LOCUS       NM_004164                694 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens retinol binding protein 2 (RBP2), mRNA.
ACCESSION   NM_004164
VERSION     NM_004164.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 694)
  AUTHORS   Feng,T.F., Yao,D.M., Zheng,R., Jiang,D.S., Zhang,L.L., Xing,Q. and
            Li,L.
  TITLE     [Effect of RBP2 gene silencing on proliferation, migration and
            invasion of ovarian epithelial cancer SKOV3/DDP cells and its
            mechanism]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 44 (2), 139-146 (2022)
   PUBMED   35184457
  REMARK    GeneRIF: [Effect of RBP2 gene silencing on proliferation, migration
            and invasion of ovarian epithelial cancer SKOV3/DDP cells and its
            mechanism].
REFERENCE   2  (bases 1 to 694)
  AUTHORS   Silvaroli,J.A., Plau,J., Adams,C.H., Banerjee,S.,
            Widjaja-Adhi,M.A.K., Blaner,W.S. and Golczak,M.
  TITLE     Molecular basis for the interaction of cellular retinol binding
            protein 2 (CRBP2) with nonretinoid ligands
  JOURNAL   J Lipid Res 62, 100054 (2021)
   PUBMED   33631211
  REMARK    GeneRIF: Molecular basis for the interaction of cellular retinol
            binding protein 2 (CRBP2) with nonretinoid ligands.
REFERENCE   3  (bases 1 to 694)
  AUTHORS   Menozzi,I., Polverini,E. and Berni,R.
  TITLE     Deciphering protein dynamics changes along the pathway of retinol
            uptake by cellular retinol-binding proteins 1 and 2
  JOURNAL   Arch Biochem Biophys 645, 107-116 (2018)
   PUBMED   29567208
  REMARK    GeneRIF: molecular dynamics simulations for the uptake of retinol
            by CRBP 1 and 2
REFERENCE   4  (bases 1 to 694)
  AUTHORS   Yu,X., Chen,H., Zuo,C., Jin,X., Yin,Y., Wang,H., Jin,M., Ozato,K.
            and Xu,S.
  TITLE     Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by
            Rbp2 through interacting with Piasy for transcriptional attenuation
  JOURNAL   FASEB J 32 (2), 552-567 (2018)
   PUBMED   28970247
  REMARK    GeneRIF: study demonstrates that Piasy may prevent exaggerated
            transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of
            IFNI, avoiding excessive immune responses
REFERENCE   5  (bases 1 to 694)
  AUTHORS   Zargar,Z.U., Kimidi,M.R. and Tyagi,S.
  TITLE     Dynamic site-specific recruitment of RBP2 by pocket protein p130
            modulates H3K4 methylation on E2F-responsive promoters
  JOURNAL   Nucleic Acids Res 46 (1), 174-188 (2018)
   PUBMED   29059406
REFERENCE   6  (bases 1 to 694)
  AUTHORS   Herr,F.M. and Ong,D.E.
  TITLE     Differential interaction of lecithin-retinol acyltransferase with
            cellular retinol binding proteins
  JOURNAL   Biochemistry 31 (29), 6748-6755 (1992)
   PUBMED   1322170
REFERENCE   7  (bases 1 to 694)
  AUTHORS   Inagami,S. and Ong,D.E.
  TITLE     Purification and partial characterization of cellular
            retinol-binding protein, type two, from human small intestine
  JOURNAL   J Nutr 122 (3), 450-456 (1992)
   PUBMED   1542003
REFERENCE   8  (bases 1 to 694)
  AUTHORS   Astrom,A., Tavakkol,A., Pettersson,U., Cromie,M., Elder,J.T. and
            Voorhees,J.J.
  TITLE     Molecular cloning of two human cellular retinoic acid-binding
            proteins (CRABP). Retinoic acid-induced expression of CRABP-II but
            not CRABP-I in adult human skin in vivo and in skin fibroblasts in
            vitro
  JOURNAL   J Biol Chem 266 (26), 17662-17666 (1991)
   PUBMED   1654334
REFERENCE   9  (bases 1 to 694)
  AUTHORS   Colantuoni,V., Cortese,R., Nilsson,M., Lundvall,J., Bavik,C.O.,
            Eriksson,U., Peterson,P.A. and Sundelin,J.
