LOCUS       NM_001323518            1009 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens retinol binding protein 4 (RBP4), transcript variant
            3, mRNA.
ACCESSION   NM_001323518
VERSION     NM_001323518.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1009)
  AUTHORS   Fan,J. and Hu,J.
  TITLE     Retinol binding protein 4 and type 2 diabetes: from insulin
            resistance to pancreatic beta-cell function
  JOURNAL   Endocrine 85 (3), 1020-1034 (2024)
   PUBMED   38520616
  REMARK    GeneRIF: Retinol binding protein 4 and type 2 diabetes: from
            insulin resistance to pancreatic beta-cell function.
            Review article
REFERENCE   2  (bases 1 to 1009)
  AUTHORS   Wang,H., Zhang,Z., Xie,L., Lu,K., Zhang,S. and Xing,S.
  TITLE     Retinol and retinol binding protein 4 levels and COVID-19: a
            Mendelian randomization study
  JOURNAL   BMC Pulm Med 24 (1), 206 (2024)
   PUBMED   38671384
  REMARK    GeneRIF: Retinol and retinol binding protein 4 levels and COVID-19:
            a Mendelian randomization study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1009)
  AUTHORS   Rychter,A.M., Skrzypczak-Zielinska,M., Naskret,D., Michalak,M.,
            Zawada,A., Walczak,M., Slomski,R., Dobrowolska,A. and
            Krela-Kazmierczak,I.
  TITLE     Are variants of the RBP4 gene associated with serum retinol-binding
            protein 4 concentrations and carotid intima-media thickness values
            in women with obesity?
  JOURNAL   Gene 893, 147909 (2024)
   PUBMED   37858746
  REMARK    GeneRIF: Are variants of the RBP4 gene associated with serum
            retinol-binding protein 4 concentrations and carotid intima-media
            thickness values in women with obesity?
REFERENCE   4  (bases 1 to 1009)
  AUTHORS   Oluwamodupe,C. and Adeleye,A.O.
  TITLE     Targeting Retinol-Binding Protein 4 (RBP4) in the Management of
            Cardiometabolic Diseases
  JOURNAL   Cardiovasc Toxicol 23 (9-10), 285-294 (2023)
   PUBMED   37587250
  REMARK    GeneRIF: Targeting Retinol-Binding Protein 4 (RBP4) in the
            Management of Cardiometabolic Diseases.
            Review article
REFERENCE   5  (bases 1 to 1009)
  AUTHORS   Kiuchi,S., Ihara,H., Sega,M., Tani,A., Nishiguchi,Y. and
            Hashizume,N.
  TITLE     Does Retinol-Binding Protein 4 (holo- and apo-RBP4) Increase or
            Remain Constant in Sera from Patients with Hypothyroidism?
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 69 (6), 412-419 (2023)
   PUBMED   38171813
  REMARK    GeneRIF: Does Retinol-Binding Protein 4 (holo- and apo-RBP4)
            Increase or Remain Constant in Sera from Patients with
            Hypothyroidism?
REFERENCE   6  (bases 1 to 1009)
  AUTHORS   Monaco,H.L. and Zanotti,G.
  TITLE     Three-dimensional structure and active site of three hydrophobic
            molecule-binding proteins with significant amino acid sequence
            similarity
  JOURNAL   Biopolymers 32 (4), 457-465 (1992)
   PUBMED   1623143
REFERENCE   7  (bases 1 to 1009)
  AUTHORS   Fex,G., Albertsson,P.A. and Hansson,B.
  TITLE     Interaction between prealbumin and retinol-binding protein studied
            by affinity chromatography, gel filtration and two-phase partition
  JOURNAL   Eur J Biochem 99 (2), 353-360 (1979)
   PUBMED   574085
REFERENCE   8  (bases 1 to 1009)
  AUTHORS   Rask,L., Anundi,H. and Peterson,P.A.
  TITLE     The primary structure of the human retinol-binding protein
  JOURNAL   FEBS Lett 104 (1), 55-58 (1979)
   PUBMED   573217
REFERENCE   9  (bases 1 to 1009)
  AUTHORS   Fex,G. and Hansson,B.
  TITLE     Retinol-binding protein from human urine and its interaction with
            retinol and prealbumin
  JOURNAL   Eur J Biochem 94 (1), 307-313 (1979)
   PUBMED   571335
REFERENCE   10 (bases 1 to 1009)
  AUTHORS   Kopelman,M., Cogan,U., Mokady,S. and Shinitzky,M.
