=21072
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1956
     mat_peptide     19..201
                     /product="retinol-binding protein 4 isoform a"
                     /calculated_mol_wt=21072
     Region          22..192
                     /region_name="lipocalin_RBP_like"
                     /note="retinol-binding protein 4 and similar proteins;
                     cd00743"
                     /db_xref="CDD:381184"
     Site            order(38,42,47,50,53..55,61,63,71,73..75,79,81,91..93,95,
                     104,106,108,114..116,120,122,124,133,135,137,139,151,153,
                     155)
                     /site_type="other"
                     /note="ligand binding cavity [chemical binding]"
                     /db_xref="CDD:381184"
     Site            order(47,50,53..55,61,63,73..75,79,81,91..93,95,106,108,
                     114..116,120,122,135,139,151,153,155)
                     /site_type="other"
                     /note="retinol binding site [chemical binding]"
                     /db_xref="CDD:381184"
     Site            order(81..85,107,109,113..117)
                     /site_type="other"
                     /note="transthyretin interface [polypeptide binding]"
                     /db_xref="CDD:381184"
     Site            139
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q00724; propagated from
                     UniProtKB/Swiss-Prot (P02753.3)"
     CDS             1..201
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /coded_by="NM_006744.4:84..689"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS31249.1"
                     /db_xref="GeneID:5950"
                     /db_xref="HGNC:HGNC:9922"
                     /db_xref="MIM:180250"
ORIGIN      
        1 mkwvwallll aalgsgraer dcrvssfrvk enfdkarfsg twyamakkdp eglflqdniv
       61 aefsvdetgq msatakgrvr llnnwdvcad mvgtftdted pakfkmkywg vasflqkgnd
      121 dhwivdtdyd tyavqyscrl lnldgtcads ysfvfsrdpn glppeaqkiv rqrqeelcla
      181 rqyrlivhng ycdgrsernl l
//