  TITLE     Cloning and sequencing of a full length cDNA corresponding to human
            cellular retinol-binding protein
  JOURNAL   Biochem Biophys Res Commun 130 (1), 431-439 (1985)
   PUBMED   2992469
REFERENCE   10 (bases 1 to 694)
  AUTHORS   van Eijk,H.G., Tio,T.H. and Bos,G.
  TITLE     Iron in skin biopsies
  JOURNAL   Arch Dermatol Forsch 251 (3), 245-248 (1975)
   PUBMED   1115525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097103.8, BX282005.1 and
            AW772327.1.
            
            On May 17, 2019 this sequence version replaced NM_004164.2.
            
            Summary: This gene encodes an abundant protein present in the small
            intestinal epithelium. It is thought to participate in the uptake
            and/or intracellular metabolism of vitamin A. Vitamin A is a
            fat-soluble vitamin necessary for growth, reproduction,
            differentiation of epithelial tissues, and vision. This protein may
            also modulate the supply of retinoic acid to the nuclei of
            endometrial cells during the menstrual cycle. [provided by RefSeq,
            Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW772327.1, AK291978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000232217.6/ ENSP00000232217.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC097103.8         33652-33657
            7-309               BX282005.1         128-430
            310-694             AW772327.1         1-385               c
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..694
                     /gene="RBP2"
                     /gene_synonym="CRABP-II; CRBP2; CRBPII; RBPC2"
                     /note="retinol binding protein 2"
                     /db_xref="GeneID:5948"
                     /db_xref="HGNC:HGNC:9920"
                     /db_xref="MIM:180280"
     exon            1..130
                     /gene="RBP2"
                     /gene_synonym="CRABP-II; CRBP2; CRBPII; RBPC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..462
                     /gene="RBP2"
                     /gene_synonym="CRABP-II; CRBP2; CRBPII; RBPC2"
                     /note="CRBP-II; cellular retinol-binding protein II;
                     retinol binding protein 2, cellular"
                     /codon_start=1
                     /product="retinol-binding protein 2"
                     /protein_id="NP_004155.2"
                     /db_xref="CCDS:CCDS3109.1"
                     /db_xref="GeneID:5948"
                     /db_xref="HGNC:HGNC:9920"
                     /db_xref="MIM:180280"
                     /translation="MTRDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKVID
                     QDGDNFKTKTTSTFRNYDVDFTVGVEFDEYTKSLDNRHVKALVTWEGDVLVCVQKGEK
                     ENRGWKQWIEGDKLYLELTCGDQVCRQVFKKK"
     exon            131..309
                     /gene="RBP2"
                     /gene_synonym="CRABP-II; CRBP2; CRBPII; RBPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            310..411
                     /gene="RBP2"
                     /gene_synonym="CRABP-II; CRBP2; CRBPII; RBPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..694
                     /gene="RBP2"
                     /gene_synonym="CRABP-II; CRBP2; CRBPII; RBPC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      661..666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RBP2"
                     /gene_synonym="CRABP-II; CRBP2; CRBPII; RBPC2"
                     /note="hexamer: AACAAA"
     polyA_site      694
                     /gene="RBP2"
                     /gene_synonym="CRABP-II; CRBP2; CRBPII; RBPC2"
                     /note="major polyA site"
ORIGIN      
        1 ctgcagcctg ctccttgcca tccaccacaa accctcaccg aaccagtggc caccaccatg
       61 acaagggacc agaatggaac ctgggagatg gagagtaatg aaaactttga gggctacatg
      121 aaggccctgg atattgattt tgccacccgc aagattgcag tacgtctcac tcagacgaag
      181 gttattgatc aagatggtga taacttcaag acaaaaacca ctagcacatt ccgcaactat
      241 gatgtggatt tcactgttgg agtagagttt gacgagtaca caaagagcct ggataaccgg
      301 catgttaagg cactggtcac ctgggaaggt gatgtccttg tgtgtgtgca aaagggggag
      361 aaggagaacc gcggctggaa gcagtggatt gagggggaca agctgtacct ggagctgacc
      421 tgtggtgacc aggtgtgccg tcaagtgttc aaaaagaaat gatggcgacg tgggaggcct
      481 gccaagcaca agctccccac tgcccacact gagtggtcta ctggctttga gaaacagctg
      541 tggggacctt cccactcttg acagagcccc attaaggcat ctgggtgggt tttaaacaga
      601 atgcctatgt agcagtgata gacatattcc cctcctttga aacctagcat taaatggaaa
      661 aacaaaaatt actcccatat tttgaaaccc ttta
//