  TITLE     The interaction between retinol-binding proteins and prealbumins
            studied by fluorescence polarization
  JOURNAL   Biochim Biophys Acta 439 (2), 449-460 (1976)
   PUBMED   986177
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG565176.1, AL356214.20,
            BC020633.1 and BI712834.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001323518.1.
            
            Summary:  This protein belongs to the lipocalin family and is the
            specific carrier for retinol (vitamin A alcohol) in the blood. It
            delivers retinol from the liver stores to the peripheral tissues.
            In plasma, the RBP-retinol complex interacts with transthyretin
            which prevents its loss by filtration through the kidney glomeruli.
            A deficiency of vitamin A blocks secretion of the binding protein
            posttranslationally and results in defective delivery and supply to
            the epidermal cells. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG565176.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2142680,
                                           SAMEA2145122 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BG565176.1         2-74
            74-74               AL356214.20        117821-117821       c
            75-377              BG565176.1         76-378
            378-857             BC020633.1         440-919
            858-867             BI712834.1         23-32               c
            868-1009            AL356214.20        107844-107985       c
FEATURES             Location/Qualifiers
     source          1..1009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..1009
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /note="retinol binding protein 4"
                     /db_xref="GeneID:5950"
                     /db_xref="HGNC:HGNC:9922"
                     /db_xref="MIM:180250"
     exon            1..79
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..628
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /note="isoform b is encoded by transcript variant 3;
                     retinol-binding protein 4, interstitial; RBP; PRBP; plasma
                     retinol-binding protein; retinol binding protein 4,
                     plasma"
                     /codon_start=1
                     /product="retinol-binding protein 4 isoform b"
                     /protein_id="NP_001310447.1"
                     /db_xref="CCDS:CCDS81488.1"
                     /db_xref="GeneID:5950"
                     /db_xref="HGNC:HGNC:9922"
                     /db_xref="MIM:180250"
                     /translation="MNYSKIPAQVDLRRQTERDCRVSSFRVKENFDKARFSGTWYAMA
                     KKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKF
                     KMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGL
                     PPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL"
     exon            80..133
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            134..270
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            271..377
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            378..590
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /inference="alignment:Splign:2.1.0"
     exon            591..1009
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      839..844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /note="hexamer: ATTAAA"
     polyA_site      859
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /note="major polyA site"
     regulatory      988..993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
                     /note="hexamer: ATTAAA"
     polyA_site      1009
                     /gene="RBP4"
                     /gene_synonym="MCOPCB10; RDCCAS"
ORIGIN      
        1 atcctttata aaatgaaaaa ctacttggat gaattattcc aaaattcctg cacaagtgga
       61 cctcagaagg cagacggagc gcgactgccg agtgagcagc ttccgagtca aggagaactt
      121 cgacaaggct cgcttctctg ggacctggta cgccatggcc aagaaggacc ccgagggcct
      181 ctttctgcag gacaacatcg tcgcggagtt ctccgtggac gagaccggcc agatgagcgc
      241 cacagccaag ggccgagtcc gtcttttgaa taactgggac gtgtgcgcag acatggtggg
      301 caccttcaca gacaccgagg accctgccaa gttcaagatg aagtactggg gcgtagcctc
      361 ctttctccag aaaggaaatg atgaccactg gatcgtcgac acagactacg acacgtatgc
      421 cgtgcagtac tcctgccgcc tcctgaacct cgatggcacc tgtgctgaca gctactcctt
      481 cgtgttttcc cgggacccca acggcctgcc cccagaagcg cagaagattg taaggcagcg
      541 gcaggaggag ctgtgcctgg ccaggcagta caggctgatc gtccacaacg gttactgcga
      601 tggcagatca gaaagaaacc ttttgtagca atatcaagaa tctagtttca tctgagaact
      661 tctgattagc tctcagtctt cagctctatt tatcttagga gtttaatttg cccttctctc
      721 cccatcttcc ctcagttccc ataaaacctt cattacacat aaagatacac gtgggggtca
      781 gtgaatctgc ttgcctttcc tgaaagtttc tggggcttaa gattccagac tctgattcat
      841 taaactatag tcacccgtgt cctgtgattt tagttttcat ttgtgtttat gtctgtgctg
      901 cagacggatg ggtggggtgc gcttctttat accaggagca cgtggctctt tctgaccttt
      961 ggcctgttct agtgcctaat ctccattatt aaatactggc ttctcccaa
//
